Abstract:
:We examined auto-correlation and interval distribution characteristics of neuronal discharge from patients with complex partial seizures. The objective was to compare the interictal firing patterns of neurons in mesial temporal structures ipsilateral to the site of seizure onset with firing patterns of neurons in homologous contralateral structures. Spontaneous interictal recordings of 258 single neurons were acquired from 23 patients. A "burst area" measure was derived from the neuronal auto-correlation to assess the likelihood of grouped action potential discharge (burst discharge). Large burst area measures indicate a tendency for single neuronal burst discharge, but do not disclose information about interspike intervals within bursts. Although several measures based on single neuronal interspike interval distributions showed no overall difference between hemispheres, burst area was significantly reduced in mesial temporal structures ipsilateral to the site of seizure onset. Possible mechanisms of decreased burst discharge in epileptogenic regions include selective loss of burst-discharging neurons and increased recurrent inhibition.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Colder BW,Frysinger RC,Wilson CL,Harper RM,Engel J Jrdoi
10.1111/j.1528-1157.1996.tb00001.xsubject
Has Abstractpub_date
1996-02-01 00:00:00pages
113-21issue
2eissn
0013-9580issn
1528-1167journal_volume
37pub_type
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