Voxel-based morphometry of sporadic epileptic patients with mesiotemporal sclerosis.

abstract：PURPOSE:Validity studies on health-related quality of life (HRQOL) scales for pediatric epilepsy are few, and cross-validation with other samples has not been reported. This study was designed to assess the validity of three parent-rated measures of HRQOL in pediatric epilepsy: (a) the Impact of Childhood Illness Scale...

journal_title：Epilepsia

authors： Sherman EM,Slick DJ,Connolly MB,Steinbok P,Camfield C,Eyrl KL,Massey C,Farrell K

更新日期：2002-10-01 00:00:00

abstract：:The aim was to systematically review studies that have focused on symptoms of anxiety reported by parents of children (0-18 years) with epilepsy. PubMed was used to identify relevant studies. Selected studies were reviewed with respect to prevalence of above threshold scores and comparisons with controls on standardiz...

journal_title：Epilepsia

authors： Jones C,Reilly C

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:To assess anger/hostility during treatment with lamotrigine adjunctive therapy versus levetiracetam adjunctive therapy in patients with partial seizures. METHODS:This randomized, double-blind, parallel-group study in adults with partial seizures included an 8-week escalation phase, during which adjunctive lamo...

journal_title：Epilepsia

authors： Labiner DM,Ettinger AB,Fakhoury TA,Chung SS,Shneker B,Tatum Iv WO,Mitchell Miller J,Vuong A,Hammer AE,Messenheimer JA

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. METHODS:A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical I...

journal_title：Epilepsia

authors： Mady MA,Kossoff EH,McGregor AL,Wheless JW,Pyzik PL,Freeman JM

更新日期：2003-06-01 00:00:00

abstract：:Our study investigated public attitudes toward epilepsy, and knowledge and understanding of epilepsy in Hungary. We compared changes of public attitudes in the last six years, hypothesizing a trend of positive changes because of recent national initiatives for acceptance and integration of people with epilepsy (e.g., ...

journal_title：Epilepsia

authors： Mirnics Z,Czikora G,Závecz T,Halász P

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Ablation surgery has become the first line of treatment for hypothalamic hamartomas (HHs). For effective treatment, optimum targeting of ablation is mandatory. The present study aimed to evaluate the correspondence between the electrophysiological features of HHs and morphological targeting by semimicrorecord...

journal_title：Epilepsia

authors： Shirozu H,Masuda H,Kameyama S

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome. Here we describe imaging features of subtle parahippocampal dysplasia in five cases that were ...

journal_title：Epilepsia

authors： Pillay N,Fabinyi GC,Myles TS,Fitt GJ,Berkovic SF,Jackson GD

更新日期：2009-12-01 00:00:00

abstract：PURPOSE:To evaluate the pharmacokinetics and safety of multiple oral doses of tiagabine HCl in subjects with different degrees of hepatic impairment. METHODS:Four subjects with mild hepatic impairment, three subjects with moderate hepatic impairment, and six matched normal subjects received twice daily oral tiagabine ...

journal_title：Epilepsia

authors： Lau AH,Gustavson LE,Sperelakis R,Lam NP,El-Shourbagy T,Qian JX,Layden T

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To identify features of ablations and trajectories that correlate with optimal seizure control and minimize the risk of neurocognitive deficits in patients undergoing laser interstitial thermal therapy (LiTT) for mesiotemporal epilepsy (mTLE). METHODS:Clinical and radiographic data were reviewed from a prosp...

journal_title：Epilepsia

authors： Jermakowicz WJ,Kanner AM,Sur S,Bermudez C,D'Haese PF,Kolcun JPG,Cajigas I,Li R,Millan C,Ribot R,Serrano EA,Velez N,Lowe MR,Rey GJ,Jagid JR

更新日期：2017-05-01 00:00:00

abstract：:Nonconvulsive status epilepticus may be subdivided into generalized (absence) status and complex partial status. The latter is regarded as a rarity, whereas the former constitutes the dominant part of the hitherto reported cases. We report 10 consecutive cases of adult patients with nonconvulsive status epilepticus, a...

journal_title：Epilepsia

authors： Tomson T,Svanborg E,Wedlund JE

更新日期：1986-05-01 00:00:00

abstract：:To study the effect of age on seizure latency, intensity, reproducibility, and mortality in genetically epilepsy-prone rats of the severe colony (GEPR-9s), 472 seizure-naive rats, ranging in age from 14 to 65 days, received a series of three audiogenic stimulations. Both the percentage of rats having one or more seizu...

journal_title：Epilepsia

authors： Thompson JL,Carl FG,Holmes GL

更新日期：1991-03-01 00:00:00

abstract：OBJECTIVE:Stress is a known trigger for seizures in patients with epilepsy (PWE). However, the association between stress and seizures has not been thoroughly investigated. In December 2019, an outbreak of coronavirus disease (COVID-19) occurred in Wuhan, Hubei province, China, causing tremendous collateral stress. Thi...

journal_title：Epilepsia

authors： Huang S,Wu C,Jia Y,Li G,Zhu Z,Lu K,Yang Y,Wang F,Zhu S

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous malformations (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis of epilepsy in patients with vascular malformations. Intracerebral deposits of iron-containi...

journal_title：Epilepsia

authors： Raabe A,Schmitz AK,Pernhorst K,Grote A,von der Brelie C,Urbach H,Friedman A,Becker AJ,Elger CE,Niehusmann P

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Despite the reported diagnostic value of the intracarotid amobarbital procedure (IAP) or "Wada test" for determining hemispheric lateralization and memory functioning, it has never undergone formal reliability testing because a prospective test-retest study design is neither feasible nor ethical. However, some ...

journal_title：Epilepsia

authors： Whitman LA,Morrison CE,Becske T,Barr WB,Carlson C

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Dravet syndrome (DS) or severe myoclonic epilepsy of infancy is an intractable epileptic encephalopathy of early childhood that is caused by a mutation in the SCN1A gene in most patients. The aim of this study was to identify a syndrome-specific epileptic network underlying interictal epileptiform discharges (I...

journal_title：Epilepsia

authors： Moehring J,von Spiczak S,Moeller F,Helbig I,Wolff S,Jansen O,Muhle H,Boor R,Stephani U,Siniatchkin M

更新日期：2013-05-01 00:00:00

abstract：:We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG di...

journal_title：Epilepsia

authors： Kumlien E,Bergström M,Lilja A,Andersson J,Szekeres V,Westerberg CE,Westerberg G,Antoni G,Långström B

更新日期：1995-07-01 00:00:00

abstract：:Use of antiepileptic drugs (AEDs) in pregnant women with epilepsy (WWE) is associated with an increased risk of major congenital malformations (MCM). Previous studies have suggested that WWE who had a malformation in their index pregnancy were at an increased risk of recurrence in future pregnancies. We aimed to asses...

journal_title：Epilepsia

authors： Begum S,Sarma SP,Thomas SV

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Because several reports have described the relation between epilepsy and cardiac arrhythmias and suggest that changes in autonomic neural control of the heart could be involved in the pathogenesis of sudden unexplained death in patients with epilepsy, the aim of this study was to evaluate cardiac function in pa...

journal_title：Epilepsia

authors： Massetani R,Strata G,Galli R,Gori S,Gneri C,Limbruno U,Di Santo D,Mariani M,Murri L

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:To advance the development of (2S,3S)-sec-butylpropylacetamide (SPD) as a new treatment for acute repetitive seizures (ARS), by studying its pharmacokinetics (PK) in pigs and its PK-pharmacodynamic (PK-PD) correlation in rats. METHODS:Two (2S,3S)-SPD intramuscular formulations (FA and FB ) were administered...

journal_title：Epilepsia

authors： Bibi D,Bialer M

更新日期：2020-01-01 00:00:00

abstract：:Patients with epilepsy have 20-fold risk of sudden death when compared to the general population. Uncontrolled seizures is the most consistent risk factor, and death often occurs at night or in relation to sleep. We examined seizure-related respiratory disturbances in sleep versus wakefulness, focusing on periictal ox...

journal_title：Epilepsia

authors： Latreille V,Abdennadher M,Dworetzky BA,Ramel J,White D,Katz E,Zarowski M,Kothare S,Pavlova M

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:To test the sensitivity of extracranial magnetoencephalography (MEG) for epileptic spikes in different cerebral sites. METHODS:We simultaneously recorded MEG and electrocorticography (ECoG) by using subdural electrodes with 1-cm interelectrode distances for one patient with lateral frontal epilepsy and one pat...

journal_title：Epilepsia

authors： Oishi M,Otsubo H,Kameyama S,Morota N,Masuda H,Kitayama M,Tanaka R

更新日期：2002-11-01 00:00:00

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Some evidence suggests that levetiracetam (LEV) possesses antiepileptogenic characteristics. The purpose of this study was to investigate the time course of seizure protection by LEV compared with that of phenytoin (PHT), phenobarbital (PB), valproate (VPA), and carbamazepine (CBZ) in the spontaneously epilepti...

journal_title：Epilepsia

authors： Ji-qun C,Ishihara K,Nagayama T,Serikawa T,Sasa M

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To evaluate the safety, tolerability, and efficacy of long-term pregabalin as add-on therapy for patients with poorly controlled partial seizures. METHODS:Analysis of data from six long-term clinical trials involving 2,061 patients receiving open-label pregabalin 75-600 mg/day adjunctive therapy for partial on...

journal_title：Epilepsia

authors： Uthman BM,Bazil CW,Beydoun A,Schulze-Bonhage A,Benabou R,Whalen E,Emir B,Griesing T,Leon T

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:The presence of specific neurocognitive deficits may help explain why school achievement and psychosocial functioning are often worse in children with epilepsy than would be predicted by their global intellectual functioning. This study compared children with two forms of epilepsy: localization-related epilepsy...

journal_title：Epilepsia

authors： Kernan CL,Asarnow R,Siddarth P,Gurbani S,Lanphier EK,Sankar R,Caplan R

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To evaluate the antiepileptic and neuroprotective properties of topiramate (TPM) alone and with coadministration of the N-methyl-D-aspartate (NMDA)-receptor antagonist budipine in a rat model of refractory status epilepticus. METHODS:Male Sprague-Dawley rats had electrodes implanted into the perforant path and...

journal_title：Epilepsia

authors： Fisher A,Wang X,Cock HR,Thom M,Patsalos PN,Walker MC

更新日期：2004-11-01 00:00:00

abstract：:Benzodiazepines (BDZ) interact with components of neuronal membranes to modify excitability in three different ways. Action at a high affinity central receptor (dissociation constant, KD, of 3 nM) linked to the GABAA recognition site enhances the inhibitory action of GABA by increasing the number of openings of Cl- ch...

journal_title：Epilepsia

authors： Meldrum BS,Chapman AG

更新日期：1986-01-01 00:00:00

abstract：:An 8-year-old Chinese girl had a first episode of symptomatic partial epilepsy at age 2 years. Despite regular treatment with antiepileptic drugs (AEDs), the seizures remitted and exacerbated. Epileptiform EEG discharges were evident, arising from the left centroparietal region. Magnetic resonance imaging (MRI) and co...

journal_title：Epilepsia

authors： Wang PJ,Liu HM,Young C,Lin MY,Shen YZ

更新日期：1994-11-01 00:00:00

abstract：:Lennox-Gastaut syndrome (LGS) is a rare epileptic encephalopathy with a peak age of onset of 3-5 years of age. Reported prevalence rates for LGS vary widely from 1-10% of all childhood epilepsies. Incidence rates are much lower. LGS is characterized by intractable, multiple, generalized seizure types and an interictal...

journal_title：Epilepsia

authors： Camfield PR

更新日期：2011-08-01 00:00:00

abstract：:We present a review of phenotype-genotype correlation and the genetics of photosensitivity. The photoparoxysmal response in EEG (PPR) is still one of the best paradigms for exogenously triggered brain responses based on a genetic predisposition. The definition of the PPR phenotype requires multiple, precise methodolog...

journal_title：Epilepsia

authors： Stephani U,Tauer U,Koeleman B,Pinto D,Neubauer BA,Lindhout D

更新日期：2004-01-01 00:00:00