Nitric oxide synthase expression in the cerebral cortex of patients with epilepsy.

abstract：:The effect of short-term withdrawal of antiepileptic drugs (AEDs) on auditory event-related potentials (ERPs) was studied in 16 patients undergoing preoperative evaluation for epilepsy surgery. ERPs were performed for all patients during treatment with full medication and after a 1-week period during ongoing tapering ...

journal_title：Epilepsia

authors： Tuunainen A,Nousiainen U,Pilke A,Mervaala E,Riekkinen P

更新日期：1995-03-01 00:00:00

abstract：:The Commission on Classification and Terminology and the Commission on Epidemiology of the International League Against Epilepsy (ILAE) have charged a Task Force to revise concepts, definition, and classification of status epilepticus (SE). The proposed new definition of SE is as follows: Status epilepticus is a condi...

journal_title：Epilepsia

authors： Trinka E,Cock H,Hesdorffer D,Rossetti AO,Scheffer IE,Shinnar S,Shorvon S,Lowenstein DH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Prior single-photon emission tomography studies showed losses of muscarinic acetylcholine receptor (MAChR) binding in patients with refractory mesial temporal lobe epilepsy. Experimental animal studies demonstrated transient losses of MAChR due to electrically induced seizures originating in the amygdala. Howev...

journal_title：Epilepsia

authors： Pennell PB,Burdette DE,Ross DA,Henry TR,Albin RL,Sackellares JC,Frey KA

更新日期：1999-01-01 00:00:00

abstract：:The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is widely expressed in the brain, but recent work also implicates cannabinoid receptor 2 (CB2) in modulating neuronal activity. Both recept...

journal_title：Epilepsia

authors： Rowley S,Sun X,Lima IV,Tavenier A,de Oliveira ACP,Dey SK,Danzer SC

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Interest in the association of epilepsy and pseudobulbar palsy was rekindled since the identification through magnetic resonance imaging (MRI) of bilateral perisylvian polymicrogyria (PMG). Seizures are often intractable, but resective epilepsy surgery has not been recommended. However, a similar clinical pictu...

journal_title：Epilepsia

authors： Schilling LP,Kieling RR,Pascoal TA,Kim HI,Lee MC,Kim YH,Paglioli E,Neto PR,Costa JC,Palmini A

更新日期：2013-08-01 00:00:00

abstract：:Fluoxetine was evaluated for anticonvulsant effects in a rat model of focally evoked complex partial seizures (CPS) secondarily generalized. Fluoxetine was administered intraperitoneally (i.p.) 1 h before seizures were induced by focal intracerebral application of the GABAA receptor antagonist, bicuculline methiodide ...

journal_title：Epilepsia

authors： Prendiville S,Gale K

更新日期：1993-03-01 00:00:00

abstract：:Status epilepticus (SE) is associated with significant mortality and morbidity. A reliable prognosis may help better manage medical resources and treatment strategies. We examined the role of preexisting comorbidities on the outcome of patients with SE, an aspect that has received little attention to date. We prospect...

journal_title：Epilepsia

authors： Alvarez V,Januel JM,Burnand B,Rossetti AO

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:To characterize seizure types and electroencephalographic features of glucose transporter type 1 deficiency syndrome (Glut-1 DS). METHODS:Twenty children with clinical and laboratory features of Glut-1 DS were evaluated. Age at seizure diagnosis, seizure classification, and response to treatment were determine...

journal_title：Epilepsia

authors： Leary LD,Wang D,Nordli DR Jr,Engelstad K,De Vivo DC

更新日期：2003-05-01 00:00:00

abstract：:In the nineteenth and early twentieth centuries, many important discoveries in nervous system structure and function involved the electrical properties of nerve tissue. The application of these advances, as well as those in electronic amplification and recording, led to the discovery of the human electroencephalogram ...

journal_title：Epilepsia

authors： Zifkin BG,Avanzini G

更新日期：2009-03-01 00:00:00

abstract：:Sudden unexpected death of an individual with epilepsy can pose a challenge to death investigators, as most deaths are unwitnessed, and the individual is commonly found dead in bed. Anatomic findings (eg, tongue/lip bite) are commonly absent and of varying specificity, thereby limiting the evidence to implicate epilep...

journal_title：Epilepsia

authors： Middleton O,Atherton D,Bundock E,Donner E,Friedman D,Hesdorffer D,Jarrell H,McCrillis A,Mena OJ,Morey M,Thurman D,Tian N,Tomson T,Tseng Z,White S,Wright C,Devinsky O

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:To estimate the incidence and mortality associated with first unprovoked seizure or newly diagnosed epilepsy in a low-income, predominantly Hispanic community in Northern Manhattan, New York City. METHODS:We performed a population-based study to determine the incidence of first unprovoked seizure or newly diag...

journal_title：Epilepsia

authors： Benn EK,Hauser WA,Shih T,Leary L,Bagiella E,Dayan P,Green R,Andrews H,Thurman DJ,Hesdorffer DC

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To evaluate the effect of stress on seizure frequency in childhood epilepsy, and to assess possible differences between children in whom seizures are precipitated by stress and those in whom they are not. METHODS:Parents or caregivers of children with active epilepsy (aged 2-16 years) were sent questionnaires ...

journal_title：Epilepsia

authors： van Campen JS,Jansen FE,Steinbusch LC,Joëls M,Braun KP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:The low glycemic index treatment (LGIT) is a high fat, limited carbohydrate diet used in the treatment of epilepsy. The purpose of this study was to assess the efficacy and tolerability of the LGIT for the treatment of refractory seizures in pediatric patients with Angelman syndrome. METHODS:A pediatric Angelm...

journal_title：Epilepsia

authors： Thibert RL,Pfeifer HH,Larson AM,Raby AR,Reynolds AA,Morgan AK,Thiele EA

更新日期：2012-09-01 00:00:00

abstract：:Twenty-seven patients with medically refractory paroxysmal disorders underwent EEG-video-audio (EVA) monitoring in an inpatient neurology-neurosurgery unit over 1-15 (mean 8.9) days. Fast visual review of all EEG records (5,784 h) and subsequent analysis of synchronized EVA patterns demonstrated a total of 208 partial...

journal_title：Epilepsia

authors： Pierelli F,Chatrian GE,Erdly WW,Swanson PD

更新日期：1989-09-01 00:00:00

abstract：:This study evaluated the effects of cinromide in patients with Lennox-Gastaut Syndrome. No difference between cinromide and placebo was shown in terms of seizure reduction or global evaluations. This study is important, however, because it represents an effort to overcome methodologic difficulties inherent in evaluati...

journal_title：Epilepsia

authors：

更新日期：1989-07-01 00:00:00

abstract：:Little is known about what factors predict intractable epilepsy at the time of initial diagnosis. We performed a case-control study to identify early predictors of medically intractable epilepsy in children. Cases were children who had an average of one seizure or more a month over a 2-year period and who, during that...

journal_title：Epilepsia

authors： Berg AT,Levy SR,Novotny EJ,Shinnar S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Because several reports have described the relation between epilepsy and cardiac arrhythmias and suggest that changes in autonomic neural control of the heart could be involved in the pathogenesis of sudden unexplained death in patients with epilepsy, the aim of this study was to evaluate cardiac function in pa...

journal_title：Epilepsia

authors： Massetani R,Strata G,Galli R,Gori S,Gneri C,Limbruno U,Di Santo D,Mariani M,Murri L

更新日期：1997-03-01 00:00:00

abstract：PURPOSE:To explore the cellular mechanisms of cobalt-induced epileptiform discharges in mouse hippocampal slices. METHODS:Hippocampal slices were prepared from adult mice and briefly exposed to a CoCl(2)-containing external solution. Population and single cell activities were examined via extracellular and whole-cell ...

journal_title：Epilepsia

authors： He J,Hsiang HL,Wu C,Mylvagnanam S,Carlen PL,Zhang L

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS:Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: p...

journal_title：Epilepsia

authors： Shin DS,Yu W,Sutton A,Calos M,Puil E,Carlen PL

更新日期：2011-11-01 00:00:00

abstract：:The International League Against Epilepsy (ILAE) presents a revised operational classification of seizure types. The purpose of such a revision is to recognize that some seizure types can have either a focal or generalized onset, to allow classification when the onset is unobserved, to include some missing seizure typ...

journal_title：Epilepsia

authors： Fisher RS,Cross JH,French JA,Higurashi N,Hirsch E,Jansen FE,Lagae L,Moshé SL,Peltola J,Roulet Perez E,Scheffer IE,Zuberi SM

更新日期：2017-04-01 00:00:00

abstract：:The success of surgery for seizure focus resection depends on postoperative reduction or disappearance in number of seizures, improvement in psychosocial functioning, and low morbidity and mortality. Permanent neurologic sequelae are most often not discussed in this context. Deficits more than a superior quadrantanops...

journal_title：Epilepsia

authors： Helgason CM,Bergen D,Bleck TP,Morrell F,Whisler W

更新日期：1987-07-01 00:00:00

abstract：:The anticonvulsant hypersensitivity syndrome (AHS) is an idiosyncratic immunologic reaction to certain anticonvulsant medications, in which internal organ involvement may lead to fatal multisystemic failure. This syndrome has been associated with the use of aromatic ring-containing agents such as phenytoin, carbamazep...

journal_title：Epilepsia

authors： Cumbo-Nacheli G,Weinberger J,Alkhalil M,Thati N,Baptist AP

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Under an expanded access investigational new drug (IND) trial, cannabidiol (CBD) is being studied as a possible adjuvant treatment of refractory epilepsy in children. Of the 25 subjects in the trial, 13 were being treated with clobazam (CLB). Because CLB and CBD are both metabolized in the cytochrome P450 (CY...

journal_title：Epilepsia

authors： Geffrey AL,Pollack SF,Bruno PL,Thiele EA

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:The Atkins diet may induce ketosis as does the ketogenic diet, without restrictions on calories, fluids, protein, or need for an inpatient fast and admission. Our objective was to evaluate the efficacy and tolerability of a modified Atkins diet for intractable childhood epilepsy. METHODS:Twenty children were t...

journal_title：Epilepsia

authors： Kossoff EH,McGrogan JR,Bluml RM,Pillas DJ,Rubenstein JE,Vining EP

更新日期：2006-02-01 00:00:00

abstract：:Both early life inflammation and prolonged febrile seizures have been associated with increased excitation in the adult brain. We hypothesized this may be due in part to changes in the cation-chloride cotransporter system. Rat pups received saline or lipopolysaccharide/kainic acid (LPS/KA) resulting in inflammation, f...

journal_title：Epilepsia

authors： Reid AY,Riazi K,Campbell Teskey G,Pittman QJ

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Dravet syndrome (DS) or severe myoclonic epilepsy of infancy is an intractable epileptic encephalopathy of early childhood that is caused by a mutation in the SCN1A gene in most patients. The aim of this study was to identify a syndrome-specific epileptic network underlying interictal epileptiform discharges (I...

journal_title：Epilepsia

authors： Moehring J,von Spiczak S,Moeller F,Helbig I,Wolff S,Jansen O,Muhle H,Boor R,Stephani U,Siniatchkin M

更新日期：2013-05-01 00:00:00

abstract：PURPOSE:To investigate relationships between regional brain metabolites, social communication deficits, and seizure frequency in children and adolescents with cryptogenic epilepsy with complex partial seizures (CPS). METHODS:In 12 children and adolescents with CPS and 23 age- and gender-matched healthy controls, we ac...

journal_title：Epilepsia

authors： O'Neill J,Seese R,Hudkins M,Siddarth P,Levitt J,Tseng PB,Wu KN,Gurbani S,Shields WD,Caplan R

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD. METHODS:We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verifi...

journal_title：Epilepsia

authors： Srikijvilaikul T,Najm IM,Hovinga CA,Prayson RA,Gonzalez-Martinez J,Bingaman WE

更新日期：2003-11-01 00:00:00

abstract：:Deletions and duplications/amplifications of the α1-sodium channel subunit (SCN1A) gene occur in about 12% of patients with Dravet syndrome (DS) who are otherwise mutation-negative. Such genomic abnormalities cause loss of function, with severe phenotypes, reproductive disadvantage and, therefore, sporadic occurrence....

journal_title：Epilepsia

authors： Guerrini R,Cellini E,Mei D,Metitieri T,Petrelli C,Pucatti D,Marini C,Zamponi N

更新日期：2010-12-01 00:00:00

abstract：:In evaluation of patients with complex partial seizures who are candidates for surgical treatment, exact definition of the epileptogenic focus is essential for a good surgical outcome. We report a new technique which permits detailed mapping of the epileptogenic activity in the basal temporal lobe and the convexity of...

journal_title：Epilepsia

authors： Lüders H,Hahn J,Lesser RP,Dinner DS,Morris HH 3rd,Wyllie E,Friedman L,Friedman D,Skipper G

更新日期：1989-03-01 00:00:00