Cellular mechanisms of cobalt-induced hippocampal epileptiform discharges.

abstract：:Since the clinical data have been equivocal in regard to the effects of clonazepam (CZP) in focal-motor seizures, an alumina gel monkey model was used to evaluate quantitatively its efficacy with respect to this seizure category. The insolubility of CZP and its short biological half-life in monkey necessitated its eva...

journal_title：Epilepsia

authors： Lockard JS,Levy RH,Congdon WC,DuCharme LL,Salonen LD

更新日期：1979-12-01 00:00:00

abstract：:Between 1929 and 1980, 284 patients with refractory nontumoral frontal lobe epilepsy (FLE) underwent operation at the Montreal Neurological Institute (MNI). We studied 39 patients (14%) who required reoperation. Mean age at the time of first operation was 18 years and at reoperation was 22 years. Clinical manifestatio...

journal_title：Epilepsia

authors： Salanova V,Quesney LF,Rasmussen T,Andermann F,Olivier A

更新日期：1994-01-01 00:00:00

abstract：:Since its introduction into clinical practice in 1999, levetiracetam, the S enantiomer of piracetam, has rapidly found a secure place, initially in the therapy of partial onset seizures and subsequently in the treatment of idiopathic generalized epilepsies (IGE). It has many of the properties of an "ideal" antiepilept...

journal_title：Epilepsia

authors： Grünewald R

更新日期：2005-01-01 00:00:00

abstract：:A transient functional depression of thalamic activity (TFDTA) was induced in acute experiments in cats by the microinjection of 25% KCl into the thalamus. Spontaneous and evoked thalamic electrical activity was markedly depressed at the site of KCl microinjection. Spread of this depression to other thalamic areas oft...

journal_title：Epilepsia

authors： Avoli M,Gloor P

更新日期：1981-08-01 00:00:00

abstract：:The research literature is consistent in reporting somewhat less familial aggregation in partial than in generalized epilepsy. However, relatives of patients with partial seizures do appear to have higher seizure risks than relatives of controls, suggesting that genetic factors are important in at least some partial e...

journal_title：Epilepsia

authors： Ottman R

更新日期：1989-01-01 00:00:00

abstract：:Genomic findings are emerging rapidly in 2 large, closely related epilepsy research consortia: the Epilepsy Phenome/Genome Project and Epi4K. Disclosure of individual results to participants in genomic research is increasingly viewed as an ethical obligation, but strategies for return of results were not included in t...

journal_title：Epilepsia

authors： Ottman R,Freyer C,Mefford HC,Poduri A,Lowenstein DH,Epilepsy Return of Results Workshop Participants.

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:The selection of a minimal active sequence of erythropoietin allowed the design of peptide mimetics that exert beneficial effects in the central nervous system but lack an erythropoietic effect. Erythropoietin has been suggested as a promising therapeutic and prophylactic for epilepsies based on its neuroprotec...

journal_title：Epilepsia

authors： Seeger N,Zellinger C,Rode A,Roloff F,Bicker G,Russmann V,Fischborn S,Wendt H,Potschka H

更新日期：2011-12-01 00:00:00

abstract：:We report the case of a 3-year-old boy with status gelasticus symptomatic to a giant hypothalamic hamartoma despite two previous hypothalamic hamartoma surgeries using pterional approaches from each side. Following his third resection employing an endoscopic, transventricular approach, he has been seizure free for 6 m...

journal_title：Epilepsia

authors： Ng YT,Rekate HL

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Health-related quality of life (HRQOL) is an important indicator of well-being in patients with epilepsy. When assessing changes in HRQOL over time, some of the changes observed may be due to the patients' change in the internal standards, value, or meaning that they attribute to the HRQOL domain being measu...

journal_title：Epilepsia

authors： Sajobi TT,Fiest KM,Wiebe S

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:We determined the prevalence of oral disorders and the dental treatment needs of outpatients with epilepsy. METHODS:A questionnaire was administered to 56 consecutive patients (35 males, 21 females) presenting to an outpatient clinic. All patients underwent dental examinations. The clinical and diagnostic feat...

journal_title：Epilepsia

authors： Ogunbodede EO,Adamolekun B,Akintomide AO

更新日期：1998-06-01 00:00:00

abstract：:Impaired cortical inhibition may be involved in epileptogenic mechanisms. In a positron-emission tomography (PET) study, we demonstrated a reduction of the cortical benzodiazepine (BZD) receptor density in the epileptic foci of patients with partial epileptic seizures. In the present study, we used the same method in ...

journal_title：Epilepsia

authors： Savic I,Widen L,Thorell JO,Blomqvist G,Ericson K,Roland P

更新日期：1990-11-01 00:00:00

abstract：PURPOSE:To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS:Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2008-03-01 00:00:00

abstract：:Reliably detecting focal seizures without secondary generalization during daily life activities, chronically, using convenient portable or wearable devices, would offer patients with active epilepsy a number of potential benefits, such as providing more reliable seizure count to optimize treatment and seizure forecast...

journal_title：Epilepsia

authors： Ryvlin P,Cammoun L,Hubbard I,Ravey F,Beniczky S,Atienza D

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:Cortical stimulation to abort seizures is under human investigation. Ideal electrode placement and stimulating parameters are unknown with poor understanding of tissue volume affected by stimulation or duration and nature of its effect on cortical activity. To help characterize this effect, we analyzed electroc...

journal_title：Epilepsia

authors： Gwinn RP,Spencer DD,Spencer SS,Duckrow RB,Vives K,Wu K,Tkeshelashvili D,Zaveri HP

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Lennox-Gastaut syndrome (LGS) is a severe epileptic condition characterized by multiple seizure types including tonic seizures, slow spike-and-wave discharges on electroencephalography (EEG), and cognitive impairment. LGS can occur in apparently healthy subjects or in patients with preexisting brain damage. The...

journal_title：Epilepsia

authors： Ferlazzo E,Adjien CK,Guerrini R,Calarese T,Crespel A,Elia M,Striano P,Gelisse P,Bramanti P,di Bella P,Genton P

更新日期：2009-06-01 00:00:00

abstract：PURPOSE:To determine if the clinical characteristics of nonepileptic seizures (NES) are different in children younger than 13 years age as compared to adolescents. METHODS:Retrospective review of medical records and video-EEGs (VEEG) of all patients with NES confirmed on VEEG monitoring was performed. RESULTS:Sixty-e...

journal_title：Epilepsia

authors： Patel H,Scott E,Dunn D,Garg B

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：:Hippocampal afterdischarges can induce increased Purkinje cell activity that characteristically shows a pronounced acceleration during the period of the afterdischarges. Increased Purkinje cell activity may continue for many seconds after termination of the hippocampal activity. Typical frequency histograms are presen...

journal_title：Epilepsia

authors： Mitra J,Snider RS

更新日期：1975-06-01 00:00:00

abstract：:Early treatment of prolonged seizures with benzodiazepines given intravenously by paramedics in the prehospital setting had been shown to be associated with improved outcomes, but the comparative efficacy and safety of an intramuscular (IM) route, which is faster and consistently achievable, was previously unknown. RA...

journal_title：Epilepsia

authors： Silbergleit R,Lowenstein D,Durkalski V,Conwit R,NETT Investigators.

更新日期：2013-09-01 00:00:00

abstract：:The kinetic profiles of diazepam (DZP) were investigated in plasma, erythrocytes, and discrete brain areas in the rat, and the effects of valproic acid (VPA), given as sodium valproate, on kinetic parameters were analyzed. The experiments were performed on two groups of rats treated daily for 15 days, the first receiv...

journal_title：Epilepsia

authors： Hariton C,Jadot G,Valli M,Mesdjian E,Mandel P

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:To explore the correlations between treatment modalities and selected disease parameters with outcome in febrile infection-related epilepsy syndrome (FIRES), a catastrophic epileptic encephalopathy with a yet undefined etiology. METHODS:We conducted a retrospective multicenter study on children who had been in...

journal_title：Epilepsia

authors： Kramer U,Chi CS,Lin KL,Specchio N,Sahin M,Olson H,Nabbout R,Kluger G,Lin JJ,van Baalen A

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Previous studies have documented a synaptic translocation of calcineurin (CaN) and increased CaN activity following status epilepticus (SE); however, the cellular effect of these changes in CaN in the pathology of SE remains to be elucidated. This study examined a CaN-dependent modification of the dendritic cyt...

journal_title：Epilepsia

authors： Kurz JE,Moore BJ,Henderson SC,Campbell JN,Churn SB

更新日期：2008-10-01 00:00:00

abstract：PURPOSE:Exposure to toxic levels of organophosphorus (OP) nerve agents can lead to seizures, respiratory failure, and, if untreated, death. The cholinesterase inhibitor soman belongs to the class of OP nerve agents and can cause status epilepticus (SE) and brain damage due to neuroexcitotoxicity. In the present study, ...

journal_title：Epilepsia

authors： de Araujo Furtado M,Lumley LA,Robison C,Tong LC,Lichtenstein S,Yourick DL

更新日期：2010-08-01 00:00:00

abstract：:This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age of a planned transition of adolesce...

journal_title：Epilepsia

authors： Camfield CS,Berg A,Stephani U,Wirrell EC

更新日期：2014-08-01 00:00:00

abstract：:We showed that hypoxia is acutely epileptogenic in immature but not in adult rats. In the present study, we evaluated whether hypoxia results in an increase in long-term seizure susceptibility to flurothyl and whether this is associated with impaired performance on behavioral tests. We also determined whether these lo...

journal_title：Epilepsia

authors： Jensen FE,Holmes GL,Lombroso CT,Blume HK,Firkusny IR

更新日期：1992-11-01 00:00:00

abstract：:The 1981 International Classification of Epileptic Seizures (ICES) was used to study the distribution of seizure types in 1,250 patients attending an Epilepsy Clinic in Sri Lanka. Based on seizure symptomatology 94.6% of the cases could be classified, and by adding the routine interictal EEG findings the percentage of...

journal_title：Epilepsia

authors： Senanayake N

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:Angelman syndrome (AS) is a neurogenetic disorder characterized by developmental delay and a frequently refractory epileptic condition. Valproate, clonazepam and/or phenytoin are said to be the most effective antiepileptic drugs (AEDs) against the seizures in AS. Experience with the newer AEDs is very limited d...

journal_title：Epilepsia

authors： Dion MH,Novotny EJ Jr,Carmant L,Cossette P,Nguyen DK

更新日期：2007-03-01 00:00:00

abstract：:Approximately three-quarters of epileptic patients seen in consultation by specialists can easily be assigned to one of the diagnostic categories of the International League against Epilepsy. When patient age is taken into account, such a distribution shows that partial epilepsy is more common than generalized epileps...

journal_title：Epilepsia

authors： Gastaut H,Gastaut JL,Gonçalves e Silva GE,Fernandez Sanchez GR

更新日期：1975-09-01 00:00:00

abstract：:Cortical dysplasia (CD, also known as malformations of cortical development) are the pathological substrates in a large percentage of patients with pharmacoresistant epilepsy who may be amenable to surgical treatment. Therefore, research on the mechanisms of dysplastic lesion formation and epileptogenicity is of param...

journal_title：Epilepsia

authors： Najm IM,Tilelli CQ,Oghlakian R

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS:We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 recognized epilepsy surgery reference centers in 10 European countries. RESULTS:We analyzed retrospectiv...

journal_title：Epilepsia

authors： Barba C,Cross JH,Braun K,Cossu M,Klotz KA,De Masi S,Perez Jiménez MA,Gaily E,Specchio N,Cabral P,Toulouse J,Dimova P,Battaglia D,Freri E,Consales A,Cesaroni E,Tarta-Arsene O,Gil-Nagel A,Mindruta I,Di Gennaro G,Giu

更新日期：2020-02-01 00:00:00