Neuroanatomic correlates of psychogenic nonepileptic seizures: a cortical thickness and VBM study.

abstract：OBJECTIVE:Inhibition of microRNA-134 by an oligonucleotide antagomir (ant-134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess what potential adverse effects it may have on naive brain tissue...

journal_title：Epilepsia

authors： Morris G,Brennan GP,Reschke CR,Henshall DC,Schorge S

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether...

journal_title：Epilepsia

authors： Taraschenko O,Fox HS,Pittock SJ,Zekeridou A,Gafurova M,Eldridge E,Liu J,Dravid SM,Dingledine R

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Genetic testing has become a routine part of the diagnostic workup in children with early onset epilepsies. In the present study, we sought to investigate a cohort of adult patients with epilepsy, to determinate the diagnostic yield and explore the gain of personalized treatment approaches in adult patients. ...

journal_title：Epilepsia

authors： Johannesen KM,Nikanorova N,Marjanovic D,Pavbro A,Larsen LHG,Rubboli G,Møller RS

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Genetic variants in STXBP1, which encodes the conserved exocytosis protein Munc18-1, are associated with a variety of infantile epilepsy syndromes. We aimed to develop an in vivo Caenorhabditis elegans model that could be used to test the pathogenicity of such variants in a cost-effective manner. METHODS:The...

journal_title：Epilepsia

authors： Zhu B,Mak JCH,Morris AP,Marson AG,Barclay JW,Sills GJ,Morgan A

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To systematically review the methodology and use of neuropsychological tests in randomized controlled trials (RCTs) of antiepileptic drugs (AEDs) in patients with epilepsy. METHODS:Trial reports were found by searching Medline 1966-1996 and searching through journals by hand. Inclusion and exclusion criteria w...

journal_title：Epilepsia

authors： Cochrane HC,Marson AG,Baker GA,Chadwick DW

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:To assess the usefulness of an early postictal EEG in neurologically normal children with complex febrile seizures. METHODS:We conducted a retrospective chart review of all neurologically normal children who were hospitalized over a period of 2.5 years after complex febrile seizures, and had an EEG up to 1 wee...

journal_title：Epilepsia

authors： Maytal J,Steele R,Eviatar L,Novak G

更新日期：2000-02-01 00:00:00

abstract：:This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age of a planned transition of adolesce...

journal_title：Epilepsia

authors： Camfield CS,Berg A,Stephani U,Wirrell EC

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Inducing sleep deprivation is supposed to increase interictal epileptic discharges on EEGs from children suspected of having epilepsy. Although it is supposed that depriving a child from sleep is a burden for both child and parent, this assumption has not been investigated in any study so far. M...

journal_title：Epilepsia

authors： Nijhof SL,Bakker AL,Van Nieuwenhuizen O,Oostrom K,van Huffelen AC

更新日期：2005-08-01 00:00:00

abstract：:A case of Rasmussen encephalitis with bilateral involvement and onset at age 2 years is reviewed. Rasmussen encephalitis is a rare progressive disease that causes intractable seizures, cognitive decline, and inflammatory changes in the brain. The neurologic involvement is characteristically unilateral. Bilateral invol...

journal_title：Epilepsia

authors： Tobias SM,Robitaille Y,Hickey WF,Rhodes CH,Nordgren R,Andermann F

更新日期：2003-01-01 00:00:00

abstract：:Status epilepticus (SE) is a major neurological and medical emergency associated with a high morbidity and mortality. Retrospective and prospective studies from the Medical College of Virginia Epilepsy Research Center have been utilized to investigate several clinical and epidemiological factors associated with SE. Un...

journal_title：Epilepsia

authors： DeLorenzo RJ,Towne AR,Pellock JM,Ko D

更新日期：1992-01-01 00:00:00

abstract：:Little is known about what factors predict intractable epilepsy at the time of initial diagnosis. We performed a case-control study to identify early predictors of medically intractable epilepsy in children. Cases were children who had an average of one seizure or more a month over a 2-year period and who, during that...

journal_title：Epilepsia

authors： Berg AT,Levy SR,Novotny EJ,Shinnar S

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:We aimed to compare the efficacy, safety, and tolerability of a modified Atkins diet (MAD) with the classic ketogenic diet (KD) for the treatment of intractable childhood epilepsy. METHODS:From March 2011 to March 2014, 104 patients aged 1-18 years who had refractory epilepsy were randomly assigned to each d...

journal_title：Epilepsia

authors： Kim JA,Yoon JR,Lee EJ,Lee JS,Kim JT,Kim HD,Kang HC

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:There is some structural similarity between the androgen receptor antagonist, flutamide (Flut) and benzodiazepines (BZDs). We evaluated the possible anticonvulsant effect and interaction of Flut with BZD receptors in common seizure models. METHODS:(a) Different groups of mice each were pretreated i.p. with Flu...

journal_title：Epilepsia

authors： Ahmadiani A,Mandgary A,Sayyah M

更新日期：2003-05-01 00:00:00

abstract：:Study of patients with temporal lobe epilepsy and generalized epilepsy revealed no overall seizure type differences, nor overall age-at-onset effects, on MMPI measures of psychopathology. However, statistically significant interactions between seizure type and age at onset were obtained on several MMPI measures, and s...

journal_title：Epilepsia

authors： Hermann BP,Schwartz MS,Karnes WE,Vahdat P

更新日期：1980-02-01 00:00:00

abstract：PURPOSE:We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS:Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: p...

journal_title：Epilepsia

authors： Shin DS,Yu W,Sutton A,Calos M,Puil E,Carlen PL

更新日期：2011-11-01 00:00:00

abstract：:The identification and correction of adverse physiological changes that lead to seizures in children can improve the effectiveness of current therapeutic practices in epilepsy. It is proposed that various circadian rhythms (respiration, hormones, water balance, electrolytes, intracranial pressure, blood pressure), met...

journal_title：Epilepsia

authors： LeWinn EB

更新日期：1980-08-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：:This essay explores the usefulness of the concept of consciousness in epileptology and concludes that it does not further the understanding of seizure mechanisms and brain function. The reasons for this are both theoretical and empirical. Consciousness cannot be adequately defined. This may explain why attempts at acc...

journal_title：Epilepsia

authors： Gloor P

更新日期：1986-01-01 00:00:00

abstract：:Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain triglyceride ketogenic diet for the treatment of patients with drug-resistant epilepsy. Bec...

journal_title：Epilepsia

authors： Augustin K,Williams S,Cunningham M,Devlin AM,Friedrich M,Jayasekera A,Hussain MA,Holliman D,Mitchell P,Jenkins A,Chen PE,Walker MC,Williams RSB

更新日期：2018-11-01 00:00:00

abstract：:Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated anim...

journal_title：Epilepsia

authors： Diehl RG,Smialowski A,Gotwo T

更新日期：1984-08-01 00:00:00

abstract：:Clinical and epidemiological research studies are essential to advancing our understanding of human health conditions such as epilepsy. To be of value, studies must not only address important questions, they must do so in such a way as to contribute usefully to existing knowledge. Comprehensive understanding of the su...

journal_title：Epilepsia

authors： Berg AT

更新日期：2007-12-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：PURPOSE:Absence epilepsies are common, with a major genetic contribution to etiology. Certain environmental factors can influence absence occurrence but a complete understanding of absence precipitation is lacking. Herein we investigate if lowering blood glucose increases spike-wave activity in mouse models with varyin...

journal_title：Epilepsia

authors： Reid CA,Kim TH,Berkovic SF,Petrou S

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The need for alternative pharmacologic strategies in treatment of epilepsies is pressing for about 30% of patients with epilepsy who do not experience satisfactory seizure control with present treatments. In temporal lobe epilepsy (TLE) even up to 80% of patients are pharmacoresistant, and surgical resection ...

journal_title：Epilepsia

authors： Klaft ZJ,Hollnagel JO,Salar S,Calişkan G,Schulz SB,Schneider UC,Horn P,Koch A,Holtkamp M,Gabriel S,Gerevich Z,Heinemann U

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Mutations involving the cyclin-dependent kinase-like 5 (CDKL5) gene cause an early onset epileptic encephalopathy (EE) with severe neurologic impairment and a skewed 12:1 female-to-male ratio. To date, 18 mutations have been described in boys. We analyzed our cohort of boys with early onset EE to assess the d...

journal_title：Epilepsia

authors： Mei D,Darra F,Barba C,Marini C,Fontana E,Chiti L,Parrini E,Dalla Bernardina B,Guerrini R

更新日期：2014-11-01 00:00:00

abstract：:In a prospective study of 117 adult ambulatory patients, 110 of whom were epileptics treated only with oral diphenylhydantoin (DPH), plasma levels of this drug were determined by gas-liquid chromatography. The average follow-up time was 6 months (range, 3 to 13 months); satisfactory control of seizures was obtained wi...

journal_title：Epilepsia

authors： Galdames DG,Saavedra IN,Ortiz MA,Aguilera LI,Valenzuela AL,Concha GL,Droguett PA,Morales ER

更新日期：1980-10-01 00:00:00

abstract：PURPOSE:To assess the efficacy and safety of multiple subpial transection (MST), a new technique in epilepsy surgery, alone and in combination with resection. METHODS:MST was performed in 22 patients with intractable epilepsy, 10 of whom were treated with a combination of a resection and MST in functionally important ...

journal_title：Epilepsia

authors： Hufnagel A,Zentner J,Fernandez G,Wolf HK,Schramm J,Elger CE

更新日期：1997-06-01 00:00:00

abstract：PURPOSE:Intracerebral vascular malformations including cavernous angiomas (CAs) and arteriovenous malformations (AVMs) are an important cause of chronic pharmacoresistant epilepsies. Little is known about the pathogenetic basis of epilepsy in patients with vascular malformations. Intracerebral deposits of iron-containi...

journal_title：Epilepsia

authors： Raabe A,Schmitz AK,Pernhorst K,Grote A,von der Brelie C,Urbach H,Friedman A,Becker AJ,Elger CE,Niehusmann P

更新日期：2012-03-01 00:00:00

abstract：:The diagnostic goals in nonsurgical (conservative) epileptology differ from presurgical diagnostic aims. The resulting development of diagnostic methods in a tertiary-level epilepsy center is shown and the major technical and organizational consequences of this difference for diagnostic long-term monitoring (LTM) as o...

journal_title：Epilepsia

authors： Ried S,Hilfiker P,Mothersill IW,Krämer G

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Benzodiazepines (BZD) are recommended as first-line treatment for status epilepticus (SE), with lorazepam (LZP) and midazolam (MDZ) being the most widely used drugs and part of current treatment guidelines. Clonazepam (CLZ) is also utilized in many countries; however, there is no systematic comparison of thes...

journal_title：Epilepsia

authors： Alvarez V,Lee JW,Drislane FW,Westover MB,Novy J,Dworetzky BA,Rossetti AO

更新日期：2015-08-01 00:00:00