Pharmacokinetics and drug interactions of eslicarbazepine acetate.

abstract：:Focal epilepsy can be produced by a blood-brain barrier (BBB)-excluded systemic convulsant (penicillin, folic acid, etc.) in the presence of a focal BBB lesion. Bicuculline methiodide, a gamma-aminobutyric acid blocking epileptogen, crosses the normal BBB of rats poorly and produces no consistent abnormality behaviora...

journal_title：Epilepsia

authors： Remler MP,Marcussen WH

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:  Despite the consistent observation that γ-aminobutyric acid A (GABA(A) ) receptors mediate excitatory responses at perinatal stages, the role of the GABAergic system in the generation of neonatal epileptiform activity remains controversial. Therefore, we analyzed whether tonic and phasic GABAergic transmissio...

journal_title：Epilepsia

authors： Kolbaev SN,Sharopov S,Dierkes PW,Luhmann HJ,Kilb W

更新日期：2012-05-01 00:00:00

abstract：:Over the past decade, much progress has been made in understanding the mechanisms of ketogenic diet (KD) action. From the complex systemic and metabolic changes induced by the KD have emerged innovative hypotheses attempting to link biochemical adaptations to its clinical effects. Despite such developments, the fundam...

journal_title：Epilepsia

authors： Rho JM,Sankar R

更新日期：2008-11-01 00:00:00

abstract：:No reports of the Washington Psychosocial Seizure Inventory (WPSI) have yet been presented from Asian countries in detail. We performed a multiinstitutional study of this test in 652 Japanese subjects. The mean value of the Lie Scale was high, and only one third of our subjects were under the limit of the original cri...

journal_title：Epilepsia

authors： Hosokawa K,Kugoh T,Mino S

更新日期：1994-11-01 00:00:00

abstract：:Epilepsy surgery (ES) is addressed in relation to economic classifications of national resources and welfare in developing countries. A decade ago, ten developing countries conducted ES; now 26 such countries have reported results of ES. A number of international authorities define indicators of national economic welf...

journal_title：Epilepsia

authors： Wieser HG,Silfvenius H

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:To study the course and outcome of childhood-onset epilepsy during 15-year follow-up (FU). METHODS:We extended FU in 413 of 494 children with new-onset epilepsy recruited in a previously described prospective hospital-based study by questionnaire. RESULTS:Mean FU was 14.8 years (range 11.6-17.5 years). Five-y...

journal_title：Epilepsia

authors： Geerts A,Arts WF,Stroink H,Peeters E,Brouwer O,Peters B,Laan L,van Donselaar C

更新日期：2010-07-01 00:00:00

abstract：:A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome. The questionnaire was delivered to 246 hospitals at which physicians were treating childhood epilepsy to gain information about the total number of patients with Dravet syndrome and the prevalenc...

journal_title：Epilepsia

authors： Sakauchi M,Oguni H,Kato I,Osawa M,Hirose S,Kaneko S,Takahashi Y,Takayama R,Fujiwara T

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:To study the anticonvulsant action of a gamma-aminobutyric acid (GABA) uptake inhibitor NNC-711 in two models of cortical epileptogenesis in immature rats. METHODS:Twelve-, 18-, and 25-day-old rat pups with implanted electrodes were used in this study. Epileptogenic foci were elicited by a local application of...

journal_title：Epilepsia

authors： Bernásková K,Slamberová R,Mares P

更新日期：1999-09-01 00:00:00

abstract：PURPOSE:To develop a population pharmacokinetic model to evaluate the demographic and physiologic determinants of levetiracetam (LEV) pharmacokinetics (PK) and to suggest recommended doses of LEV in children. METHODS:LEV PK were investigated in a prospective open trial of LEV as adjunctive therapy using a population a...

journal_title：Epilepsia

authors： Chhun S,Jullien V,Rey E,Dulac O,Chiron C,Pons G

更新日期：2009-05-01 00:00:00

abstract：:There has been a recent surge of interest in chronic animal models of epilepsy. Proper assessment of these models requires documentation of spontaneous seizures by EEG, observation, or both in each individual animal to confirm the presumed epileptic condition. We used the same automatic seizure detection system as tha...

journal_title：Epilepsia

authors： Mascott CR,Gotman J,Beaudet A

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:To define the phenotypic spectrum of phosphatidylinositol glycan class A protein (PIGA)-related congenital disorder of glycosylation (PIGA-CDG) and evaluate genotype-phenotype correlations. METHODS:Our cohort encompasses 40 affected males with a pathogenic PIGA variant. We performed a detailed phenotypic ass...

journal_title：Epilepsia

authors： Bayat A,Knaus A,Pendziwiat M,Afenjar A,Barakat TS,Bosch F,Callewaert B,Calvas P,Ceulemans B,Chassaing N,Depienne C,Endziniene M,Ferreira CR,Moura de Souza CF,Freihuber C,Ganesan S,Gataullina S,Guerrini R,Guerrot AM,

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：:Epilepsy is frequently associated with cognitive dysfunction. However, the reasons for this correlation are unclear. Possible influential factors include patient age; duration, frequency, etiology, and type of seizures; hereditary factors; psychosocial issues; and antiepileptic drug (AED) therapy. Whereas many of thes...

journal_title：Epilepsia

authors： Vining EP

更新日期：1987-01-01 00:00:00

abstract：:Multiple studies have highlighted how seizures induce different molecular, cellular, and physiologic consequences in an immature brain as compared to a mature brain. In keeping with these studies, seizures early in life alter dentate granule cell birth in different, and even opposing, fashion to adult seizure models (...

journal_title：Epilepsia

authors： Porter BE

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Substantia nigra (SN) and locus coeruleus (LC) neurons are implicated in the propagation and suppression of amygdaloid seizures. Both structures are activated concomitant with amygdaloid seizure discharges. Their mechanisms of activation, however, remain to be elucidated. SN firing is not associated with the in...

journal_title：Epilepsia

authors： Silveira DC,Liu Z,de LaCalle S,Lu J,Klein P,Holmes GL,Herzog AG

更新日期：1998-12-01 00:00:00

abstract：:We report the case of a 3-year-old boy with status gelasticus symptomatic to a giant hypothalamic hamartoma despite two previous hypothalamic hamartoma surgeries using pterional approaches from each side. Following his third resection employing an endoscopic, transventricular approach, he has been seizure free for 6 m...

journal_title：Epilepsia

authors： Ng YT,Rekate HL

更新日期：2011-01-01 00:00:00

abstract：:We examined auto-correlation and interval distribution characteristics of neuronal discharge from patients with complex partial seizures. The objective was to compare the interictal firing patterns of neurons in mesial temporal structures ipsilateral to the site of seizure onset with firing patterns of neurons in homo...

journal_title：Epilepsia

authors： Colder BW,Frysinger RC,Wilson CL,Harper RM,Engel J Jr

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:To determine whether methsuximide (MSM) affects lamotrigine (LTG) blood levels and whether any change is of clinical significance. METHODS:LTG serum levels in 16 patients taking MSM were compared with those before starting or after stopping the MSM. The 16 patients, (11 boys, five girls) were young people (mea...

journal_title：Epilepsia

authors： Besag FM,Berry DJ,Pool F

更新日期：2000-05-01 00:00:00

abstract：:The purpose of this study was to determine whether seizure frequency and cycle days with seizure occurrence vary across the menstrual cycle. The subjects were the first 100 women with intractable focal onset seizures, 13-45 years old, who completed the baseline phase of the National Institutes of Health (NIH) Progeste...

journal_title：Epilepsia

authors： Herzog AG,Fowler KM,Sperling MR,Massaro JM,Progesterone Trial Study Group.

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...

journal_title：Epilepsia

authors： Tran TA,Spencer SS,Javidan M,Pacia S,Marks D,Spencer DD

更新日期：1997-10-01 00:00:00

abstract：PURPOSE:Focal cortical dysplasia type IIb (FCD IIb) lesions are highly epileptogenic and frequently cause pharmacoresistant epilepsy. Complete surgical resection leads to seizure freedom in most cases. However, the term "complete" resection is controversial with regard to the necessity of performing resections of the s...

journal_title：Epilepsia

authors： Wagner J,Urbach H,Niehusmann P,von Lehe M,Elger CE,Wellmer J

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To determine if the clinical characteristics of nonepileptic seizures (NES) are different in children younger than 13 years age as compared to adolescents. METHODS:Retrospective review of medical records and video-EEGs (VEEG) of all patients with NES confirmed on VEEG monitoring was performed. RESULTS:Sixty-e...

journal_title：Epilepsia

authors： Patel H,Scott E,Dunn D,Garg B

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:In 2015, the International League Against Epilepsy (ILAE) proposed a new definition of status epilepticus (SE): 5 minutes of ongoing seizure activity to diagnose convulsive SE (CSE, ie, bilateral tonic-clonic SE) and 10 minutes for focal SE and absence SE, rather than the earlier criterion of 30 minutes. Base...

journal_title：Epilepsia

authors： Leitinger M,Trinka E,Giovannini G,Zimmermann G,Florea C,Rohracher A,Kalss G,Neuray C,Kreidenhuber R,Höfler J,Kuchukhidze G,Granbichler C,Dobesberger J,Novak HF,Pilz G,Meletti S,Siebert U

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:To assess the usefulness of an early postictal EEG in neurologically normal children with complex febrile seizures. METHODS:We conducted a retrospective chart review of all neurologically normal children who were hospitalized over a period of 2.5 years after complex febrile seizures, and had an EEG up to 1 wee...

journal_title：Epilepsia

authors： Maytal J,Steele R,Eviatar L,Novak G

更新日期：2000-02-01 00:00:00

abstract：:This chapter covers the syndromes of benign epilepsy with centrotemporal spikes (BECTS), nonlesional focal epilepsy in otherwise normal children (NLFN), and the genetic generalized epilepsies. BECTS is an epilepsy syndrome that always enters terminal remission before the general age of a planned transition of adolesce...

journal_title：Epilepsia

authors： Camfield CS,Berg A,Stephani U,Wirrell EC

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:In one third of patients, seizures remain after epilepsy surgery, meaning that improved preoperative evaluation methods are needed to identify the epileptogenic zone. A potential framework for such a method is network theory, as it can be applied to noninvasive recordings, even in the absence of epileptiform ...

journal_title：Epilepsia

authors： Nissen IA,Stam CJ,Reijneveld JC,van Straaten IE,Hendriks EJ,Baayen JC,De Witt Hamer PC,Idema S,Hillebrand A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Kindled seizures are widely used to model epileptogenesis, but the molecular mechanisms underlying the attainment of kindling status are largely unknown. Recently we showed that achievement of kindling status in the Sprague-Dawley rat is associated with a critical developmental interval of 25 +/- 1 days; the id...

journal_title：Epilepsia

authors： Junker H,Späte K,Suofu Y,Walther R,Schwarz G,Kammer W,Nordheim A,Walker LC,Runge U,Kessler C,Popa-Wagner A

更新日期：2005-03-01 00:00:00

abstract：:A case of Rasmussen encephalitis with bilateral involvement and onset at age 2 years is reviewed. Rasmussen encephalitis is a rare progressive disease that causes intractable seizures, cognitive decline, and inflammatory changes in the brain. The neurologic involvement is characteristically unilateral. Bilateral invol...

journal_title：Epilepsia

authors： Tobias SM,Robitaille Y,Hickey WF,Rhodes CH,Nordgren R,Andermann F

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The rat electrical amygdala kindling model is one of the most widely studied animal models of temporal lobe epilepsy (TLE); however, the processes underlying epileptogenesis in this model remain incompletely understood. Magnetic resonance imaging (MRI) is a powerful method to investigate epileptogenesis, allowi...

journal_title：Epilepsia

authors： Jupp B,Williams JP,Tesiram YA,Vosmansky M,O'Brien TJ

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS:Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2008-03-01 00:00:00