Abstract:
:The hypothesis was tested that epileptiform alterations of brain excitability may be elicited by a conditioning stimulus (CS) in a classical conditioning paradigm. Fifteen male albino rats were chronically implanted with electrodes in the amygdala and over the visual cortex. A train of six stroboscopic flashes served as the CS and the unconditioned stimulus was the amygdaloid electrical stimulation, delivered together with the sixth flash in the course of the kindling procedure. Rats were randomly assigned to two groups. Rats in Group 1 were exposed to one or two kindling sessions per day, and those in Group 2 were exposed to 10 such sessions every day. All rats in Group 1 showed fully mature seizures within 15 +/- 5.5 sessions, whereas none of those in Group 2 displayed kindled seizures. There was no evidence of amygdaloid afterdischarges or enhanced spiking as a response to the CS. A gradual selective suppression of the visual evoked potentials (VEP) secondary components, i.e., slow negative wave and sensory afterdischarge, paralleled kindling in Group 1. This effect was weak in Group 2. There was no change in the primary response of VEPs in either group. No recovery of VEPs followed the extinction of conditioning.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Myslobodsky MS,Mintz M,Lerner T,Mostofsky DIdoi
10.1111/j.1528-1157.1983.tb04890.xsubject
Has Abstractpub_date
1983-06-01 00:00:00pages
275-83issue
3eissn
0013-9580issn
1528-1167journal_volume
24pub_type
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