Memory function and verbal learning ability in patients with complex partial seizures of temporal lobe origin.

abstract：:We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ...

journal_title：Epilepsia

authors： Zumsteg D,Lozano AM,Wennberg RA

更新日期：2006-11-01 00:00:00

abstract：:Rufinamide (RUF) is a novel antiepileptic drug considered as second-line therapy in the treatment of Lennox-Gastaut syndrome. Treatment-emergent adverse events (AEs) have consisted mainly of drowsiness, irritability, vomiting, and loss of appetite. RUF is considered as a "weight-neutral" drug. We found clinically sign...

journal_title：Epilepsia

authors： Mourand I,Crespel A,Gelisse P

更新日期：2013-01-01 00:00:00

abstract：:Alterations in the balance of K-Na-2Cl cotransporter (NKCC1) and Na-Cl cotransporter (KCC2) activity may cause depolarizing effect of γ-aminobutyric Acid (GABA), and contribute to epileptogenesis in human temporal lobe epilepsy. NKCC1 facilitates accumulation of chloride inside neurons and favors depolarizing response...

journal_title：Epilepsia

authors： Eftekhari S,Mehvari Habibabadi J,Najafi Ziarani M,Hashemi Fesharaki SS,Gharakhani M,Mostafavi H,Joghataei MT,Beladimoghadam N,Rahimian E,Hadjighassem MR

更新日期：2013-01-01 00:00:00

abstract：:Estrogens are essential for normal brain functions. The effects of estrogens on seizures are contradictory. More studies are necessary to determine under which conditions the estrogens have proconvulsant effects and when the estrogens may have beneficial action in patients with epilepsy. ...

journal_title：Epilepsia

authors： Velísková J,De Jesus G,Kaur R,Velísek L

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:In a previous investigation (Lah et al., 2004), we found deficits in retrograde memory in patients who had undergone temporal lobectomy (TL). In this study, we set out to determine whether such deficits are present before surgery in patients with temporal lobe epilepsy (TLE). METHODS:Memory for public and auto...

journal_title：Epilepsia

authors： Lah S,Lee T,Grayson S,Miller L

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Diffusion-weighted magnetic resonance imaging (DWI) after focal status epilepticus has demonstrated focal alterations of the apparent diffusion coefficient (ADC) in the epileptogenic zone. We hypothesized that localized dynamic alterations of brain diffusion during the immediate postictal state will be detectab...

journal_title：Epilepsia

authors： Hufnagel A,Weber J,Marks S,Ludwig T,De Greiff A,Leonhardt G,Widmann G,Stolke D,Forsting M

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The current understanding of epilepsy has changed significantly in the past 2 decades. This report presents a description of newly diagnosed childhood-onset epilepsy, with a special emphasis on epilepsy syndromes, in a large, prospectively ascertained community-based cohort evaluated and diagnosed in the mid-19...

journal_title：Epilepsia

authors： Berg AT,Shinnar S,Levy SR,Testa FM

更新日期：1999-04-01 00:00:00

abstract：:We examined the clinical significance of bisynchronous spike-wave complexes which appear in EEGs of some patients with focal spikes in one or both temporal lobes. Few features distinguished patients with bisynchronous spike-waves from those with only focal temporal spikes: a higher incidence of patients with more than...

journal_title：Epilepsia

authors： Sadler RM,Blume WT

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS:A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infant...

journal_title：Epilepsia

authors： Chu-Shore CJ,Major P,Camposano S,Muzykewicz D,Thiele EA

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:Posterior cortex epilepsies (PCEs) encompass a group of epilepsies originating from the occipital, parietal, or occipital border of the temporal lobe, or from any combination of these regions. When their seizures are refractory to pharmacologic treatment, these patients are usually referred for surgery. The aim...

journal_title：Epilepsia

authors： Dalmagro CL,Bianchin MM,Velasco TR,Alexandre V Jr,Walz R,Terra-Bustamante VC,Inuzuka LM,Wichert-Ana L,Araújo D Jr,Serafini LN,Carlotti CG Jr,Assirati JA Jr,Machado HR,Santos AC,Sakamoto AC

更新日期：2005-09-01 00:00:00

abstract：PURPOSE:To investigate in vitro, the cellular network activity of the hippocampus in Q54 mice that display spontaneous seizures because of a gain-of-function mutation of the Scn2a sodium channel gene. METHODS:Extacellular recordings were obtained from CA1 and CA3 pyramidal neurons in hippocampal slices prepared from Q...

journal_title：Epilepsia

authors： Kile KB,Tian N,Durand DM

更新日期：2008-03-01 00:00:00

abstract：PURPOSE:Vigabatrin (VGB) and lamotrigine (LTG) are two new antiepileptic drugs (AEDs) with different mechanisms of action for treatment of refractory epilepsies. Previous reports have indicated efficacy of both drugs in a number of epileptic syndromes. METHODS:We compared these new AEDs drugs to determine their respec...

journal_title：Epilepsia

authors： Bélanger S,Coulombe G,Carmant L

更新日期：1998-08-01 00:00:00

abstract：:Mutations of the SCN1A subunit of the sodium channel is a cause of genetic epilepsy with febrile seizures plus (GEFS(+) ) in multiplex families and accounts for 70-80% of Dravet syndrome (DS). DS cases without SCN1A mutation inherited have predicted SCN9A susceptibility variants, which may contribute to complex inheri...

journal_title：Epilepsia

authors： Mulley JC,Hodgson B,McMahon JM,Iona X,Bellows S,Mullen SA,Farrell K,Mackay M,Sadleir L,Bleasel A,Gill D,Webster R,Wirrell EC,Harbord M,Sisodiya S,Andermann E,Kivity S,Berkovic SF,Scheffer IE,Dibbens LM

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Benign epilepsy with centrotemporal spikes (BECTS) is associated with mild cognitive deficits, especially language impairment. This study aimed to clarify whether children with BECTS with left- or right-hemispheric, or bilateral focus have specific neuropsychological language deficits when compared to healthy c...

journal_title：Epilepsia

authors： Datta AN,Oser N,Bauder F,Maier O,Martin F,Ramelli GP,Steinlin M,Weber P,Penner IK

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To study the mechanisms of startle-induced supplementary sensorimotor area (SSMA) seizures. METHODS:We present a patient investigated with indwelling subdural grid electrodes covering both the SSMA and the dorsolateral frontal lobe. RESULTS:We found a simultaneous seizure onset in the right dorsolateral premo...

journal_title：Epilepsia

authors： Serles W,Leutmezer F,Pataraia E,Olbrich A,Gröppel G,Czech T,Baumgartner C

更新日期：1999-07-01 00:00:00

abstract：PURPOSE:Presurgical language mapping in dominant hemisphere epilepsy to evaluate the risk of postoperative deficit is particularly difficult in children. Extraoperative invasive cortical stimulation can show some areas critical to language, but not all of them, due to scarce sampling, poor cooperation, cortical immatur...

journal_title：Epilepsia

authors： de Ribaupierre S,Fohlen M,Bulteau C,Dorfmüller G,Delalande O,Dulac O,Chiron C,Hertz-Pannier L

更新日期：2012-01-01 00:00:00

abstract：:The 1981 International Classification of Epileptic Seizures (ICES) was used to study the distribution of seizure types in 1,250 patients attending an Epilepsy Clinic in Sri Lanka. Based on seizure symptomatology 94.6% of the cases could be classified, and by adding the routine interictal EEG findings the percentage of...

journal_title：Epilepsia

authors： Senanayake N

更新日期：1993-09-01 00:00:00

abstract：PURPOSE:To investigate possible predictive factors for seizure control in a group of children and adults with low IQs (IQ, < or =70) who underwent resective surgery for intractable focal epilepsy and to study outcome with respect to seizures and neuropsychological functioning. We also studied psychosocial outcome in th...

journal_title：Epilepsia

authors： Bjørnaes H,Stabell KE,Heminghyt E,Røste GK,Bakke SJ

更新日期：2004-02-01 00:00:00

abstract：:Seventy-eight patients with temporal lobe type seizures were precisely matched for age, sex, and Wechsler I.Q. levels with patients suffering from other seizure types. Statistically significant differences were established between the groups in regard to treatment response, etiologies, and behavioral variables. Furthe...

journal_title：Epilepsia

authors： Rodin EA,Katz M,Lennox K

更新日期：1976-09-01 00:00:00

abstract：:A group of patients with benign epilepsy of children with centrotemporal EEG foci, consisting of 40 patients reported 10 years ago, has been reinvestigated. Thirty-seven of these patients were reinvestigated. They were 26-34 years old (mean, 29 years). The observation time from the first seizure was 13-27 years (mean,...

journal_title：Epilepsia

authors： Blom S,Heijbel J

更新日期：1982-12-01 00:00:00

abstract：:The efficacy of surgery to treat drug-resistant temporal lobe epilepsy (TLE) has been demonstrated in a prospective randomized trial. It remains controversial which resection method gives best results for seizure freedom and neuropsychological function. This review of 53 studies addressing extent of resection in surge...

journal_title：Epilepsia

authors： Schramm J

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:Neuropsychological studies suggest frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy (JME). In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectrosc...

journal_title：Epilepsia

authors： Savic I,Lekvall A,Greitz D,Helms G

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Although the general utility of voxel-based processing of structural magnetic resonance imaging (MRI) data for detecting occult lesions in focal epilepsy is established, many differences exist among studies, and it is unclear which processing method is preferable. The aim of this study was to compare the abil...

journal_title：Epilepsia

authors： Martin P,Winston GP,Bartlett P,de Tisi J,Duncan JS,Focke NK

更新日期：2017-09-01 00:00:00

abstract：PURPOSE:Trials of antiepileptic medications are usually based in tertiary referral centers with teaching hospital resources. Epilepsy Research & Services (ERS) is part of a private outpatient neurological clinic that is involved in research as part of multicenter clinical trials, adhering to Good Clinical Research Prac...

journal_title：Epilepsia

authors： Beran RG,Beran ME

更新日期：2000-07-01 00:00:00

abstract：PURPOSE:This report concerns the 2-year extension of the study of mortality and sudden, unexpected, unexplained death in epilepsy (SUDEP) in the cohort of patients receiving vagal nerve stimulation by the NCP System for the treatment of epilepsy. METHODS:A cohort of 1,819 individuals was followed 3,176.3 person-years ...

journal_title：Epilepsia

authors： Annegers JF,Coan SP,Hauser WA,Leestma J

更新日期：2000-05-01 00:00:00

abstract：:Although the technical and human resources for epilepsy care and classification are located largely in high income countries, most people with epilepsy reside in developing regions of the world. Advances over the past two decades in the clinical and basic neurosciences have transformed epilepsy care and largely drive ...

journal_title：Epilepsia

authors： Birbeck GL

更新日期：2012-07-01 00:00:00

abstract：:Toxic causes of seizures are numerous: alcohol and other substances of abuse, drugs, and industrial and household products. However, in the absence of a clearly suggestive history and/or associated symptoms and signs, identification of the toxic origin of new-onset seizures may be extremely difficult. We report here t...

journal_title：Epilepsia

authors： Denays R,Kumba C,Lison D,De Bels D

更新日期：2005-06-01 00:00:00

abstract：:Since the clinical data have been equivocal in regard to the effects of clonazepam (CZP) in focal-motor seizures, an alumina gel monkey model was used to evaluate quantitatively its efficacy with respect to this seizure category. The insolubility of CZP and its short biological half-life in monkey necessitated its eva...

journal_title：Epilepsia

authors： Lockard JS,Levy RH,Congdon WC,DuCharme LL,Salonen LD

更新日期：1979-12-01 00:00:00

abstract：:Ictal and interictal epileptic activity was recorded for the first time by multichannel magnetoencephalography (MEG) in three patients with partial epilepsy. Pre- and intra-operative localization of the epileptogenic region was compared. The interictal epileptic activity was localized at the same region of the tempora...

journal_title：Epilepsia

authors： Stefan H,Schneider S,Feistel H,Pawlik G,Schüler P,Abraham-Fuchs K,Schlegel T,Neubauer U,Huk WJ

更新日期：1992-09-01 00:00:00

abstract：:In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography (PET) using a radiotracer sensitive to brain inflammation in a patient with frontal epilepsy ~36 h after a seizure as well as during a se...

journal_title：Epilepsia

authors： Butler T,Li Y,Tsui W,Friedman D,Maoz A,Wang X,Harvey P,Tanzi E,Morim S,Kang Y,Mosconi L,Talos D,Kuzniecky R,Vallhabjosula S,Thesen T,Glodzik L,Ichise M,Silbersweig D,Stern E,de Leon MJ,French J

更新日期：2016-09-01 00:00:00