Significance of bisynchronous spike-waves in patients with temporal lobe spikes.

abstract：:Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...

journal_title：Epilepsia

authors： Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To characterize features influencing marital status in a group of patients with refractory epilepsy before and after epilepsy surgery and to assess the effect of seizure control on marital status after epilepsy surgery. METHODS:We analyzed marital status in 430 epilepsy surgery patients and in a subset with te...

journal_title：Epilepsia

authors： Carran MA,Kohler CG,O'Connor MJ,Cloud B,Sperling MR

更新日期：1999-12-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) can be used for noninvasive measurement of more than two dozen small metabolites in the brains of living animals and humans. In the first decade of its use for study of seizure phenomena in animals, MRS successfully detected in vivo seizure-induced cerebral acidosis and reduction ...

journal_title：Epilepsia

authors： Prichard JW

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:Angelman syndrome (AS) is a neurogenetic disorder characterized by developmental delay and a frequently refractory epileptic condition. Valproate, clonazepam and/or phenytoin are said to be the most effective antiepileptic drugs (AEDs) against the seizures in AS. Experience with the newer AEDs is very limited d...

journal_title：Epilepsia

authors： Dion MH,Novotny EJ Jr,Carmant L,Cossette P,Nguyen DK

更新日期：2007-03-01 00:00:00

abstract：:The longstanding dichotomy between the concepts of "focal" and "primary generalized" epilepsy has become increasingly blurred, raising fundamental questions about the nature of ictal onset in localized brain regions versus large-scale brain networks. We hypothesize that whether an EEG discharge appears focal or genera...

journal_title：Epilepsia

authors： Terry JR,Benjamin O,Richardson MP

更新日期：2012-09-01 00:00:00

abstract：PURPOSE:Chronic cellular inflammation closely associated with epilepsy without an active infection is a hallmark of Rasmussen encephalitis (RE). RE has typical and defining features lacking in other rare epilepsy patients who also have neocortical lymphocytes without an identifiable cause. A patient with malformations ...

journal_title：Epilepsia

authors： Rhodes RH,Lehman RM,Wu BY,Roychowdhury S

更新日期：2007-06-01 00:00:00

abstract：:We report the case of a 3-year-old boy with status gelasticus symptomatic to a giant hypothalamic hamartoma despite two previous hypothalamic hamartoma surgeries using pterional approaches from each side. Following his third resection employing an endoscopic, transventricular approach, he has been seizure free for 6 m...

journal_title：Epilepsia

authors： Ng YT,Rekate HL

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Patients with gliomas frequently present with seizures, but the factors associated with seizure development are still poorly understood. In this study, we assessed peritumoral synaptic network activity in a glioma animal model and tested the contribution of aberrant glutamate release from gliomas on glioma-asso...

journal_title：Epilepsia

authors： Campbell SL,Buckingham SC,Sontheimer H

更新日期：2012-08-01 00:00:00

abstract：:Men are different from women, and patients with epilepsy are different in many aspects from healthy control subjects. Quantitative or semiquantitative analysis of neuroimaging data depends on the comparison between either a single patient against a group of healthy or unaffected controls, or comparisons between groups...

journal_title：Epilepsia

authors： Koepp MJ

更新日期：2011-07-01 00:00:00

abstract：:Over the past decade, much progress has been made in understanding the mechanisms of ketogenic diet (KD) action. From the complex systemic and metabolic changes induced by the KD have emerged innovative hypotheses attempting to link biochemical adaptations to its clinical effects. Despite such developments, the fundam...

journal_title：Epilepsia

authors： Rho JM,Sankar R

更新日期：2008-11-01 00:00:00

abstract：OBJECTIVE:To investigate whether the link between epilepsy and deprivation is due to factors associated with deprivation (social causation) or factors associated with a diagnosis of epilepsy (social drift). METHODS:We reviewed electronic primary health care records from 2004 to 2010, identifying prevalent and incident...

journal_title：Epilepsia

authors： Pickrell WO,Lacey AS,Bodger OG,Demmler JC,Thomas RH,Lyons RA,Smith PE,Rees MI,Kerr MP

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effe...

journal_title：Epilepsia

authors： Kahriman M,Minecan D,Kutluay E,Selwa L,Beydoun A

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that ...

journal_title：Epilepsia

authors： Carriero G,Arcieri S,Cattalini A,Corsi L,Gnatkovsky V,de Curtis M

更新日期：2012-11-01 00:00:00

abstract：:We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG di...

journal_title：Epilepsia

authors： Kumlien E,Bergström M,Lilja A,Andersson J,Szekeres V,Westerberg CE,Westerberg G,Antoni G,Långström B

更新日期：1995-07-01 00:00:00

abstract：:The acute effects of valproate (200 and 400 mg/kg), ethosuximide (200 and 400 mg/kg), phenytoin (25 and 50 mg/kg), and pentobarbital (30 and 60 mg/kg) on cerebral energy metabolism of rats were studied by measuring the cerebral content of energy metabolites and by evaluating the rate of metabolite utilization followin...

journal_title：Epilepsia

authors： Gueldry S,Rochette L,Bralet J

更新日期：1987-03-01 00:00:00

abstract：:A 30-year-old man with long-standing localization-related epilepsy and mental retardation had seizures that were partially controlled with valproate (VPA) 500 mg four times daily. Routine examination showed severe thrombocytopenia with mild leukopenia and chronic low-grade hemolytic anemia. Pertinent laboratory result...

journal_title：Epilepsia

authors： Asconapé JJ,Manning KR,Lancman ME

更新日期：1994-01-01 00:00:00

abstract：:Children with epilepsy often grow into adults with significant social problems including decreased employment, marriage, social relationships, and independent living arrangements. These problems are noted in population-based longitudinal and cross-sectional studies from many countries. Learning disorder and mental han...

journal_title：Epilepsia

authors： Camfield CS,Camfield PR

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Acute encephalopathy is the most serious complication of pediatric viral infections, such as influenza and exanthema subitum. It occurs worldwide, but is most prevalent in East Asia. Recently, there have been sporadic case reports of epilepsy/febrile seizure and acute encephalopathy with a neuronal sodium chann...

journal_title：Epilepsia

authors： Saitoh M,Shinohara M,Hoshino H,Kubota M,Amemiya K,Takanashi JL,Hwang SK,Hirose S,Mizuguchi M

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:To evaluate reproductive endocrine function in boys and young men with epilepsy taking an antiepileptic drug in a population-based, controlled study. METHODS:Seventy patients and 70 controls matched for age and pubertal stage participated in this study. Twenty-eight patients were taking carbamazepine (CBZ); fi...

journal_title：Epilepsia

authors： Mikkonen K,Tapanainen P,Pakarinen AJ,Päivänsalo M,Isojärvi JI,Vainionpää LK

更新日期：2004-07-01 00:00:00

abstract：PURPOSE:Patients with medically intractable epilepsy due to brain tumors may undergo resective surgery for treatment of both the tumor and the epilepsy. In this instance, the extent of surgical resection is sometimes guided by spikes recorded on intraoperative electrocorticography (ECoG). Whether spikes recorded by ele...

journal_title：Epilepsia

authors： Tran TA,Spencer SS,Javidan M,Pacia S,Marks D,Spencer DD

更新日期：1997-10-01 00:00:00

abstract：:Mutations in a number of genes encoding voltage-gated sodium channels cause a variety of epilepsy syndromes in humans, including genetic (generalized) epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome (DS, severe myoclonic epilepsy of infancy). Most of these mutations are in the SCN1A gene, and all are d...

journal_title：Epilepsia

authors： Escayg A,Goldin AL

更新日期：2010-09-01 00:00:00

abstract：:The ketogenic diet (KD) is a medical nutrition therapy (MNT) for the treatment of epilepsy. As such, it can affect the outcome of an individual's health and chronic medical condition. The components of MNT which have been established by the American Dietetic Association as core guidelines for nutrition care include a ...

journal_title：Epilepsia

authors： Zupec-Kania B,Zupanc ML

更新日期：2008-11-01 00:00:00

abstract：:Sudden unexplained death syndrome (SUDS) accounts for about 10% of deaths in patients with epilepsy. It is associated with subtherapeutic postmortem serum antiepileptic drug (AED) levels but no anatomic cause of death on autopsy. The mechanisms of death are not known. We investigated 44 cases of SUDS for details of se...

journal_title：Epilepsia

authors： Earnest MP,Thomas GE,Eden RA,Hossack KF

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). METHODS:Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing...

journal_title：Epilepsia

authors： Kälviäinen R,Genton P,Andermann E,Andermann F,Magaudda A,Frucht SJ,Schlit AF,Gerard D,de la Loge C,von Rosenstiel P

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:In CSWS (continuous spike waves during sleep) activation of spike waves during slow wave sleep has been causally linked to neuropsychological deficits, but the pathophysiologic mechanisms are still unknown. In healthy subjects, the overnight decrease of the slope of slow waves in NREM (non-rapid eye movement)...

journal_title：Epilepsia

authors： Bölsterli Heinzle BK,Fattinger S,Kurth S,Lebourgeois MK,Ringli M,Bast T,Critelli H,Schmitt B,Huber R

更新日期：2014-04-01 00:00:00

abstract：:The use of rescue benzodiazepines in the management of seizures is widely accepted in emergency pediatric practice. They can, however, cause severe side effects, such as respiratory depression. We describe five patients who presented with severe respiratory depression following benzodiazepine administration for seizur...

journal_title：Epilepsia

authors： Lacroix L,Fluss J,Gervaix A,Korff CM

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Ictal single-photon emission computed tomography (SPECT) may help localize the seizure-onset zone (SOZ) by detecting changes in regional cerebral blood flow induced by epileptic discharges. This imaging method also reveals hyperperfusions in areas of seizure propagation, including the hemisphere contralateral t...

journal_title：Epilepsia

authors： Huberfeld G,Habert MO,Clemenceau S,Maksud P,Baulac M,Adam C

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The role of alpha 1b-adrenergic receptor (alpha 1b-AR) in relation with neuronal degeneration, drug addiction, and seizure susceptibility has recently emerged. In particular, mice that overexpress alpha 1b-AR undergo spontaneous epileptic seizures and progressive neuronal loss in a variety of brain areas. There...

journal_title：Epilepsia

authors： Pizzanelli C,Lazzeri G,Fulceri F,Giorgi FS,Pasquali L,Cifelli G,Murri L,Fornai F

更新日期：2009-01-01 00:00:00

abstract：:Our understanding of the neural mechanisms of non-rapid eye movement sleep (NREM) is steadily increasing. Given the intriguing activation of paroxysmal activity during NREM sleep in patients with Landau-Kleffner syndrome (LKS), a thorough characterization of commonalities and differences between the neural correlates ...

journal_title：Epilepsia

authors： Mascetti L,Foret A,Bonjean M,Matarazzo L,Dang-Vu T,Maquet P

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:This report concerns the 2-year extension of the study of mortality and sudden, unexpected, unexplained death in epilepsy (SUDEP) in the cohort of patients receiving vagal nerve stimulation by the NCP System for the treatment of epilepsy. METHODS:A cohort of 1,819 individuals was followed 3,176.3 person-years ...

journal_title：Epilepsia

authors： Annegers JF,Coan SP,Hauser WA,Leestma J

更新日期：2000-05-01 00:00:00