Abstract:
:We determined changes in serum concentrations of thyroid hormones during carbamazepine (CBZ) therapy during a 5-year prospective follow-up study of 20 patients with newly diagnosed epilepsy. In addition, we evaluated the effects of replacing CBZ with oxcarbazepine (OCBZ) in 12 male patients with epilepsy in a 6-month prospective follow-up study. Circulating thyroxine and free thyroxine levels decreased after 2-month CBZ treatment and remained at a low level during the 5-year follow-up. There were no associated changes in serum thyrotropin (TSH) concentrations. When CBZ was replaced by OCBZ, the function of the liver's P450 enzyme system normalized, as shown by an increase in antipyrineT1/2, and a decrease in antipyrineCL. Serum total and free thyroxine levels increased, and thereafter serum TSH levels decreased. Indexes of diastolic heart function improved concomitantly, which may reflect subclinical hypothyroidism at the cellular level during CBZ treatment. We conclude that normal thyroid function can be restored in patients with epilepsy by replacing CBZ with OCBZ.
journal_name
Epilepsiajournal_title
Epilepsiaauthors
Isojärvi JI,Airaksinen KE,Mustonen JN,Pakarinen AJ,Rautio A,Pelkonen O,Myllylä VVdoi
10.1111/j.1528-1157.1995.tb01619.xsubject
Has Abstractpub_date
1995-08-01 00:00:00pages
810-6issue
8eissn
0013-9580issn
1528-1167journal_volume
36pub_type
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