Lesion localization in periodic lateralized epileptiform discharges: gray or white matter.


:We analyzed the results of neuroimaging studies in patients with periodic lateralized epileptiform discharges (PLEDs) or bilateral independent periodic lateralized epileptiform discharges (BIPLEDs) for localization of lesions in gray or white matter to determine if "cortical isolation" is a critical mechanism in the pathogenesis of this phenomena. We assessed 32 patients who had undergone computed tomography (CT) exclusively and 8 patients who had undergone magnetic resonance imaging (MRI) with or without CT. The superior resolution necessary for adequate lesion localization allowed use of only the MRI scans from the 8 patients. Six patients had scans with cortical and subcortical gray and white matter lesions, and 1 patient had a cortical gray matter lesion only. One patient had an indeterminate scan. No patient had white matter lesions only. Our findings in patients with PLEDs and BIPLEDs correlate with postmortem data in patients with generalized periodic EEG patterns that show consistent localization of lesions in the gray matter. These findings do not support cortical isolation as the critical or sole mechanism in PLEDs or BIPLEDs.






Raroque HG Jr,Purdy P




Has Abstract


1995-01-01 00:00:00












  • Self-discontinuation of antiepileptic medication in pregnancy: detection by hair analysis.

    abstract:PURPOSE:Concerns over teratogenicity of antiepileptic drugs (AEDs) during pregnancy must be balanced against the risks of seizures to the mother and developing fetus. Pharmacokinetic changes and vomiting may alter drug levels, but more important may be the patient's decision to stop medication before or during pregnanc...


    pub_type: 杂志文章


    authors: Williams J,Myson V,Steward S,Jones G,Wilson JF,Kerr MP,Smith PE

    更新日期:2002-08-01 00:00:00

  • Mutation of CHRNA2 in a family with benign familial infantile seizures: Potential role of nicotinic acetylcholine receptor in various phenotypes of epilepsy.

    abstract::Nicotinic acetylcholine receptor genes are involved mainly in nocturnal frontal epilepsy. Despite extensive studies, to date, the α2 subunit did not show a strong association with this peculiar epileptic phenotype. We report CHRNA2 missense mutation in a family with benign familial infantile seizures (BFIS). TrueSeq C...


    pub_type: 杂志文章


    authors: Trivisano M,Terracciano A,Milano T,Cappelletti S,Pietrafusa N,Bertini ES,Vigevano F,Specchio N

    更新日期:2015-05-01 00:00:00

  • New onset epilepsy among patients with periodic discharges on continuous electroencephalographic monitoring.

    abstract:OBJECTIVE:To evaluate the incidence of new onset epilepsy and associated risk factors in patients with periodic patterns on continuous electroencephalography (cEEG) during critical illness. METHODS:The local cEEG database and then medical records were reviewed from January 1, 2013 to June 30, 2013 to find adult patien...


    pub_type: 杂志文章


    authors: Punia V,Bena J,Krishnan B,Newey C,Hantus S

    更新日期:2018-08-01 00:00:00

  • Orthogonal wave propagation of epileptiform activity in the planar mouse hippocampus in vitro.

    abstract:PURPOSE:In vitro brain preparations have been used extensively to study the generation and propagation of epileptiform activity. Transverse and longitudinal slices of the rodent hippocampus have revealed various patterns of propagation. Yet intact connections between the transverse and longitudinal pathways should gene...


    pub_type: 杂志文章


    authors: Kibler AB,Durand DM

    更新日期:2011-09-01 00:00:00

  • Epilepsy duration, febrile seizures, and cerebral glucose metabolism.

    abstract:PURPOSE:Studies using magnetic resonance imaging have shown that reduced hippocampal volume is associated with a history of febrile seizures, the duration of epilepsy, and the number of generalized tonic-clonic seizures. It is uncertain whether these factors have the same influence on functional as on structural measur...


    pub_type: 杂志文章


    authors: Theodore WH,Kelley K,Toczek MT,Gaillard WD

    更新日期:2004-03-01 00:00:00

  • Distribution of pyramidal cell density and hyperexcitability in the epileptic human hippocampal formation.

    abstract::Pyramidal cell densities in various regions of the anterior and posterior hippocampal formation were measured from en bloc temporal lobe resections and compared with presurgical stereoelectroencephalography (SEEG) data derived from depth electrodes in 12 patients with temporal lobe epilepsy. These data were compared w...


    pub_type: 杂志文章


    authors: Babb TL,Lieb JP,Brown WJ,Pretorius J,Crandall PH

    更新日期:1984-12-01 00:00:00

  • Pharmacokinetic profile of a 300-mg extended phenytoin sodium capsule (Dilantin) formulation.

    abstract::The pharmacokinetic profile of a newly developed Dilantin 300-mg Kapseal formulation was compared with that of currently marketed Dilantin 100-mg Kapseals in both a 300-mg single-dose bioequivalence study in nine healthy volunteers and a once-daily 300-mg multiple-dose study in 18 patients with seizures. Results of th...


    pub_type: 杂志文章


    authors: Randinitis EJ,Buchanan RA,Kinkel AW

    更新日期:1990-07-01 00:00:00

  • Fixation-off and eyes closed catamenial generalized nonconvulsive status epilepticus with eyelid myoclonic jerks.

    abstract:PURPOSE:Eyelid myoclonic jerks have been described in fixation-off-sensitive (FOS) epilepsy, but their relationship to nonconvulsive status epilepticus (NCSE) or to catamenial exacerbations is little reported. METHODS:We describe a woman of normal intelligence with catamenial periods of prolonged NCSE who exhibited va...


    pub_type: 杂志文章


    authors: Ming X,Kaplan PW

    更新日期:1998-06-01 00:00:00

  • Novel features for capturing temporal variations of rhythmic limb movement to distinguish convulsive epileptic and psychogenic nonepileptic seizures.

    abstract:OBJECTIVE:To investigate the characteristics of motor manifestation during convulsive epileptic and psychogenic nonepileptic seizures (PNES), captured using a wrist-worn accelerometer (ACM) device. The main goal was to find quantitative ACM features that can differentiate between convulsive epileptic and convulsive PNE...


    pub_type: 杂志文章


    authors: Kusmakar S,Karmakar C,Yan B,Muthuganapathy R,Kwan P,O'Brien TJ,Palaniswami MS

    更新日期:2019-01-01 00:00:00

  • Ictal hyperperfusion patterns in relation to ictal scalp EEG patterns in patients with unilateral hippocampal sclerosis: a SPECT study.

    abstract:PURPOSE:The aims of the present study were to explore the relation between ictal scalp EEG patterns and ictal hyperperfusion patterns in patients with unilateral hippocampal sclerosis-associated mesial temporal lobe epilepsy (HS-MTLE) by using semiquantitative single-photon emission computed tomography (SPECT) analysis...


    pub_type: 杂志文章


    authors: Kim JH,Im KC,Kim JS,Lee SA,Lee JK,Khang SK,Kang JK

    更新日期:2007-02-01 00:00:00

  • Single and multiple clusters of magnetoencephalographic dipoles in neocortical epilepsy: significance in characterizing the epileptogenic zone.

    abstract:PURPOSE:To characterize the epileptogenic zone in neocortical epilepsy (NE) by using magnetoencephalography (MEG). METHODS:We defined and compared locations of single and multiple clusters of equivalent current dipoles (ECDs) for interictal spikes with MRI findings, ictal-onset zones (IOZs) from subdural electroenceph...


    pub_type: 杂志文章


    authors: Oishi M,Kameyama S,Masuda H,Tohyama J,Kanazawa O,Sasagawa M,Otsubo H

    更新日期:2006-02-01 00:00:00

  • Effects of hippocampus-sparing resections in the temporal lobe: Hippocampal atrophy is associated with a decline in memory performance.

    abstract:OBJECTIVE:In patients with temporal lobe epilepsy (TLE) with a nonlesional and nonepileptogenic hippocampus (HC), in order to preserve functionally intact brain tissue, the HC is not resected. However, some patients experience postoperative memory decline, possibly due to disruption of the extrahippocampal memory netwo...


    pub_type: 杂志文章


    authors: Wagner K,Gau K,Metternich B,Geiger MJ,Wendling AS,Kadish NE,Reuner G,Mayer H,Mader I,Beck J,Zentner J,Urbach H,Schulze-Bonhage A,Kaller CP,Foit NA

    更新日期:2020-04-01 00:00:00

  • Distribution of seizure types in an epileptic population.

    abstract::The distribution of seizure types was investigated in an epidemiological survey of 1,220 patients over 15 years of age. Classification of clinically dominant seizure type according to the International Classification of Epileptic Seizures (ICES) was possible in 1,005 cases (82.5%). Fifty-six percent of patients had pa...


    pub_type: 杂志文章


    authors: Keränen T,Sillanpää M,Riekkinen PJ

    更新日期:1988-01-01 00:00:00

  • Nocturnal frontal lobe epilepsy.

    abstract::Nocturnal frontal lobe epilepsy (NFLE) is a condition primarily characterized by seizures occurring exclusively or predominantly during sleep, the semiology of which suggest a frontal lobe origin and, more specifically, the involvement of the orbitofrontal or mesial frontal regions. It is usually considered as a relat...


    pub_type: 杂志文章,评审


    authors: Ryvlin P,Rheims S,Risse G

    更新日期:2006-01-01 00:00:00

  • Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy.

    abstract:OBJECTIVES:Patients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collate...


    pub_type: 临床试验,杂志文章


    authors: Drane DL,Loring DW,Voets NL,Price M,Ojemann JG,Willie JT,Saindane AM,Phatak V,Ivanisevic M,Millis S,Helmers SL,Miller JW,Meador KJ,Gross RE

    更新日期:2015-01-01 00:00:00

  • The development of intellectual abilities in pediatric temporal lobe epilepsy.

    abstract:PURPOSE:The aim of this study was to examine the impact of clinical variables, particularly age at onset of epilepsy, on intellectual function in a group of children with temporal lobe epilepsy (TLE). METHODS:We reviewed the preoperative neuropsychological test results of 79 children with unilateral TLE who subsequent...


    pub_type: 杂志文章


    authors: Cormack F,Cross JH,Isaacs E,Harkness W,Wright I,Vargha-Khadem F,Baldeweg T

    更新日期:2007-01-01 00:00:00

  • Benign epilepsy of children with centrotemporal EEG foci: a follow-up study in adulthood of patients initially studied as children.

    abstract::A group of patients with benign epilepsy of children with centrotemporal EEG foci, consisting of 40 patients reported 10 years ago, has been reinvestigated. Thirty-seven of these patients were reinvestigated. They were 26-34 years old (mean, 29 years). The observation time from the first seizure was 13-27 years (mean,...


    pub_type: 杂志文章


    authors: Blom S,Heijbel J

    更新日期:1982-12-01 00:00:00

  • EEG abnormalities in children with a first unprovoked seizure.

    abstract::We examined EEG findings from an ongoing study of 347 children with a first unprovoked seizure. EEGs were available in 321 (93%), and 135 (42%) had an abnormal EEG. EEG abnormalities included focal spikes (n = 77), generalized spike and wave discharges (n = 28), slowing (n = 43), and nonspecific abnormalities (n = 7)....


    pub_type: 杂志文章


    authors: Shinnar S,Kang H,Berg AT,Goldensohn ES,Hauser WA,Moshé SL

    更新日期:1994-05-01 00:00:00

  • Clonazepam (Rivotril) and carbamazepine (Tegretol) in psychomotor epilepsy: a randomized multicenter trial.

    abstract::The antiepileptic properties of carbamazepine (Tegretol) and clonazepam (Rivotril) were compared in a double-blind randomized study comprising 36 patients with newly diagnosed, untreated psychomotor epilepsy (partial seizures with complex symptomatology). No significant differences were found between the two drugs dur...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mikkelsen B,Berggreen P,Joensen P,Kristensen O,Køhler O,Mikkelsen BO

    更新日期:1981-08-01 00:00:00

  • Refractory status epilepticus during pregnancy secondary to cavernous angioma.

    abstract:SUMMARY:First-time seizure and status epilepticus during pregnancy have been previously reported as the initial manifestation of intracranial cavernous hemangioma. We report a woman with no history of seizures who presented with refractory status epilepticus at 10 weeks gestation. Cranial MRI revealed a right frontal c...


    pub_type: 杂志文章


    authors: Aladdin Y,Gross DW

    更新日期:2008-09-01 00:00:00

  • Epilepsy in general practice: the Dutch situation.

    abstract::Treatment and supervision of epileptic patients is part of specialist medicine. A possible change in the role of specialists and general practitioners in the care of these patients was explored by a questionnaire mailed to all Dutch neurologists and a random sample of general practitioners. Patients were also asked th...


    pub_type: 杂志文章


    authors: Rutgers MJ

    更新日期:1986-11-01 00:00:00

  • Functional anatomy of spontaneous seizures in a rat model of limbic epilepsy.

    abstract:PURPOSE:The substrate of seizure initiation in partial epilepsy is not well understood. Although many studies imply a focus that is will localized to a single structure, some information suggests that seizures arise regionally with simultaneous or near-simultaneous onset at several separate sites. To determine the phys...


    pub_type: 杂志文章


    authors: Bertram EH

    更新日期:1997-01-01 00:00:00

  • A method for identifying associations between seizures and possible trigger events in adults with intellectual disability.

    abstract:OBJECTIVES:Precipitants of seizures are often reported by patients and carers, but the accuracy of these claims remains unknown. Focusing on epilepsy in people with intellectual disability (ID), the aims of this work were to (1) identify a set of methods for assessing the validity of reported seizure triggers in indivi...


    pub_type: 杂志文章


    authors: Illingworth JL,Watson P,Xu S,Manford M,Ring H

    更新日期:2015-11-01 00:00:00

  • Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.

    abstract::The effects of antiepileptic drugs (AEDs) on cognitive function and behavior in children are reviewed on the basis of published studies. Individual AEDs have been shown to differ--the deleterious effects of phenytoin generally contrasting with the relatively minimal effects of valproate and carbamazepine. Some of the ...


    pub_type: 杂志文章,评审


    authors: Trimble MR

    更新日期:1990-01-01 00:00:00

  • Further evidence that pathologic high-frequency oscillations are bursts of population spikes derived from recordings of identified cells in dentate gyrus.

    abstract:PURPOSE:To analyze activity of identified dentate gyrus granular cells and interneurons during pathologic high-frequency oscillations (pHFOs). METHODS:Pilocarpine-treated epileptic mice were anesthetized with urethane and ketamine. Their heads were fixed in a stereotaxic frame. Extracellular unit activity was recoded ...


    pub_type: 杂志文章


    authors: Bragin A,Benassi SK,Kheiri F,Engel J Jr

    更新日期:2011-01-01 00:00:00

  • Seizures in patients with Alzheimer's disease or vascular dementia: a population-based nested case-control analysis.

    abstract:PURPOSE:Patients with Alzheimer's disease (AD) have an increased risk of developing seizures or epilepsy. Little is known about the role of risk factors and about the risk of developing seizures/epilepsy in patients with vascular dementia (VD). The aim of this study was to assess incidence rates (IRs) of seizures/epile...


    pub_type: 杂志文章


    authors: Imfeld P,Bodmer M,Schuerch M,Jick SS,Meier CR

    更新日期:2013-04-01 00:00:00

  • Vagus nerve stimulation reduces cardiac electrical instability assessed by quantitative T-wave alternans analysis in patients with drug-resistant focal epilepsy.

    abstract:OBJECTIVE:The cardiac component of risk for sudden unexpected death in epilepsy (SUDEP) and alterations in cardiac risk by vagus nerve stimulation (VNS) are not well understood. We determined changes in T-wave alternans (TWA), a proven noninvasive marker of risk for sudden cardiac death in patients with cardiovascular ...


    pub_type: 杂志文章


    authors: Schomer AC,Nearing BD,Schachter SC,Verrier RL

    更新日期:2014-12-01 00:00:00

  • Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment.

    abstract::The mean gamma-aminobutyric acid (GABA) level in lumbar CSF of 31 children with epilepsy was not significantly different from that of 41 age-matched controls. However, when the epileptic children were subdivided into untreated patients and patients treated with antiepileptic drugs, the medication-free subgroup had a s...


    pub_type: 杂志文章


    authors: Löscher W,Siemes H

    更新日期:1985-07-01 00:00:00

  • How phenobarbital revolutionized epilepsy therapy: the story of phenobarbital therapy in epilepsy in the last 100 years.

    abstract::Phenobarbital (phenobarbitone) was first used as an antiepileptic drug 100 years ago, in 1912. This article tells the story of the discovery of its antiepileptic action, its early development, and the subsequent course of its clinical use over the 100-year period. The side effects, pharmacokinetics, and misuse of barb...


    pub_type: 历史文章,杂志文章


    authors: Yasiry Z,Shorvon SD

    更新日期:2012-12-01 00:00:00

  • An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures.

    abstract:PURPOSE:Higher homocysteine levels were found in actively drinking patients with alcohol dependence. Recent studies have shown that high homocysteine levels are associated with alcohol-withdrawal seizures. The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in ac...


    pub_type: 杂志文章


    authors: Bleich S,Bayerlein K,Hillemacher T,Degner D,Kornhuber J,Frieling H

    更新日期:2006-05-01 00:00:00