Abstract：
:Part of the symptomatology of post-traumatic stress disorder (PTSD) are alterations in arousal and reactivity which could be related to a maladaptive increase in the automated sensory change detection system of the brain. In the current EEG study we investigated whether the brain's response to a simple auditory sensory change was altered in patients with PTSD relative to trauma-exposed matched controls who did not develop the disorder. Thirteen male PTSD patients and trauma-exposed controls matched for age and educational level were presented with regular auditory pure tones (1000 Hz, 200 ms duration), with 11% of the tones deviating in both duration (50 ms) and frequency (1200 Hz) while watching a silent movie. Relative to the controls, patients who had developed PTSD showed enhanced mismatch negativity (MMN), increased theta power (5-7 Hz), and stronger suppression of upper alpha activity (13-15 Hz) after deviant vs. standard tones. Behaviourally, the alpha suppression in PTSD correlated with decreased spatial working memory performance suggesting it might reflect enhanced stimulus-feature representations in auditory memory. These results taken together suggest that PTSD patients and trauma-exposed controls can be distinguished by enhanced involuntary attention to changes in sensory patterns.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Bangel KA,van Buschbach S,Smit DJA,Mazaheri A,Olff Mdoi
10.1038/s41598-017-16669-8subject
Has Abstractpub_date
2017-11-29 00:00:00pages
16596issue
1issn
2045-2322pii
10.1038/s41598-017-16669-8journal_volume
7pub_type
杂志文章abstract：:Interferon (IFN)-γ is the major mediator of anti-tumor immune responses; nevertheless, cancer cells use intrigue strategies to alter IFN-γ signaling and avoid elimination. Understanding the immune regulatory mechanisms employed by acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) cells upon exposure to I...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48256-4
更新日期：2019-08-12 00:00:00
abstract：:Appropriate isolation methods are essential for unravelling the relative contribution of extracellular vesicles (EVs) and the EV-free secretome to homeostasis and disease. We hypothesized that ultrafiltration followed by size exclusion chromatography (UF-SEC) provides well-matched concentrates of EVs and free secreted...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15717-7
更新日期：2017-11-10 00:00:00
abstract：:The 6SA-CASSCF(10, 10)/6-31G (d, p) quantum chemistry method has been applied to perform on-the-fly trajectory surface hopping simulation with global switching algorithm and to explore excited-state intramolecular proton transfer reactions for the o-nitrophenol molecule within low-lying electronic singlet states (S0 a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26768
更新日期：2016-05-25 00:00:00
abstract：:TLR4 location, and bacterial species-derived lipopolysaccharides, play a significant role in the downstream activation of transcription factors, accessory molecules, and products. Here, this is demonstrated through the use of classically-activated and alternatively-activated macrophages. We show that, when polarized, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79145-w
更新日期：2021-01-14 00:00:00
abstract：:Tumor cell invasion requires the molecular and physical adaptation of both the cell and its microenvironment. Here we show that tumor cells are able to switch between the use of microvesicles and invadopodia to facilitate invasion through the extracellular matrix. Invadopodia formation accompanies the mesenchymal mode...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14748
更新日期：2015-10-13 00:00:00
abstract：:Sorption and desorption determine the amount of an herbicide in soil solution. Therefore, knowledge of the sorption and desorption coefficients in different soils is an essential factor to estimate the potential for environmental contamination by herbicides. We evaluated the feasibility of multivariate and linear disc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44405-x
更新日期：2019-05-27 00:00:00
abstract：:While safety of fasting therapy is debated in humans, extended fasting occurs routinely and safely in wild animals. To do so, food deprived animals like breeding penguins anticipate the critical limit of fasting by resuming feeding. To date, however, no molecular indices of the physiological state that links spontaneo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39008
更新日期：2016-12-19 00:00:00
abstract：:The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05525
更新日期：2014-07-02 00:00:00
abstract：:This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case-control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70195-8
更新日期：2020-09-01 00:00:00
abstract：:Parasites may severely impact the fitness and life-history of their hosts. After infection, surviving individuals may suppress the growth of the parasite, or completely clear the infection and develop immunity. Consequently, parasite prevalence is predicted to decline with age. Among elderly individuals, immunosenesce...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29720
更新日期：2016-07-19 00:00:00
abstract：:Mammalian sperm are unable to fertilize the egg immediately after ejaculation. To gain fertilization competence, they need to undergo a series of modifications inside the female reproductive tract, known as capacitation. Capacitation involves several molecular events such as phosphorylation cascades, hyperpolarization...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-31557-5
更新日期：2018-09-06 00:00:00
abstract：:Glass is an ultraviscous liquid that ceases to flow on a laboratory timescale but continues to relax on a geological timescale. Quintessentially, it has become hopeless for humans to explore the equilibrium behavior of glass, although the technology of glass making witness a remarkable advance. In this work, we propos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43091
更新日期：2017-02-22 00:00:00
abstract：:A brain-computer interface (BCI) is an advanced human-machine interaction technology. The BCI speller is a typical application that detects the stimulated source-induced EEG signal to identify the expected characters of the subjects. The current mainstream matrix-based BCI speller involves two problems that remain uns...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21717-y
更新日期：2018-02-20 00:00:00
abstract：:Protein kinase C-δ (PKC-δ), a member of the lipid-regulated serine/threonine PKC family, has been implicated in a wide range of important cellular processes, such as cell growth, differentiation, and apoptosis. Lampreys belong to the most primitive class of vertebrates, and there is little information on PKC-δ in thes...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12526-w
更新日期：2017-09-22 00:00:00
abstract：:To unravel the molecular mechanism of defense against blister blight (BB) disease caused by an obligate biotrophic fungus, Exobasidium vexans, transcriptome of BB interaction with resistance and susceptible tea genotypes was analysed through RNA-seq using Illumina GAIIx at four different stages during ~20-day disease ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30412
更新日期：2016-07-28 00:00:00
abstract：:Recent studies demonstrate the functions of long non-coding RNAs (lncRNAs) in mediating gene expression at the transcriptional or translational level. Our previous study identified a Sirt1 antisense (AS) lncRNA transcribed from the Sirt1 AS strand. However, its role and regulatory mechanism is still unknown in myogene...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21865
更新日期：2016-02-23 00:00:00
abstract：:Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and its xenogeneicity in animals. IVIG can alter the viability of human neutrophils v...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01404-0
更新日期：2017-05-02 00:00:00
abstract：:Twirling is a technique widely used for converting arbitrary noise channels into Pauli channels in error threshold estimations of quantum error correction codes. It is vitally useful both in real experiments and in classical quantum simulations. Minimising the size of the twirling gate set increases the efficiency of ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46722-7
更新日期：2019-08-02 00:00:00
abstract：:We have developed an optimized protocol for plasma targeted mRNA sequencing in our previous study. Here, we performed plasma targeted mRNA sequencing for 40 colorectal adenoma patients and 39 colonoscopy-proven normal controls in order to find potential circulating mRNA markers for colorectal adenoma. Results showed t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49445-x
更新日期：2019-09-10 00:00:00
abstract：:The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39628-x
更新日期：2019-02-26 00:00:00
abstract：:Phaseonium is a three-level Λ quantum system, in which a coherent microwave and an optical control (pump) beams can be used to actively modulate the dielectric response. Here we propose a new metamaterial structure comprising of a periodic array of triangular phaseonium metamolecules arranged as a trefoil. We present ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21083
更新日期：2016-02-16 00:00:00
abstract：:Adult hippocampal neurogenesis is associated with learning and affective behavioural regulation. Its diverse functionality is segregated along the septotemporal axis from the dorsal to ventral hippocampus. However, features distinguishing immature neurons in these regions have yet to be characterized. Additionally, al...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30467
更新日期：2016-07-29 00:00:00
abstract：:Surface enhanced Raman scattering (SERS) spectroscopy becomes increasingly used in biosensors for its capacity to detect and identify single molecules. In practice, a large number of SERS spectra are acquired and reliable ranking methods are thus essential for analysing all these data. Supervised classification strate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep20383
更新日期：2016-02-02 00:00:00
abstract：:The role of soil organic carbon in global carbon cycles is receiving increasing attention both as a potentially large and uncertain source of CO2 emissions in response to predicted global temperature rises, and as a natural sink for carbon able to reduce atmospheric CO2. There is general agreement that the technical p...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15794-8
更新日期：2017-11-14 00:00:00
abstract：:Cellular interactions can be modeled as complex dynamical systems represented by weighted graphs. The functionality of such networks, including measures of robustness, reliability, performance, and efficiency, are intrinsically tied to the topology and geometry of the underlying graph. Utilizing recently proposed geom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12323
更新日期：2015-07-14 00:00:00
abstract：:Plasmonics offer an exciting way to mediate the interaction between light and matter, allowing strong field enhancement and confinement, large absorption and scattering at resonance. However, simultaneous realization of ultra-narrow band perfect absorption and electromagnetic field enhancement is challenging due to th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24063
更新日期：2016-04-05 00:00:00
abstract：:The mechanism whereby lactic acid bacteria extend the lifespan of Caenorhabditis elegans has previously been elucidated. However, the role of Weissella species has yet not been studied. We show that Weissella koreensis and Weissella cibaria significantly (p < 0.05) extend the lifespan of C. elegans compared with Esche...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17128
更新日期：2015-11-25 00:00:00
abstract：:Survival analyses for malignancies, including renal cell carcinoma (RCC), have primarily been conducted using the Cox proportional hazards (CPH) model. We compared the random survival forest (RSF) and DeepSurv models with the CPH model to predict recurrence-free survival (RFS) and cancer-specific survival (CSS) in non...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80262-9
更新日期：2021-01-13 00:00:00
abstract：:The purpose of this work is to make a case for epidemiological models with fractional exponent in the contribution of sub-populations to the incidence rate. More specifically, we question the standard assumption in the literature on epidemiological models, where the incidence rate dictating propagation of infections i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77849-7
更新日期：2020-11-30 00:00:00
abstract：:Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and Epi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79666-4
更新日期：2021-01-14 00:00:00
