Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.

abstract：:The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like p...

journal_title：Experimental neurology

authors： Pogorelov V,Xu M,Smith HR,Buchanan GF,Pittenger C

更新日期：2015-03-01 00:00:00

abstract：:Physiological/anatomical studies of rat frontal cortex in vitro have distinguished subpopulations of gamma-aminobutyric acid (GABA)-expressing inhibitory interneurons defined by expression of the calcium-binding proteins, parvalbumin (PV) and calbindin (CA). Using a novel 2DG/immunostaining technique to double-label h...

journal_title：Experimental neurology

authors： Maier DL,McCasland JS

更新日期：1997-05-01 00:00:00

abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...

journal_title：Experimental neurology

authors： Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PM

更新日期：1999-08-01 00:00:00

abstract：:Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...

journal_title：Experimental neurology

authors： Shannon R,Lindsey BG

更新日期：1987-09-01 00:00:00

abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...

journal_title：Experimental neurology

authors： Hendrickson RC,Raskind MA

更新日期：2016-10-01 00:00:00

abstract：:Abuse of stimulant drugs such as methamphetamine (METH) and cocaine has been associated with long-lasting persistent behavioral alterations. Although METH-induced changes in the striatal dopaminergic system might play a role in these effects, the potential underlying neuroanatomical substrate for the chronic cognitive...

journal_title：Experimental neurology

authors： Kuczenski R,Everall IP,Crews L,Adame A,Grant I,Masliah E

更新日期：2007-09-01 00:00:00

abstract：:In this study, the effects of testosterone propionate (TP) on recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters were examined. In the first experiment, TP (5 mg/ml sesame oil; 0.1 ml) was injected subcutaneously and on alternate days in one-half of the animals subjected to cru...

journal_title：Experimental neurology

authors： Kujawa KA,Kinderman NB,Jones KJ

更新日期：1989-07-01 00:00:00

abstract：:Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropathic hyperalgesia. ...

journal_title：Experimental neurology

authors： El Maarouf A,Kolesnikov Y,Pasternak G,Rutishauser U

更新日期：2012-02-01 00:00:00

abstract：:The effects of aspirin or 5-hydroxytryptamine (5-HT)-related drugs on the dental pain induced by electrical stimulation of tooth pulp afferent fibers were assessed in conscious monkeys. The electrical current required for producing jaw opening is referred to as the pain threshold. Both systemic (25 to 75 mg/kg, i.p.) ...

journal_title：Experimental neurology

authors： Shyu KW,Lin MT,Wu TC

更新日期：1984-04-01 00:00:00

abstract：:Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplyi...

journal_title：Experimental neurology

authors： Morrison BM,Tsingalia A,Vidensky S,Lee Y,Jin L,Farah MH,Lengacher S,Magistretti PJ,Pellerin L,Rothstein JD

更新日期：2015-01-01 00:00:00

abstract：:The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved...

journal_title：Experimental neurology

authors： Gramsbergen A,Ijkema-Paassen J,Westerga J,Geisler HC

更新日期：1996-01-01 00:00:00

abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

journal_title：Experimental neurology

authors： Aoki F,Nakamura S

更新日期：1991-06-01 00:00:00

abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...

journal_title：Experimental neurology

authors： Coleman JR,McDonald AJ,Pinek B,Zrull MC

更新日期：1992-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke mod...

journal_title：Experimental neurology

authors： Song S,Kamath S,Mosquera D,Zigova T,Sanberg P,Vesely DL,Sanchez-Ramos J

更新日期：2004-01-01 00:00:00

abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

journal_title：Experimental neurology

authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

更新日期：2018-11-01 00:00:00

abstract：:Neurons lesioned in the peripheral nervous system (PNS) generally regenerate and survive, while neurons lesioned in the central nervous system (CNS) do not regenerate and often die. Investigators have traditionally compared the neuronal responses to PNS and CNS lesions in two separate populations of neurons. In this s...

journal_title：Experimental neurology

authors： Book AA,Fischer I,Yu XJ,Iannuzzelli P,Murphy EH

更新日期：1996-04-01 00:00:00

abstract：:Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fib...

journal_title：Experimental neurology

authors： Girlanda P,Muglia U,Vita G,Dattola R,Santoro M,Toscano A,Venuto C,Roberto ML,Baradello A,Romano M

更新日期：1988-02-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non-neuronal cells. We have studied fibroblast cultures from four family members harbouring the homozygous p.Q456X mutation in...

journal_title：Experimental neurology

authors： Grünewald A,Gegg ME,Taanman JW,King RH,Kock N,Klein C,Schapira AH

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized and the expression of the endogenous hydrogen sulfide pr...

journal_title：Experimental neurology

authors： Hu S,Xu W,Miao X,Gao Y,Zhu L,Zhou Y,Xiao Y,Xu GY

更新日期：2013-10-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto...

journal_title：Experimental neurology

authors： Sarter M,Albin RL,Kucinski A,Lustig C

更新日期：2014-07-01 00:00:00

abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...

journal_title：Experimental neurology

authors： Spenger C,Josephson A,Klason T,Hoehn M,Schwindt W,Ingvar M,Olson L

更新日期：2000-12-01 00:00:00

abstract：:The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...

journal_title：Experimental neurology

authors： Kamber D,Erez H,Spira ME

更新日期：2009-09-01 00:00:00

abstract：:Cats were kindled in the amygdala. After completion of kindling, their EEG was monitored almost continuously by a computer system which allowed the detection of spontaneous seizures and the quantification of interictal spikes. The relationships between seizures triggered by stimulation, spontaneous seizures, and inter...

journal_title：Experimental neurology

authors： Gotman J

更新日期：1984-05-01 00:00:00

abstract：:Various limbic system structures have been implicated in processing noxious information. One such structure is the anterior cingulate cortex (ACC), a region that is thought to modulate higher order processing of noxious input related to the affective/motivational component of pain. The present experiment examined the ...

journal_title：Experimental neurology

authors： LaGraize SC,Labuda CJ,Rutledge MA,Jackson RL,Fuchs PN

更新日期：2004-07-01 00:00:00

abstract：:A number of neuron-supporting functions have been ascribed to astrocytes. In this study we found that a proliferation of Purkinje cell dendritic spines, a target site for presynaptic axon terminals, was induced in cytosine arabinoside-treated cerebellar cultures by exposure to astrocyte-conditioned medium. This result...

journal_title：Experimental neurology

authors： Seil FJ,Eckenstein FP,Reier PJ

更新日期：1992-07-01 00:00:00

abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...

journal_title：Experimental neurology

authors： Paula-Barbosa MM,Andrade JP,Castedo JL,Azevedo FP,Camões I,Volk B,Tavares MA

更新日期：1989-02-01 00:00:00