Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat.

abstract：:Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is kno...

journal_title：Experimental neurology

authors： Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RA

更新日期：2016-11-01 00:00:00

abstract：:The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB integrity, permeability, and blood flow. Pericyte loss has been implicated in injury; however, how the crosstalk among pericytes, endothel...

journal_title：Experimental neurology

authors： Bhowmick S,D'Mello V,Caruso D,Wallerstein A,Abdul-Muneer PM

更新日期：2019-07-01 00:00:00

abstract：:Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain trauma) are accompanied by hydrocephalus, the present study sought to evaluate the relationship between oxidative stress and the progression of hydrocephalus. Assa...

journal_title：Experimental neurology

authors： Socci DJ,Bjugstad KB,Jones HC,Pattisapu JV,Arendash GW

更新日期：1999-01-01 00:00:00

abstract：:Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisiti...

journal_title：Experimental neurology

authors： Trulson ME,Babb S,Joe JC,Raese JD

更新日期：1986-12-01 00:00:00

abstract：:The role of capsaicin-sensitive afferents in neurogenic voiding dysfunction was studied in chronic spinal cord injured rats (SCI). Cystometry and external urethral sphincter (EUS) electromyography were performed on 2 consecutive days after induction of urethane anesthesia in SCI rats 6-8 weeks after spinal cord injury...

journal_title：Experimental neurology

authors： Cheng CL,de Groat WC

更新日期：2004-06-01 00:00:00

abstract：:The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat primary cortical neuronal cultures was compared with the apoptotic death induced by staurosporine and the necrotic death induced by glutamate. Both SIN-1 and Cu...

journal_title：Experimental neurology

authors： Hill IE,Murray C,Richard J,Rasquinha I,MacManus JP

更新日期：2000-03-01 00:00:00

abstract：:Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...

journal_title：Experimental neurology

authors： Chen LF,FitzGibbon T,He JR,Yin ZQ

更新日期：2012-04-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:The possible pain inhibitory effects of periaqueductal gray (PAG) stimulation were investigated in cats anesthetized with Nembutal and immobilized with Flaxedil. Unitary responses evoked by electrical stimulation of the upper canine dentine and by cutaneous facial noxious and nonnoxious stimuli were recorded extracell...

journal_title：Experimental neurology

authors： Figueiras R,Buño W Jr,García-Austt E,Delgado JM

更新日期：1983-07-01 00:00:00

abstract：:We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr) sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to determine their potential role in the development of trigeminal neuropathic pain. In seven anaesthetised ferrets, fluorogold (2%) was injected ...

journal_title：Experimental neurology

authors： Davies SL,Loescher AR,Clayton NM,Bountra C,Robinson PP,Boissonade FM

更新日期：2006-11-01 00:00:00

abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

journal_title：Experimental neurology

authors： Lemons ML,Howland DR,Anderson DK

更新日期：1999-11-01 00:00:00

abstract：:Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ganglia,...

journal_title：Experimental neurology

authors： Hodgson RA,Bedard PJ,Varty GB,Kazdoba TM,Di Paolo T,Grzelak ME,Pond AJ,Hadjtahar A,Belanger N,Gregoire L,Dare A,Neustadt BR,Stamford AW,Hunter JC

更新日期：2010-10-01 00:00:00

abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...

journal_title：Experimental neurology

authors： Liesi P

更新日期：1992-08-01 00:00:00

abstract：:Successful clinical application of fMRI tasks requires reliable knowledge about the brain structures mapped by the task. With memory fMRI, diverging evidence exists concerning the location of major signal sources as well as hippocampal contributions. To clarify these issues, we investigated a frequently applied memory...

journal_title：Experimental neurology

authors： Beisteiner R,Drabeck K,Foki T,Geissler A,Gartus A,Lehner-Baumgartner E,Baumgartner C

更新日期：2008-09-01 00:00:00

abstract：:We have previously demonstrated that systemic administration of testosterone propionate (TP) to adult hamsters accelerates the rate of facial nerve regeneration following crush axotomy of the facial nerve at its exit from the stylomastoid foramen. In this study, we utilized flutamide, a potent nonsteroidal antiandroge...

journal_title：Experimental neurology

authors： Kujawa KA,Tanzer L,Jones KJ

更新日期：1995-06-01 00:00:00

abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...

journal_title：Experimental neurology

authors： Weiss ML,Mitchell KE,Hix JE,Medicetty S,El-Zarkouny SZ,Grieger D,Troyer DL

更新日期：2003-08-01 00:00:00

abstract：:Demyelinating diseases comprise a spectrum of immunopathologic syndromes in which myelin, the fatty covering of nerve cell fibers in the brain and spinal cord, is destroyed. In this study, we have shown for the first time that ocular infection of BALB/c mice with a recombinant herpes simplex virus type 1 (HSV-1) expre...

journal_title：Experimental neurology

authors： Osorio Y,La Point SF,Nusinowitz S,Hofman FM,Ghiasi H

更新日期：2005-05-01 00:00:00

abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

journal_title：Experimental neurology

authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

更新日期：2015-05-01 00:00:00

abstract：:The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. Because terminal field loss appears to precede cell body loss, we tested whether the mouse mutant Wld(S), which delays axonal degeneration in a variety of disorders, would ameliorate nigrostriatal degeneration followi...

journal_title：Experimental neurology

authors： Hasbani DM,O'Malley KL

更新日期：2006-11-01 00:00:00

abstract：:Acute volume expansion is associated with a specific pattern of Fos expression and the goal of the present study was to evaluate the contribution of cardiac receptors to this response. Adult male rats were instrumented with pericardial catheters introduced at the level of the thymus. Rats were also catheterized for me...

journal_title：Experimental neurology

authors： Cunningham JT,Bruno SB,Higgs KA,Sullivan MJ

更新日期：2002-04-01 00:00:00

abstract：:AMPA receptors (AMPARs) are responsible for fast excitatory neurotransmission, and their prolonged activation can result in the generation and spread of epileptic seizures. At early stages of postnatal development, the majority of AMPARs are permeable to both Na(+) and Ca(2+) ions. This permeability, which increases n...

journal_title：Experimental neurology

authors： Szczurowska E,Ergang P,Kubová H,Druga R,Salaj M,Mareš P

更新日期：2016-09-01 00:00:00

abstract：:The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like p...

journal_title：Experimental neurology

authors： Pogorelov V,Xu M,Smith HR,Buchanan GF,Pittenger C

更新日期：2015-03-01 00:00:00

abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause manifesting with progressive autonomic failure (AF), cerebellar ataxia and parkinsonism due to neuronal loss in multiple brain areas associated with (oligodendro)glial cytoplasmic alpha-synuclein (alpha SYN) inclusions (GCIs). Usin...

journal_title：Experimental neurology

authors： Stemberger S,Poewe W,Wenning GK,Stefanova N

更新日期：2010-08-01 00:00:00

abstract：:Russian knapweed is a perennial weed found in many parts of the world, including southern California. Chronic ingestion of this plant by horses has been reported to cause equine nigropallidal encephalomalacia (ENE), which is associated with a movement disorder simulating Parkinson's disease (PD). Repin, a principal in...

journal_title：Experimental neurology

authors： Robles M,Choi BH,Han B,Santa Cruz K,Kim RC

更新日期：1998-07-01 00:00:00

abstract：:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes...

journal_title：Experimental neurology

authors： Takashima S,Becker LE,Chan FW,Augustin R

更新日期：1985-06-01 00:00:00

abstract：:We have previously demonstrated an opioid link in nucleus accumbens (NAc) that mediates antinociception produced by a novel ascending pain modulation pathway. For example, noxious stimulation induces heterosegmental antinociception that is mediated by both mu- and delta-opioid receptors in NAc. However, spinal intrath...

journal_title：Experimental neurology

authors： Gear RW,Levine JD

更新日期：2011-06-01 00:00:00

abstract：:Although aluminum (Al) contributes to a variety of cognitive dysfunctions and mental diseases, the underlying mechanisms of Al interactions with the nervous system are still unknown. We have studied the action of Al on synaptic transmission and long-term potentiation (LTP) by performing electrophysiological recordings...

journal_title：Experimental neurology

authors： Platt B,Carpenter DO,Büsselberg D,Reymann KG,Riedel G

更新日期：1995-07-01 00:00:00

abstract：:Recent evidence suggests interactions between primary afferent nociceptors and postganglionic sympathetic efferents in the pathogenesis of inflammation. The effect of unilateral removal of the superior cervical ganglion on the innervation pattern of nerve fibers immunoreactive (IR) to calcitonin gene-related peptide (...

journal_title：Experimental neurology

authors： Haug SR,Berggreen E,Heyeraas KJ

更新日期：2001-05-01 00:00:00

abstract：:We present here an example case of neuropathic pain with heat allodynia as a major symptom to illustrate how the functional imaging of pain may provide new insights into the pathophysiology of painful sensory disorders. Tissue injury of almost any kind, but especially peripheral or central neural tissue injury, can le...

journal_title：Experimental neurology

authors： Casey KL,Lorenz J,Minoshima S

更新日期：2003-11-01 00:00:00