Abstract：
:Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is known about the relationship between misfolded α-synuclein and endothelial function. In the present study, we therefore examined whether α-synuclein preformed fibrils affect endothelial function in vitro. Using a well-established endothelial cell model, we found that the expression of tight junction proteins, in particular zona occludens-1 and occludin, was significantly perturbed in the presence of fibril-seeded neurotoxicity. Disrupted expression of these proteins was also found in the postmortem brains of patients dying with Parkinson's disease. There was though little evidence in vitro of functional impairments in endothelial cell function in terms of transendothelial electrical resistance and permeability. This study therefore shows for the first time that misfolded α-synuclein can interact and affect the cerebral endothelial system, although its relevance to the pathogenesis of Parkinson's disease remains to be elucidated.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RAdoi
10.1016/j.expneurol.2016.09.003subject
Has Abstractpub_date
2016-11-01 00:00:00pages
72-81issue
Pt Aeissn
0014-4886issn
1090-2430pii
S0014-4886(16)30271-0journal_volume
285pub_type
杂志文章abstract：:Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...
journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 临床试验,杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.023
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90065-z
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doi：10.1016/j.expneurol.2004.12.004
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90328-x
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.02.004
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.04.003
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7058
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00030-x
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(05)80012-3
更新日期：1990-07-01 00:00:00
