Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1.

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00

abstract：:Several lines of evidence have demonstrated beneficial effects of the hematopoietic factor G-CSF in experimental stroke. A conclusive demonstration of this effect in G-CSF deficient mice is, however, lacking. We therefore investigated the effect of G-CSF deficiency on infarct volumes, functional recovery, mRNA and pro...

journal_title：Experimental neurology

authors： Sevimli S,Diederich K,Strecker JK,Schilling M,Klocke R,Nikol S,Kirsch F,Schneider A,Schäbitz WR

更新日期：2009-06-01 00:00:00

abstract：:Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can pre...

journal_title：Experimental neurology

authors： Mattis VB,Wakeman DR,Tom C,Dodiya HB,Yeung SY,Tran AH,Bernau K,Ornelas L,Sahabian A,Reidling J,Sareen D,Thompson LM,Kordower JH,Svendsen CN

更新日期：2014-04-01 00:00:00

abstract：:Successful clinical application of fMRI tasks requires reliable knowledge about the brain structures mapped by the task. With memory fMRI, diverging evidence exists concerning the location of major signal sources as well as hippocampal contributions. To clarify these issues, we investigated a frequently applied memory...

journal_title：Experimental neurology

authors： Beisteiner R,Drabeck K,Foki T,Geissler A,Gartus A,Lehner-Baumgartner E,Baumgartner C

更新日期：2008-09-01 00:00:00

abstract：:Extracellular single-unit responses of neurons in the ipsilateral pulvinar-lateral posterior complex were recorded in 10 encéphale isolé cats with stimulating electrodes implanted in the substantia nigra pars reticulata and pars lateralis. Fifteen percent of 101 pulvinar-lateral posterior complex thalamic neurons incr...

journal_title：Experimental neurology

authors： Infante C,Leiva J,Motles E,Saavedra H

更新日期：1988-02-01 00:00:00

abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

journal_title：Experimental neurology

authors： Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

更新日期：1995-01-01 00:00:00

abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...

journal_title：Experimental neurology

authors： Pajenda G,Hercher D,Márton G,Pajer K,Feichtinger GA,Maléth J,Redl H,Nógrádi A

更新日期：2014-11-01 00:00:00

abstract：:Our primary aim was to determine if there exists a preferential involvement of the fast-twitch or slow-twitch skeletal muscle fibers in the dy2J/dy2J strain of murine dystrophy. The changes in the contractile properties of the slow-twitch soleus (SOL) and the fast-twitch extensor digitorum longus (EDL) muscles of norm...

journal_title：Experimental neurology

authors： Bressler BH,Jasch LG,Ovalle WK,Slonecker CE

更新日期：1983-05-01 00:00:00

abstract：:Spinal lamina II, where nociceptive C-fibers terminate, expresses high amounts of the polysialylated form of neural cell adhesion molecule (PSA-NCAM). While enzymatic removal of the PSA moiety from NCAM did not affect normal sensitivity to thermal stimuli, it exacerbated nerve injury-induced neuropathic hyperalgesia. ...

journal_title：Experimental neurology

authors： El Maarouf A,Kolesnikov Y,Pasternak G,Rutishauser U

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The pathogenesis of pain in irritable bowel syndrome (IBS) is poorly understood and treatment remains difficult. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized and the expression of the endogenous hydrogen sulfide pr...

journal_title：Experimental neurology

authors： Hu S,Xu W,Miao X,Gao Y,Zhu L,Zhou Y,Xiao Y,Xu GY

更新日期：2013-10-01 00:00:00

abstract：:Neurosphere-forming cells (NSFCs) derived from primary cultures of adult human olfactory epithelium were established in minimum essential medium (MEM) with Hanks balanced salts and 10% heat-inactivated fetal bovine serum (FBS). A totally defined medium (DM) was employed to examine their proliferation, lineage restrict...

journal_title：Experimental neurology

authors： Zhang X,Klueber KM,Guo Z,Lu C,Roisen FJ

更新日期：2004-04-01 00:00:00

abstract：:Posttraumatic inflammation has been implicated in secondary tissue damage after spinal cord injury (SCI). Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator that is increasingly expressed after SCI. The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whet...

journal_title：Experimental neurology

authors： Yan P,Liu N,Kim GM,Xu J,Xu J,Li Q,Hsu CY,Xu XM

更新日期：2003-10-01 00:00:00

abstract：:After spinal cord injury, proteoglycans with growth-inhibitory glycosaminoglycan (GAG-) side chains in scar tissue limit spontaneous axonal sprouting/regeneration. Interventions that reduce scar-related inhibition facilitate an axonal growth response and possibly plasticity-based spinal cord repair. Xylosyltransferase...

journal_title：Experimental neurology

authors： Oudega M,Chao OY,Avison DL,Bronson RT,Buchser WJ,Hurtado A,Grimpe B

更新日期：2012-09-01 00:00:00

abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

journal_title：Experimental neurology

authors： Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

更新日期：2003-12-01 00:00:00

abstract：:Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...

journal_title：Experimental neurology

authors： Pellegrini A,Zanotto L,Ermani M,Chemello R,Testa G

更新日期：1986-12-01 00:00:00

abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

journal_title：Experimental neurology

authors： Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

journal_title：Experimental neurology

authors： Hess CW,Vaillancourt DE,Okun MS

更新日期：2013-09-01 00:00:00

abstract：:A cerebrospinal fluid (CSF) to brain exchange has been postulated for lipid-soluble and small molecular substances and has led to nearly 100 attempts per year to produce central effects via intrathecal injections. With few exceptions, however, modern neurological practice has avoided this approach because of its demon...

journal_title：Experimental neurology

authors： Aird RB

更新日期：1984-11-01 00:00:00

abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

journal_title：Experimental neurology

authors： Lelard T,Jamon M,Gasc JP,Vidal PP

更新日期：2006-11-01 00:00:00

abstract：:There is compelling evidence that excessive exposure to manganese (Mn) produces neurotoxicity, especially in the basal ganglia, resulting in a dystonic Parkinsonian disorder. Several experimental or clinical observations suggest that Mn neurotoxicity could involve impairment of energy metabolism. We examined the neuro...

journal_title：Experimental neurology

authors： Brouillet EP,Shinobu L,McGarvey U,Hochberg F,Beal MF

更新日期：1993-03-01 00:00:00

abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...

journal_title：Experimental neurology

authors： Lipartiti M,Lazzaro A,Zanoni R,Mazzari S,Toffano G,Leon A

更新日期：1991-09-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neu...

journal_title：Experimental neurology

authors： Shijo T,Warita H,Suzuki N,Ikeda K,Mitsuzawa S,Akiyama T,Ono H,Nishiyama A,Izumi R,Kitajima Y,Aoki M

更新日期：2018-09-01 00:00:00

abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

journal_title：Experimental neurology

authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

更新日期：2009-03-01 00:00:00

abstract：:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a n...

journal_title：Experimental neurology

authors： Petersén A,Chase K,Puschban Z,DiFiglia M,Brundin P,Aronin N

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:N,N-dimethyltryptamine (DMT) is an endogenous ligand of the Sigma 1 receptor (Sig-1R) with documented in vitro cytoprotective properties against hypoxia. Our aim was to demonstrate the in vivo neuroprotective effect of DMT following ischemia-reperfusion injury in the rat brain. METHODS:Transient...

journal_title：Experimental neurology

authors： Nardai S,László M,Szabó A,Alpár A,Hanics J,Zahola P,Merkely B,Frecska E,Nagy Z

更新日期：2020-05-01 00:00:00

abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

journal_title：Experimental neurology

authors： Shao YP,Sutin J

更新日期：1991-11-01 00:00:00

abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

journal_title：Experimental neurology

authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

更新日期：1989-11-01 00:00:00

abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

journal_title：Experimental neurology

authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

更新日期：2009-09-01 00:00:00

abstract：:Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to maintain immune function when glucocorticoids are elevated by trauma or stress. Here we show that MIF is essential for the development of neuropath...

journal_title：Experimental neurology

authors： Alexander JK,Cox GM,Tian JB,Zha AM,Wei P,Kigerl KA,Reddy MK,Dagia NM,Sielecki T,Zhu MX,Satoskar AR,McTigue DM,Whitacre CC,Popovich PG

更新日期：2012-08-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

journal_title：Experimental neurology

authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

更新日期：2014-06-01 00:00:00