当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury.

Systemic administration of a deoxyribozyme to xylosyltransferase-1 mRNA promotes recovery after a spinal cord contusion injury.

Abstract：

:After spinal cord injury, proteoglycans with growth-inhibitory glycosaminoglycan (GAG-) side chains in scar tissue limit spontaneous axonal sprouting/regeneration. Interventions that reduce scar-related inhibition facilitate an axonal growth response and possibly plasticity-based spinal cord repair. Xylosyltransferase-1 (XT-1) is the enzyme that initiates GAG-chain formation. We investigated whether intravenous administration of a deoxyribozyme (DNA enzyme) to XT-1 mRNA (DNAXT-1as) would elicit plasticity after a clinically relevant contusion of the spinal cord in adult rats. Our data showed that systemic DNAXT-1as administration resulted in a significant increase in sensorimotor function and serotonergic axon presence caudal to the injury. DNAXT1as treatment did not cause pathological or toxicological side effects. Importantly, intravenous delivery of DNAXT-1as did not exacerbate contusion-induced neuropathic pain. Collectively, our data demonstrate that DNAXT-1as is a safe neurotherapeutic, which holds promise to become an integral component of therapies that aim to improve the quality of life of persons with spinal cord injury.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Oudega M,Chao OY,Avison DL,Bronson RT,Buchser WJ,Hurtado A,Grimpe B

doi

10.1016/j.expneurol.2012.06.006

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

170-9

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(12)00241-5

journal_volume

237

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Noradrenergic facilitation of motor neurons: localization of adrenergic receptors in neurons and nonneuronal cells in the trigeminal motor nucleus.

    abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90038-e

    authors： Shao YP,Sutin J

    更新日期：1991-11-01 00:00:00

  • The nucleus raphe magnus OFF-cells are involved in diffuse noxious inhibitory controls.

    abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.03.006

    authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

    更新日期：2014-06-01 00:00:00

  • Changes in metabotropic glutamate receptor expression following spinal cord injury.

    abstract：:Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic events. These receptors include the three groups of metabotropic glutamate receptors (mGluRs). Group I mGluR activation can initiate...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7721

    authors： Mills CD,Fullwood SD,Hulsebosch CE

    更新日期：2001-08-01 00:00:00

  • TNF-α enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury.

    abstract：:The ectopic discharges observed in uninjured dorsal root ganglion (DRG) neurons following various lesions of spinal nerves have been attributed to functional alterations of voltage-gated sodium channels (VGSCs). Such mechanisms may be important for the development of neuropathic pain. However, the pathophysiology unde...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.11.017

    authors： Chen X,Pang RP,Shen KF,Zimmermann M,Xin WJ,Li YY,Liu XG

    更新日期：2011-02-01 00:00:00

  • Neural heme oxygenase-1 expression in idiopathic Parkinson's disease.

    abstract：:Heme oxygenase-1 is a cellular stress protein expressed in brain and other tissues in response to oxidative challenge and other noxious stimuli. In the present study, immunohistochemistry was used to assess HO-1 expression in various postmortem human brain specimens derived from PD and control subjects. In the substan...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6752

    authors： Schipper HM,Liberman A,Stopa EG

    更新日期：1998-03-01 00:00:00

  • Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog.

    abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.09.025

    authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

    更新日期：2008-01-01 00:00:00

  • Adult human olfactory neural progenitors cultured in defined medium.

    abstract：:Neurosphere-forming cells (NSFCs) derived from primary cultures of adult human olfactory epithelium were established in minimum essential medium (MEM) with Hanks balanced salts and 10% heat-inactivated fetal bovine serum (FBS). A totally defined medium (DM) was employed to examine their proliferation, lineage restrict...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.10.022

    authors： Zhang X,Klueber KM,Guo Z,Lu C,Roisen FJ

    更新日期：2004-04-01 00:00:00

  • Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.

    abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.09.002

    authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

    更新日期：2006-01-01 00:00:00

  • Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception.

    abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.08.004

    authors： Dimitrov EL,Petrus E,Usdin TB

    更新日期：2010-11-01 00:00:00

  • Measurement of alpha- and beta-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients.

    abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...

    journal_title：Experimental neurology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0014-4886(03)00027-x

    authors： Olsson A,Höglund K,Sjögren M,Andreasen N,Minthon L,Lannfelt L,Buerger K,Möller HJ,Hampel H,Davidsson P,Blennow K

    更新日期：2003-09-01 00:00:00

  • Neurite outgrowth is enhanced by anti-idiotypic monoclonal antibodies to the ganglioside GM1.

    abstract：:Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether binding to membrane proteins is sufficient for ganglioside-mediate...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6459

    authors： Riggott MJ,Matthew WD

    更新日期：1997-05-01 00:00:00

  • Sensory nerves impair sympathetic reinnervation and recovery of smooth muscle function.

    abstract：:Neuronal populations projecting to a common target may compete for neurotrophic substances. To determine if competition impairs target reinnervation, we examined the effect of capsaicin-induced sensory denervation on sympathetic nerve ingrowth to the sympathectomized rat superior tarsal smooth muscle. In tarsal muscle...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(92)90025-l

    authors： Fike EA 4th,Simons E,Boswell C,Smith PG

    更新日期：1992-10-01 00:00:00

  • Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.

    abstract：:Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in various models of central nervous system (CNS) injury. Here, in an attempt to induce a neuroprotective microglial cell pheno...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.08.021

    authors： Gowing G,Lalancette-Hébert M,Audet JN,Dequen F,Julien JP

    更新日期：2009-12-01 00:00:00

  • Synemin expression in developing normal and pathological human retina and lens.

    abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00240-1

    authors： Tawk M,Titeux M,Fallet C,Li Z,Daumas-Duport C,Cavalcante LA,Paulin D,Moura-Neto V

    更新日期：2003-10-01 00:00:00

  • Effect of cytosine arabinoside on the composition of the nonneuronal cell population in cerebral explants.

    abstract：:Rat cortical explants were cultured in the presence or absence of the mitotic inhibitor cytosine arabinoside to determine whether or not it affects the composition of the nonneuronal cell population within the outgrowth zone. Ultrastructural morphometric analysis of the incidence of fibroblasts, fibrous astrocytes, an...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90092-0

    authors： Oorschot DE,Jones DG

    更新日期：1986-05-01 00:00:00

  • Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats.

    abstract：:An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impai...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2019.01.017

    authors： Fortress AM,Avcu P,Wagner AK,Dixon CE,Pang KCH

    更新日期：2019-05-01 00:00:00

  • Effect of L-carnitine on nucleic acid status of aged rat brain.

    abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.09.009

    authors： Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

    更新日期：2005-01-01 00:00:00

  • Autoradiographic deoxyglucose study of visually activated extrastriate cortex in the primate: three-dimensional reconstruction.

    abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(84)90148-1

    authors： Herdman SJ,Hand CL,Hand PJ

    更新日期：1984-08-01 00:00:00

  • Sexual dimorphism in the fibers of a "clasp" muscle of Xenopus laevis.

    abstract：:When antibodies specific to fast-twitch, slow-twitch, and slow-tonic myosins were used to stain the clasp muscle, m. sternoradialis, of Xenopus laevis, three predominant fiber types were identified in both males and females. Three fiber types can also be distinguished by the diameters and conduction velocities of thei...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90414-4

    authors： Rubinstein NA,Erulkar SD,Schneider GT

    更新日期：1983-11-01 00:00:00

  • Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.

    abstract：:Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research a...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2017.07.021

    authors： Bauman MD,Schumann CM

    更新日期：2018-01-01 00:00:00

  • Gene transfer by adeno-associated virus vectors into the central nervous system.

    abstract：:Adeno-associated virus (AAV) vectors are derived from a nonpathogenic and defective human parvovirus. Although currently unable to display the integration specificity featured by its wild-type parent, the recombinant AAV (rAAV) system has continued to attract enormous interest primarily due to its unique features such...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1006/exnr.1996.6396

    authors： Xiao X,Li J,McCown TJ,Samulski RJ

    更新日期：1997-03-01 00:00:00

  • Optogenetic exploration and modulation of pain processing.

    abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2018.05.003

    authors： Xie YF,Wang J,Bonin RP

    更新日期：2018-08-01 00:00:00

  • Effect of diabetes on motor conduction velocity in different branches of the rat sciatic nerve.

    abstract：:Motor nerve conduction velocity was measured in six branches of the sciatic nerve in streptozotocin-diabetic rats. It was markedly reduced in nerves to the gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles. The branch to the plantaris muscle remained unaffected. In control rats none of th...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(86)90315-8

    authors： Cameron NE,Cotter MA,Harrison J

    更新日期：1986-06-01 00:00:00

  • Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.

    abstract：:We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.05.010

    authors： Morelli E,Ghiglieri V,Pendolino V,Bagetta V,Pignataro A,Fejtova A,Costa C,Ammassari-Teule M,Gundelfinger ED,Picconi B,Calabresi P

    更新日期：2014-11-01 00:00:00

  • In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF.

    abstract：:Dopamine (DA) release and metabolism within the substantia nigra (SN) were studied in normal rats, rats with unilateral 6-hydroxydopamine (6-OHDA) lesions, and 6-OHDA-lesioned rats treated with glial cells line-derived neurotrophic factor (GDNF). Animals with > 99% DA depletions, as determined by apomorphine-induced c...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6571

    authors： Hoffman AF,van Horne CG,Eken S,Hoffer BJ,Gerhardt GA

    更新日期：1997-09-01 00:00:00

  • Increased susceptibility to hippocampal and amygdala kindling following intrahippocampal kainic acid.

    abstract：:The effects of unilateral intrahippocampal injection of kainic acid, a potent neuroexcitant and neurotoxin, on subsequent susceptibility to kindling of the contralateral hippocampus or contralateral amygdala were investigated in albino rats. At the chosen doses (0.20 to 1.25 micrograms dissolved in physiologic saline)...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90087-2

    authors： Feldblum S,Ackermann RF

    更新日期：1987-08-01 00:00:00

  • Changes in sodium channel expression following trigeminal nerve injury.

    abstract：:We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr) sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to determine their potential role in the development of trigeminal neuropathic pain. In seven anaesthetised ferrets, fluorogold (2%) was injected ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.035

    authors： Davies SL,Loescher AR,Clayton NM,Bountra C,Robinson PP,Boissonade FM

    更新日期：2006-11-01 00:00:00

  • MPTP-Induced hemiparkinsonism in nonhuman primates 6-8 years after a single unilateral intracarotid dose.

    abstract：:Five female adult Macaca nemestrina monkeys, given a unilateral intracarotid (ic) infusion of 2.3-3.5 mg of MPTP-HCl, were studied for 6-8 years. Two to 3 days after MPTP, the animals developed hemiparkinsonism characterized by rigidity and flexed posture of the arm contralateral to the side of infusion with episodes ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6845

    authors： Emborg-Knott ME,Domino EF

    更新日期：1998-08-01 00:00:00

  • Effect of ACTH4-10 on nerve fiber regeneration after sciatic nerve crush in rabbits: an electrophysiological and morphological study.

    abstract：:Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fib...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90162-8

    authors： Girlanda P,Muglia U,Vita G,Dattola R,Santoro M,Toscano A,Venuto C,Roberto ML,Baradello A,Romano M

    更新日期：1988-02-01 00:00:00

  • Variations of synaptotagmin I, synaptotagmin IV, and synaptophysin mRNA levels in rat hippocampus during the estrous cycle.

    abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7186

    authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

    更新日期：1999-10-01 00:00:00