Sensory nerves impair sympathetic reinnervation and recovery of smooth muscle function.

abstract：:Peripheral nerve injury can result in formation of a neuroma, which is often associated with heightened sensitivity to normally innocuous stimuli as well as spontaneous dysesthesia and pain. The onset and persistence of neuropathic pain have been linked to spontaneous ectopic electrogenesis in axons within neuromas, s...

journal_title：Experimental neurology

authors： Persson AK,Gasser A,Black JA,Waxman SG

更新日期：2011-08-01 00:00:00

abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...

journal_title：Experimental neurology

authors： Brook GA,Spitzer C,Nacimiento W,Kouchtir-Devanne N,Woodhams PL,Noth J

更新日期：1997-07-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:Infants born very preterm are at high risk for neurological deficits including cerebral palsy. In this study we assessed the neuroprotective effects of umbilical cord blood cells (UCBCs) and optimal administration timing in a fetal sheep model of preterm brain injury. 50 million allogeneic UCBCs were intravenously adm...

journal_title：Experimental neurology

authors： Li J,Yawno T,Sutherland A,Loose J,Nitsos I,Bischof R,Castillo-Melendez M,McDonald CA,Wong FY,Jenkin G,Miller SL

更新日期：2016-09-01 00:00:00

abstract：:The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

journal_title：Experimental neurology

authors： Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

更新日期：2002-02-01 00:00:00

abstract：:Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid-β (Aβ), disturbances of which are believed to contribute to the pathogenesis of Alzheimer's disease (AD). To examine the effe...

journal_title：Experimental neurology

authors： Tachibana M,Yamazaki Y,Liu CC,Bu G,Kanekiyo T

更新日期：2018-02-01 00:00:00

abstract：:Axons are the anatomical link between neuronal cell bodies and their target organs, and thus axonal degeneration is the pathological substrate that underlies neurological dysfunction in a large number of neurological conditions. Recent advances in the field of axonal biology demonstrate that axons possess programs for...

journal_title：Experimental neurology

authors： Fischer-Hayes LR,Brotherton T,Glass JD

更新日期：2013-08-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

journal_title：Experimental neurology

authors： Löscher W,Schwark WS

更新日期：1985-11-01 00:00:00

abstract：:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...

journal_title：Experimental neurology

authors： Immonen T,Alakuijala A,Hytönen M,Sainio K,Poteryaev D,Saarma M,Pasternack M,Sariola H

更新日期：2008-04-01 00:00:00

abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...

journal_title：Experimental neurology

authors： Kanju PM,Parameshwaran K,Sims C,Bahr BA,Shonesy BC,Suppiramaniam V

更新日期：2008-11-01 00:00:00

abstract：:Synemin (Syn) is an intermediate filament (IF) protein. To gain insight into a morphogenetic role of Syn, we have studied its expression patterns in the developing human retina and lens and compared it with those of other IF proteins. In addition, we have tested Syn expression in fetuses (23 and 28 weeks) affected by ...

journal_title：Experimental neurology

authors： Tawk M,Titeux M,Fallet C,Li Z,Daumas-Duport C,Cavalcante LA,Paulin D,Moura-Neto V

更新日期：2003-10-01 00:00:00

abstract：:Hydrocephalic mutant mice and matched siblings at different ages were used to measure the pressure and the resistance to drainage of the cerebrospinal fluid (CSF) from the lateral ventricles and from the cisterna magna with glass micropipets. The resting CSF pressure in normal mice increased between 1 to 2 and 4 to 8 ...

journal_title：Experimental neurology

authors： Jones HC

更新日期：1985-10-01 00:00:00

abstract：:Purkinje neurons are a sensitive and specialised cell type important for fine motor movement and coordination. Purkinje cell damage manifests as motor incoordination and ataxia - a prominent feature of many human disorders including spinocerebellar ataxia and Huntington's disease. A correlation between Purkinje degene...

journal_title：Experimental neurology

authors： Cops EJ,Sashindranath M,Daglas M,Short KM,da Fonseca Pereira C,Pang TY,Lijnen RH,Smyth IM,Hannan AJ,Samson AL,Medcalf RL

更新日期：2013-11-01 00:00:00

abstract：:Many reports indicate that GM1 ganglioside is effective in reducing CNS ischemic injury in animal models. These models employ invasive surgery to induce ischemic damage in otherwise healthy animals. The purpose of this study was to determine if the beneficial effects of GM1 could be generalized to Spontaneously Hypert...

journal_title：Experimental neurology

authors： Hernandez NE,MacDonall JS,Stier CT Jr,Belmonte A,Fernandez R,Karpiak SE

更新日期：1994-03-01 00:00:00

abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...

journal_title：Experimental neurology

authors： Noireaud J,Léoty C

更新日期：1984-03-01 00:00:00

abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

journal_title：Experimental neurology

authors： Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patients. Previous studies in Parkinson's Disease (PD) models have shown pro...

journal_title：Experimental neurology

authors： Gross SK,Shim BS,Bartus RT,Deaver D,McEachin Z,Bétourné A,Boulis NM,Maragakis NJ

更新日期：2020-01-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:Zebrafish is an excellent model to study central nervous system (CNS) axonal degeneration and regeneration since we can observe these processes in vivo and in real time in transparent larvae. Previous studies have shown that Mauthner cell (M-cell) axon regenerates poorly after mechanical spinal cord injury. Inconsiste...

journal_title：Experimental neurology

authors： Hu BB,Chen M,Huang RC,Huang YB,Xu Y,Yin W,Li L,Hu B

更新日期：2018-02-01 00:00:00

abstract：:The effect of sinusoidal magnetic field stimulation on regeneration of the rat sciatic nerve was studied. Rats were exposed, after crush lesioning of the nerve, between a pair of Helmholtz coils to a 50 Hz magnetic field of 0.2 mT or 0.4 mT, respectively. Regeneration of the sciatic nerve was measured by the "pinch te...

journal_title：Experimental neurology

authors： Rusovan A,Kanje M

更新日期：1991-06-01 00:00:00

abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

journal_title：Experimental neurology

authors： Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

更新日期：2019-12-01 00:00:00

abstract：:The repair of nerve gap injuries with tubular nerve guides has been used extensively as an in vivo test model in identifying substances which may enhance nerve regeneration. The model has also been used clinical nerve repair. The objective of this study was to compare three different gel matrix-forming materials as po...

journal_title：Experimental neurology

authors： Wells MR,Kraus K,Batter DK,Blunt DG,Weremowitz J,Lynch SE,Antoniades HN,Hansson HA

更新日期：1997-08-01 00:00:00

abstract：:In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing thera...

journal_title：Experimental neurology

authors： Hedlund E

更新日期：2011-09-01 00:00:00

abstract：:The effects of a trigeminal tractotomy on nociceptive reactions induced by electrical stimulation of an inferior incisor were studied in freely moving rats. Behavioral tests were based on the observation of three reactions: jaw opening reflex, face scratching with forepaws, and head rotation toward the stimulated side...

journal_title：Experimental neurology

authors： Dallel R,Clavelou P,Woda A

更新日期：1989-10-01 00:00:00

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

journal_title：Experimental neurology

authors： Cruz CD,McMahon SB,Cruz F

更新日期：2006-07-01 00:00:00

abstract：:Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal period brain metabolism experience changes that might greatly affect the outco...

journal_title：Experimental neurology

authors： Odorcyk FK,Duran-Carabali LE,Rocha DS,Sanches EF,Martini AP,Venturin GT,Greggio S,da Costa JC,Kucharski LC,Zimmer ER,Netto CA

更新日期：2020-08-01 00:00:00

abstract：:Recent work has indicated that photobiomodulation (PBM) may beneficially alter the pathological status of several neurological disorders, although the mechanism currently remains unclear. The current study was designed to investigate the beneficial effect of PBM on behavioral deficits and neurogenesis in a photothromb...

journal_title：Experimental neurology

authors： Yang L,Tucker D,Dong Y,Wu C,Lu Y,Li Y,Zhang J,Liu TC,Zhang Q

更新日期：2018-01-01 00:00:00

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00

abstract：:After spinal cord injury at birth, axotomized brainstem-spinal and corticospinal neurons are capable of permanent regenerative axonal growth into and through a fetal spinal cord transplant placed into the site of either a spinal cord hemisection or transection. In contrast, if fetal tissue which is not a normal target...

journal_title：Experimental neurology

authors： Bernstein-Goral H,Diener PS,Bregman BS

更新日期：1997-11-01 00:00:00