A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampus.

abstract：:Typical antipsychotic drugs (APDs) with D2antagonistic properties impede functional outcome after experimental traumatic brain injury (TBI) and reduce the effectiveness of environmental enrichment (EE). Here we test the hypothesis that aripiprazole (ARIP), an atypical APD with partial D2and 5-HT1Areceptor agonist acti...

journal_title：Experimental neurology

authors： Besagar S,Radabaugh HL,Bleimeister IH,Meyer EA,Niesman PJ,Cheng JP,Bondi CO,Kline AE

更新日期：2019-04-01 00:00:00

abstract：:Based on their differentiation ability, bone marrow stromal cells (MSCs) are a good source for cell therapy. Using a cynomolgus monkey peripheral nervous system injury model, we examined the safety and efficacy of Schwann cells induced from MSCs as a source for auto-cell transplantation therapy in nerve injury. Serial...

journal_title：Experimental neurology

authors： Wakao S,Hayashi T,Kitada M,Kohama M,Matsue D,Teramoto N,Ose T,Itokazu Y,Koshino K,Watabe H,Iida H,Takamoto T,Tabata Y,Dezawa M

更新日期：2010-06-01 00:00:00

abstract：:We assessed the potential of different MRI measures to detect and quantify skeletal muscle changes with denervation in two mouse models of denervation/neurogenic atrophy. Acute complete denervation and chronic partial denervation were examined in calf muscles after sciatic nerve axotomy and in transgenic SOD1(G93A) mi...

journal_title：Experimental neurology

authors： Zhang J,Zhang G,Morrison B,Mori S,Sheikh KA

更新日期：2008-08-01 00:00:00

abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...

journal_title：Experimental neurology

authors： Necchi D,Lomoio S,Scherini E

更新日期：2011-12-01 00:00:00

abstract：:Tuberoinfundibular peptide of 39 residues (TIP39) synthesizing neurons at the caudal border of the thalamus and in the lateral pons project to areas rich in its receptor, the parathyroid hormone 2 receptor (PTH2R). These areas include many involved in processing nociceptive information. Here we examined the potential ...

journal_title：Experimental neurology

authors： Dimitrov EL,Petrus E,Usdin TB

更新日期：2010-11-01 00:00:00

abstract：:Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis ...

journal_title：Experimental neurology

authors： Mi Z,Liu H,Rose ME,Ma X,Reay DP,Ma J,Henchir J,Dixon CE,Graham SH

更新日期：2021-02-01 00:00:00

abstract：:The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...

journal_title：Experimental neurology

authors： Narciso MS,Mietto Bde S,Marques SA,Soares CP,Mermelstein Cdos S,El-Cheikh MC,Martinez AM

更新日期：2009-05-01 00:00:00

abstract：:Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...

journal_title：Experimental neurology

authors： Tom VJ,Sandrow-Feinberg HR,Miller K,Domitrovich C,Bouyer J,Zhukareva V,Klaw MC,Lemay MA,Houlé JD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...

journal_title：Experimental neurology

authors： Wu D,Lai N,Deng R,Liang T,Pan P,Yuan G,Li X,Li H,Shen H,Wang Z,Chen G

更新日期：2020-10-01 00:00:00

abstract：:Rat cortical explants were cultured in the presence or absence of the mitotic inhibitor cytosine arabinoside to determine whether or not it affects the composition of the nonneuronal cell population within the outgrowth zone. Ultrastructural morphometric analysis of the incidence of fibroblasts, fibrous astrocytes, an...

journal_title：Experimental neurology

authors： Oorschot DE,Jones DG

更新日期：1986-05-01 00:00:00

abstract：:Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive w...

journal_title：Experimental neurology

authors： del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG

更新日期：2015-09-01 00:00:00

abstract：:The development and maturation of sensory systems depends on the correct pattern of connections which occurs during a critical period when axonal elimination and synaptic plasticity are involved in the formation of topographical maps. Among the mechanisms involved in synaptic stabilization, essential fatty acids (EFAs...

journal_title：Experimental neurology

authors： de Velasco PC,Mendonça HR,Borba JM,Andrade da Costa BL,Guedes RC,Navarro DM,Santos GK,Faria-Melibeu Ada C,Campello Costa P,Serfaty CA

更新日期：2012-03-01 00:00:00

abstract：:A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendroc...

journal_title：Experimental neurology

authors： Huang Y,Dreyfus CF

更新日期：2016-09-01 00:00:00

abstract：:Rat axial muscle previously has not been studied histochemically. We were interested in determining the fiber composition and fiber distribution in rat lateral longissimus (LL), the large epaxial dorsiflexor muscle active during sexual posturing in the female rat and to determine if estrogen replacement in ovariectomi...

journal_title：Experimental neurology

authors： Schwartz-Giblin S,Rosello L,Pfaff DW

更新日期：1983-02-01 00:00:00

abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...

journal_title：Experimental neurology

authors： Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PM

更新日期：1999-08-01 00:00:00

abstract：:Extracellular deposits of fibrillar beta-amyloid are a characteristic neuropathology of Alzheimer's disease (AD). We have developed a novel antibody to a hypothesized "older isomer" of the amyloid protein. This antibody, raised against a synthetic beta-amyloid peptide containing isoaspartic acid at position 7 (isoaspa...

journal_title：Experimental neurology

authors： Fonseca MI,Head E,Velazquez P,Cotman CW,Tenner AJ

更新日期：1999-06-01 00:00:00

abstract：:Synthesis of leukemia inhibitory factor (LIF) is increased in lesioned peripheral nerves and it is thought that this may cause increased expression of galanin (GAL) in axotomized dorsal root ganglia (DRG) neurons and also to promote axonal regeneration. We therefore compared effects of LIF and nerve growth factor (NGF...

journal_title：Experimental neurology

authors： Oztürk G,Tonge DA

更新日期：2001-06-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease associated with a CAG trinucleotide repeat expansion in a large gene on chromosome 4. The gene encodes the protein huntingtin with a polyglutamine tract encoded by the CAG repeat at the N-terminus. The number of CAG repeats in HD are signific...

journal_title：Experimental neurology

authors： Singhrao SK,Thomas P,Wood JD,MacMillan JC,Neal JW,Harper PS,Jones AL

更新日期：1998-04-01 00:00:00

abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...

journal_title：Experimental neurology

authors： Greer JJ,Martin-Caraballo M

更新日期：2017-01-01 00:00:00

abstract：:Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patients. Previous studies in Parkinson's Disease (PD) models have shown pro...

journal_title：Experimental neurology

authors： Gross SK,Shim BS,Bartus RT,Deaver D,McEachin Z,Bétourné A,Boulis NM,Maragakis NJ

更新日期：2020-01-01 00:00:00

abstract：:With the use of four independent cell markers and Brd-U birthdating we have charted the earliest stages of neuronal differentiation and migration in the developing rat central nervous system, including the cortex, spinal cord, and retina. One of the markers, the monoclonal antibody 2G12, labeled a large subpopulation ...

journal_title：Experimental neurology

authors： Brittis PA,Meiri K,Dent E,Silver J

更新日期：1995-07-01 00:00:00

abstract：:NMDA receptors in postmortem human spinal cord were analyzed using [3H]MK-801 ligand binding and immunoblotting with NMDA receptor subunit-specific antibodies. The average KD for [3H]MK-801 binding was 1.77 nM with a Bmax of 0.103 pmol/mg. The EC50 for stimulation of -3H-MK-801 binding with L-glutamate was 0.34 microM...

journal_title：Experimental neurology

authors： Sundström E,Whittemore S,Mo LL,Seiger A

更新日期：1997-12-01 00:00:00

abstract：:The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala...

journal_title：Experimental neurology

authors： Stanford SC,Jefferys JG

更新日期：1985-10-01 00:00:00

abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...

journal_title：Experimental neurology

authors： Ribes D,Colomina MT,Vicens P,Domingo JL

更新日期：2008-12-01 00:00:00

abstract：:Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...

journal_title：Experimental neurology

authors： Patrickson JW,Smith TE

更新日期：1987-08-01 00:00:00

abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...

journal_title：Experimental neurology

authors： Olsson A,Höglund K,Sjögren M,Andreasen N,Minthon L,Lannfelt L,Buerger K,Möller HJ,Hampel H,Davidsson P,Blennow K

更新日期：2003-09-01 00:00:00

abstract：:Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...

journal_title：Experimental neurology

authors： Sato M,Sagawa Y,Hirai N,Sato S,Okuro M,Kumar S,Kanbayashi T,Shimizu T,Sakai N,Nishino S

更新日期：2014-11-01 00:00:00

abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

journal_title：Experimental neurology

authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

更新日期：2004-05-01 00:00:00

abstract：:Seizures were induced in immature 18-day-old rats by i.p. administration of homocysteine (11 mmol/kg) and the effects of selected antagonists of NMDA receptors [MK-801 (0.5 mg/kg), AP7 (0.33 mmol/kg), CGP 40116 (10 mg/kg)] and non-NMDA receptors [GDEE (4 mmol/kg), NBQX (two doses, 30 mg/kg each)] were studied. The eff...

journal_title：Experimental neurology

authors： Folbergrová J

更新日期：1997-06-01 00:00:00

abstract：:Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...

journal_title：Experimental neurology

authors： Evrard SG,Duhalde-Vega M,Tagliaferro P,Mirochnic S,Caltana LR,Brusco A

更新日期：2006-08-01 00:00:00