The protective effects of β-lactam antibiotics in motor neuron disorders.

abstract：:Chronic nerve compression (CNC) injuries induce a robust Schwann cell proliferation in a distinct spatial and temporal pattern, which is accompanied by an increase in the number of small un-myelinated axons in the area of the injury. These findings suggest that this local proliferation of Schwann cells may induce loca...

journal_title：Experimental neurology

authors： Gupta R,Rummler LS,Palispis W,Truong L,Chao T,Rowshan K,Mozaffar T,Steward O

更新日期：2006-08-01 00:00:00

abstract：:Previous studies have suggested that defective high-affinity glutamate uptake, due mainly to a major loss of the astroglial-specific GLT-1 glutamate transporter, underlies the selective motoneuron degeneration observed in sporadic ALS (24, 28). If a defect in glutamate transport underlies the pathogenesis of sporadic ...

journal_title：Experimental neurology

authors： Medina L,Figueredo-Cardenas G,Rothstein JD,Reiner A

更新日期：1996-12-01 00:00:00

abstract：:As early as 1928, Cajal suggested that plaques contain a trophic substance which attracts neurites. Recently, basic fibroblast growth factor (bFGF) levels were shown to be elevated in Alzheimer's disease (AD) and localized to plaques and neurofibrillary tangles. We sought to clarify the subtype of plaques which contai...

journal_title：Experimental neurology

authors： Cummings BJ,Su JH,Cotman CW

更新日期：1993-12-01 00:00:00

abstract：:The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used beca...

journal_title：Experimental neurology

authors： Wainwright P,Gagnon M

更新日期：1984-07-01 00:00:00

abstract：:Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalop...

journal_title：Experimental neurology

authors： Tskitishvili E,Nisolle M,Munaut C,Pequeux C,Gerard C,Noel A,Foidart JM

更新日期：2014-11-01 00:00:00

abstract：:The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...

journal_title：Experimental neurology

authors： Deckner M,Lindholm T,Cullheim S,Risling M

更新日期：2000-12-01 00:00:00

abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...

journal_title：Experimental neurology

authors： Zhu C,Ghabriel MN,Blumbergs PC,Reilly PL,Manavis J,Youssef J,Hatami S,Finnie JW

更新日期：2001-05-01 00:00:00

abstract：:The development of the spinal cord represents one of the most complex structure developments of the central nervous system (CNS) as it has to unfold along the longitudinal axis and within segmental cues. There it has to cope with on the one hand connection to the periphery (skeletal muscle, dermomyotome, smooth muscle...

journal_title：Experimental neurology

authors： Wiese S,Faissner A

更新日期：2015-12-01 00:00:00

abstract：:Effective spread of stimulating current from macroelectrodes was measured using antidromic responses of axons of the pyramidal tract as an indicator of excitation. Both monopolar and concentric bipolar electrode configurations were tested with stimulating distances as large as 7mm. The effective stimulation distance w...

journal_title：Experimental neurology

authors： Follett KA,Mann MD

更新日期：1986-04-01 00:00:00

abstract：:Diffuse noxious inhibitory controls (DNIC) are very powerful long-lasting descending inhibitory controls which are pivotal in modulating the activity of spinal and trigeminal nociceptive neurons. DNIC are subserved by a loop involving supraspinal structures such as the lateral parabrachial nucleus and the subnucleus r...

journal_title：Experimental neurology

authors： Chebbi R,Boyer N,Monconduit L,Artola A,Luccarini P,Dallel R

更新日期：2014-06-01 00:00:00

abstract：:Diabetes mellitus is a common metabolic disease in human beings with characteristic symptoms of hyperglycemia, chronic inflammation and insulin resistance. One of the most common complications of early-onset diabetes mellitus is peripheral diabetic neuropathy, which is manifested either by loss of nociception or by al...

journal_title：Experimental neurology

authors： Heng LJ,Qi R,Yang RH,Xu GZ

更新日期：2015-09-01 00:00:00

abstract：:Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral habenula (LHb) is a key element in controlling DRN 5-HT neurons. We ...

journal_title：Experimental neurology

authors： Li J,Yang S,Liu X,Han Y,Li Y,Feng J,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...

journal_title：Experimental neurology

authors： Ladak A,Olson J,Tredget EE,Gordon T

更新日期：2011-04-01 00:00:00

abstract：:Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant. We aimed to characterize i) maturational age-related regulation of neuroglobin in the developing mouse brain under normoxic and hypoxic conditions, and ii) the role ...

journal_title：Experimental neurology

authors： Hümmler N,Schneider C,Giessl A,Bauer R,Walkinshaw G,Gassmann M,Rascher W,Trollmann R

更新日期：2012-07-01 00:00:00

abstract：:Motor nerve conduction velocity was measured in six branches of the sciatic nerve in streptozotocin-diabetic rats. It was markedly reduced in nerves to the gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles. The branch to the plantaris muscle remained unaffected. In control rats none of th...

journal_title：Experimental neurology

authors： Cameron NE,Cotter MA,Harrison J

更新日期：1986-06-01 00:00:00

abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...

journal_title：Experimental neurology

authors： Bankiewicz KS,Eberling JL,Kohutnicka M,Jagust W,Pivirotto P,Bringas J,Cunningham J,Budinger TF,Harvey-White J

更新日期：2000-07-01 00:00:00

abstract：:Assessing the efficacy of human stem cell transplantation in rodent models is complicated by the significant immune rejection that occurs. Two recent reports have shown conflicting results using neonatal tolerance to xenografts in rats. Here we extend this approach to mice and assess whether neonatal tolerance can pre...

journal_title：Experimental neurology

authors： Mattis VB,Wakeman DR,Tom C,Dodiya HB,Yeung SY,Tran AH,Bernau K,Ornelas L,Sahabian A,Reidling J,Sareen D,Thompson LM,Kordower JH,Svendsen CN

更新日期：2014-04-01 00:00:00

abstract：:Outcome following stroke is difficult to measure because the behavioral response to infarction is variable. We hypothesized that cognitive function, such as spatial learning, may be a reproducible and sensitive outcome variable. We developed an animal model of multifocal cerebral ischemia in order to study the effects...

journal_title：Experimental neurology

authors： Lyden PD,Zivin JA,Chabolla DR,Jacobs MA,Gage FH

更新日期：1992-05-01 00:00:00

abstract：:Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligode...

journal_title：Experimental neurology

authors： Zhang W,Wang H,Zhang H,Leak RK,Shi Y,Hu X,Gao Y,Chen J

更新日期：2015-10-01 00:00:00

abstract：:Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive...

journal_title：Experimental neurology

authors： Pickering-Brown SM,Owen F,Isaacs A,Snowden J,Varma A,Neary D,Furlong R,Daniel SE,Cairns NJ,Mann DM

更新日期：2000-06-01 00:00:00

abstract：:An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impai...

journal_title：Experimental neurology

authors： Fortress AM,Avcu P,Wagner AK,Dixon CE,Pang KCH

更新日期：2019-05-01 00:00:00

abstract：:Despite the importance of the periaqueductal gray (PAG) in the modulation of nociception and pain, many aspects of the roles of the different columns of the PAG in descending controls: facilitation and inhibition, are not understood. Employing a tonic muscle pain model established by i.m. injection of 5.8% saline into...

journal_title：Experimental neurology

authors： Lei J,Sun T,Lumb BM,You HJ

更新日期：2014-07-01 00:00:00

abstract：:Peripheral nerve regeneration proceeds through a series of phases which include axonal sprouting, elongation, and maturation. Each phase requires interaction between intrinsic properties of the injured neuron and nonneural elements in the environment into which the nerve grows. It has been difficult, however, to separ...

journal_title：Experimental neurology

authors： Carlsen RC

更新日期：1983-10-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:The respiratory central pattern generator must respond to chemosensory cues to maintain oxygen (O2) and carbon dioxide (CO2) homeostasis in the blood and tissues. To do this, sensorial cells located in the periphery and central nervous system monitor the arterial partial pressure of O2 and CO2 and initiate respiratory...

journal_title：Experimental neurology

authors： Barnett WH,Abdala AP,Paton JF,Rybak IA,Zoccal DB,Molkov YI

更新日期：2017-01-01 00:00:00

abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...

journal_title：Experimental neurology

authors： Dinopoulos A,Dori I,Davies SW,Parnavelas JG

更新日期：1989-07-01 00:00:00

abstract：:The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces Parkinsonism, is mediated by its metabolite 1-methyl-4-phenylpyridinium ion (MPP+). When injected into the striatum MPP+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta...

journal_title：Experimental neurology

authors： Fallon J,Matthews RT,Hyman BT,Beal MF

更新日期：1997-03-01 00:00:00

abstract：:The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

journal_title：Experimental neurology

authors： Hall ED,Oostveen JA,Dunn E,Carter DB

更新日期：1995-09-01 00:00:00

abstract：:Silent strokes occur more frequently than classic strokes; however, symptoms may go unreported in spite of lasting tissue damage. A silent stroke may indicate elevated susceptibility to recurrent stroke, which may eventually result in apparent and lasting impairments. Here we investigated if multiple silent strokes to...

journal_title：Experimental neurology

authors： Faraji J,Kurio K,Metz GA

更新日期：2012-08-01 00:00:00

abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

journal_title：Experimental neurology

authors： Gess B,Röhr D,Lange E,Halfter H,Young P

更新日期：2015-02-01 00:00:00