Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.

abstract：:Repeatedly it was reported that a short ischemic episode may ameliorate biochemical and morphological impairment upon succeeding severe ischemia. We investigated whether the pattern of respiratory enzyme activity (RA), adenine nucleotides, and membrane potential in hippocampal slices following low-dose in vivo (20 mg/...

journal_title：Experimental neurology

authors： Riepe MW,Niemi WN,Megow D,Ludolph AC,Carpenter DO

更新日期：1996-03-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...

journal_title：Experimental neurology

authors： Raphael Y,Altschuler RA

更新日期：1992-01-01 00:00:00

abstract：:An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel EL...

journal_title：Experimental neurology

authors： Double KL,Rowe DB,Carew-Jones FM,Hayes M,Chan DK,Blackie J,Corbett A,Joffe R,Fung VS,Morris J,Riederer P,Gerlach M,Halliday GM

更新日期：2009-06-01 00:00:00

abstract：:Oscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease ...

journal_title：Experimental neurology

authors： Li M,Zhou M,Wen P,Wang Q,Yang Y,Xiao H,Xie Z,Li X,Wang N,Wang J,Luo F,Chang J,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

journal_title：Experimental neurology

authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

更新日期：2006-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:In the intraluminal suture model of middle cerebral artery occlusion (MCAO) in the rat, lesions of the masticator muscles associated with impaired functional outcome occur. We evaluated the role of external carotid artery (ECA) transection. We assessed whether isolated interruption of an arterial or a venous connectio...

journal_title：Experimental neurology

authors： Dittmar MS,Vatankhah B,Fehm NP,Retzl G,Schuierer G,Bogdahn U,Schlachetzki F,Horn M

更新日期：2005-10-01 00:00:00

abstract：:The role of interferon-gamma (IFN-gamma) in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still controversial. We have studied the function of IFN-gamma and its receptor in the EAE model using two different IFN-gamma receptor knockout (IFN-gamma R(-/-)) mouse types: C57B...

journal_title：Experimental neurology

authors： Espejo C,Penkowa M,Sáez-Torres I,Xaus J,Celada A,Montalban X,Martínez-Cáceres EM

更新日期：2001-12-01 00:00:00

abstract：:Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drug...

journal_title：Experimental neurology

authors： Joshi S,Rajasekaran K,Kapur J

更新日期：2013-06-01 00:00:00

abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

journal_title：Experimental neurology

authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

更新日期：2000-01-01 00:00:00

abstract：:Gene transfer to the central nervous system provides powerful methodology for the study of gene function and gene-environment interactions in vivo, in addition to a vehicle for the delivery of therapeutic transgenes for gene therapy. The aim of the present study was to determine patterns of tropism exhibited by pseudo...

journal_title：Experimental neurology

authors： Cannon JR,Sew T,Montero L,Burton EA,Greenamyre JT

更新日期：2011-03-01 00:00:00

abstract：:Exposure to early life stress (ELS), such as childhood abuse and neglect is a well established major risk factor for developing psychiatric and behavioral disorders later in life. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult pathological states where the type and timing ...

journal_title：Experimental neurology

authors： Provençal N,Binder EB

更新日期：2015-06-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

journal_title：Experimental neurology

authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

更新日期：2008-03-01 00:00:00

abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...

journal_title：Experimental neurology

authors： Kawamura S,Yasui N

更新日期：1992-09-01 00:00:00

abstract：:To analyze the role of endogenous opioids on epileptogenesis the effect of repeated doses of naloxone alone (NA) (2, 4, and 8 mg/kg every 15 min) or along with intermittent photic stimulation (NPS) (1, 3, and 10 Hz) was tested on acute "Encephale isolé" cats. The electrical activity recordings of sensorimotor cortex (...

journal_title：Experimental neurology

authors： Fernández-Guardiola A,Pellicer F,Rocha L,Gutiérrez R

更新日期：1988-08-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:The effects of a trigeminal tractotomy on nociceptive reactions induced by electrical stimulation of an inferior incisor were studied in freely moving rats. Behavioral tests were based on the observation of three reactions: jaw opening reflex, face scratching with forepaws, and head rotation toward the stimulated side...

journal_title：Experimental neurology

authors： Dallel R,Clavelou P,Woda A

更新日期：1989-10-01 00:00:00

abstract：:Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while o...

journal_title：Experimental neurology

authors： Bjugn R,Nyengaard JR,Rosland JH

更新日期：1997-11-01 00:00:00

abstract：:Experimental autoimmune neuritis (EAN) is an animal model of the human disease Guillain-Barré syndrome. In this autoimmune inflammatory disease, CD4(+) T cells mediate demyelination in the peripheral nervous system (PNS). Infiltrating macrophages and T cells as well as cytokines like interferon (IFN)-gamma are intimat...

journal_title：Experimental neurology

authors： Zhu Y,Ljunggren HG,Mix E,Li HL,van der Meide P,Elhassan AM,Winblad B,Zhu J

更新日期：2001-06-01 00:00:00

abstract：:Chewing rhythms are set by a putative central pattern generator whose output is influenced by sensory feedback. In this study we assessed how an altered feedback imposed by changing the hardness of a gum bolus modifies the timing of chewing, the maximal gape, and the activity in the masseter muscle on the chewing side...

journal_title：Experimental neurology

authors： Plesh O,Bishop B,McCall W

更新日期：1986-06-01 00:00:00

abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...

journal_title：Experimental neurology

authors： Hurelbrink CB,Armstrong RJ,Luheshi LM,Dunnett SB,Rosser AE,Barker RA

更新日期：2001-09-01 00:00:00

abstract：:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited ...

journal_title：Experimental neurology

authors： Eickhoff SB,Dafotakis M,Grefkes C,Stöcker T,Shah NJ,Schnitzler A,Zilles K,Siebler M

更新日期：2008-12-01 00:00:00

abstract：:Twenty-eight-day-old (juvenile) rats were kindled with hourly stimulations to partial or fully kindled status. Adult rats were stimulated with hourly or daily stimulations. Alterations in [3H]dihydroalprenolol binding were determined 3 weeks after the last stimulation. We found that partially kindled, hourly stimulate...

journal_title：Experimental neurology

authors： Michelson HB,Buterbaugh GG

更新日期：1987-01-01 00:00:00

abstract：:Bilateral lesions of the ventromedial nucleus of the hypothalamus (VMN) significantly attentuated lordosis behavior in the female rat. The degree of this deficit was significantly correlated with the amount of damage to the VMN. There was no improvement in lordosis performance even after an extended recovery period. ...

journal_title：Experimental neurology

authors： Mathews D,Donovan KM,Hollingsworth EM,Hutson VB,Overstreet CT

更新日期：1983-03-01 00:00:00

abstract：:The left external auditory meatus was removed in 4-day-old CBA/J mice; after killing at 45 days, serial sections of the cochleae and brain stem were prepared. From these, the cross-sectional areas of spiral ganglion neurons and of 14 auditory brain stem neuronal types were measured, using a total of 210 neurons of eac...

journal_title：Experimental neurology

authors： Webster DB

更新日期：1983-01-01 00:00:00

abstract：:Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the G...

journal_title：Experimental neurology

authors： Noguchi T,Sugisaki T

更新日期：1985-07-01 00:00:00

abstract：:Although aluminum (Al) contributes to a variety of cognitive dysfunctions and mental diseases, the underlying mechanisms of Al interactions with the nervous system are still unknown. We have studied the action of Al on synaptic transmission and long-term potentiation (LTP) by performing electrophysiological recordings...

journal_title：Experimental neurology

authors： Platt B,Carpenter DO,Büsselberg D,Reymann KG,Riedel G

更新日期：1995-07-01 00:00:00

abstract：:In previous studies of our group, we have reported differential alterations in opioidergic receptor subtypes densities in infarcted and periinfarcted brain tissue following middle cerebral artery occlusion (MCAO) in mice. Other studies have also described subcortical alterations consecutive to focal cortical ischemia....

journal_title：Experimental neurology

authors： Boutin H,Dauphin F,Jauzac P,MacKenzie ET

更新日期：2000-08-01 00:00:00