Abstract：
:Modification of GABAergic inhibition is an intensely investigated hypothesis guiding research into mechanisms underlying temporal lobe epilepsy (TLE). Seizures can be initiated by blocking γ amino butyric acid type A (GABAA receptors, GABARs), which mediate fast synaptic inhibition in the brain, and controlled by drugs that enhance their function. Derivatives of steroid hormones called neurosteroids are natural substances that physiologically enhance GABAR function and suppress seizures. GABAR structure, function, expression, assembly, and pharmacological properties are changed in the hippocampus of epileptic animals. These alterations render GABARs less sensitive to neurosteroid modulation, which may contribute to seizure susceptibility. Plasticity of GABARs could play a role in periodic exacerbation of seizures experienced by women with epilepsy, commonly referred to as catamenial epilepsy.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Joshi S,Rajasekaran K,Kapur Jdoi
10.1016/j.expneurol.2011.10.028subject
Has Abstractpub_date
2013-06-01 00:00:00pages
36-42eissn
0014-4886issn
1090-2430pii
S0014-4886(11)00400-6journal_volume
244pub_type
杂志文章,评审abstract：:The beta-amyloid precursor protein (betaAPP) is found in skeletal muscle localized to the base of the postsynaptic folds of the neuromuscular junction; yet here, as well as in neurons, its function remains enigmatic. Here we report that the motor nerve-derived trophic factor neuregulin-1 (NRG1) regulates both steady-s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00031-1
更新日期：2003-06-01 00:00:00
abstract：:Mice genetically deficient in growth hormone were compared with normal littermates for evidence of altered neuronal development. In the lit/lit motor cortex, area 6 of Caviness, cell number, stratification of neurons, and the proportionate layer widths were identical to those of the controls (lit/+). Examined by the G...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90284-5
更新日期：1985-07-01 00:00:00
abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.12.003
更新日期：2012-03-01 00:00:00
abstract：:Rats were given unilateral 6-hydroxydopamine lesions and tested 4 weeks later for rotational behavior elicited by either systemic or intranigral injections of dopamine agonists. Subsequently, transplants of fetal (E14) ventral mesencephalic (VM) or cortical tissue were implanted into the lesioned substantia nigra and ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.6359
更新日期：1997-01-01 00:00:00
abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(84)90100-6
更新日期：1984-02-01 00:00:00
abstract：:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or v...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90105-l
更新日期：1991-03-01 00:00:00
abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(03)00128-6
更新日期：2003-08-01 00:00:00
abstract：:Poor survival of embryonic dopamine neurons is a primary problem limiting the value of neurotransplantation for Parkinson's disease. Several neurotrophic factors have been shown to promote dopamine neuron survival when used individually in culture. We have found that two peptides, insulin-like growth factor-I (IGF-I) ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0115
更新日期：1996-07-01 00:00:00
abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6893
更新日期：1998-11-01 00:00:00
abstract：:Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7101
更新日期：1999-07-01 00:00:00
abstract：:Peripheral nerve regeneration proceeds through a series of phases which include axonal sprouting, elongation, and maturation. Each phase requires interaction between intrinsic properties of the injured neuron and nonneural elements in the environment into which the nerve grows. It has been difficult, however, to separ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90251-0
更新日期：1983-10-01 00:00:00
abstract：:Mitochondrial dysfunction and pathology that contribute to a host of neurodegenerative diseases are deduced from changes in ultrastructure, routinely examined by a host of optical techniques. We adapted the technique of photon correlation spectroscopy (PCS) to evaluate calcium-induced structural alterations in isolate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.10.002
更新日期：2006-02-01 00:00:00
abstract：:The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's disease. We show here that when a clonal line (C17.2) of undifferentiated NSCs is transplanted into the intact or 6-hydroxydopamine-...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7989
更新日期：2002-09-01 00:00:00
abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113386
更新日期：2020-10-01 00:00:00
abstract：:Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1092
更新日期：1994-06-01 00:00:00
abstract：:A graded contusion spinal cord injury (SCI) was created in the adult rat spinal cord using the Infinite Horizons (IH) impactor to study the correlation between injury severity and anatomical, behavioral, and electrophysiological outcomes. Adult Fisher rats were equally divided into five groups and received contusion i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.08.026
更新日期：2005-02-01 00:00:00
abstract：:Infant, juvenile, and adult brain growth is modulated by corticosterone. This study was designed to determine whether such modulation is confined to certain specific brain areas, and if the pattern of growth revealed is consistent across strains of rats. Young female Sprague-Dawley-derived rats were either adrenalecto...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90229-4
更新日期：1988-12-01 00:00:00
abstract：:Sympathetic axons have been shown to invade the rat hippocampal formation after lesions of the septohippocampal (cholinergic) projection. To test the generality of this type of transmitter-specific sprouting within the central nervous system, lesions were placed within the horizontal limb of the diagonal band in order...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90235-8
更新日期：1984-05-01 00:00:00
abstract：:MK-801, a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, was tested for anticonvulsant effects in rats using two seizure models, coadministration of lithium and pilocarpine and administration of a high dose of pilocarpine alone. Three major results are reported. First, pretreatment with MK-801 produce...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90091-5
更新日期：1989-11-01 00:00:00
abstract：:The perirhinal cortex (PRh) has been suggested as a substrate for the expression of generalized clonic seizures in the late stages of kindling development (stages 4-5). Using the induction of Fos as a marker of neuronal activation, the PRh region was investigated after kindling or nonkindling electrical stimulation. N...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6794
更新日期：1998-05-01 00:00:00
abstract：:Brain swelling is a serious complication associated with focal ischemia in stroke and severe head injury. Experimentally, reperfusion following focal cerebral ischemia exacerbates the level of brain swelling. In this study, the permeability of the blood-brain barrier has been investigated as a possible cause of reperf...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6635
更新日期：1997-10-01 00:00:00
abstract：:We investigated whether administration of neurotrophin-3 (NT-3) and NMDA-2D-expressing units, found previously to enhance transmission in neonatal rat spinal cord, strengthens synaptic connections in the injured neonatal cord. We employed electrophysiological methods to evaluate the strength of synaptic transmission t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.10.008
更新日期：2006-02-01 00:00:00
abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.11.016
更新日期：2006-03-01 00:00:00
abstract：:The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6886
更新日期：1998-10-01 00:00:00
abstract：:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6813
更新日期：1998-06-01 00:00:00
abstract：:The afferent pathway involved in initiation of audiogenic seizures in the genetically epilepsy-prone rat was investigated by bilateral microinfusion of the excitant amino acid antagonist 2-amino-7-phosphonoheptanoate into the major brain stem and subcortical nuclei of the auditory system. This antagonist has been show...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90184-7
更新日期：1988-03-01 00:00:00
abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90128-y
更新日期：1991-06-01 00:00:00
abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.007
更新日期：2008-09-01 00:00:00
abstract：:A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and s...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90160-7
更新日期：1983-07-01 00:00:00
abstract：:Spinal ischemia is a frequent cause of paralysis. Here we explore the biological basis of ischemic preconditioning (IPC), the phenomenon in which a brief period of ischemia can confer protection against subsequent longer and normally injurious ischemia, to identify mediators of endogenous neuroprotection. Using microa...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2003.09.007
更新日期：2004-01-01 00:00:00
