Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway.

abstract：:This study describes the short-term effects of intracaudate microinjections of carbachol in temporarily isolated and restrained Java monkeys. The monkeys were found to display a series of motor disturbances including blepharoptosis, facial twitches, tongue protrusions, ear flattening, torticollis, and compulsive alter...

journal_title：Experimental neurology

authors： Vrijmoed-de Vries MC,Cools AR

更新日期：1985-01-01 00:00:00

abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

journal_title：Experimental neurology

authors： Greco T,Vespa PM,Prins ML

更新日期：2020-07-01 00:00:00

abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...

journal_title：Experimental neurology

authors： Eckenstein FP,McGovern T,Kern D,Deignan J

更新日期：2006-04-01 00:00:00

abstract：:Rats were given unilateral 6-hydroxydopamine lesions and tested 4 weeks later for rotational behavior elicited by either systemic or intranigral injections of dopamine agonists. Subsequently, transplants of fetal (E14) ventral mesencephalic (VM) or cortical tissue were implanted into the lesioned substantia nigra and ...

journal_title：Experimental neurology

authors： Yurek DM

更新日期：1997-01-01 00:00:00

abstract：:Exposure to early life stress (ELS), such as childhood abuse and neglect is a well established major risk factor for developing psychiatric and behavioral disorders later in life. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult pathological states where the type and timing ...

journal_title：Experimental neurology

authors： Provençal N,Binder EB

更新日期：2015-06-01 00:00:00

abstract：:C2 spinal cord hemisection results in synaptic and astroglial changes in the phrenic nucleus which have been associated with the recovery of the ipsilateral hemidiaphragm during expression of the crossed phrenic phenomenon. As part of our ongoing analysis of the neurotransmitters involved, the present study investigat...

journal_title：Experimental neurology

authors： Hadley SD,Walker PD,Goshgarian HG

更新日期：1999-12-01 00:00:00

abstract：:Neuronal apoptosis is a central pathological process in subarachnoid hemorrhage (SAH)-induced early brain injury. Previous studies indicated that ErbB4 (EGFR family member v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) is essential for normal development and maintenance of the nervous system. In this...

journal_title：Experimental neurology

authors： Yan F,Tan X,Wan W,Dixon BJ,Fan R,Enkhjargal B,Li Q,Zhang J,Chen G,Zhang JH

更新日期：2017-11-01 00:00:00

abstract：:Neurons lesioned in the peripheral nervous system (PNS) generally regenerate and survive, while neurons lesioned in the central nervous system (CNS) do not regenerate and often die. Investigators have traditionally compared the neuronal responses to PNS and CNS lesions in two separate populations of neurons. In this s...

journal_title：Experimental neurology

authors： Book AA,Fischer I,Yu XJ,Iannuzzelli P,Murphy EH

更新日期：1996-04-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:Using a measure of nonlinear dynamical changes we term marginal predictability, we report evidence of robust changes in this parameter on scalp EEG in a cohort of patients with medically refractory mesiobasal temporal lobe epilepsy (MBTLE). In the baseline (interictal) state there are distinct differences in this nonl...

journal_title：Experimental neurology

authors： Drury I,Smith B,Li D,Savit R

更新日期：2003-11-01 00:00:00

abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...

journal_title：Experimental neurology

authors： Graham JB,Neubauer D,Xue QS,Muir D

更新日期：2007-01-01 00:00:00

abstract：:Sympathetic innervation of lymphoid tissues is localized to specific tissue compartments, but little is known of the "factors" that are important in establishing this pattern during development. Numerous studies have shown interactions of nerve growth factor (NGF) with the immune system, which may include modulation o...

journal_title：Experimental neurology

authors： Carlson SL,Johnson S,Parrish ME,Cass WA

更新日期：1998-01-01 00:00:00

abstract：:Primary spinal cord trauma can initiate a cascade of pathophysiologic events which markedly contribute to the expansion and amplification of the primary insult. The detailed mechanisms of these secondary neurochemical reactions are largely unknown; however, they involve membrane lipid derangements with the release of ...

journal_title：Experimental neurology

authors： Toborek M,Garrido R,Malecki A,Kaiser S,Mattson MP,Hennig B,Young B

更新日期：2000-02-01 00:00:00

abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

journal_title：Experimental neurology

authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

更新日期：1998-07-01 00:00:00

abstract：:Oxaliplatin is first-line chemotherapy for colorectal cancer, but produces dose-limiting neurotoxicity. Acute neurotoxicity following infusion produces symptoms including cold-triggered fasciculations and cramps, with subsequent chronic neuropathy developing at higher cumulative doses. Axonal excitability studies were...

journal_title：Experimental neurology

authors： Park SB,Lin CS,Krishnan AV,Goldstein D,Friedlander ML,Kiernan MC

更新日期：2011-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

journal_title：Experimental neurology

authors： Parameshwaran K,Dhanasekaran M,Suppiramaniam V

更新日期：2008-03-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

journal_title：Experimental neurology

authors： Hill JM,Cuasay K,Abebe DT

更新日期：2007-07-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha), previously identified as a major member of the epidermal growth factor (EGF) family of growth factors, plays a role in proliferation, differentiation, and survival of neuronal and glial precursors and is implicated in development of the nervous system. However, its roles i...

journal_title：Experimental neurology

authors： Xian CJ,Li L,Deng YS,Zhao SP,Zhou XF

更新日期：2001-11-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...

journal_title：Experimental neurology

authors： Olsson A,Höglund K,Sjögren M,Andreasen N,Minthon L,Lannfelt L,Buerger K,Möller HJ,Hampel H,Davidsson P,Blennow K

更新日期：2003-09-01 00:00:00

abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

journal_title：Experimental neurology

authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

更新日期：2000-01-01 00:00:00

abstract：:We evaluated the effects of allogeneic bone marrow stromal cell treatment of stroke on functional outcome, glial-axonal architecture, and immune reaction. Female Wistar rats were subjected to 2 h of middle cerebral artery occlusion. Rats were injected intravenously with PBS, male allogeneic ACI--or syngeneic Wistar--b...

journal_title：Experimental neurology

authors： Li Y,McIntosh K,Chen J,Zhang C,Gao Q,Borneman J,Raginski K,Mitchell J,Shen L,Zhang J,Lu D,Chopp M

更新日期：2006-04-01 00:00:00

abstract：:Genetically dystrophic chicks (line 413) were administered 0.3 mg/kg dexamethasone (DEX), a corticosteroid, from 2 to 28 days ex ovo. Diluent-injected dystrophic and normal (line 412) chicks served as controls. The effects of DEX on muscle function were evaluated weekly by the exhaustion score (ES) method. Proton magn...

journal_title：Experimental neurology

authors： Misra LK,Entrikin RK

更新日期：1988-11-01 00:00:00

abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...

journal_title：Experimental neurology

authors： Xi M,Fung SJ,Zhang J,Sampogna S,Chase MH

更新日期：2012-11-01 00:00:00

abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

journal_title：Experimental neurology

authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

更新日期：2004-05-01 00:00:00

abstract：:Adenoviral-mediated gene transfer to the caudate nucleus of Macaca mulatta was accomplished using stereotactic injection of two distinct recombinant Ad5 vectors containing the gene for Escherichia coli beta-galactosidase and the cDNA for rat hypoxanthine-guanine phosphoribosylphosphotransferase (HPRT), respectively. M...

journal_title：Experimental neurology

authors： Davidson BL,Doran SE,Shewach DS,Latta JM,Hartman JW,Roessler BJ

更新日期：1994-02-01 00:00:00

abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...

journal_title：Experimental neurology

authors： dos Santos AA,Pinheiro PC,de Lima DS,Ozias MG,de Oliveira MB,Guimarães NX,Guedes RC

更新日期：2006-08-01 00:00:00

abstract：:The present study evaluates the temporal relationships between increases in glial fibrillary acidic protein (GFAP) mRNA, GFA protein levels, and GFAP immunostaining in the hippocampus of adult rats following unilateral lesions of the entorhinal cortex (EC). GFAP mRNA levels were assessed at 12 h, 1, 2, 4, 6, 8, 10, 12...

journal_title：Experimental neurology

authors： Steward O,Kelley MS,Torre ER

更新日期：1993-12-01 00:00:00

abstract：:The pathogenic factors leading to selective degeneration of motoneurons in ALS are not yet understood. However, altered functionality of voltage-dependent Na(+) channels may play a role since cortical hyperexcitability was described in ALS patients and riluzole, the only drug approved to treat ALS, seems to decrease g...

journal_title：Experimental neurology

authors： DiFebo F,Curti D,Botti F,Biella G,Bigini P,Mennini T,Toselli M

更新日期：2012-08-01 00:00:00

abstract：:Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...

journal_title：Experimental neurology

authors： Hagg T,Varon S

更新日期：1993-01-01 00:00:00