ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage.

abstract：:Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...

journal_title：Experimental neurology

authors： Quilty MC,Gai WP,Pountney DL,West AK,Vickers JC

更新日期：2003-07-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback fo...

journal_title：Experimental neurology

authors： Pandey N,Schmidt RE,Galvin JE

更新日期：2006-02-01 00:00:00

abstract：:A new mutant, peroneal muscular atrophy (pma) mouse in CF#1 strain has an autosomal recessively inherited equinovarus (club foot deformity) of the hind legs because of the absence of the common peroneal nerve branch of the sciatic nerve. We found the peroneal muscles were hypoplastic with histochemical and electron mi...

journal_title：Experimental neurology

authors： Nonaka I,Kikuchi A,Suzuki T,Esaki K

更新日期：1986-03-01 00:00:00

abstract：:We have used retrograde labeling with horseradish peroxidase (HRP) and a wheat germ agglutinin conjugate of HRP (WGA:HRP) to investigate the projections of the nucleus postglomerulosus (nPg) both in normal goldfish and in animals which had undergone retinal removal. In normal animals, our evidence indicates that nPg p...

journal_title：Experimental neurology

authors： Levine RL,Dethier S

更新日期：1988-11-01 00:00:00

abstract：:Adult mammalian retinal ganglion cells (RGCs) can regenerate through peripheral nerve (PN) grafts and innervate central nervous system (CNS) targets. Previous studies have demonstrated a basic level of differentiation of such projections. To further assess the specificity and functionality of regenerated CNS connectio...

journal_title：Experimental neurology

authors： Carter DA,Jhaveri S

更新日期：1997-08-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:It is clear that there are events which occur in response to neuromuscular activity that are essential to maintain normal muscle properties. Two factors though to influence muscle contractile properties are tension and electrical activity. To study these variables the hind limbs of 10 postpubertal female Sprague-Dawle...

journal_title：Experimental neurology

authors： Winiarski AM,Roy RR,Alford EK,Chiang PC,Edgerton VR

更新日期：1987-06-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...

journal_title：Experimental neurology

authors： Pasterkamp RJ,Giger RJ,Verhaagen J

更新日期：1998-10-01 00:00:00

abstract：:The Alzheimer's disease-related peptide beta(1-40) amyloid self-associates to form fibrils exhibiting a morphology characteristic of amyloidogenic proteins. The mechanism of this fibrillization process has yet to be fully elucidated. In this study we have immobilized the beta(1-40) amyloid to flat gold surfaces using ...

journal_title：Experimental neurology

authors： Blackley HK,Patel N,Davies MC,Roberts CJ,Tendler SJ,Wilkinson MJ,Williams PM

更新日期：1999-08-01 00:00:00

abstract：:It is difficult to assess cerebral function in comatose patients. Because earlier functional neuroimaging studies demonstrate associations between cerebral metabolism and levels of consciousness, fMRI in comatose survivors of cardiac arrest could provide further insight into cerebral function during coma. Using fMRI, ...

journal_title：Experimental neurology

authors： Gofton TE,Chouinard PA,Young GB,Bihari F,Nicolle MW,Lee DH,Sharpe MD,Yen YF,Takahashi AM,Mirsattari SM

更新日期：2009-06-01 00:00:00

abstract：:After spinal cord injury at birth, axotomized brainstem-spinal and corticospinal neurons are capable of permanent regenerative axonal growth into and through a fetal spinal cord transplant placed into the site of either a spinal cord hemisection or transection. In contrast, if fetal tissue which is not a normal target...

journal_title：Experimental neurology

authors： Bernstein-Goral H,Diener PS,Bregman BS

更新日期：1997-11-01 00:00:00

abstract：:Adult New Zealand Red (NZR) rabbits were used to determine if the techniques developed in the rat to transplant sheets of photoreceptors could be adapted to larger eyes of the rabbit. Adult donor NZR rabbit retina was cut into small strips, oriented, and drawn up in a small and flat polyethylene tube. By transscleral ...

journal_title：Experimental neurology

authors： Schuschereba ST,Silverman MS

更新日期：1992-01-01 00:00:00

abstract：:Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically dist...

journal_title：Experimental neurology

authors： Skoff AM,Zhao C,Adler JE

更新日期：2009-06-01 00:00:00

abstract：:Impaired olfaction is an early symptom of Alzheimer disease (AD). This likely to reflect neurodegenerative processes taking place in basal telencephalic structures that mediate olfactory processing, including the anterior olfactory nucleus. Betaeta-amyloid (Abeta) accumulation in AD brain may relate to decline in soma...

journal_title：Experimental neurology

authors： Saiz-Sanchez D,Ubeda-Bañon I,de la Rosa-Prieto C,Argandoña-Palacios L,Garcia-Muñozguren S,Insausti R,Martinez-Marcos A

更新日期：2010-06-01 00:00:00

abstract：:Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisiti...

journal_title：Experimental neurology

authors： Trulson ME,Babb S,Joe JC,Raese JD

更新日期：1986-12-01 00:00:00

abstract：:Following a unilateral fimbria-fornix lesion, the delivery of nerve growth factor (NGF) to the ipsilateral lateral ventricle of the rat can prevent the lesion-induced loss of choline acetyltransferase (ChAT) expression in the ipsilateral medial septum and vertical diagonal band region. In the present study, the abilit...

journal_title：Experimental neurology

authors： Hoffman D,Wahlberg L,Aebischer P

更新日期：1990-10-01 00:00:00

abstract：:Three-day-old rats received an infusion of a small dose of 6-hydroxydopamine (6-OHDA) (12 micrograms) directly into the locus ceruleus nuclei, in order to induce a subtotal lesion of the noradrenergic system. Significant modifications in cerebellum maturation were observed, mainly a regression failure in the perisomat...

journal_title：Experimental neurology

authors： Robain O,Lanfumey L,Adrien J,Farkas E

更新日期：1985-04-01 00:00:00

abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

journal_title：Experimental neurology

authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

更新日期：1988-03-01 00:00:00

abstract：:Primary spinal cord trauma can initiate a cascade of pathophysiologic events which markedly contribute to the expansion and amplification of the primary insult. The detailed mechanisms of these secondary neurochemical reactions are largely unknown; however, they involve membrane lipid derangements with the release of ...

journal_title：Experimental neurology

authors： Toborek M,Garrido R,Malecki A,Kaiser S,Mattson MP,Hennig B,Young B

更新日期：2000-02-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...

journal_title：Experimental neurology

authors： Vogt MA,Chourbaji S,Brandwein C,Dormann C,Sprengel R,Gass P

更新日期：2008-05-01 00:00:00

abstract：:After optic nerve transection beta cells of cat retinal ganglion cells (RGCs) suffer from rapid cell death from 3 to 7 days, whereas alpha cells gradual cell death until 14 days. Here we report electrophysiological properties of Y- (morphological alpha) and X- (morphological beta) cells at 5 and 14 days after axotomy ...

journal_title：Experimental neurology

authors： Takao M,Miyoshi T,Watanabe M,Fukuda Y

更新日期：2002-09-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...

journal_title：Experimental neurology

authors： Casha S,Yu WR,Fehlings MG

更新日期：2005-12-01 00:00:00

abstract：:A comparison of regenerated and normal frog sciatic nerves showed a marked reduction in conduction velocity from 37.5 to 15.2 m/s with little change in the absolute refractory period. Changes in conduction velocity corresponded to a reduced mean axon caliber (4.8 versus 6.6 micron). Regenerated nerves also had markedl...

journal_title：Experimental neurology

authors： Minwegen P,Friede RL

更新日期：1985-01-01 00:00:00

abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...

journal_title：Experimental neurology

authors： Mohan Kumar V,Mallick BN,Chhina GS,Singh B

更新日期：1984-10-01 00:00:00

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:Hypobaric hypoxia has been implicated with neural degeneration and memory loss. Though there has been considerable knowledge on the role of the p75(NTR) in triggering apoptosis, the occurrence of a similar mechanism in hypoxic stress still remains to be explored. We, in the present study, have tried to explore the rol...

journal_title：Experimental neurology

authors： Hota SK,Barhwal K,Singh SB,Ilavazhagan G

更新日期：2008-07-01 00:00:00