当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Incidence of seizures that follow rehydration of hypernatremic rabbits with intravenous glucose or fructose solutions.

Incidence of seizures that follow rehydration of hypernatremic rabbits with intravenous glucose or fructose solutions.

Abstract：

:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample showed a significant (P less than 0.05) increase in brain water content above normal in the rehydrated groups. Brain water content was significantly (P less than 0.01) greater in those animals with seizures compared with those without seizures, suggesting the importance of water intoxication in the pathogenesis of seizure activity. Changes in muscle Na, K, Cl, and water content were not similar to those of brain, indicating that muscle content of these substances was not an accurate reflection of the brain content specific time. The incidence of seizures was significantly (P less than 0.05) greater when glucose solution was used for rehydration (49%) compared with the use of fructose solution (25%). The mechanism(s) by which fructose resulted in a lower incidence of seizures is not known. The frequency of seizure activity was directly proportional to the rate of administration of intravenous solutions utilized to correct hypernatremia. In addition, the specific carbohydrate of the solution appeared to play an important role in the pathophysiology of the development of seizures.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

doi

10.1016/0014-4886(85)90215-8

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

249-59

issue

2

eissn

0014-4886

issn

1090-2430

pii

0014-4886(85)90215-8

journal_volume

87

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.

    abstract：:The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat primary cortical neuronal cultures was compared with the apoptotic death induced by staurosporine and the necrotic death induced by glutamate. Both SIN-1 and Cu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7322

    authors： Hill IE,Murray C,Richard J,Rasquinha I,MacManus JP

    更新日期：2000-03-01 00:00:00

  • FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury.

    abstract：:After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.08.020

    authors： Casha S,Yu WR,Fehlings MG

    更新日期：2005-12-01 00:00:00

  • Testosterone-induced acceleration of recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters.

    abstract：:In this study, the effects of testosterone propionate (TP) on recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters were examined. In the first experiment, TP (5 mg/ml sesame oil; 0.1 ml) was injected subcutaneously and on alternate days in one-half of the animals subjected to cru...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90174-x

    authors： Kujawa KA,Kinderman NB,Jones KJ

    更新日期：1989-07-01 00:00:00

  • The need for cellular elements during axonal regeneration in the sea lamprey spinal cord.

    abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90114-r

    authors： Lurie DI,Selzer ME

    更新日期：1991-04-01 00:00:00

  • Death of dopaminergic neurons in vitro and in nigral grafts: reevaluating the role of caspase activation.

    abstract：:Caspases are cysteine proteases involved in apoptotic cell death, and pharmacological caspase inhibition has been demonstrated to prevent neuronal cell death in certain experimental paradigms. In this study, the role of caspase-1 and -3 in the death of dopaminergic neurons derived from the E14 rat ventral mesencephalo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7749

    authors： Hurelbrink CB,Armstrong RJ,Luheshi LM,Dunnett SB,Rosser AE,Barker RA

    更新日期：2001-09-01 00:00:00

  • Quisqualate injection into the nucleus basalis magnocellularis produces seizure-related brain damage that is prevented by MK-801.

    abstract：:Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1046

    authors： Wozniak DF,Huss J,Olney JW

    更新日期：1994-03-01 00:00:00

  • Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat.

    abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90169-d

    authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

    更新日期：1991-08-01 00:00:00

  • Vestibuloocular reflex, optokinetic response, and their interactions in the alert cat.

    abstract：:Ocular movements of alert cats were recorded by classical electronystagmography techniques during (a) vestibular stimulation (sinusoidal rotation of the cat in complete darkness), (b) optokinetic stimulation (sinusoidal rotation of the visual surroundings around the stationary cat), (c) additive visual-vestibular stim...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90005-5

    authors： Godaux E,Gobert C,Halleux J

    更新日期：1983-04-01 00:00:00

  • Overexpression of HA-Bax but not Bcl-2 or Bcl-XL attenuates 6-hydroxydopamine-induced neuronal apoptosis.

    abstract：:Bax, a member of the Bcl-2 gene family, is known to promote apoptosis in many cases but to block cell death under certain conditions. To investigate the potential role of Bax in 6-hydroxydopamine (6-OHDA)-induced cell death, we first established and characterized a dopaminergic neuronal cell line (MN9D) stably overexp...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6923

    authors： Oh JH,Choi WS,Kim JE,Seo JW,O'Malley KL,Oh YJ

    更新日期：1998-11-01 00:00:00

  • Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord.

    abstract：:Contusion of the spinal cord causes an immediate local loss of neurons and disruption of vasculature; additional loss continues thereafter. To explore the possibility of a causal link between delayed endothelial cell (EC) death and secondary neural cell loss, we evaluated neural and endothelial cell survival, and meas...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.028

    authors： Casella GT,Bunge MB,Wood PM

    更新日期：2006-11-01 00:00:00

  • Exosomal shuttled miR-424-5p from ischemic preconditioned microglia mediates cerebral endothelial cell injury through negatively regulation of FGF2/STAT3 pathway.

    abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113411

    authors： Xie L,Zhao H,Wang Y,Chen Z

    更新日期：2020-11-01 00:00:00

  • Progesterone and allopregnanolone exacerbate hypoxic-ischemic brain injury in immature rats.

    abstract：:Progesterone and its metabolite, allopregnanolone, are neurosteroids that are present at high concentrations in fetal brains that decrease right after birth. Allopregnanolone is a potent positive modulator of γ-aminobutyric acid A (GABA(A)) receptor function. We examined the effect of exogenous administration of these...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.10.004

    authors： Tsuji M,Taguchi A,Ohshima M,Kasahara Y,Ikeda T

    更新日期：2012-01-01 00:00:00

  • Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid.

    abstract：:In this study we have characterised the locomotor recovery, and temporal profile of cell loss, in a novel thoracic compression spinal cord injury (SCI) in the mouse. We have also shown that treatment with docosahexaenoic acid (DHA) is neuroprotective in this model of SCI, strengthening the growing literature demonstra...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.09.015

    authors： Lim SN,Huang W,Hall JC,Michael-Titus AT,Priestley JV

    更新日期：2013-01-01 00:00:00

  • Inhibition of tumor necrosis factor is protective against neurologic dysfunction after active immunization of Lewis rats with myelin basic protein.

    abstract：:Increasing evidence indicates that the cytokines, tumor necrosis factor (TNF), interleukin-1, and/or interferon-gamma, may play a crucial role in the pathogenesis of multiple sclerosis. Several reports demonstrated that inhibition of TNF is highly protective in experimental allergic encephalomyelitis (EAE) when sensit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(95)90044-6

    authors： Martin D,Near SL,Bendele A,Russell DA

    更新日期：1995-02-01 00:00:00

  • Excitation of visual cortex neurons by local intracortical microstimulation.

    abstract：:The threshold current required for the excitation of visual cortex neurons in the vicinity (approximately 1 mm) of an intracortical stimulating electrode was measured as a function of the stimulus pulse duration in the anesthetized cat. For cortical neurons with latencies of activation from 0.4 to 3.4 ms and for stimu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(83)90270-4

    authors： Ronner SF,Lee BG

    更新日期：1983-08-01 00:00:00

  • Variations of synaptotagmin I, synaptotagmin IV, and synaptophysin mRNA levels in rat hippocampus during the estrous cycle.

    abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7186

    authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

    更新日期：1999-10-01 00:00:00

  • Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats.

    abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/S0014-4886(84)90100-6

    authors： Rasmussen K,Heym J,Jacobs BL

    更新日期：1984-02-01 00:00:00

  • Nerve growth factor influences the distribution of sympathetic sprouting into the hippocampal formation by implanted superior cervical ganglia.

    abstract：:Following cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers from the superior cervical ganglion (SCG) sprout into hippocampal tissue. The molecular mechanism controlling this process is unknown, although a role by trophic factors seems likely. In the present study, neonatal SCG were u...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1180

    authors： Conner JM,Varon S

    更新日期：1994-11-01 00:00:00

  • Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats.

    abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90026-3

    authors： Löscher W,Schwark WS

    更新日期：1985-11-01 00:00:00

  • Neurotropism of nerve growth factor for adult rat septal cholinergic axons in vivo.

    abstract：:Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1993.1005

    authors： Hagg T,Varon S

    更新日期：1993-01-01 00:00:00

  • Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.

    abstract：:Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7387

    authors： Pickering-Brown SM,Owen F,Isaacs A,Snowden J,Varma A,Neary D,Furlong R,Daniel SE,Cairns NJ,Mann DM

    更新日期：2000-06-01 00:00:00

  • Analysis of NMDA receptors in the human spinal cord.

    abstract：:NMDA receptors in postmortem human spinal cord were analyzed using [3H]MK-801 ligand binding and immunoblotting with NMDA receptor subunit-specific antibodies. The average KD for [3H]MK-801 binding was 1.77 nM with a Bmax of 0.103 pmol/mg. The EC50 for stimulation of -3H-MK-801 binding with L-glutamate was 0.34 microM...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6691

    authors： Sundström E,Whittemore S,Mo LL,Seiger A

    更新日期：1997-12-01 00:00:00

  • Fusion of neural stem cells in culture.

    abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.11.016

    authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

    更新日期：2006-03-01 00:00:00

  • Wld(S) mice are protected against the Parkinsonian mimetic MPTP.

    abstract：:The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. Because terminal field loss appears to precede cell body loss, we tested whether the mouse mutant Wld(S), which delays axonal degeneration in a variety of disorders, would ameliorate nigrostriatal degeneration followi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.017

    authors： Hasbani DM,O'Malley KL

    更新日期：2006-11-01 00:00:00

  • Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome.

    abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.11.033

    authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

    更新日期：2012-02-01 00:00:00

  • Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats.

    abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.11.005

    authors： Sayeed I,Turan N,Stein DG,Wali B

    更新日期：2019-02-01 00:00:00

  • Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

    abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.01.031

    authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

    更新日期：2006-07-01 00:00:00

  • c-Fos expression mediated by N-methyl-D-aspartate receptors following anodal polarization in the rat brain.

    abstract：:c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1995.1004

    authors： Islam N,Moriwaki A,Hattori Y,Hayashi Y,Lu YF,Hori Y

    更新日期：1995-05-01 00:00:00

  • In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.

    abstract：:Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases. Excitatory amino acid receptor antagonists are therefore of great therapeutic interest, but untoward side effects often prevent their clinical use. Targeting the glycine coagonist site of the (NMDA)...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7284

    authors： Guidetti P,Wu HQ,Schwarcz R

    更新日期：2000-05-01 00:00:00

  • Increased beta-actin and tubulin polymerization in regrowing axons: relationship to the conditioning lesion effect.

    abstract：:Spinal motor neurons of Sprague-Dawley rats were examined to determine which of the neuronal isoforms of actin (beta or gamma) upregulate following axon injury. In situ hybridization studies showed greater beta-actin mRNA levels but no change in gamma-actin mRNA levels-suggesting that axon regrowth utilizes beta-actin...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2002.8034

    authors： Lund LM,Machado VM,McQuarrie IG

    更新日期：2002-12-01 00:00:00