Abstract:
:The progressive loss of the nigrostriatal pathway is a distinguishing feature of Parkinson's disease. Because terminal field loss appears to precede cell body loss, we tested whether the mouse mutant Wld(S), which delays axonal degeneration in a variety of disorders, would ameliorate nigrostriatal degeneration following treatment with the Parkinsonian mimetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The present findings show that the Wld(S) gene product enhances survival, prevents nigrostriatal axon degeneration, and attenuates neurotransmitter loss but does not rescue cell bodies. As MPTP is thought to impair mitochondrial energy production, these data suggest that disease pathology due to metabolic dysfunction could be improved by the Wld(S) gene product. These results suggest new therapeutic avenues for Parkinson's disease.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Hasbani DM,O'Malley KLdoi
10.1016/j.expneurol.2006.05.017subject
Has Abstractpub_date
2006-11-01 00:00:00pages
93-9issue
1eissn
0014-4886issn
1090-2430pii
S0014-4886(06)00304-9journal_volume
202pub_type
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