Longitudinal diffusion tensor imaging in Huntington's Disease.

abstract：:The role of interferon-gamma (IFN-gamma) in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still controversial. We have studied the function of IFN-gamma and its receptor in the EAE model using two different IFN-gamma receptor knockout (IFN-gamma R(-/-)) mouse types: C57B...

journal_title：Experimental neurology

authors： Espejo C,Penkowa M,Sáez-Torres I,Xaus J,Celada A,Montalban X,Martínez-Cáceres EM

更新日期：2001-12-01 00:00:00

abstract：:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striat...

journal_title：Experimental neurology

authors： Sarchielli E,Marini M,Ambrosini S,Peri A,Mazzanti B,Pinzani P,Barletta E,Ballerini L,Paternostro F,Paganini M,Porfirio B,Morelli A,Gallina P,Vannelli GB

更新日期：2014-07-01 00:00:00

abstract：:Neuronal migration was investigated in rodent cerebellum in vitro and in vivo. Time-lapse video recording showed that cultured neurons migrated on laminin by first extending neurites that formed contacts with other neurons. This was followed by movement of the cell nucleus inside the preformed process. No guidance cue...

journal_title：Experimental neurology

authors： Liesi P

更新日期：1992-08-01 00:00:00

abstract：:The nontoxic C fragment of tetanus toxin (TC) can transport other proteins from the circulation to central nervous system (CNS) motor neurons. Increased levels of CuZn superoxide dismutase (SOD) are protective in experimental models of stroke and Parkinson's disease, whereas mutations in SOD can cause motor neuron dis...

journal_title：Experimental neurology

authors： Figueiredo DM,Hallewell RA,Chen LL,Fairweather NF,Dougan G,Savitt JM,Parks DA,Fishman PS

更新日期：1997-06-01 00:00:00

abstract：:The dependence of movement on visual information was compared for healthy individuals and Stage II-III patients with Parkinson's disease (PD). A time delay (0-1400 ms) was introduced into a visually guided motor tracking task which required the subject to maintain constant index finger position relative to a stationar...

journal_title：Experimental neurology

authors： Beuter A,Milton JG,Labrie C,Glass L,Gauthier S

更新日期：1990-11-01 00:00:00

abstract：:Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...

journal_title：Experimental neurology

authors： Chen LF,FitzGibbon T,He JR,Yin ZQ

更新日期：2012-04-01 00:00:00

abstract：:Sulforaphane (SFN) is an organosulfur compound present in vegetables and has potent anti-oxidant and anti-inflammatory activities. This study was aimed at investigating the effect of treatment with SFN on inflammation and oxidative stress, and the potential mechanisms underlying the action of SFN in experimental autoi...

journal_title：Experimental neurology

authors： Li B,Cui W,Liu J,Li R,Liu Q,Xie XH,Ge XL,Zhang J,Song XJ,Wang Y,Guo L

更新日期：2013-12-01 00:00:00

abstract：:The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of...

journal_title：Experimental neurology

authors： Wright PW,Archambault AS,Peek S,Bauer AQ,Culican SM,Ances BM,Culver JP,Wu GF

更新日期：2017-09-01 00:00:00

abstract：:This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral exte...

journal_title：Experimental neurology

authors： Biran V,Joly LM,Héron A,Vernet A,Véga C,Mariani J,Renolleau S,Charriaut-Marlangue C

更新日期：2006-05-01 00:00:00

abstract：:Five subjects matched the force of a sustained isometric contraction with a contraction of the contralateral muscle. Estimates of the sustained constant forces increased with time despite the direction to disregard the increased effort associated with the fatiguing contraction. These instructions did not produce a not...

journal_title：Experimental neurology

authors： Jones LA

更新日期：1983-08-01 00:00:00

abstract：:A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...

journal_title：Experimental neurology

authors： Andreoni G,Angeretti N,Lucca E,Forloni G

更新日期：1997-11-01 00:00:00

abstract：:The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

journal_title：Experimental neurology

authors： Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

更新日期：2013-09-01 00:00:00

abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...

journal_title：Experimental neurology

authors： Cheng L,Allore RJ,Richardson PM

更新日期：1998-02-01 00:00:00

abstract：:Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to maintain immune function when glucocorticoids are elevated by trauma or stress. Here we show that MIF is essential for the development of neuropath...

journal_title：Experimental neurology

authors： Alexander JK,Cox GM,Tian JB,Zha AM,Wei P,Kigerl KA,Reddy MK,Dagia NM,Sielecki T,Zhu MX,Satoskar AR,McTigue DM,Whitacre CC,Popovich PG

更新日期：2012-08-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study is to determine whether the expansion and mobilization of circulating bone marrow (BM) stem cells by in vivo treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) increase the amount of BM-derived neuronal cells in mouse brain. The presence of BM-derived c...

journal_title：Experimental neurology

authors： Corti S,Locatelli F,Strazzer S,Salani S,Del Bo R,Soligo D,Bossolasco P,Bresolin N,Scarlato G,Comi GP

更新日期：2002-10-01 00:00:00

abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...

journal_title：Experimental neurology

authors： Noireaud J,Léoty C

更新日期：1984-03-01 00:00:00

abstract：:Estrogens and N-methyl-D-aspartate (NMDA) receptors regulate multiple aspects of morphological and functional plasticity in young animals. For example, estrogens increase spine density in the hippocampus, and NMDA antagonists block these effects. Few studies have examined the effects of age, postovariectomy interval, ...

journal_title：Experimental neurology

authors： Adams MM,Oung T,Morrison JH,Gore AC

更新日期：2001-08-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by chorea, psychiatric disturbances, and dementia. It is caused by a polyglutamine repeat expansion in the huntingtin protein. The striatum is a major site of neuronal loss in HD, but the mechanisms underlying the neurodegenerative pro...

journal_title：Experimental neurology

authors： Duan W,Guo Z,Mattson MP

更新日期：2000-09-01 00:00:00

abstract：:Five female adult Macaca nemestrina monkeys, given a unilateral intracarotid (ic) infusion of 2.3-3.5 mg of MPTP-HCl, were studied for 6-8 years. Two to 3 days after MPTP, the animals developed hemiparkinsonism characterized by rigidity and flexed posture of the arm contralateral to the side of infusion with episodes ...

journal_title：Experimental neurology

authors： Emborg-Knott ME,Domino EF

更新日期：1998-08-01 00:00:00

abstract：:Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. DBH immunoreactive (DBH+) axons ramified extensively within the SI and appeared to be contiguous with the DBH+ terminal fie...

journal_title：Experimental neurology

authors： Chang HT

更新日期：1989-05-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:The gastrointestinal tract of vertebrates is a heterogeneous organ system innervated to varying degrees by a local enteric neural network as well as extrinsic parasympathetic and sympathetic neural circuits located along the brainstem and spinal axis. This diverse organ system serves to regulate the secretory and prop...

journal_title：Experimental neurology

authors： Holmes GM,Blanke EN

更新日期：2019-10-01 00:00:00

abstract：:We previously reported that 1 month following unilateral loss (>95%) of striatal dopamine, there is an increase in striatal glutamate function as measured by in vivo microdialysis and quantitative immuno-gold electron microscopy, Neuroscience 88, 1-16). The goal of this study was to determine the effect of bilateral l...

journal_title：Experimental neurology

authors： Robinson S,Freeman P,Moore C,Touchon JC,Krentz L,Meshul CK

更新日期：2003-03-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

journal_title：Experimental neurology

authors： Rose DF,Eswaran H

更新日期：2004-11-01 00:00:00

abstract：:We have investigated the formation of DNA adducts and oxidative base damage produced by copper sulfate activation of dopamine and 6-hydroxydopamine. In the presence of 10 microM copper sulfate both 100 microM dopamine and 100 microM 6-hydroxydopamine formed three similar DNA adducts with relative adduct levels of 8.36...

journal_title：Experimental neurology

authors： Lévay G,Ye Q,Bodell WJ

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Cognitive impairment in humans with Alzheimer's disease (AD) and in animal models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ) agonists, such as rosiglitazone (RSG). Previously, we demonstrated that in the Tg2576 animal mo...

journal_title：Experimental neurology

authors： Hsu WJ,Wildburger NC,Haidacher SJ,Nenov MN,Folorunso O,Singh AK,Chesson BC,Franklin WF,Cortez I,Sadygov RG,Dineley KT,Rudra JS,Taglialatela G,Lichti CF,Denner L,Laezza F

更新日期：2017-09-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

journal_title：Experimental neurology

authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

更新日期：2009-09-01 00:00:00