Gastrointestinal dysfunction after spinal cord injury.

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:Chewing rhythms are set by a putative central pattern generator whose output is influenced by sensory feedback. In this study we assessed how an altered feedback imposed by changing the hardness of a gum bolus modifies the timing of chewing, the maximal gape, and the activity in the masseter muscle on the chewing side...

journal_title：Experimental neurology

authors： Plesh O,Bishop B,McCall W

更新日期：1986-06-01 00:00:00

abstract：:Axons of the CNS do normally not regenerate after injury, in contrast to axons of the PNS. This is due to a different microenvironment at the site of the lesion as well as a particular intrinsic program of axonal regrowth. Although transplantation of peripheral nerve tissue bridges is perhaps the most successful appro...

journal_title：Experimental neurology

authors： Blits B,Dijkhuizen PA,Carlstedt TP,Poldervaart H,Schiemanck S,Boer GJ,Verhaagen J

更新日期：1999-11-01 00:00:00

abstract：:Mesiotemporal lobe Epilepsy (MTLE), the most frequent form of focal epilepsy, is often drug-resistant. Enriching the epileptic focus with GABA-releasing engineered cells has been proposed as a strategy to prevent seizures. However, ex vivo data from animal models and MTLE patients suggest that, due to changes in chlor...

journal_title：Experimental neurology

authors： Stamboulian-Platel S,Legendre A,Chabrol T,Platel JC,Pernot F,Duveau V,Roucard C,Baudry M,Depaulis A

更新日期：2016-10-01 00:00:00

abstract：:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (...

journal_title：Experimental neurology

authors： Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

更新日期：2006-07-01 00:00:00

abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...

journal_title：Experimental neurology

authors： Pendleton JC,Shamblott MJ,Gary DS,Belegu V,Hurtado A,Malone ML,McDonald JW

更新日期：2013-09-01 00:00:00

abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...

journal_title：Experimental neurology

authors： Kanju PM,Parameshwaran K,Sims C,Bahr BA,Shonesy BC,Suppiramaniam V

更新日期：2008-11-01 00:00:00

abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...

journal_title：Experimental neurology

authors： Cabral A,Isoardi N,Salum C,Macedo CE,Nobre MJ,Molina VA,Brandão ML

更新日期：2006-07-01 00:00:00

abstract：:Methylmalonic acidemia is an inherited metabolic disorder that leads to brain damage associated to the accumulation of methylmalonic acid (MMA) and impairment of energy metabolism. We demonstrate here that treatment with diazoxide, an agonist of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)), can prevent death...

journal_title：Experimental neurology

authors： Kowaltowski AJ,Maciel EN,Fornazari M,Castilho RF

更新日期：2006-09-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-2 (TREM2) was a newly identified receptor expressed on microglia. Several observations support the hypothesis that TREM2 variation may confer susceptibility to Parkinson's disease (PD). Therefore, in this paper, we explored the role of TREM2 in the 1-methyl-4-phenyl-1,2,3...

journal_title：Experimental neurology

authors： Ren M,Guo Y,Wei X,Yan S,Qin Y,Zhang X,Jiang F,Lou H

更新日期：2018-04-01 00:00:00

abstract：:The present study evaluated the growth potential and differentiation of human fetal spinal cord (FSC) tissue in the injured adult rat spinal cord under different lesion and grafting conditions. Donor tissue at 6-9 weeks of gestational age was obtained through elective abortions and transplanted either immediately into...

journal_title：Experimental neurology

authors： Giovanini MA,Reier PJ,Eskin TA,Wirth E,Anderson DK

更新日期：1997-12-01 00:00:00

abstract：:Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

journal_title：Experimental neurology

authors： Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

更新日期：2010-03-01 00:00:00

abstract：:The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA). Striatal tyrosine hydroxylase (TH) levels are decreased while the numb...

journal_title：Experimental neurology

authors： Zeng BY,Heales SJ,Canevari L,Rose S,Jenner P

更新日期：2004-12-01 00:00:00

abstract：:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes...

journal_title：Experimental neurology

authors： Takashima S,Becker LE,Chan FW,Augustin R

更新日期：1985-06-01 00:00:00

abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...

journal_title：Experimental neurology

authors： Patel JR,Brewer GJ

更新日期：2008-09-01 00:00:00

abstract：:Cyclic nucleotides are thought to act as second messengers of neurotransmission inside central neurons, and cyclic guanosine monophosphate (cGMP) has been postulated to act as a messenger for muscarinic, cholinergic transmission. Nonetheless, the action of cGMP has not yet been established in identified cortical neuro...

journal_title：Experimental neurology

authors： Woody C,Gruen E,Sakai H,Sakai M,Swartz B

更新日期：1986-03-01 00:00:00

abstract：:Hyperbaric oxygen preconditioning (HBO-PC) has been demonstrated to attenuate hemorrhagic transformation (HT) after middle cerebral artery occlusion (MCAO) in hyperglycemic rats. However, the mechanisms remain to be illustrated. Recently, HBO-PC has been shown to activate peroxisome proliferator-activated receptor-gam...

journal_title：Experimental neurology

authors： Bian H,Hu Q,Liang X,Chen D,Li B,Tang J,Zhang JH

更新日期：2015-03-01 00:00:00

abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

journal_title：Experimental neurology

authors： Sholomenko GN,Delaney KR

更新日期：1998-12-01 00:00:00

abstract：:We examined c-Fos and FosB staining in the central nervous system 8 and 24 h following acute volume expansion in unanesthetized rats. Male rats were instrumented with a femoral artery catheter for measurement of blood pressure and heart rate (HR), a jugular venous catheter for measurement of central venous pressure (C...

journal_title：Experimental neurology

authors： Howe BM,Bruno SB,Higgs KA,Stigers RL,Cunningham JT

更新日期：2004-05-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Medial forebrain bundle (MFB) deep brain stimulation (DBS) has anti-depressant effects clinically and in depression models. Currently, therapeutic mechanisms of MFB DBS or how stimulation parameters acutely impact neurotransmitter release, particularly dopamine, are unknown. Experimentally, MFB DBS has been ...

journal_title：Experimental neurology

authors： Ashouri Vajari D,Ramanathan C,Tong Y,Stieglitz T,Coenen VA,Döbrössy MD

更新日期：2020-05-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) have been investigated extensively as a therapy to promote repair in the injured CNS, with variable efficacy in numerous studies over the previous decade. In many studies that report anatomical and functional recovery, the beneficial effects have been attributed to the ability of OEC...

journal_title：Experimental neurology

authors： Chuah MI,Hale DM,West AK

更新日期：2011-05-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of G...

journal_title：Experimental neurology

authors： Müller MC,Osswald M,Tinnes S,Häussler U,Jacobi A,Förster E,Frotscher M,Haas CA

更新日期：2009-04-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

journal_title：Experimental neurology

authors： Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

更新日期：2020-05-01 00:00:00

abstract：:The extensive period of retinal ganglion cell (RGC) neurogenesis in the rat is associated with a protracted sequence of arrival of their axons into central targets such as the superior colliculus (SC) (Dallimore et al., 2002). Using in utero 5-bromo-2'-deoxyrudine (BrdU) injections to label early (embryonic day (E) 15...

journal_title：Experimental neurology

authors： Dallimore EJ,Park KK,Pollett MA,Taylor JS,Harvey AR

更新日期：2010-10-01 00:00:00

abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

journal_title：Experimental neurology

authors： Bennion Callister J,Pickering-Brown SM

更新日期：2014-12-01 00:00:00

abstract：:As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases ...

journal_title：Experimental neurology

authors： Esclaire F,Kisby G,Spencer P,Milne J,Lesort M,Hugon J

更新日期：1999-01-01 00:00:00