当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats.

Abstract：

:Patients with neuropathic pain frequently experience hypersensitivity to cold stimulation. However, the underlying mechanisms of this enhanced sensitivity to cold are not well understood. After partial nerve injury, the transient receptor potential ion channel TRPV1 increases in the intact small dorsal root ganglion (DRG) neurons in several neuropathic pain models. In the present study, we precisely examined the incidence of cold hyperalgesia and the changes of TRPA1 and TRPM8 expression in the L4 and L5 DRG following L5 spinal nerve ligation (SNL), because it is likely that the activation of two distinct populations of TRPA1- and TRPM8-expressing small neurons underlie the sensation of cold. We first confirmed that L5 SNL rats developed cold hyperalgesia for more than 14 days after surgery. In the nearby uninjured L4 DRG, TRPA1 mRNA expression increased in trkA-expressing small-to-medium diameter neurons from the 1st to 14th day after the L5 SNL. This upregulation corresponded well with the development and maintenance of nerve injury-induced cold hyperalgesia of the hind paw. In contrast, there was no change in the expression of the TRPM8 mRNA/protein in the L4 DRG throughout the 2-week time course of the experiment. In the injured L5 DRG, on the other hand, both TRPA1 and TRPM8 expression decreased over 2 weeks after ligation. Furthermore, intrathecal administration of TRPA1, but not TRPM8, antisense oligodeoxynucleotide suppressed the L5 SNL-induced cold hyperalgesia. Our data suggest that increased TRPA1 in uninjured primary afferent neurons may contribute to the exaggerated response to cold observed in the neuropathic pain model.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Katsura H,Obata K,Mizushima T,Yamanaka H,Kobayashi K,Dai Y,Fukuoka T,Tokunaga A,Sakagami M,Noguchi K

doi

10.1016/j.expneurol.2006.01.031

keywords:

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

112-23

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(06)00033-1

journal_volume

200

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Overlapping and additive effects of neurotrophins and CNTF on cultured human spinal cord neurons.

    abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1994.1198

    authors： Kato AC,Lindsay RM

    更新日期：1994-12-01 00:00:00

  • Anti-CD40 ligand monoclonal antibody induces a permissive state, but not tolerance, for murine peripheral nerve allografts.

    abstract：:Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.10.002

    authors： Brenner MJ,Tung TH,Mackinnon SE,Myckatyn TM,Hunter DA,Mohanakumar T

    更新日期：2004-03-01 00:00:00

  • Volumetric changes in the anterior olfactory nucleus of the rat after neonatal olfactory deprivation.

    abstract：:The effect of olfactory deprivation in the postnatal development of the anterior olfactory nucleus (AON) was studied in 60-day-old rats which underwent unilateral naris closure after birth (postnatal day 1). Volumetric and morphometric analyses of the AON ipsilateral and contralateral to the closed naris were performe...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7760

    authors： Barbado MV,Briñón JG,Weruaga E,Porteros A,Arévalo R,Aijón J,Alonso JR

    更新日期：2001-10-01 00:00:00

  • Development of immune hyperinnervation in NGF-transgenic mice.

    abstract：:Sympathetic innervation of lymphoid tissues is localized to specific tissue compartments, but little is known of the "factors" that are important in establishing this pattern during development. Numerous studies have shown interactions of nerve growth factor (NGF) with the immune system, which may include modulation o...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1997.6711

    authors： Carlson SL,Johnson S,Parrish ME,Cass WA

    更新日期：1998-01-01 00:00:00

  • Transplantation of mesencephalic cell suspension in dopamine-denervated striatum of the rat.I. Effects on spontaneous activity of striatal neurons.

    abstract：:These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1996.0070

    authors： Di Loreto S,Florio T,Capozzo A,Napolitano A,Adorno D,Scarnati E

    更新日期：1996-04-01 00:00:00

  • Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice.

    abstract：:Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. However, the underlying mechanisms are unknown. Here, we treated ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.06.004

    authors： Chen Y,Zhao Y,Dai CL,Liang Z,Run X,Iqbal K,Liu F,Gong CX

    更新日期：2014-11-01 00:00:00

  • Recovery after spinal cord injury by modulation of the proteoglycan receptor PTPσ.

    abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2018.08.003

    authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

    更新日期：2018-11-01 00:00:00

  • Fusion of neural stem cells in culture.

    abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.11.016

    authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

    更新日期：2006-03-01 00:00:00

  • Cell loss in the cerebellum and hippocampal formation of adult rats after long-term low-protein diet.

    abstract：:Whereas quite a number of previous reports have shown that the developing brain is vulnerable to protein deprivation, the mature CNS is usually considered resistant to this condition. To explore this assumption the present experimental model was built on groups of 2-month-old rats fed with a low-protein diet (8% casei...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(89)90081-2

    authors： Paula-Barbosa MM,Andrade JP,Castedo JL,Azevedo FP,Camões I,Volk B,Tavares MA

    更新日期：1989-02-01 00:00:00

  • Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system.

    abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2009.05.013

    authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

    更新日期：2009-09-01 00:00:00

  • The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

    abstract：:We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7515

    authors： Xu K,Dluzen DE

    更新日期：2000-12-01 00:00:00

  • NAD+ precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms.

    abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2019.113144

    authors： Klimova N,Fearnow A,Long A,Kristian T

    更新日期：2020-03-01 00:00:00

  • Herpes simplex virus vector-mediated expression of Bcl-2 protects spinal motor neurons from degeneration following root avulsion.

    abstract：:Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based v...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7597

    authors： Yamada M,Natsume A,Mata M,Oligino T,Goss J,Glorioso J,Fink DJ

    更新日期：2001-04-01 00:00:00

  • Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition.

    abstract：:The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like p...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2015.01.001

    authors： Pogorelov V,Xu M,Smith HR,Buchanan GF,Pittenger C

    更新日期：2015-03-01 00:00:00

  • Glutamate induces rapid loss of axonal neurofilament proteins from cortical neurons in vitro.

    abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.01.005

    authors： Chung RS,McCormack GH,King AE,West AK,Vickers JC

    更新日期：2005-06-01 00:00:00

  • Electromyogram coactivation patterns of the elbow antagonist muscles during slow isokinetic movement.

    abstract：:Electromyograms from the flexor and extensor muscles of normal human elbows were simultaneously recorded during maximal-effort isokinetic movement at 15 degrees/s over the joint's full range of motion. The antagonist electromyogram was normalized with respect to its electromyogram when acting as agonist at maximal eff...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(88)90032-5

    authors： Solomonow M,Baratta R,Zhou BH,D'Ambrosia R

    更新日期：1988-06-01 00:00:00

  • Cyclic AMP elevates tubulin expression without increasing intrinsic axon growth capacity.

    abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.03.010

    authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

    更新日期：2004-10-01 00:00:00

  • Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease.

    abstract：:Parkinson's disease (PD) is associated with complex compensatory changes in the functional and neurochemical anatomy of the basal ganglia resulting from striatal dopamine deficiency. Available evidence suggests that glutamatergic corticostriatal pathway becomes overactive following nigrostriatal dopaminergic denervati...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2003.12.012

    authors： Betarbet R,Poisik O,Sherer TB,Greenamyre JT

    更新日期：2004-05-01 00:00:00

  • GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons.

    abstract：:The retrograde axonal transport mechanism of motor neurons has been exploited to deliver the gene encoding Glial cell line-derived neurotrophic factor (GDNF) into the central nervous system to provide trophic support following injury. A nonviral gene delivery system, consisting of a monoclonal antibody (MC192) that bi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.027

    authors： Barati S,Hurtado PR,Zhang SH,Tinsley R,Ferguson IA,Rush RA

    更新日期：2006-11-01 00:00:00

  • Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.

    abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.09.002

    authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

    更新日期：2006-01-01 00:00:00

  • Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation.

    abstract：:Regeneration of axons in the peripheral nervous system is enhanced by the removal of glycosaminoglycan side chains (GAGs) of chondroitin sulfate proteoglycans. However, some axons regenerate poorly despite such treatment, suggesting the existence of additional inhibitors. We compared the effects of enzymatic removal o...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2005.04.007

    authors： Groves ML,McKeon R,Werner E,Nagarsheth M,Meador W,English AW

    更新日期：2005-10-01 00:00:00

  • Selective susceptibility to inhibitors of GABA synthesis and antagonists of GABA(A) receptor in rats with genetic absence epilepsy.

    abstract：:Thalamocortical spike-and-wave discharges characterize the nonconvulsive absence seizures that occur spontaneously in genetic absence epilepsy rats from Strasbourg (GAERS), a selected strain of Wistar rats. GABA is crucial in the generation of absence seizures. The susceptibility to convulsions induced by threshold do...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7302

    authors： Vergnes M,Boehrer A,Reibel S,Simler S,Marescaux C

    更新日期：2000-02-01 00:00:00

  • Differential expression of ErbB3 and ErbB4 neuregulin receptors in dopamine neurons and forebrain areas of the adult rat.

    abstract：:Neuregulins have been shown to play an important role in the development of the central nervous system, but their function in adult tissues is still unclear. We investigated the expression of the neuregulin receptors erbB3 and erbB4 in the adult rat brain by in situ hybridization histochemistry. Areas with considerabl...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7163

    authors： Steiner H,Blum M,Kitai ST,Fedi P

    更新日期：1999-10-01 00:00:00

  • Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.

    abstract：:Given the prevalence and societal impact of autism spectrum disorders (ASD), there is an urgent need to develop innovative preventative strategies and treatments to reduce the alarming number of cases and improve core symptoms for afflicted individuals. Translational efforts between clinical and preclinical research a...

    journal_title：Experimental neurology

    pub_type： 杂志文章,评审

    doi：10.1016/j.expneurol.2017.07.021

    authors： Bauman MD,Schumann CM

    更新日期：2018-01-01 00:00:00

  • Prolonged induction of neuronal NOS expression and activity following cortical spreading depression (SD): implications for SD- and NO-mediated neuroprotection.

    abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7218

    authors： Shen PJ,Gundlach AL

    更新日期：1999-12-01 00:00:00

  • Erythropoietin and caffeine exert similar protective impact against neonatal intermittent hypoxia: Apnea of prematurity and sex dimorphism.

    abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2019.112985

    authors： Laouafa S,Iturri P,Arias-Reyes C,Marcouiller F,Gonzales M,Joseph V,Bairam A,Soliz J

    更新日期：2019-10-01 00:00:00

  • Allosteric modulation of NMDA receptors alters neurotransmission in the striatum of a mouse model of Parkinson's disease.

    abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.03.001

    authors： Feng ZJ,Zhang X,Chergui K

    更新日期：2014-05-01 00:00:00

  • Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury.

    abstract：:A prospective, multicenter, randomized trial did not demonstrate improved outcomes in severe traumatic brain injured patients treated with mild hypothermia [Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Jr., Muizelaar, J.P., Wagner, F.C., Jr., Marion, D.W., Luerssen, T.G., Chesnut, R...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2008.09.024

    authors： Ma M,Matthews BT,Lampe JW,Meaney DF,Shofer FS,Neumar RW

    更新日期：2009-01-01 00:00:00

  • Fatiguability and oxidative capacity of forelimb and hind limb muscles of dystrophic mice.

    abstract：:Fatigue indices and succinic dehydrogenase (SDH) activities were determined in the extensor digitorum longus (EDL) and soleus muscles of the hind limb and the extensor carpi radialis longus of the forelimb in control and dystrophic mice aged 4 to 26 weeks. A good correlation was found between SDH activities and fatigu...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90226-2

    authors： Parry DJ,Desypris G

    更新日期：1985-02-01 00:00:00

  • Localization and developmental expression patterns of CSPG-cs56 (aggrecan) in normal and dystrophic retinas in two rat strains.

    abstract：:Proteoglycans have a number of important functions in the central nervous system. Aggrecan (hyaluronan-binding proteoglycan, CSPG-cs56) is found in the extracellular matrix of cartilage as well as in the developing brain. We compared the postnatal distribution of CSPG-cs56 in Long Evans (LE) and Royal College of Surge...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.01.023

    authors： Chen LF,FitzGibbon T,He JR,Yin ZQ

    更新日期：2012-04-01 00:00:00