Abstract:
:We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related to vesicular storage and release of dopamine (DA). The effects of two 20-min infusions of K(+) (70 mM) upon DA and dihydroxyphenylacetic acid (DOPAC) output from the striatum of rats which received a single ipsilateral intrastriatal injection of vehicle, 1 microgram GDNF, or 10 microgram GDNF 1 week before microdialysis were examined. In the 10 microgram GDNF-treated rats, there was a significant increase in the peak DA output in response to the second versus first K(+) infusion, a significant increase in both basal and overall K(+)-evoked DOPAC responses, and significantly increased striatal DA and DOPAC contents compared with vehicle- or 1 microgram GDNF-treated rats. These data demonstrate that two-pulse K(+) stimulation is a useful means to detect significant mechanistic changes in DA neurons resulting from GDNF treatment. These results suggest the possibility for GDNF to modulate vesicular pools of DA for release.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Xu K,Dluzen DEdoi
10.1006/exnr.2000.7515keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
450-7issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(00)97515-0journal_volume
166pub_type
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