Fatiguability and oxidative capacity of forelimb and hind limb muscles of dystrophic mice.

abstract：:Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brain-enriched regulato...

journal_title：Experimental neurology

authors： Jain N,Lim LW,Tan WT,George B,Makeyev E,Thanabalu T

更新日期：2014-04-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:Altered activity in one of the output nuclei of the basal ganglia, the internal segment of the globus pallidus, is known to play an important role in the generation of parkinsonism. These inactivation studies tested the hypothesis that altered activity in the second major output nucleus of the basal ganglia, the subst...

journal_title：Experimental neurology

authors： Wichmann T,Kliem MA,DeLong MR

更新日期：2001-02-01 00:00:00

abstract：:Demyelinating diseases comprise a spectrum of immunopathologic syndromes in which myelin, the fatty covering of nerve cell fibers in the brain and spinal cord, is destroyed. In this study, we have shown for the first time that ocular infection of BALB/c mice with a recombinant herpes simplex virus type 1 (HSV-1) expre...

journal_title：Experimental neurology

authors： Osorio Y,La Point SF,Nusinowitz S,Hofman FM,Ghiasi H

更新日期：2005-05-01 00:00:00

abstract：:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited ...

journal_title：Experimental neurology

authors： Eickhoff SB,Dafotakis M,Grefkes C,Stöcker T,Shah NJ,Schnitzler A,Zilles K,Siebler M

更新日期：2008-12-01 00:00:00

abstract：:Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

journal_title：Experimental neurology

authors： Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

更新日期：2010-03-01 00:00:00

abstract：:Oxidative stress has been implicated in several neurodegenerative diseases affecting both neuronal and glial cells. The aim of this study was to investigate the involvement of reactive oxygen species in glutamate-evoked activation of NF-kappaB in primary astrocytes. A prolonged exposure to glutamate (24 h) caused a de...

journal_title：Experimental neurology

authors： Caccamo D,Campisi A,Marini H,Adamo EB,Li Volti G,Squadrito F,Ientile R

更新日期：2005-06-01 00:00:00

abstract：:Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalop...

journal_title：Experimental neurology

authors： Tskitishvili E,Nisolle M,Munaut C,Pequeux C,Gerard C,Noel A,Foidart JM

更新日期：2014-11-01 00:00:00

abstract：:Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region ...

journal_title：Experimental neurology

authors： Saito H,Katagiri A,Okada S,Mikuzuki L,Kubo A,Suzuki T,Ohara K,Lee J,Gionhaku N,Iinuma T,Bereiter DA,Iwata K

更新日期：2017-07-01 00:00:00

abstract：:Mutations in the human NOTCH3 gene cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but the pathogenesis of CADASIL has remained unclear. Recently, endocytosis of the Notch ectodermal domain into ligand-expressing cells, called transendocytosis, has come to be...

journal_title：Experimental neurology

authors： Watanabe-Hosomi A,Watanabe Y,Tanaka M,Nakagawa M,Mizuno T

更新日期：2012-01-01 00:00:00

abstract：:Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimu...

journal_title：Experimental neurology

authors： Zareen N,Shinozaki M,Ryan D,Alexander H,Amer A,Truong DQ,Khadka N,Sarkar A,Naeem S,Bikson M,Martin JH

更新日期：2017-11-01 00:00:00

abstract：:The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...

journal_title：Experimental neurology

authors： Marescaux C,Vergnes M,Kiesmann M,Depaulis A,Micheletti G,Warter JM

更新日期：1987-07-01 00:00:00

abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...

journal_title：Experimental neurology

authors： Hocker AD,Stokes JA,Powell FL,Huxtable AG

更新日期：2017-01-01 00:00:00

abstract：:Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male...

journal_title：Experimental neurology

authors： Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

更新日期：2021-01-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...

journal_title：Experimental neurology

authors： Sabelström H,Stenudd M,Frisén J

更新日期：2014-10-01 00:00:00

abstract：:The control of gene expression by miRNAs has been widely investigated in different species and cell types. Following a probabilistic rather than a deterministic regimen, the action of these short nucleotide sequences on specific genes depends on intracellular concentration, which in turn reflects the balance between b...

journal_title：Experimental neurology

authors： Kinjo ER,Higa GS,de Sousa E,Casado OA,Damico MV,Britto LR,Kihara AH

更新日期：2013-10-01 00:00:00

abstract：:Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected bi...

journal_title：Experimental neurology

authors： Speciale C,Schwarcz R

更新日期：1988-01-01 00:00:00

abstract：:the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...

journal_title：Experimental neurology

authors： Giusti P,Gusella M,Lipartiti M,Milani D,Zhu W,Vicini S,Manev H

更新日期：1995-01-01 00:00:00

abstract：:Effective spread of stimulating current from macroelectrodes was measured using antidromic responses of axons of the pyramidal tract as an indicator of excitation. Both monopolar and concentric bipolar electrode configurations were tested with stimulating distances as large as 7mm. The effective stimulation distance w...

journal_title：Experimental neurology

authors： Follett KA,Mann MD

更新日期：1986-04-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:In chronically implanted rats, we examined the respiratory EMG activity of the two parts of the diaphragm, costal and crural, during sleep and wakefulness. Their activity was compared and contrasted with that of the EMG activity of the cricothyroid muscle. Whether in wakefulness, while grooming and drinking, or in non...

journal_title：Experimental neurology

authors： Pollard MJ,Megirian D,Sherrey JH

更新日期：1985-10-01 00:00:00

abstract：:Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared the neurotoxic effect...

journal_title：Experimental neurology

authors： Alvarez S,Moldovan M,Krarup C

更新日期：2008-07-01 00:00:00

abstract：:The purpose of this study was to assess the respiratory and tonic activity of the abdominal muscles and the postinspiratory activity of the diaphragm (stage 1 expiration) in rats during sleep while they breathed air, hypercapnic, and hypoxic gas mixtures. ECoG and neck EMG recordings enabled the differentiation to be ...

journal_title：Experimental neurology

authors： Sherrey JH,Pollard MJ,Megirian D

更新日期：1988-07-01 00:00:00

abstract：:Anisotropy indices derived from diffusion tensor imaging (DTI) are being increasingly used as biomarkers of central WM structural maturation, myelination and even functional development. Our hypothesis was that the rate of functional changes in central WM tracts directly reflects rate of changes in structural developm...

journal_title：Experimental neurology

authors： Drobyshevsky A,Jiang R,Derrick M,Luo K,Tan S

更新日期：2014-11-01 00:00:00

abstract：:We demonstrated previously that the hypothalamic supraoptic nucleus (SON) undergoes a robust axonal sprouting response following unilateral transection of the hypothalamo-neurohypophysial tract. Concomitant with this response is an increase in ciliary neurotrophic factor (CNTF) and CNTF receptor alpha (CNTFRα) express...

journal_title：Experimental neurology

authors： Askvig JM,Leiphon LJ,Watt JA

更新日期：2012-01-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:Traumatic brain injury (TBI) affects millions of individuals every year. Many of these injuries lead to lasting effects, particularly impairments in domains broadly classified as executive functions, such as impulse control and decision-making. While these impairments have been historically associated with frontal bra...

journal_title：Experimental neurology

authors： Ozga-Hess JE,Whirtley C,O'Hearn C,Pechacek K,Vonder Haar C

更新日期：2020-05-01 00:00:00

abstract：:The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are controversial. We analyzed the pathological manifestations in two EAE models, the chronic oligodendrocyte glycoprotein (MOG)-induced ver...

journal_title：Experimental neurology

authors： Aharoni R,Sasson E,Blumenfeld-Katzir T,Eilam R,Sela M,Assaf Y,Arnon R

更新日期：2013-02-01 00:00:00

abstract：:Human apolipoprotein E (apoE) is a 34.2kDa glycosylated protein with three isoforms (apoE2, apoE3 and apoE4). Experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome, is an immune-mediated experimental disorder of the peripheral nervous system (PNS). Increased susceptibility to EAN in...

journal_title：Experimental neurology

authors： Zhang HL,Mao XJ,Zhang XM,Li HF,Zheng XY,Adem A,Mix E,Zhu J

更新日期：2011-08-01 00:00:00