Septations in chronic spinal cord injury cavities contain axons.

abstract：:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-bas...

journal_title：Experimental neurology

authors： Giacobbe P,Mayberg HS,Lozano AM

更新日期：2009-09-01 00:00:00

abstract：:An electron microscope study of 2- and 8-week-old normal and dystrophic chickens compared sarcomere lengths in relaxed and passively extended Patagialis (PAT) muscles. Sarcomeres were measured in dystrophic muscles only in fibers which exhibited no morphological signs of degeneration. Sarcomere lengths were not differ...

journal_title：Experimental neurology

authors： Ashmore CR,Mechling K,Lee YB

更新日期：1988-08-01 00:00:00

abstract：:The majority of human spinal cord injuries involve gray matter loss from the cervical or lumbar enlargements. However, the deficits that arise from gray matter damage are largely masked by the severe deficits due to associated white matter damage. We have developed a model to examine gray matter-specific deficits and ...

journal_title：Experimental neurology

authors： Magnuson DS,Trinder TC,Zhang YP,Burke D,Morassutti DJ,Shields CB

更新日期：1999-03-01 00:00:00

abstract：:To analyze the role of endogenous opioids on epileptogenesis the effect of repeated doses of naloxone alone (NA) (2, 4, and 8 mg/kg every 15 min) or along with intermittent photic stimulation (NPS) (1, 3, and 10 Hz) was tested on acute "Encephale isolé" cats. The electrical activity recordings of sensorimotor cortex (...

journal_title：Experimental neurology

authors： Fernández-Guardiola A,Pellicer F,Rocha L,Gutiérrez R

更新日期：1988-08-01 00:00:00

abstract：:After optic nerve transection beta cells of cat retinal ganglion cells (RGCs) suffer from rapid cell death from 3 to 7 days, whereas alpha cells gradual cell death until 14 days. Here we report electrophysiological properties of Y- (morphological alpha) and X- (morphological beta) cells at 5 and 14 days after axotomy ...

journal_title：Experimental neurology

authors： Takao M,Miyoshi T,Watanabe M,Fukuda Y

更新日期：2002-09-01 00:00:00

abstract：:Falls are a major source of hospitalization, long-term institutionalization, and death in older adults and patients with Parkinson's disease (PD). Limited attentional resources are a major risk factor for falls. In this review, we specify cognitive-behavioral mechanisms that produce falls and map these mechanisms onto...

journal_title：Experimental neurology

authors： Sarter M,Albin RL,Kucinski A,Lustig C

更新日期：2014-07-01 00:00:00

abstract：:Acute volume expansion is associated with a specific pattern of Fos expression and the goal of the present study was to evaluate the contribution of cardiac receptors to this response. Adult male rats were instrumented with pericardial catheters introduced at the level of the thymus. Rats were also catheterized for me...

journal_title：Experimental neurology

authors： Cunningham JT,Bruno SB,Higgs KA,Sullivan MJ

更新日期：2002-04-01 00:00:00

abstract：:Cinnamophilin (CINN, (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan) protects against ischemic stroke in mice. While some anti-oxidative effects of CINN have been characterized, its therapeutic window and molecular basis for neuroprotection remain unclear. We evaluated antioxidant and anti-inflammator...

journal_title：Experimental neurology

authors： Lee EJ,Chen HY,Hung YC,Chen TY,Lee MY,Yu SC,Chen YH,Chuang IC,Wu TS

更新日期：2009-05-01 00:00:00

abstract：:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...

journal_title：Experimental neurology

authors： Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu J

更新日期：2020-12-01 00:00:00

abstract：:In the June issue of Experimental Neurology, Nizzardo and colleagues demonstrate that the beta-lactam antibiotic ceftriaxone is neuroprotective in a mouse model of spinal muscular atrophy. Here I review their main findings and the relevance to previous and future work on motor neuron disorders and for developing thera...

journal_title：Experimental neurology

authors： Hedlund E

更新日期：2011-09-01 00:00:00

abstract：:To ascertain whether signaling due to peripheral inflammation affects motoneuron vulnerability, we examined in adult rats the reaction to axonal injury of facial motoneurons primed by muscle inflammation. In this double-hit paradigm, preconditioning was achieved by injections into the facial muscles of the T cell mito...

journal_title：Experimental neurology

authors： Mariotti R,Tongiorgi E,Bressan C,Kristensson K,Bentivoglio M

更新日期：2002-07-01 00:00:00

abstract：:Exposure to early life stress (ELS), such as childhood abuse and neglect is a well established major risk factor for developing psychiatric and behavioral disorders later in life. Both prenatal and postnatal stressors have been shown to have a long-lasting impact on adult pathological states where the type and timing ...

journal_title：Experimental neurology

authors： Provençal N,Binder EB

更新日期：2015-06-01 00:00:00

abstract：:The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat primary cortical neuronal cultures was compared with the apoptotic death induced by staurosporine and the necrotic death induced by glutamate. Both SIN-1 and Cu...

journal_title：Experimental neurology

authors： Hill IE,Murray C,Richard J,Rasquinha I,MacManus JP

更新日期：2000-03-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, in which the myelin sheath has been considered to be the primary target for many years. However, an increasing number of reports have focused on neurodegenerative aspects of the disease pathogenesis. Recent studies i...

journal_title：Experimental neurology

authors： Herz J,Zipp F,Siffrin V

更新日期：2010-09-01 00:00:00

abstract：:Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these two events have not bee...

journal_title：Experimental neurology

authors： Wigerblad G,Huie JR,Yin HZ,Leinders M,Pritchard RA,Koehrn FJ,Xiao WH,Bennett GJ,Huganir RL,Ferguson AR,Weiss JH,Svensson CI,Sorkin LS

更新日期：2017-07-01 00:00:00

abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

journal_title：Experimental neurology

authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

更新日期：2003-10-01 00:00:00

abstract：:The focus of this study is the expression of Toll-like receptor-3 (TLR-3), a receptor for double-stranded RNA, in human brains affected by Alzheimer's disease (AD) pathology. Toll-like receptors are a family of pattern recognition molecules primarily involved in host defenses to microbial pathogens, but roles in neuro...

journal_title：Experimental neurology

authors： Walker DG,Tang TM,Lue LF

更新日期：2018-11-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

journal_title：Experimental neurology

authors： Hill JM,Cuasay K,Abebe DT

更新日期：2007-07-01 00:00:00

abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

journal_title：Experimental neurology

authors： Feng ZJ,Zhang X,Chergui K

更新日期：2014-05-01 00:00:00

abstract：:Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...

journal_title：Experimental neurology

authors： Meves JM,Geoffroy CG,Kim ND,Kim JJ,Zheng B

更新日期：2018-11-01 00:00:00

abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...

journal_title：Experimental neurology

authors： Mohan Kumar V,Mallick BN,Chhina GS,Singh B

更新日期：1984-10-01 00:00:00

abstract：:In previous studies on sensory axons we reported that the effect of a conditioning lesion on increasing regeneration rate was enhanced if the two lesions were superimposed, rather than made at separate sites on the nerve, and proposed that this was due to the growth of axons through nerve predegenerated by the conditi...

journal_title：Experimental neurology

authors： Bisby MA

更新日期：1985-11-01 00:00:00

abstract：:Caloric restriction (CR) is a daily reduction of total caloric intake without a decrease in micronutrients or disproportionate reduction of any one dietary component. CR can increase lifespan reliably in a wide range of species and appears to counteract some aspects of the aging process throughout the body. The effect...

journal_title：Experimental neurology

authors： Adams MM,Shi L,Linville MC,Forbes ME,Long AB,Bennett C,Newton IG,Carter CS,Sonntag WE,Riddle DR,Brunso-Bechtold JK

更新日期：2008-05-01 00:00:00

abstract：:Astrocytes are relatively resistant to injury compared to neurons and oligodendrocytes. Here, we report transient region-specific loss of astrocytes in mice early after pilocarpine-induced status epilepticus (SE). In the dentate hilus, immunoreactivity for glial acidic fibrillary protein (GFAP) was decreased, and the ...

journal_title：Experimental neurology

authors： Borges K,McDermott D,Irier H,Smith Y,Dingledine R

更新日期：2006-10-01 00:00:00

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...

journal_title：Experimental neurology

authors： Fifková E,Tonks M,Cullen-Dockstader K

更新日期：1987-03-01 00:00:00

abstract：:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes...

journal_title：Experimental neurology

authors： Takashima S,Becker LE,Chan FW,Augustin R

更新日期：1985-06-01 00:00:00

abstract：:Hydrocephalic mutant mice and matched siblings at different ages were used to measure the pressure and the resistance to drainage of the cerebrospinal fluid (CSF) from the lateral ventricles and from the cisterna magna with glass micropipets. The resting CSF pressure in normal mice increased between 1 to 2 and 4 to 8 ...

journal_title：Experimental neurology

authors： Jones HC

更新日期：1985-10-01 00:00:00

abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...

journal_title：Experimental neurology

authors： Stavniichuk R,Drel VR,Shevalye H,Maksimchyk Y,Kuchmerovska TM,Nadler JL,Obrosova IG

更新日期：2011-07-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00