当前位置： SCI文献检索 > EXPERIMENTAL NEUROLOGY期刊下所有文献 > Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death.

Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death.

Abstract：

:Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male C57BL/6 wild-type (WT), LCN-2 heterozygous (LCN-2 HET), and LCN-2 knockout (LCN-2 KO) mice received either an intracaudate injection of recombinant PRX-2 or saline. In the second part, adult male C57BL/6 WT and male LCN-2 KO mice received recombinant PRX-2 with either recombinant mouse LCN-2 protein or control. In the third part, adult female C57BL/6 WT, LCN-2 HET, and LCN-2 KO mice received recombinant PRX-2. Behavioral tests, and T2- and T2*- weighted magnetic resonance imaging was obtained for all mice. Mice were then euthanized, and their brains used for Western blotting, histology and immunohistochemistry. Intracerebral PRX-2 injections resulted in increased expression of LCN-2 protein. PRX-2-induced brain swelling, neutrophil infiltration, microglia/macrophage activation, neuronal cell death, and neurological deficits were reduced in male LCN-2 HET and LCN-2 KO mice (P < 0.01) compared to WT and were exacerbated by exogenous LCN-2 co-injection. Additionally, intracerebral PRX-2 injections caused brain injury and neurological deficits in female WT mice; effects reduced in female LCN-2 KO mice. In conclusion, intracerebral injection of PRX-2 upregulates LCN-2, and LCN-2 is crucial in the effects of PRX-2 on neutrophil infiltration and microglia/macrophage activation, and ultimately brain damage.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

doi

10.1016/j.expneurol.2020.113521

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

113521

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(20)30352-6

journal_volume

335

pub_type

杂志文章

相关文献

EXPERIMENTAL NEUROLOGY文献大全
  • Hemodynamic monitoring of intracranial collateral flow predicts tissue and functional outcome in experimental ischemic stroke.

    abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.12.006

    authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

    更新日期：2012-02-01 00:00:00

  • Golgi and computer morphometric analysis of cortical dendrites in metabolic storage disease.

    abstract：:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90078-0

    authors： Takashima S,Becker LE,Chan FW,Augustin R

    更新日期：1985-06-01 00:00:00

  • Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra.

    abstract：:Gene transfer to the central nervous system provides powerful methodology for the study of gene function and gene-environment interactions in vivo, in addition to a vehicle for the delivery of therapeutic transgenes for gene therapy. The aim of the present study was to determine patterns of tropism exhibited by pseudo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2010.10.016

    authors： Cannon JR,Sew T,Montero L,Burton EA,Greenamyre JT

    更新日期：2011-03-01 00:00:00

  • Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT.

    abstract：:Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and pre...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2020.113175

    authors： Winne J,Boerner BC,Malfatti T,Brisa E,Doerl J,Nogueira I,Leão KE,Leão RN

    更新日期：2020-04-01 00:00:00

  • The mode of axonal regeneration of locus coeruleus neurons in the lateral geniculate nucleus following neonatal 6-hydroxydopamine treatment.

    abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(91)90128-y

    authors： Aoki F,Nakamura S

    更新日期：1991-06-01 00:00:00

  • The role of capsaicin-sensitive afferent fibers in the lower urinary tract dysfunction induced by chronic spinal cord injury in rats.

    abstract：:The role of capsaicin-sensitive afferents in neurogenic voiding dysfunction was studied in chronic spinal cord injured rats (SCI). Cystometry and external urethral sphincter (EUS) electromyography were performed on 2 consecutive days after induction of urethane anesthesia in SCI rats 6-8 weeks after spinal cord injury...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2004.02.014

    authors： Cheng CL,de Groat WC

    更新日期：2004-06-01 00:00:00

  • Neurotrophic properties of olfactory ensheathing glia.

    abstract：:Olfactory ensheathing cells (OEC) constitute a specialized population of glia that accompany primary olfactory axons and have been reported to facilitate axonal regeneration after spinal cord injury in vivo. In the present report we describe OEC neurotrophic factor expression and neurotrophic properties of OECs in vit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(02)00058-4

    authors： Lipson AC,Widenfalk J,Lindqvist E,Ebendal T,Olson L

    更新日期：2003-04-01 00:00:00

  • Functional connectivity alterations in a murine model of optic neuritis.

    abstract：:The basis for neuronal dysfunction following inflammatory demyelination of the central nervous system (CNS) remains poorly understood. We characterized the network response to white matter injury in the anterior visual pathway using an experimental model of optic neuritis (ON), as ON is often an early manifestation of...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.05.004

    authors： Wright PW,Archambault AS,Peek S,Bauer AQ,Culican SM,Ances BM,Culver JP,Wu GF

    更新日期：2017-09-01 00:00:00

  • Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury.

    abstract：:The precise mechanisms underlying the efficacy of intravenous immunoglobulin (IVIg) in autoimmune neurological disorders including Guillain-Barré syndrome (GBS) are not known. Anti-ganglioside antibodies have been reported to be pathogenic in some variants of GBS, and we have developed passive transfer animal models t...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2016.05.020

    authors： Zhang G,Massaad CA,Gao T,Pillai L,Bogdanova N,Ghauri S,Sheikh KA

    更新日期：2016-08-01 00:00:00

  • Comparison of tyrosine hydroxylase and preproenkephalin expression in rat adrenal medullary explants in vitro and transplanted into subarachnoid space.

    abstract：:When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1999.7267

    authors： Wang XT,Unnerstall JR,Ibuki T,Wang H,Pappas GD

    更新日期：2000-01-01 00:00:00

  • Noradrenergic innervation of the substantia innominata: a light and electron microscopic analysis of dopamine beta-hydroxylase immunoreactive elements in the rat.

    abstract：:Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. DBH immunoreactive (DBH+) axons ramified extensively within the SI and appeared to be contiguous with the DBH+ terminal fie...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(89)80002-0

    authors： Chang HT

    更新日期：1989-05-01 00:00:00

  • A decline in glial cell-line-derived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation.

    abstract：:In the peripheral nervous system, regeneration of motor and sensory axons into chronically denervated distal nerve segments is impaired compared to regeneration into acutely denervated nerves. In order to find possible causes for this phenomenon we examined the changes in the expression pattern of the glial cell-line-...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7826

    authors： Höke A,Gordon T,Zochodne DW,Sulaiman OA

    更新日期：2002-01-01 00:00:00

  • Inhibition of heterosensory thalamocortical evoked potentials by delta-9-tetrahydrocannabinol.

    abstract：:The effects of delta-9-tetrahydrocannabinol on sensory activity in the thalamic intralaminar nuclei, centralis lateralis and the mesencephalic reticular formation were compared with the effects on cortical association or heterosensory systems in alpha-chloralose-anesthetized cats. The drug depressed the anterior margi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90121-x

    authors： Pontzer NJ,Wilkison DM

    更新日期：1987-09-01 00:00:00

  • Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats.

    abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/S0014-4886(84)90100-6

    authors： Rasmussen K,Heym J,Jacobs BL

    更新日期：1984-02-01 00:00:00

  • Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ.

    abstract：:CNS damage often results in demyelination of spared axons due to oligodendroglial cell death and dysfunction near the injury site. Although new oligodendroglia are generated following CNS injury and disease, the process of remyelination is typically incomplete resulting in long-term functional deficits. Chondroitin su...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.04.003

    authors： Pendleton JC,Shamblott MJ,Gary DS,Belegu V,Hurtado A,Malone ML,McDonald JW

    更新日期：2013-09-01 00:00:00

  • Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion.

    abstract：:A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of noradrenergic activity. This includes cannabinoid-induced 1) increases in...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.03.010

    authors： Reyes BAS,Carvalho AF,Szot P,Kalamarides DJ,Wang Q,Kirby LG,Van Bockstaele EJ

    更新日期：2017-06-01 00:00:00

  • Voltage-gated Ca2+ entry promotes oligodendrocyte progenitor cell maturation and myelination in vitro.

    abstract：:We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type, in oligodendrocyte maturation. We used ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2014.12.012

    authors： Cheli VT,Santiago González DA,Spreuer V,Paez PM

    更新日期：2015-03-01 00:00:00

  • Influence of a serotonin receptor antagonist, 5-HTP-DP-hex, on spinal and thalamic nociceptive neurons in rats.

    abstract：:The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ven...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(87)90214-7

    authors： Emmers R,Tamir H,Wilchek M

    更新日期：1987-06-01 00:00:00

  • Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation.

    abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.04.002

    authors： Stavniichuk R,Drel VR,Shevalye H,Maksimchyk Y,Kuchmerovska TM,Nadler JL,Obrosova IG

    更新日期：2011-07-01 00:00:00

  • Potassium and caffeine contractures in limb muscles of normal and dystrophic (C57 BL/6J dy2J/dy2J) mice.

    abstract：:The strength of contractures, produced by 15 to 146 mM [K]0 (as L-glutamate), was measured in isolated small bundles of muscle fibers from the fast-twitch extensor digitorum longus and from the slow-twitch soleus of normal and dystrophic (C57 BL/6J dy2J/dy2J) mice. The analysis of the relation between the maximal ampl...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/0014-4886(85)90179-7

    authors： Noireaud J,Léoty C

    更新日期：1985-03-01 00:00:00

  • A reassessment of P2X7 receptor inhibition as a neuroprotective strategy in rat models of contusion injury.

    abstract：:These experiments were completed as part of an NIH "Facilities of Research Excellence in Spinal Cord Injury" contract to support independent replication of published studies that could be considered for eventual clinical testing. Recent studies have reported that selective inhibition of the P2X7 receptor improves both...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2011.06.008

    authors： Marcillo A,Frydel B,Bramlett HM,Dietrich WD

    更新日期：2012-02-01 00:00:00

  • The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.

    abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2007.10.015

    authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

    更新日期：2008-03-01 00:00:00

  • Intranasal cotinine improves memory, and reduces depressive-like behavior, and GFAP+ cells loss induced by restraint stress in mice.

    abstract：:Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-li...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2017.06.016

    authors： Perez-Urrutia N,Mendoza C,Alvarez-Ricartes N,Oliveros-Matus P,Echeverria F,Grizzell JA,Barreto GE,Iarkov A,Echeverria V

    更新日期：2017-09-01 00:00:00

  • Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of Parkinson's disease.

    abstract：:The effects of intranigral iron injection on dopamine (DA) release and content in the caudate putamen (CPu) and their relationship to DA-related behavioral response were investigated in rats. Different concentrations of FeCl(3) (10, 20, and 40 microg) and saline were injected separately into the left substantia nigra....

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/s0014-4886(03)00123-7

    authors： Junxia X,Hong J,Wenfang C,Ming Q

    更新日期：2003-08-01 00:00:00

  • A role for the bilateral involvement of perirhinal cortex in generalized kindled seizure expression.

    abstract：:The perirhinal cortex (PRh) has been suggested as a substrate for the expression of generalized clonic seizures in the late stages of kindling development (stages 4-5). Using the induction of Fos as a marker of neuronal activation, the PRh region was investigated after kindling or nonkindling electrical stimulation. N...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.1998.6794

    authors： Ferland RJ,Nierenberg J,Applegate CD

    更新日期：1998-05-01 00:00:00

  • Postural development in rats.

    abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2006.05.018

    authors： Lelard T,Jamon M,Gasc JP,Vidal PP

    更新日期：2006-11-01 00:00:00

  • Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus.

    abstract：:Germinal matrix hemorrhage (GMH) is the most common neurological disease of premature newborns. GMH causes neurological sequelae such as cerebral palsy, post-hemorrhagic hydrocephalus, and mental retardation. Despite this, there is no standardized animal model of spontaneous GMH using newborn rats to depict the condit...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2012.04.003

    authors： Lekic T,Manaenko A,Rolland W,Krafft PR,Peters R,Hartman RE,Altay O,Tang J,Zhang JH

    更新日期：2012-07-01 00:00:00

  • Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats.

    abstract：:Estrogens and N-methyl-D-aspartate (NMDA) receptors regulate multiple aspects of morphological and functional plasticity in young animals. For example, estrogens increase spine density in the hippocampus, and NMDA antagonists block these effects. Few studies have examined the effects of age, postovariectomy interval, ...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2001.7716

    authors： Adams MM,Oung T,Morrison JH,Gore AC

    更新日期：2001-08-01 00:00:00

  • Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain.

    abstract：:Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1006/exnr.2000.7466

    authors： Galasso JM,Miller MJ,Cowell RM,Harrison JK,Warren JS,Silverstein FS

    更新日期：2000-10-01 00:00:00

  • Intermittent hypoxia training after C2 hemisection modifies the expression of PTEN and mTOR.

    abstract：:In this study, we examined modulations in phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 hemisection and subsequent intermittent hypoxia (IH) exposure and training, which initiates respiratory motor plasticity and recovery. PTEN and mTOR are signifi...

    journal_title：Experimental neurology

    pub_type： 杂志文章

    doi：10.1016/j.expneurol.2013.05.013

    authors： Gutierrez DV,Clark M,Nwanna O,Alilain WJ

    更新日期：2013-10-01 00:00:00