Effect of systemic kainate administration on cerebral quinolinic acid metabolism in the rat.


:Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected biosynthesis of quinolinic acid production is likely to be related to astrocytic proliferation Increased quinolinic acid production is likely to be related to astrocytic proliferation and may be involved in the precipitation of secondary lesions in extrahippocampal brain regions.


Exp Neurol


Experimental neurology


Speciale C,Schwarcz R




Has Abstract


1988-01-01 00:00:00














  • Quinolinate immunoreactivity in experimental rat brain tumors is present in macrophages but not in astrocytes.

    abstract::Experimental tumors of the central nervous system were investigated with antibodies to quinolinate to assess the cellular distribution of this endogenous neurotoxin. In advanced F98 and RG-2 glioblastomas and E367 neuroblastomas in the striatum of rats, variable numbers of quinolinate immunoreactive cells were observe...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Moffett JR,Els T,Espey MG,Walter SA,Streit WJ,Namboodiri MA

    更新日期:1997-04-01 00:00:00

  • The life, death and regenerative ability of immature and mature rat retinal ganglion cells are influenced by their birthdate.

    abstract::The extensive period of retinal ganglion cell (RGC) neurogenesis in the rat is associated with a protracted sequence of arrival of their axons into central targets such as the superior colliculus (SC) (Dallimore et al., 2002). Using in utero 5-bromo-2'-deoxyrudine (BrdU) injections to label early (embryonic day (E) 15...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Dallimore EJ,Park KK,Pollett MA,Taylor JS,Harvey AR

    更新日期:2010-10-01 00:00:00

  • P38 MAP kinase is activated at early stages in Alzheimer's disease brain.

    abstract::The regional, cellular, and subcellular localization of phosphorylated p38 MAPK (pp38) was examined by immunocytochemistry, immuofluorescent multiple labeling, and immunoblotting of extracts as well as immunoprecipitates of human postmortem tissue from control and Alzheimer's disease (AD) cases at different Braak stag...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sun A,Liu M,Nguyen XV,Bing G

    更新日期:2003-10-01 00:00:00

  • Amyloid beta peptides and glutamatergic synaptic dysregulation.

    abstract::Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Parameshwaran K,Dhanasekaran M,Suppiramaniam V

    更新日期:2008-03-01 00:00:00

  • Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site.

    abstract::Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Tom VJ,Sandrow-Feinberg HR,Miller K,Domitrovich C,Bouyer J,Zhukareva V,Klaw MC,Lemay MA,Houlé JD

    更新日期:2013-01-01 00:00:00

  • Activated WNK3 induced by intracerebral hemorrhage deteriorates brain injury maybe via WNK3/SPAK/NKCC1 pathway.

    abstract:BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Wu D,Lai N,Deng R,Liang T,Pan P,Yuan G,Li X,Li H,Shen H,Wang Z,Chen G

    更新日期:2020-10-01 00:00:00

  • A correlative study of internode proportions and sensitivity to procaine in regenerated frog sciatic nerves.

    abstract::A comparison of regenerated and normal frog sciatic nerves showed a marked reduction in conduction velocity from 37.5 to 15.2 m/s with little change in the absolute refractory period. Changes in conduction velocity corresponded to a reduced mean axon caliber (4.8 versus 6.6 micron). Regenerated nerves also had markedl...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Minwegen P,Friede RL

    更新日期:1985-01-01 00:00:00

  • Neuronal plasticity in the nigrostriatal system of the rat after unilateral removal of vibrissae.

    abstract::The vibrissae of rats were shaved from one side of the face daily for 10 days. To see whether or not this treatment had an effect on crossed and uncrossed striatal afferent connections from the midbrain, the tract tracer horseradish peroxidase was applied to the caudate-putamen on day 11. When the tracer was deposited...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Huston JP,Morgan S,Lange KW,Steiner H

    更新日期:1986-08-01 00:00:00

  • TNF-α enhances the currents of voltage gated sodium channels in uninjured dorsal root ganglion neurons following motor nerve injury.

    abstract::The ectopic discharges observed in uninjured dorsal root ganglion (DRG) neurons following various lesions of spinal nerves have been attributed to functional alterations of voltage-gated sodium channels (VGSCs). Such mechanisms may be important for the development of neuropathic pain. However, the pathophysiology unde...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Chen X,Pang RP,Shen KF,Zimmermann M,Xin WJ,Li YY,Liu XG

    更新日期:2011-02-01 00:00:00

  • Local calcium-dependent mechanisms determine whether a cut axonal end assembles a retarded endbulb or competent growth cone.

    abstract::The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Kamber D,Erez H,Spira ME

    更新日期:2009-09-01 00:00:00

  • Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats.

    abstract::The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Cruz CD,McMahon SB,Cruz F

    更新日期:2006-07-01 00:00:00

  • Acute excitotoxic injury induces expression of monocyte chemoattractant protein-1 and its receptor, CCR2, in neonatal rat brain.

    abstract::Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Galasso JM,Miller MJ,Cowell RM,Harrison JK,Warren JS,Silverstein FS

    更新日期:2000-10-01 00:00:00

  • Nonpermissive nature of fish optic nerves to axonal growth is due to presence of myelin-associated growth inhibitors.

    abstract::Fish optic nerve sections were recently shown to be nonpermissive to growth of adult retinal axons. In addition, fish optic nerve myelin was found to inhibit growth of adult retinal axons and this inhibition was neutralized by IN-1 antibodies (known to block rat myelin-associated inhibitors). In this study we examined...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sivron T,Schwartz M

    更新日期:1994-12-01 00:00:00

  • Spatial distributions of phrenic and medial gastrocnemius motoneurons in the cat spinal cord.

    abstract::The longitudinal distributions of both phrenic and medial gastrocnemius motoneurons were quantitatively studied in the cat spinal cord. Both populations of motoneurons were retrogradely labeled by applying horseradish peroxidase (HRP) to the cut central ends of the appropriate peripheral nerves. The longitudinal posit...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Berger AJ,Cameron WE,Averill DB,Kramis RC,Binder MD

    更新日期:1984-12-01 00:00:00

  • Effect of methysergide on pudendal inhibition of micturition reflex in cats.

    abstract::The role of 5-HT2 and opioid receptors in pudendal inhibition of bladder activity induced by intravesical infusion of saline or 0.25% acetic acid (AA) was investigated in anesthetized cats using methysergide (a 5-HT2 receptor antagonist) and naloxone (an opioid receptor antagonist). AA irritated the bladder and signif...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Matsuta Y,Schwen Z,Mally AD,Shen B,Wang J,Roppolo JR,de Groat WC,Tai C

    更新日期:2013-09-01 00:00:00

  • Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration.

    abstract::Local application of exogenous agents with neurotrophic properties enhances the regenerative capacity of injured neurons, especially following reconstructions of long nerve gaps and delayed nerve repairs. Recent advances in biomaterials and biomedical engineering have provided options for the sustained and controlled ...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Tajdaran K,Chan K,Gordon T,Borschel GH

    更新日期:2019-09-01 00:00:00

  • Activation of transcription factor c-jun in dorsal root ganglia induces VIP and NPY upregulation and contributes to the pathogenesis of neuropathic pain.

    abstract::Vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY) in dorsal root ganglia (DRGs) are known to be upregulated and to contribute to the mechanisms of neuropathic pain following peripheral nerve injury. Moreover, transcription factor c-Jun regulates the expressions of both VIP and NPY in cultured DRG neurons. T...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Son SJ,Lee KM,Jeon SM,Park ES,Park KM,Cho HJ

    更新日期:2007-03-01 00:00:00

  • Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery.

    abstract::For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Kordower JH,Goetz CG,Freeman TB,Olanow CW

    更新日期:1997-03-01 00:00:00

  • Relationship between functional deficiencies and the contribution of myelin nerve fibers derived from L-4, L-5, and L-6 spinolumbar branches in adult rat sciatic nerve.

    abstract::The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

    更新日期:2002-02-01 00:00:00

  • Distribution of the human jaw stretch reflex response elicited by percutaneous, localized stretch of jaw-closing muscles.

    abstract::In the present study homonymous and heteronymous projections of muscle spindle afferent fibers in the human jaw-closing system were investigated. Stretch reflex responses were elicited with percutaneous displacement stimuli applied to the belly of the anterior superficial divisions of temporalis and masseter muscles. ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Smith A,Moore CA,Pratt CA

    更新日期:1985-06-01 00:00:00

  • Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin/ataxin-3 transgenic narcoleptic mice across the disease onset.

    abstract::Sleep and behavioral monitoring of young mice is necessary for understating the progress of symptoms in congenital and acquired diseases associated with sleep and movement disorders. In the current study, we have developed a non-invasive sleep monitoring system that identifies wake and sleep patterns of newborn mice u...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sato M,Sagawa Y,Hirai N,Sato S,Okuro M,Kumar S,Kanbayashi T,Shimizu T,Sakai N,Nishino S

    更新日期:2014-11-01 00:00:00

  • Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.

    abstract::Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

    更新日期:2009-01-01 00:00:00

  • Bilateral tactile hypersensitivity and neuroimmune responses after spared nerve injury in mice lacking vasoactive intestinal peptide.

    abstract::Vasoactive intestinal peptide (VIP) is one of the neuropeptides showing the strongest up-regulation in the nociceptive pathway after peripheral nerve injury and has been proposed to support neuropathic pain. Nevertheless, the story may be more complicated considering the known suppressive effects of the peptide on the...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Gallo A,Leerink M,Michot B,Ahmed E,Forget P,Mouraux A,Hermans E,Deumens R

    更新日期:2017-07-01 00:00:00

  • Differential expression of ErbB3 and ErbB4 neuregulin receptors in dopamine neurons and forebrain areas of the adult rat.

    abstract::Neuregulins have been shown to play an important role in the development of the central nervous system, but their function in adult tissues is still unclear. We investigated the expression of the neuregulin receptors erbB3 and erbB4 in the adult rat brain by in situ hybridization histochemistry. Areas with considerabl...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Steiner H,Blum M,Kitai ST,Fedi P

    更新日期:1999-10-01 00:00:00

  • Decussation of bulbospinal respiratory axons at the level of the phrenic nuclei in adult rats: a possible substrate for the crossed phrenic phenomenon.

    abstract::The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Goshgarian HG,Ellenberger HH,Feldman JL

    更新日期:1991-01-01 00:00:00

  • Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS.

    abstract::One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Bennion Callister J,Pickering-Brown SM

    更新日期:2014-12-01 00:00:00

  • Susceptibility to pentylenetetrazol-induced and audiogenic seizures in rats with selective fimbria-fornix lesions and intrahippocampal septal grafts.

    abstract::At the age of 31 days, Long-Evans female rats received electrolytic lesions either of the medial fimbria (N = 24), of the dorsal subcallosal fornix (N = 24), or of both structures (N = 24). Ten rats were used as sham-operated controls. Ten days later, half the rats of each lesion group received intrahippocampal grafts...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Cassel JC,Kelche C,Will BE

    更新日期:1987-09-01 00:00:00

  • Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat.

    abstract::Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

    更新日期:2012-03-01 00:00:00

  • Quisqualate injection into the nucleus basalis magnocellularis produces seizure-related brain damage that is prevented by MK-801.

    abstract::Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Wozniak DF,Huss J,Olney JW

    更新日期:1994-03-01 00:00:00

  • Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury.

    abstract::Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

    更新日期:2004-10-01 00:00:00