Effect of systemic kainate administration on cerebral quinolinic acid metabolism in the rat.

Abstract:

:Systemic administration of kainic acid (12 mg/kg, i.p.), causing the established epileptic syndrome and the associated specific pattern of limbic nerve cell loss, led to substantial time-dependent increases in the brain metabolism of the endogenous excitotoxin, quinolinic acid. These changes preferentially affected biosynthesis of quinolinic acid production is likely to be related to astrocytic proliferation Increased quinolinic acid production is likely to be related to astrocytic proliferation and may be involved in the precipitation of secondary lesions in extrahippocampal brain regions.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Speciale C,Schwarcz R

doi

10.1016/0014-4886(88)90140-9

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

213-8

issue

1

eissn

0014-4886

issn

1090-2430

pii

0014-4886(88)90140-9

journal_volume

99

pub_type

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