Kindling of audiogenic seizures in Wistar rats: an EEG study.

abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...

journal_title：Experimental neurology

authors： Cabral A,Isoardi N,Salum C,Macedo CE,Nobre MJ,Molina VA,Brandão ML

更新日期：2006-07-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group ...

journal_title：Experimental neurology

authors： Wartiovaara K,Hytönen M,Vuori M,Paulin L,Rinne J,Sariola H

更新日期：1998-08-01 00:00:00

abstract：:Although transgenic expression of oncogenes typically leads to tumorigenesis, oncogene expression directed to the rod photoreceptors leads to cell death without tumor formation. To evaluate the cellular and functional changes induced in cone photoreceptors by an oncogene, the Mas1 protooncogene was targeted to the con...

journal_title：Experimental neurology

authors： Xu X,Quiambao AB,Roveri L,Pardue MT,Marx JL,Röhlich P,Peachey NS,Al-Ubaidi MR

更新日期：2000-05-01 00:00:00

abstract：:Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component withi...

journal_title：Experimental neurology

authors： McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O

更新日期：2014-11-01 00:00:00

abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...

journal_title：Experimental neurology

authors： Cheng L,Allore RJ,Richardson PM

更新日期：1998-02-01 00:00:00

abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...

journal_title：Experimental neurology

authors： Yoo S,van Niekerk EA,Merianda TT,Twiss JL

更新日期：2010-05-01 00:00:00

abstract：:The repair of nerve gap injuries with tubular nerve guides has been used extensively as an in vivo test model in identifying substances which may enhance nerve regeneration. The model has also been used clinical nerve repair. The objective of this study was to compare three different gel matrix-forming materials as po...

journal_title：Experimental neurology

authors： Wells MR,Kraus K,Batter DK,Blunt DG,Weremowitz J,Lynch SE,Antoniades HN,Hansson HA

更新日期：1997-08-01 00:00:00

abstract：:Copyright ...

journal_title：Experimental neurology

authors：

更新日期：1998-06-01 00:00:00

abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...

journal_title：Experimental neurology

authors： Chung RS,McCormack GH,King AE,West AK,Vickers JC

更新日期：2005-06-01 00:00:00

abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

journal_title：Experimental neurology

authors： Sugimoto H,Monafo WW,Shimazaki S

更新日期：1987-08-01 00:00:00

abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...

journal_title：Experimental neurology

authors： Davis S,Brotchie J,Davies I

更新日期：2002-07-01 00:00:00

abstract：:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmo...

journal_title：Experimental neurology

authors： Gess B,Röhr D,Lange E,Halfter H,Young P

更新日期：2015-02-01 00:00:00

abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...

journal_title：Experimental neurology

authors： Shen PJ,Gundlach AL

更新日期：1999-12-01 00:00:00

abstract：:Little is known about the morphological effects of alcoholism on the developing adolescent brain and its consequences into adulthood. We studied here the relationship between two neurotransmitter systems (the serotoninergic and nitrergic) and the astrocytic and neuronal cytoskeleton immediately and long after drinking...

journal_title：Experimental neurology

authors： Evrard SG,Duhalde-Vega M,Tagliaferro P,Mirochnic S,Caltana LR,Brusco A

更新日期：2006-08-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Traumatic axonal injury (TAI) evolves within minutes to hours following traumatic brain injury (TBI). Previous studies have identified axolemmal disruption and impaired axonal transport (AxT) as key mechanisms in the evolution of TAI. While initially hypothesized that axolemmal disruption culminates in impaired AxT, p...

journal_title：Experimental neurology

authors： Stone JR,Okonkwo DO,Dialo AO,Rubin DG,Mutlu LK,Povlishock JT,Helm GA

更新日期：2004-11-01 00:00:00

abstract：:Silent strokes occur more frequently than classic strokes; however, symptoms may go unreported in spite of lasting tissue damage. A silent stroke may indicate elevated susceptibility to recurrent stroke, which may eventually result in apparent and lasting impairments. Here we investigated if multiple silent strokes to...

journal_title：Experimental neurology

authors： Faraji J,Kurio K,Metz GA

更新日期：2012-08-01 00:00:00

abstract：:Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...

journal_title：Experimental neurology

authors： Vareniuk I,Pavlov IA,Drel VR,Lyzogubov VV,Ilnytska O,Bell SR,Tibrewala J,Groves JT,Obrosova IG

更新日期：2007-06-01 00:00:00

abstract：:We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr) sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to determine their potential role in the development of trigeminal neuropathic pain. In seven anaesthetised ferrets, fluorogold (2%) was injected ...

journal_title：Experimental neurology

authors： Davies SL,Loescher AR,Clayton NM,Bountra C,Robinson PP,Boissonade FM

更新日期：2006-11-01 00:00:00

abstract：:The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

journal_title：Experimental neurology

authors： Hall ED,Oostveen JA,Dunn E,Carter DB

更新日期：1995-09-01 00:00:00

abstract：:Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta freq...

journal_title：Experimental neurology

authors： Chen CC,Pogosyan A,Zrinzo LU,Tisch S,Limousin P,Ashkan K,Yousry T,Hariz MI,Brown P

更新日期：2006-03-01 00:00:00

abstract：:Spinal cord injury (SCI) causes motor and sensory deficits that impair functional performance. While more functional recovery occurs with greater white matter sparing (WMS), it is unclear which locomotor features are more vulnerable to SCI than others, if recovery of certain features depends on specific amounts of WMS...

journal_title：Experimental neurology

authors： Kloos AD,Fisher LC,Detloff MR,Hassenzahl DL,Basso DM

更新日期：2005-02-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:Focal limbic seizures often impair consciousness/awareness with major negative impact on quality of life. Recent work has shown that limbic seizures depress brainstem arousal systems, including reduced action potential firing in a key node: cholinergic neurons of the pedunculopontine tegmental nucleus (PPT). In vivo w...

journal_title：Experimental neurology

authors： Andrews JP,Yue Z,Ryu JH,Neske G,McCormick DA,Blumenfeld H

更新日期：2019-04-01 00:00:00

abstract：:When antibodies specific to fast-twitch, slow-twitch, and slow-tonic myosins were used to stain the clasp muscle, m. sternoradialis, of Xenopus laevis, three predominant fiber types were identified in both males and females. Three fiber types can also be distinguished by the diameters and conduction velocities of thei...

journal_title：Experimental neurology

authors： Rubinstein NA,Erulkar SD,Schneider GT

更新日期：1983-11-01 00:00:00

abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

journal_title：Experimental neurology

authors： Lemons ML,Howland DR,Anderson DK

更新日期：1999-11-01 00:00:00

abstract：:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...

journal_title：Experimental neurology

authors： Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu J

更新日期：2020-12-01 00:00:00

abstract：:It has been >20 years since studies first revealed that the brain is insulin sensitive, highlighted by the expression of insulin receptors in neurons and glia, the presence of circulating brain insulin, and even localized insulin production. Following these discoveries, evidence of decreased brain insulin receptor num...

journal_title：Experimental neurology

authors： Frazier HN,Ghoweri AO,Anderson KL,Lin RL,Porter NM,Thibault O

更新日期：2019-03-01 00:00:00

abstract：:In this study we investigated whether the link between mitochondrial dysfunction and deregulation of Ca(2+) homeostasis preceding excitotoxic cell death is mediated by cellular deenergization. Glycolytic and/or mitochondrial ATP synthesis was inhibited with 2-deoxy-D-glucose (2DG) and oligomycin, respectively. Changes...

journal_title：Experimental neurology

authors： Vergun O,Han YY,Reynolds IJ

更新日期：2003-10-01 00:00:00

abstract：:We assessed the potential of different MRI measures to detect and quantify skeletal muscle changes with denervation in two mouse models of denervation/neurogenic atrophy. Acute complete denervation and chronic partial denervation were examined in calf muscles after sciatic nerve axotomy and in transgenic SOD1(G93A) mi...

journal_title：Experimental neurology

authors： Zhang J,Zhang G,Morrison B,Mori S,Sheikh KA

更新日期：2008-08-01 00:00:00