Ascending projections of nociceptive neurons from trigeminal subnucleus caudalis: A population approach.

abstract：:Substantial residual neurological function may persist after spinal cord injury (SCI) with survival of as few as 5-10% of the original number of axons. A detailed understanding of the relationships among the severity of injury, the number and origin of surviving axons at the injury site, and the extent of neurological...

journal_title：Experimental neurology

authors： Fehlings MG,Tator CH

更新日期：1995-04-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:Disease-modifying treatments remain an unmet medical need in Parkinson's disease (PD). Such treatments can be operationally defined as interventions that slow down the clinical evolution to advanced disease milestones. A treatment may achieve this outcome by either inhibiting primary neurodegenerative events ("neuropr...

journal_title：Experimental neurology

authors： Francardo V,Schmitz Y,Sulzer D,Cenci MA

更新日期：2017-12-01 00:00:00

abstract：:Although axons lose some of their intrinsic capacity for growth after their developmental period, some axons retain the potential for regrowth after injury. When provided with a growth-promoting substrate such as a peripheral nerve graft (PNG), severed axons regenerate into and through the graft; however, they stop wh...

journal_title：Experimental neurology

authors： Tom VJ,Sandrow-Feinberg HR,Miller K,Domitrovich C,Bouyer J,Zhukareva V,Klaw MC,Lemay MA,Houlé JD

更新日期：2013-01-01 00:00:00

abstract：:The loss or injury of neurons associated with oxidative and nitrosative redox stress plays an important role in the onset of various neurodegenerative diseases. Specifically, nitric oxide (NO), can affect neuronal survival through a process called S-nitrosylation, by which the NO group undergoes a redox reaction with ...

journal_title：Experimental neurology

authors： Nakamura T,Cho DH,Lipton SA

更新日期：2012-11-01 00:00:00

abstract：:This work investigated the extent to which constituent proportions of fast- and slow-twitch muscle units determine whole muscle contractile properties. We employed several self- and cross-reinnervation models using synergistic homogeneous and heterogeneous muscles. By comparing the present data with previously publish...

journal_title：Experimental neurology

authors： Foehring RC,Sypert GW,Munson JB

更新日期：1988-09-01 00:00:00

abstract：:We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related t...

journal_title：Experimental neurology

authors： Xu K,Dluzen DE

更新日期：2000-12-01 00:00:00

abstract：:The control of gene expression by miRNAs has been widely investigated in different species and cell types. Following a probabilistic rather than a deterministic regimen, the action of these short nucleotide sequences on specific genes depends on intracellular concentration, which in turn reflects the balance between b...

journal_title：Experimental neurology

authors： Kinjo ER,Higa GS,de Sousa E,Casado OA,Damico MV,Britto LR,Kihara AH

更新日期：2013-10-01 00:00:00

abstract：:Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...

journal_title：Experimental neurology

authors： Meves JM,Geoffroy CG,Kim ND,Kim JJ,Zheng B

更新日期：2018-11-01 00:00:00

abstract：:Ketamine has been reported to exert a prophylactic effect against stress-induced depressive-like behavior by modulating the guanosine-based purinergic system. However, the molecular pathways underlying its prophylactic effect and whether guanosine also elicits a similar effect remain to be determined. Here, we investi...

journal_title：Experimental neurology

authors： Camargo A,Dalmagro AP,de Souza MM,Zeni ALB,Rodrigues ALS

更新日期：2020-12-01 00:00:00

abstract：:Recent in vitro studies have shown that the periventricular subependymal zone (SEZ) of the rodent brain is capable of de novo generation of neurons and glia. There is less information available on neurogenesis in the adult human brain, and no study has shown the clonal generation of neurons and glia from in vitro-gene...

journal_title：Experimental neurology

authors： Kukekov VG,Laywell ED,Suslov O,Davies K,Scheffler B,Thomas LB,O'Brien TF,Kusakabe M,Steindler DA

更新日期：1999-04-01 00:00:00

abstract：:In the previous paper it was demonstrated that striatal dopamine (DA) D1 and D2 receptor subtypes and muscarinic M1 and M2 receptor subtypes show differing responses to lesions of the mesostriatal DA system. To examine this differential regulation further rats were given unilateral injections of 6-hydroxydopamine (6-O...

journal_title：Experimental neurology

authors： Joyce JN

更新日期：1991-09-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:Stress is a common environmental factor associated with depressive illness and the amygdala is thought to be integral for this association. For example, repeated stress impairs amygdalar neuroplasticity in rodents and these defects parallel amygdalar deficits in depressive illness patients. Because the excitatory neur...

journal_title：Experimental neurology

authors： Piroli GG,Reznikov LR,Grillo CA,Hagar JM,Fadel JR,Reagan LP

更新日期：2013-03-01 00:00:00

abstract：:Quisqualate (Quis) and other excitotoxins such as ibotenate and N-methyl aspartate, have been used to destroy neurons in the area of the nucleus basalis magnocellularis (NBM) in order to study the relationship between loss of cholinergic neurons in the basal forebrain and various behavioral deficits, including learnin...

journal_title：Experimental neurology

authors： Wozniak DF,Huss J,Olney JW

更新日期：1994-03-01 00:00:00

abstract：:Microglia express cytokines, major histocompatibility (MHC) loci, and several other immunologically important constituents. The aim of this study was to detect immunological responses of microglial cells following allogeneic dopaminergic transplantation using active and adoptive immunizations. Adult inbred Fisher 344 ...

journal_title：Experimental neurology

authors： Shinoda M,Hudson JL,Strömberg I,Hoffer BJ,Moorhead JW,Olson L

更新日期：1996-10-01 00:00:00

abstract：:Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and ga...

journal_title：Experimental neurology

authors： Adamo AM,Paez PM,Escobar Cabrera OE,Wolfson M,Franco PG,Pasquini JM,Soto EF

更新日期：2006-04-01 00:00:00

abstract：:The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...

journal_title：Experimental neurology

authors： Tolcos M,Mallard C,McGregor H,Walker D,Rees S

更新日期：2000-04-01 00:00:00

abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...

journal_title：Experimental neurology

authors： Löscher W,Schwark WS

更新日期：1985-11-01 00:00:00

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

journal_title：Experimental neurology

authors： Bennett MH

更新日期：1983-06-01 00:00:00

abstract：:Accumulating evidence shows alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease, mainly by endothelial cell (EC) damage. Repair of the altered barrier in the CNS by replacement of ECs via cell transplantation may be a new therapeutic approac...

journal_title：Experimental neurology

authors： Garbuzova-Davis S,Haller E,Navarro S,Besong TE,Boccio KJ,Hailu S,Khatib M,Sanberg PR,Appel SH,Borlongan CV

更新日期：2018-12-01 00:00:00

abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

journal_title：Experimental neurology

authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

更新日期：2006-01-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:Following a traumatic brain injury (TBI), the excessive release of interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) is a major cause of cerebral edema, which, in turn, can cause permanent neuronal loss and cognitive deficits in laboratory rats. This study examined the changes in expression of t...

journal_title：Experimental neurology

authors： He J,Evans CO,Hoffman SW,Oyesiku NM,Stein DG

更新日期：2004-10-01 00:00:00

abstract：:The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation a...

journal_title：Experimental neurology

authors： Kassed CA,Willing AE,Garbuzova-Davis S,Sanberg PR,Pennypacker KR

更新日期：2002-08-01 00:00:00

abstract：:Photic entrainment of circadian rhythms in mammals is mediated through a direct retinal projection to the core region of the suprachiasmatic nucleus (SCN), the circadian clock. A proportion of this projection contains the low-affinity p75 neurotrophic receptor (p75NTR). Neonatal monosodium glutamate (MSG) treatment, w...

journal_title：Experimental neurology

authors： Beaulé C,Amir S

更新日期：2002-08-01 00:00:00

abstract：:Neuropathic pain is common after traumatic injuries to the cauda equina/conus medullaris and brachial plexus. Clinically, this pain is difficult to treat and its mechanisms are not well understood. Lesions to the ventral roots are common in these injuries, but are rarely considered as potential contributors to pain. W...

journal_title：Experimental neurology

authors： Bigbee AJ,Hoang TX,Havton LA

更新日期：2007-03-01 00:00:00

abstract：:A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...

journal_title：Experimental neurology

authors： Andreoni G,Angeretti N,Lucca E,Forloni G

更新日期：1997-11-01 00:00:00

abstract：:Paraoxonase-2 regulates reactive oxygen species production in mitochondria. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology. Evidence suggests that the anti-diabetic drug pioglitazone may provide neuroprotection in Parkinson's disease, ...

journal_title：Experimental neurology

authors： Blackburn JK,Curry DW,Thomsen AN,Roth RH,Elsworth JD

更新日期：2020-05-01 00:00:00