Abstract：
:Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and galactocerebrosides as well as a marked decrease in myelin yield. Treatment of these animals with a single intracranial injection of 350 ng of apotransferrin at the time of withdrawal of cuprizone induced a marked increase in myelin deposition resulting in a significantly improved remyelination, evaluated by histological, immunocytochemical, and biochemical parameters, in comparison to what was observed in spontaneous recovery. Immunocytochemical studies of cryotome sections to analyze developmental parameters of the oligodendroglial cell population at the time of termination of cuprizone and at different times thereafter showed that in the untreated animals, there was a marked increase in the number of NG2-BrdU-positive precursor cells together with a marked decrease in MBP expression at the peak of cuprizone-induced demyelination. As expected, the amount of precursor cells decreased markedly during spontaneous remyelination and was accompanied by an increase in MBP reactivity. In the apotransferrin-treated animals, these phenomena occurred much faster, and remyelination was much more efficient than in the untreated controls. The results of this study suggest that apotransferrin is a very active promyelinating agent which could be important for the treatment of certain demyelinating conditions.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Adamo AM,Paez PM,Escobar Cabrera OE,Wolfson M,Franco PG,Pasquini JM,Soto EFdoi
10.1016/j.expneurol.2005.12.027keywords:
subject
Has Abstractpub_date
2006-04-01 00:00:00pages
519-29issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(05)00492-9journal_volume
198pub_type
杂志文章abstract：:Inherited neurological diseases in animals are of interest to a wide range of scientific disciplines, particularly because such animals may be suited as genetic animal models for respective human disorders. Because the pig has a number of anatomic and physiologic features similar to those of human beings, this species...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1995.1050
更新日期：1995-08-01 00:00:00
abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6748
更新日期：1998-02-01 00:00:00
abstract：:The ectopic discharges observed in uninjured dorsal root ganglion (DRG) neurons following various lesions of spinal nerves have been attributed to functional alterations of voltage-gated sodium channels (VGSCs). Such mechanisms may be important for the development of neuropathic pain. However, the pathophysiology unde...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.11.017
更新日期：2011-02-01 00:00:00
abstract：:Abnormal oscillatory activity in the basal ganglia is increasingly implicated in the pathophysiology of Parkinson's disease. Such activity is recorded in patients in the form of oscillations in the local field potential (LFP) picked up in the subthalamic nucleus. Previous studies have focused on correlations between f...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.04.024
更新日期：2012-08-01 00:00:00
abstract：:The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0004
更新日期：1996-01-01 00:00:00
abstract：:Human apolipoprotein E (apoE) is a 34.2kDa glycosylated protein with three isoforms (apoE2, apoE3 and apoE4). Experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome, is an immune-mediated experimental disorder of the peripheral nervous system (PNS). Increased susceptibility to EAN in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.04.016
更新日期：2011-08-01 00:00:00
abstract：:We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and long-term adhesion assays using monoclonal antibodies directed against topographically distinct epitopes on the molecules. Whereas antibodies to mouse liver memb...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/s0014-4886(05)80012-3
更新日期：1990-07-01 00:00:00
abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.08.017
更新日期：2009-11-01 00:00:00
abstract：:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6951
更新日期：1998-12-01 00:00:00
abstract：:Successful clinical application of fMRI tasks requires reliable knowledge about the brain structures mapped by the task. With memory fMRI, diverging evidence exists concerning the location of major signal sources as well as hippocampal contributions. To clarify these issues, we investigated a frequently applied memory...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.019
更新日期：2008-09-01 00:00:00
abstract：:By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90048-4
更新日期：1989-03-01 00:00:00
abstract：:Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. Autosomal-recessive mutations in the mitochondrial protein kinase PINK1 (PTEN-induced kinase 1) account for 1-2% of the hereditary early-onset cases. To study the mechanisms underlying disease development, we generated Pink1-deficient mic...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.01.002
更新日期：2012-05-01 00:00:00
abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.08.017
更新日期：2008-12-01 00:00:00
abstract：:Following cholinergic denervation of the hippocampal formation, peripheral sympathetic fibers from the superior cervical ganglion (SCG) sprout into hippocampal tissue. The molecular mechanism controlling this process is unknown, although a role by trophic factors seems likely. In the present study, neonatal SCG were u...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1994.1180
更新日期：1994-11-01 00:00:00
abstract：:The ability of striatal embryonic grafts to promote functional recovery on complex behavioral tasks depends on various factors, including the amount of striatal-like tissue within the grafts and the duration of post-graft training. However, how the innate paw bias of animals is affected by experience, or influences re...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.12.033
更新日期：2006-06-01 00:00:00
abstract：:Muscle disuse-induced changes in the cholinergic system of sciatic nerve, slow-twitch soleus (SOL), and fast-twitch extensor digitorum longus (EDL) muscles were studied in rats. Rats with hind limbs suspended for 2 to 3 weeks showed marked elevation in the activity of choline acetyltransferase in sciatic nerve (38%), ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90012-3
更新日期：1985-09-01 00:00:00
abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90179-8
更新日期：1987-04-01 00:00:00
abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.01.016
更新日期：2006-07-01 00:00:00
abstract：:Effective spread of stimulating current from macroelectrodes was measured using antidromic responses of axons of the pyramidal tract as an indicator of excitation. Both monopolar and concentric bipolar electrode configurations were tested with stimulating distances as large as 7mm. The effective stimulation distance w...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90126-3
更新日期：1986-04-01 00:00:00
abstract：:Explanation of the embryonic rat superior cervical ganglion initiated a retrograde response in noradrenergic neurons. By the 4th day of explanation, tyrosine hydroxylase activity per cell decreased to 62% of the day 0 control value. The rate of neurite outgrowth during the same period increased by 66%. By the 6th day ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90058-5
更新日期：1985-10-01 00:00:00
abstract：:Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90261-5
更新日期：1987-12-01 00:00:00
abstract：:Accumulating evidence shows alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease, mainly by endothelial cell (EC) damage. Repair of the altered barrier in the CNS by replacement of ECs via cell transplantation may be a new therapeutic approac...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2018.08.012
更新日期：2018-12-01 00:00:00
abstract：:Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic events. These receptors include the three groups of metabotropic glutamate receptors (mGluRs). Group I mGluR activation can initiate...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7721
更新日期：2001-08-01 00:00:00
abstract：:Stress and glucocorticoids exacerbate pain via undefined mechanisms. Macrophage migration inhibitory factor (MIF) is a constitutively expressed protein that is secreted to maintain immune function when glucocorticoids are elevated by trauma or stress. Here we show that MIF is essential for the development of neuropath...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.04.018
更新日期：2012-08-01 00:00:00
abstract：:Locally generating new proteins in subcellular regions provide means to spatially and temporally modify protein content in polarized cells. Recent years have seen resurgence of the concept that axonal processes of neurons can locally synthesize proteins. Experiments from a number of groups have now shown that axonal p...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2009.08.011
更新日期：2010-05-01 00:00:00
abstract：:Male white mice were exposed to electroshock and then injected intravenously with 5-[3H]uridine immediately after the shock. After 5, 30, or 60 min or 6, 12, or 24 h, the mice were killed, microautoradiographs were prepared, and grains were counted in the cortex, hippocampus, and basal ganglia. The results of the grai...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90269-9
更新日期：1985-07-01 00:00:00
abstract：:Ventral root avulsion (VRA) triggers a strong glial reaction which contributes to neuronal loss, as well as to synaptic detachment. To overcome the degenerative effects of VRA, treatments with neurotrophic factors and stem cells have been proposed. Thus, we investigated neuroprotection elicited by human embryonic stem...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.04.009
更新日期：2017-08-01 00:00:00
abstract：:Relatively few behavioral deficits are apparent in subjects with hereditary absence of the corpus callosum (CC). The anterior commissure (AC) has been suggested to provide an extracallosal route for the transfer of interhemispheric information in subjects with this congenital defect. Anterior commissure size, axon num...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6564
更新日期：1997-08-01 00:00:00
abstract：:The neural substrate underlying the aversive effects induced by ethanol abstinence is still unclear. One candidate for such effects is the dorsal periaqueductal gray (dPAG), a core structure of the brain aversion system. The main aim of this study is to examine the role of the dPAG as a possible locus of the aversive ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.02.004
更新日期：2006-07-01 00:00:00
abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.12.012
更新日期：2008-05-01 00:00:00
