Effect of 192 IgG-saporin on circadian activity rhythms, expression of P75 neurotrophin receptors, calbindin-D28K, and light-induced Fos in the suprachiasmatic nucleus in rats.

abstract：:The aminergic and cholinergic fibers innervating the hippocampus reach their target regions via the dorsal (dorsal fornix, fimbria, and cingulum) and ventral routes. The plasticity of this innervation after lesions of the dorsal pathway was investigated in the septal, medial, and temporal regions of the adult rat hipp...

journal_title：Experimental neurology

authors： Gasser UE,Dravid AR

更新日期：1987-05-01 00:00:00

abstract：:Estrogen has been suggested to be pro-epileptic by reducing GABA synthesis, resulting in increased spine density and a decreased threshold for seizures in the hippocampus, which, once they occur, are characterized by a dramatic spine loss in the affected brain areas. As considerable amounts of estradiol are synthesize...

journal_title：Experimental neurology

authors： Zhou L,Lehan N,Wehrenberg U,Disteldorf E,von Lossow R,Mares U,Jarry H,Rune GM

更新日期：2007-01-01 00:00:00

abstract：:The effects of unilateral intrahippocampal injection of kainic acid, a potent neuroexcitant and neurotoxin, on subsequent susceptibility to kindling of the contralateral hippocampus or contralateral amygdala were investigated in albino rats. At the chosen doses (0.20 to 1.25 micrograms dissolved in physiologic saline)...

journal_title：Experimental neurology

authors： Feldblum S,Ackermann RF

更新日期：1987-08-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:Overactivation of N-methyl-D-aspartate (NMDA) glutamate receptors is closely related to epilepsy and excitotoxicity, and the phosphorylation of these receptors may facilitate glutamate-mediated synaptic transmission. Here we show that in awake rats the microinjection into the hippocampus of okadaic acid, a potent inhi...

journal_title：Experimental neurology

authors： Arias C,Montiel T,Peña F,Ferrera P,Tapia R

更新日期：2002-09-01 00:00:00

abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

journal_title：Experimental neurology

authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

更新日期：2012-02-01 00:00:00

abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...

journal_title：Experimental neurology

authors： Fang CX,Yang X,Sreejayan N,Ren J

更新日期：2007-01-01 00:00:00

abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

journal_title：Experimental neurology

authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

更新日期：2014-01-01 00:00:00

abstract：:Excitant amino acids are implicated in audiogenic seizure (AGS) susceptibility in the genetically epilepsy-prone rat (GEPR). In the present study systemic administration of NMDA receptor antagonists significantly decreased AGS severity in the GEPR. Systemic administration of the competitive NMDA antagonists 3-((+-)-2-...

journal_title：Experimental neurology

authors： Faingold CL,Randall ME,Naritoku DK,Boersma Anderson CA

更新日期：1993-02-01 00:00:00

abstract：:Deep brain stimulation (DBS) has emerged as an important and potentially powerful treatment option for the management of carefully selected patients with advanced Parkinson's disease (PD) who are not adequately controlled by standard medication therapy. Though considerable advances have been made, the mechanisms under...

journal_title：Experimental neurology

authors： Hess CW,Vaillancourt DE,Okun MS

更新日期：2013-09-01 00:00:00

abstract：:This study reevaluated the possibility of using predegenerated nerves as donor nerve allografts for nerve repair and compared the results of functional recovery to those obtained after standard, fresh nerve allograft repair. Twenty donor rats underwent a ligature/ section of the left sciatic nerve 4 weeks before nerve...

journal_title：Experimental neurology

authors： Dubuisson AS,Foidart-Dessalle M,Reznik M,Grosdent JC,Stevenaert A

更新日期：1997-11-01 00:00:00

abstract：:Fifteen male mice (C57/Bl6J) were fed the liquid diet "Stardit" supplemented with vitamins together with phenytoin for 8 weeks; experimental animals and controls were pair-fed. After 8 weeks of treatment, the anesthetized animals were perfused with 3.5% glutaraldehyde. Tissue samples of the cerebral cortex (area 3), c...

journal_title：Experimental neurology

authors： Volk B,Kirchgässner N,Detmar M

更新日期：1986-01-01 00:00:00

abstract：:Periodic changes in ovarian steroid levels during fertility cycles affect learning both in humans and in rats in parallel with electrophysiological and morphological fluctuations in selective neuronal populations. In particular, during the estrous cycle of the female rat, hippocampal CA1 region undergoes cyclic modifi...

journal_title：Experimental neurology

authors： Crispino M,Stone DJ,Wei M,Anderson CP,Tocco G,Finch CE,Baudry M

更新日期：1999-10-01 00:00:00

abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

journal_title：Experimental neurology

authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

更新日期：2019-01-01 00:00:00

abstract：:Previously, our lab reported the isolation of patient-specific neurosphere-forming progenitor lines from human adult olfactory epithelium from cadavers as well as patients undergoing nasal sinus surgery. RT-PCR and ELISA demonstrated that the neurosphere-forming cells (NSFCs) produced BDNF. Since rubrospinal tract (RS...

journal_title：Experimental neurology

authors： Xiao M,Klueber KM,Lu C,Guo Z,Marshall CT,Wang H,Roisen FJ

更新日期：2005-07-01 00:00:00

abstract：:The cascade of events leading to post-traumatic epilepsy (PTE) after traumatic brain injury (TBI) remains unclear. Altered inhibition in the hippocampal formation and dentate gyrus is a hallmark of several neurological disorders, including TBI and PTE. Inhibitory synaptic signaling in the hippocampus is predominately ...

journal_title：Experimental neurology

authors： Butler CR,Boychuk JA,Smith BN

更新日期：2016-06-01 00:00:00

abstract：:Spinal motor neurons of Sprague-Dawley rats were examined to determine which of the neuronal isoforms of actin (beta or gamma) upregulate following axon injury. In situ hybridization studies showed greater beta-actin mRNA levels but no change in gamma-actin mRNA levels-suggesting that axon regrowth utilizes beta-actin...

journal_title：Experimental neurology

authors： Lund LM,Machado VM,McQuarrie IG

更新日期：2002-12-01 00:00:00

abstract：:Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression...

journal_title：Experimental neurology

authors： Gordon T,You S,Cassar SL,Tetzlaff W

更新日期：2015-02-01 00:00:00

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00

abstract：:Germinal matrix hemorrhage (GMH) is the most common neurological disease of premature newborns. GMH causes neurological sequelae such as cerebral palsy, post-hemorrhagic hydrocephalus, and mental retardation. Despite this, there is no standardized animal model of spontaneous GMH using newborn rats to depict the condit...

journal_title：Experimental neurology

authors： Lekic T,Manaenko A,Rolland W,Krafft PR,Peters R,Hartman RE,Altay O,Tang J,Zhang JH

更新日期：2012-07-01 00:00:00

abstract：:Proximal axotomy in adult animals results in delayed death of motor neurons. Features characteristic of both necrosis and apoptosis have been described in motor neurons of the spinal cord following proximal avulsion of the ventral roots. We have previously demonstrated that a genomic herpes simplex virus (HSV)-based v...

journal_title：Experimental neurology

authors： Yamada M,Natsume A,Mata M,Oligino T,Goss J,Glorioso J,Fink DJ

更新日期：2001-04-01 00:00:00

abstract：:Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically dist...

journal_title：Experimental neurology

authors： Skoff AM,Zhao C,Adler JE

更新日期：2009-06-01 00:00:00

abstract：:Acute volume expansion is associated with a specific pattern of Fos expression and the goal of the present study was to evaluate the contribution of cardiac receptors to this response. Adult male rats were instrumented with pericardial catheters introduced at the level of the thymus. Rats were also catheterized for me...

journal_title：Experimental neurology

authors： Cunningham JT,Bruno SB,Higgs KA,Sullivan MJ

更新日期：2002-04-01 00:00:00

abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...

journal_title：Experimental neurology

authors： Spenger C,Josephson A,Klason T,Hoehn M,Schwindt W,Ingvar M,Olson L

更新日期：2000-12-01 00:00:00

abstract：:MicroRNA-21 (miR-21) is consistently up-regulated in various neurological disorders, including epilepsy. Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats. We demonstrate that pre-miR-21 has an energeti...

journal_title：Experimental neurology

authors： Chak K,Roy-Chaudhuri B,Kim HK,Kemp KC,Porter BE,Kay MA

更新日期：2016-12-01 00:00:00

abstract：:The hph-1 mice have defective tetrahydrobiopterin biosynthesis and share many neurochemical similarities with l-dopa-responsive dystonia (DRD) in humans. In both, there are deficiencies in GTP cyclohydrolase I and low brain levels of dopamine (DA). Striatal tyrosine hydroxylase (TH) levels are decreased while the numb...

journal_title：Experimental neurology

authors： Zeng BY,Heales SJ,Canevari L,Rose S,Jenner P

更新日期：2004-12-01 00:00:00

abstract：:Physiological/anatomical studies of rat frontal cortex in vitro have distinguished subpopulations of gamma-aminobutyric acid (GABA)-expressing inhibitory interneurons defined by expression of the calcium-binding proteins, parvalbumin (PV) and calbindin (CA). Using a novel 2DG/immunostaining technique to double-label h...

journal_title：Experimental neurology

authors： Maier DL,McCasland JS

更新日期：1997-05-01 00:00:00

abstract：:Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to its well-known involvement in motivation is an interesting target in this context. Furthermore, PD is frequently asymmetrical, with side-speci...

journal_title：Experimental neurology

authors： Cunha AM,Teixeira FG,Guimarães MR,Esteves M,Pereira-Mendes J,Soares AR,Almeida A,Sousa N,Salgado AJ,Leite-Almeida H

更新日期：2020-05-01 00:00:00

abstract：:In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. ...

journal_title：Experimental neurology

authors： Timmerman V,Clowes VE,Reid E

更新日期：2013-08-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00