Improved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes.

abstract：:We compared mitochondrial respiratory chain function, mitochondrial DNA (mtDNA) integrity, and oxidative stress levels in muscle, myoblasts, fibroblasts and cybrids, from 12 amyotrophic lateral sclerosis (ALS) patients with 28 control samples. Mitochondrial respiratory chain enzyme activities were normal in muscle, my...

journal_title：Experimental neurology

authors： Bradley LJ,Taanman JW,Kallis C,Orrell RW

更新日期：2009-07-01 00:00:00

abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

journal_title：Experimental neurology

authors： Klimova N,Fearnow A,Long A,Kristian T

更新日期：2020-03-01 00:00:00

abstract：:Dravet syndrome is a severe, early-onset epileptic encephalopathy frequently resulting from de novo mutations of SCN1A. Mice with heterozygous deletion of Scn1a (Scn1a+/-) model many features of Dravet syndrome, including spontaneous seizures and premature lethality. Scn1a+/- mice exhibit variable phenotype penetrance...

journal_title：Experimental neurology

authors： Hawkins NA,Calhoun JD,Huffman AM,Kearney JA

更新日期：2019-01-01 00:00:00

abstract：:The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used beca...

journal_title：Experimental neurology

authors： Wainwright P,Gagnon M

更新日期：1984-07-01 00:00:00

abstract：:After spinal cord injury, proteoglycans with growth-inhibitory glycosaminoglycan (GAG-) side chains in scar tissue limit spontaneous axonal sprouting/regeneration. Interventions that reduce scar-related inhibition facilitate an axonal growth response and possibly plasticity-based spinal cord repair. Xylosyltransferase...

journal_title：Experimental neurology

authors： Oudega M,Chao OY,Avison DL,Bronson RT,Buchser WJ,Hurtado A,Grimpe B

更新日期：2012-09-01 00:00:00

abstract：:Here, we describe a bilateral cervical contusion model for mice. Adult female mice received graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available impactor (the IH device). Three separate experiments were carried out to define conditions that produce impairments in forelimb functio...

journal_title：Experimental neurology

authors： Aguilar RM,Steward O

更新日期：2010-01-01 00:00:00

abstract：:Several lines of evidence have demonstrated beneficial effects of the hematopoietic factor G-CSF in experimental stroke. A conclusive demonstration of this effect in G-CSF deficient mice is, however, lacking. We therefore investigated the effect of G-CSF deficiency on infarct volumes, functional recovery, mRNA and pro...

journal_title：Experimental neurology

authors： Sevimli S,Diederich K,Strecker JK,Schilling M,Klocke R,Nikol S,Kirsch F,Schneider A,Schäbitz WR

更新日期：2009-06-01 00:00:00

abstract：:Rat axial muscle previously has not been studied histochemically. We were interested in determining the fiber composition and fiber distribution in rat lateral longissimus (LL), the large epaxial dorsiflexor muscle active during sexual posturing in the female rat and to determine if estrogen replacement in ovariectomi...

journal_title：Experimental neurology

authors： Schwartz-Giblin S,Rosello L,Pfaff DW

更新日期：1983-02-01 00:00:00

abstract：:Effects of accumulation of phosphocreatine (P-creatine) on utilization and restoration of high-energy phosphates during anoxia and recovery were studied using thin hippocampal slices from the guinea pig. Incubation of slices with creatine (5 to 30 mM) increased the content of tissue P-creatine, in a linear fashion, an...

journal_title：Experimental neurology

authors： Yoneda K,Arakawa T,Asaoka Y,Fukuoka Y,Kinugasa K,Takimoto K,Okada Y

更新日期：1983-10-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Febrile seizures are the most common seizure type in children under the age of five, but mechanisms underlying seizure generation in vivo remain unclear. Animal models to address this issue primarily focus on immature rodents heated indirectly using a controlled water bath or air blower. Here we describe an in vivo mo...

journal_title：Experimental neurology

authors： Hunt RF,Hortopan GA,Gillespie A,Baraban SC

更新日期：2012-09-01 00:00:00

abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...

journal_title：Experimental neurology

authors： Cheng L,Allore RJ,Richardson PM

更新日期：1998-02-01 00:00:00

abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

journal_title：Experimental neurology

authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

更新日期：2000-01-01 00:00:00

abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

journal_title：Experimental neurology

authors： Xie L,Zhao H,Wang Y,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Oscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease ...

journal_title：Experimental neurology

authors： Li M,Zhou M,Wen P,Wang Q,Yang Y,Xiao H,Xie Z,Li X,Wang N,Wang J,Luo F,Chang J,Zhang W

更新日期：2016-08-01 00:00:00

abstract：:Olfactory ensheathing cells (OECs) are unique glia that support axon outgrowth in the olfactory system, and when used as cellular therapy after spinal cord injury, improve recovery and axon regeneration. Here we assessed the effects of combining OEC transplantation with another promising therapy, epidural electrical s...

journal_title：Experimental neurology

authors： Thornton MA,Mehta MD,Morad TT,Ingraham KL,Khankan RR,Griffis KG,Yeung AK,Zhong H,Roy RR,Edgerton VR,Phelps PE

更新日期：2018-11-01 00:00:00

abstract：:We have previously demonstrated that octanoic (OA) and decanoic acids (DA) inhibit Na+, K+ ATPase activity in synaptic plasma membranes from rat brain. The objective of the present study was to investigate the in vitro effects of the other metabolites that accumulate in tissues of medium-chain acyl-CoA dehydrogenase (...

journal_title：Experimental neurology

authors： de Assis DR,Maria RC,Ferreira GC,Schuck PF,Latini A,Dutra-Filho CS,Wannmacher CM,Wyse AT,Wajner M

更新日期：2006-01-01 00:00:00

abstract：:We investigated the involvement of central nervous system nicotinic-acetylcholine receptors in the secretory activity of the hypothalamic-hypophyseal-adrenal axis. Antiacetylcholine receptor antibodies derived from rabbits immunized with purified Torpedo-acetylcholine receptor or from myasthenia gravis patients were i...

journal_title：Experimental neurology

authors： Brenner T,Mizrachi R,Bodoff M,Weidenfeld J

更新日期：1986-12-01 00:00:00

abstract：:Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...

journal_title：Experimental neurology

authors： Humpel C,Giacobini MM,Wetmore C,Olson L

更新日期：1994-06-01 00:00:00

abstract：:Fetal spinal cord from embryonic day 14 (E14/FSC) has been used for numerous transplantation studies of injured spinal cord. E14/FSC consists primarily of neuronal (NRP)- and glial (GRP)-restricted precursors. Therefore, we reasoned that comparing the fate of E14/FSC with defined populations of lineage-restricted prec...

journal_title：Experimental neurology

authors： Lepore AC,Fischer I

更新日期：2005-07-01 00:00:00

abstract：:In the previous paper it was demonstrated that striatal dopamine (DA) D1 and D2 receptor subtypes and muscarinic M1 and M2 receptor subtypes show differing responses to lesions of the mesostriatal DA system. To examine this differential regulation further rats were given unilateral injections of 6-hydroxydopamine (6-O...

journal_title：Experimental neurology

authors： Joyce JN

更新日期：1991-09-01 00:00:00

abstract：:Seizures were induced in immature 18-day-old rats by i.p. administration of homocysteine (11 mmol/kg) and the effects of selected antagonists of NMDA receptors [MK-801 (0.5 mg/kg), AP7 (0.33 mmol/kg), CGP 40116 (10 mg/kg)] and non-NMDA receptors [GDEE (4 mmol/kg), NBQX (two doses, 30 mg/kg each)] were studied. The eff...

journal_title：Experimental neurology

authors： Folbergrová J

更新日期：1997-06-01 00:00:00

abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...

journal_title：Experimental neurology

authors： Laouafa S,Iturri P,Arias-Reyes C,Marcouiller F,Gonzales M,Joseph V,Bairam A,Soliz J

更新日期：2019-10-01 00:00:00

abstract：:In the cerebellum of adult-aging Ts65Dn mice, a murine model of Down syndrome, Purkinje cells undergo degeneration. Searching for the cause of Purkinje cell degeneration, we have studied the ubiquitin-proteasome system (UPS) in the cerebellum of aging Ts65Dn mice. Inhibition of UPS is sufficient to induce neuron degen...

journal_title：Experimental neurology

authors： Necchi D,Lomoio S,Scherini E

更新日期：2011-12-01 00:00:00

abstract：:Intranuclear inclusion bodies are a shared pathological feature of Huntington's disease (HD) and its transgenic mouse model. Using a panel of antibodies spanning the entire huntingtin molecule, we have investigated the pattern of immunoreactivity within the intranuclear inclusions in the frontal cortex and striatum of...

journal_title：Experimental neurology

authors： Sieradzan KA,Mechan AO,Jones L,Wanker EE,Nukina N,Mann DM

更新日期：1999-03-01 00:00:00

abstract：:MicroRNA-21 (miR-21) is consistently up-regulated in various neurological disorders, including epilepsy. Here, we show that the biogenesis of miR-21 is altered following pilocarpine-induced status epilepticus (SE) with an increase in precursor miR-21 (pre-miR-21) in rats. We demonstrate that pre-miR-21 has an energeti...

journal_title：Experimental neurology

authors： Chak K,Roy-Chaudhuri B,Kim HK,Kemp KC,Porter BE,Kay MA

更新日期：2016-12-01 00:00:00

abstract：:A new mutant, peroneal muscular atrophy (pma) mouse in CF#1 strain has an autosomal recessively inherited equinovarus (club foot deformity) of the hind legs because of the absence of the common peroneal nerve branch of the sciatic nerve. We found the peroneal muscles were hypoplastic with histochemical and electron mi...

journal_title：Experimental neurology

authors： Nonaka I,Kikuchi A,Suzuki T,Esaki K

更新日期：1986-03-01 00:00:00

abstract：:The precise mechanisms underlying the efficacy of intravenous immunoglobulin (IVIg) in autoimmune neurological disorders including Guillain-Barré syndrome (GBS) are not known. Anti-ganglioside antibodies have been reported to be pathogenic in some variants of GBS, and we have developed passive transfer animal models t...

journal_title：Experimental neurology

authors： Zhang G,Massaad CA,Gao T,Pillai L,Bogdanova N,Ghauri S,Sheikh KA

更新日期：2016-08-01 00:00:00

abstract：:Neuron loss in layer III of the entorhinal cortex (EC) occurs in patients with temporal lobe epilepsy and in several animal models of the disease and may play a role in the development of spontaneously recurring seizures. This damage can be reproduced in rats by a focal microinjection of the indirect excitotoxin amino...

journal_title：Experimental neurology

authors： Wu HQ,Schwarcz R

更新日期：1998-10-01 00:00:00

abstract：:Motor nerve conduction velocity was measured in six branches of the sciatic nerve in streptozotocin-diabetic rats. It was markedly reduced in nerves to the gastrocnemius, soleus, tibialis anterior, and extensor digitorum longus muscles. The branch to the plantaris muscle remained unaffected. In control rats none of th...

journal_title：Experimental neurology

authors： Cameron NE,Cotter MA,Harrison J

更新日期：1986-06-01 00:00:00