Na+, K+ ATPase activity is markedly reduced by cis-4-decenoic acid in synaptic plasma membranes from cerebral cortex of rats.

abstract：:Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistently produced important features of the disease. In this study...

journal_title：Experimental neurology

authors： Mackey S,Jing Y,Flores J,Dinelle K,Doudet DJ

更新日期：2013-09-01 00:00:00

abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...

journal_title：Experimental neurology

authors： Spenger C,Josephson A,Klason T,Hoehn M,Schwindt W,Ingvar M,Olson L

更新日期：2000-12-01 00:00:00

abstract：:By combining neurochemical measurement of norepinephrine (NE) with double-label immunocytochemistry for tyrosine hydroxylase-positive (TH+) noradrenergic nerves and specific lymphoid markers, we have examined the developmental compartmentation of noradrenergic nerves in the rat spleen. TH+ nerve fibers were present in...

journal_title：Experimental neurology

authors： Ackerman KD,Felten SY,Dijkstra CD,Livnat S,Felten DL

更新日期：1989-03-01 00:00:00

abstract：:Posttraumatic inflammation has been implicated in secondary tissue damage after spinal cord injury (SCI). Tumor necrosis factor-alpha (TNF-alpha) is a key inflammatory mediator that is increasingly expressed after SCI. The effect of TNF-alpha is mediated through its receptors TNFR1 (p55) and TNFR2 (p75). However, whet...

journal_title：Experimental neurology

authors： Yan P,Liu N,Kim GM,Xu J,Xu J,Li Q,Hsu CY,Xu XM

更新日期：2003-10-01 00:00:00

abstract：:Previously, our lab reported the isolation of patient-specific neurosphere-forming progenitor lines from human adult olfactory epithelium from cadavers as well as patients undergoing nasal sinus surgery. RT-PCR and ELISA demonstrated that the neurosphere-forming cells (NSFCs) produced BDNF. Since rubrospinal tract (RS...

journal_title：Experimental neurology

authors： Xiao M,Klueber KM,Lu C,Guo Z,Marshall CT,Wang H,Roisen FJ

更新日期：2005-07-01 00:00:00

abstract：:Laser Doppler flowmetry was utilized to examine blood flow in sciatic nerves of barbiturate-anesthetized and of unanesthetized decerebrate rats, in response to hypotension induced by graded exsanguination or by graded clamping of the descending aorta. Continuous laser Doppler flowmetry signals decreased linearly with ...

journal_title：Experimental neurology

authors： Sundqvist T,Oberg PA,Rapoport SI

更新日期：1985-10-01 00:00:00

abstract：:Spinal cord injury (SCI) results in chronic pain states in which the underlying mechanism is poorly understood. To begin to explore possible mechanisms, calcitonin gene-related peptide (CGRP), a neuropeptide confined to fine primary afferent terminals in laminae I and II in the dorsal horn of the spinal cord and impli...

journal_title：Experimental neurology

authors： Christensen MD,Hulsebosch CE

更新日期：1997-10-01 00:00:00

abstract：:Here, we describe a bilateral cervical contusion model for mice. Adult female mice received graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available impactor (the IH device). Three separate experiments were carried out to define conditions that produce impairments in forelimb functio...

journal_title：Experimental neurology

authors： Aguilar RM,Steward O

更新日期：2010-01-01 00:00:00

abstract：:Activity-dependent alteration in synaptic efficacy is referred to as synaptic plasticity and is the believed hallmark of any learning process. Here we employed a recently validated complex maze for spatial training and investigated the impact of repeated and extensive training on basal synaptic transmission of the hip...

journal_title：Experimental neurology

authors： Lange-Asschenfeldt C,Lohmann P,Riepe MW

更新日期：2007-02-01 00:00:00

abstract：:Using a measure of nonlinear dynamical changes we term marginal predictability, we report evidence of robust changes in this parameter on scalp EEG in a cohort of patients with medically refractory mesiobasal temporal lobe epilepsy (MBTLE). In the baseline (interictal) state there are distinct differences in this nonl...

journal_title：Experimental neurology

authors： Drury I,Smith B,Li D,Savit R

更新日期：2003-11-01 00:00:00

abstract：:The aim of this study was to characterize the microglial and astroglial reactions to degeneration of (a) hippocampal CA1 pyramidal cells and dentate hilar neurons induced by cerebral ischemia and (b) CA3 pyramidal cells and dentate hilar neurons induced by intraventricular injections of kainic acid (KA). The microglia...

journal_title：Experimental neurology

authors： Jørgensen MB,Finsen BR,Jensen MB,Castellano B,Diemer NH,Zimmer J

更新日期：1993-03-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00

abstract：:The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression...

journal_title：Experimental neurology

authors： Spehlmann R,Norcross K

更新日期：1984-01-01 00:00:00

abstract：:Spinal cord injury (SCI) initiates biochemical events that lead to an increase in extracellular excitatory amino acid concentrations, resulting in glutamate receptor-mediated excitotoxic events. These receptors include the three groups of metabotropic glutamate receptors (mGluRs). Group I mGluR activation can initiate...

journal_title：Experimental neurology

authors： Mills CD,Fullwood SD,Hulsebosch CE

更新日期：2001-08-01 00:00:00

abstract：:Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, in which the myelin sheath has been considered to be the primary target for many years. However, an increasing number of reports have focused on neurodegenerative aspects of the disease pathogenesis. Recent studies i...

journal_title：Experimental neurology

authors： Herz J,Zipp F,Siffrin V

更新日期：2010-09-01 00:00:00

abstract：:Nerve growth factor (NGF) enhances neuronal survival during injury to the mature central and peripheral nervous systems, but its potential as a neuroprotective factor in the enteric nervous system (ENS) has not been examined. We used the trinitrobenzene sulfonic acid (TNBS)-induced model of colitis to examine if NGF-s...

journal_title：Experimental neurology

authors： Lin A,Lourenssen S,Stanzel RD,Blennerhassett MG

更新日期：2005-02-01 00:00:00

abstract：:c-Fos protein-like immunoreactivity (IR) was investigated in the rat brain following an application of weak anodal direct current to the surface of the unilateral sensorimotor cortex in an attempt to elucidate the cellular and molecular bases of central plasticity. Anodal polarization resulted in a massive increase in...

journal_title：Experimental neurology

authors： Islam N,Moriwaki A,Hattori Y,Hayashi Y,Lu YF,Hori Y

更新日期：1995-05-01 00:00:00

abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...

journal_title：Experimental neurology

authors： Herdman SJ,Hand CL,Hand PJ

更新日期：1984-08-01 00:00:00

abstract：:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...

journal_title：Experimental neurology

authors： Zuo J,Neubauer D,Dyess K,Ferguson TA,Muir D

更新日期：1998-12-01 00:00:00

abstract：:Intracerebral transplants of ventral mesencephalic (VM) tissue have been well characterized. VM grafts contain numerous tyrosine hydroxylase immunoreactive neurons which send axons into the host brain. Transplanted neurons in VM grafts develop normally in that they contain tyrosine hydroxylase and GAP43. An overlooked...

journal_title：Experimental neurology

authors： Mahalik TJ,Hahn WE,Clayton GH,Owens GP

更新日期：1994-09-01 00:00:00

abstract：:Inherited neurological diseases in animals are of interest to a wide range of scientific disciplines, particularly because such animals may be suited as genetic animal models for respective human disorders. Because the pig has a number of anatomic and physiologic features similar to those of human beings, this species...

journal_title：Experimental neurology

authors： Richter A,Wissel J,Harlizius B,Simon D,Schelosky L,Scholz U,Poewe W,Löscher W

更新日期：1995-08-01 00:00:00

abstract：:Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of isolated myelin showed a marked decrease in myelin proteins, phospholipids, and ga...

journal_title：Experimental neurology

authors： Adamo AM,Paez PM,Escobar Cabrera OE,Wolfson M,Franco PG,Pasquini JM,Soto EF

更新日期：2006-04-01 00:00:00

abstract：:Neglect is a clinical syndrome characterized by an inability to orient, report, or respond to novel or meaningful stimuli presented to one side of the body or in one hemispace. Neglect in humans and monkeys most often results from damage to one of several interconnected cortical areas, including limbic cortex. In rats...

journal_title：Experimental neurology

authors： King V,Corwin JV,Reep RL

更新日期：1989-09-01 00:00:00

abstract：:These experiments were completed as part of an NIH "Facilities of Research Excellence in Spinal Cord Injury" contract to support independent replication of published studies that could be considered for eventual clinical testing. Recent studies have reported that selective inhibition of the P2X7 receptor improves both...

journal_title：Experimental neurology

authors： Marcillo A,Frydel B,Bramlett HM,Dietrich WD

更新日期：2012-02-01 00:00:00

abstract：:Rats were treated with single subcutaneous injections of the irreversible AChE inhibitors, sarin (90 to 100 micrograms/kg) or soman (55 micrograms/kg), and with chronic doses of the reversible carbamate inhibitor, pyridostigmine. In surviving animals with severe behavioral symptoms, we examined the end-plate regions o...

journal_title：Experimental neurology

authors： Meshul CK,Boyne AF,Deshpande SS,Albuquerque EX

更新日期：1985-07-01 00:00:00

abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....

journal_title：Experimental neurology

authors： Soja PJ,Finch DM,Chase MH

更新日期：1987-04-01 00:00:00

abstract：:The extensive period of retinal ganglion cell (RGC) neurogenesis in the rat is associated with a protracted sequence of arrival of their axons into central targets such as the superior colliculus (SC) (Dallimore et al., 2002). Using in utero 5-bromo-2'-deoxyrudine (BrdU) injections to label early (embryonic day (E) 15...

journal_title：Experimental neurology

authors： Dallimore EJ,Park KK,Pollett MA,Taylor JS,Harvey AR

更新日期：2010-10-01 00:00:00

abstract：:In a model of Parkinson's disease (PD), amphetamine, a dopamine (DA)-releasing drug, fails to induce ipsilateral drug rotations in a proportion of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle and DA neurons of the substantia nigra. To investigate this phenomenon, indi...

journal_title：Experimental neurology

authors： Moore AE,Cicchetti F,Hennen J,Isacson O

更新日期：2001-12-01 00:00:00

abstract：:A complex propriospinal network is synaptically coupled to phrenic and intercostal motoneurons, and this makes it difficult to predict how gray matter intraspinal microstimulation (ISMS) will recruit respiratory motor units. We therefore mapped the cervical and high thoracic gray matter at locations which ISMS activat...

journal_title：Experimental neurology

authors： Sunshine MD,Ganji CN,Reier PJ,Fuller DD,Moritz CT

更新日期：2018-04-01 00:00:00

abstract：:We examined the myelin repair potential of transplanted neural precursor cells derived from the adult human brain from tissue removed during surgery. Sections of removed brain indicated that nestin-positive cells were found predominantly in the subventricular zone around the anterior horns of the lateral ventricle and...

journal_title：Experimental neurology

authors： Akiyama Y,Honmou O,Kato T,Uede T,Hashi K,Kocsis JD

更新日期：2001-01-01 00:00:00