Abstract:
:Laser Doppler flowmetry was utilized to examine blood flow in sciatic nerves of barbiturate-anesthetized and of unanesthetized decerebrate rats, in response to hypotension induced by graded exsanguination or by graded clamping of the descending aorta. Continuous laser Doppler flowmetry signals decreased linearly with decreasing arterial blood pressure. In anesthetized as well as in unanesthetized rats, the signal approached zero at a systemic blood pressure of 14 mm Hg or less. The results do not demonstrate autoregulation of blood flow in the rat sciatic nerve during systemic hypotension.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Sundqvist T,Oberg PA,Rapoport SIdoi
10.1016/0014-4886(85)90047-0subject
Has Abstractpub_date
1985-10-01 00:00:00pages
139-48issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(85)90047-0journal_volume
90pub_type
杂志文章abstract::The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.12.018
更新日期:2008-04-01 00:00:00
abstract::The threshold current required for the excitation of visual cortex neurons in the vicinity (approximately 1 mm) of an intracortical stimulating electrode was measured as a function of the stimulus pulse duration in the anesthetized cat. For cortical neurons with latencies of activation from 0.4 to 3.4 ms and for stimu...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90270-4
更新日期:1983-08-01 00:00:00
abstract::Nerve growth factor (NGF) can induce sprouting of axotomized adult rat medial septum cholinergic neurons and promote their regeneration into septohippocampal nerve grafts and hippocampal formation. This study investigated the potential neurotropic (chemotactic/attracting) action of NGF in the adult rat cholinergic sep...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1005
更新日期:1993-01-01 00:00:00
abstract::This study examined the effect of experimental diabetes on the anterograde and retrograde axonal transport of phosphofructokinase activity. Rats with streptozotocin-induced diabetes of 4 weeks duration showed phosphofructokinase activity accumulation deficits both proximal (53% and 65% in two separate experiments) and...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90180-4
更新日期:1987-04-01 00:00:00
abstract::In the avian model of muscular dystrophy, electrophysiologic studies have shown alterations in the action potential characteristics of dystrophic muscle in vitro, supporting the notion that a membrane defect exists in avian dystrophy. As neurogenic and vascular etiologies have also been proposed, we examined the chara...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(86)90114-7
更新日期:1986-11-01 00:00:00
abstract::We recently described an experimental model of spinal cord contusive injury in the rat in which a modified weight-drop apparatus is used to generate reproducible mild, moderate, or severe final functional deficit. We now report several inexpensive alternatives for portions of the original apparatus which allow the pro...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90162-2
更新日期:1987-02-01 00:00:00
abstract::Cats were kindled in the amygdala. After completion of kindling, their EEG was monitored almost continuously by a computer system which allowed the detection of spontaneous seizures and the quantification of interictal spikes. The relationships between seizures triggered by stimulation, spontaneous seizures, and inter...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90223-1
更新日期:1984-05-01 00:00:00
abstract::The subchronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin (MPTP) paradigm is one of the most widely used in vivo models of Parkinson's disease (PD). However, particularly in the mouse model it has remained difficult to reliably detect behavioural correlates for PD. In the present study we apply a novel murine motor t...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.01.030
更新日期:2007-05-01 00:00:00
abstract::Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2011.02.013
更新日期:2011-06-01 00:00:00
abstract::Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0190
更新日期:1996-11-01 00:00:00
abstract::Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::Methylmalonic acidemia is an inherited metabolic disorder that leads to brain damage associated to the accumulation of methylmalonic acid (MMA) and impairment of energy metabolism. We demonstrate here that treatment with diazoxide, an agonist of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)), can prevent death...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.04.004
更新日期:2006-09-01 00:00:00
abstract::Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7466
更新日期:2000-10-01 00:00:00
abstract::There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90065-7
更新日期:1984-10-01 00:00:00
abstract::The effects of methylmercury (MeHg) on cytoplasmic microtubules in cultured neuroblastoma cells, glioma cells, and fibroblasts were compared. Neuroblastoma cells appeared to be more sensitive to disruption of microtubules by MeHg than the glioma cells or fibroblasts; cellular concentrations of mercury after MeHg were ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90147-x
更新日期:1984-08-01 00:00:00
abstract::The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(84)90059-1
更新日期:1984-01-01 00:00:00
abstract::Recovery from injury to the central nervous system (CNS) is limited in the mammalian adult. Nonetheless, some degree of spontaneous recovery occurs after partial CNS injury. Compensatory axonal growth from uninjured neurons, termed sprouting, contributes to this naturally occurring recovery process and can be modulate...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.07.013
更新日期:2018-11-01 00:00:00
abstract::The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb a...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7543
更新日期:2000-12-01 00:00:00
abstract::Deep brain stimulation (DBS) of the subthalamic nucleus (STN) can be a highly effective treatment for Parkinson's disease (PD). However, therapeutic efficacy is limited by difficulties in consistently and correctly targeting this nucleus. Increasing evidence suggests that there is abnormal synchronization of beta freq...
journal_title:Experimental neurology
pub_type: 临床试验,杂志文章
doi:10.1016/j.expneurol.2005.11.019
更新日期:2006-03-01 00:00:00
abstract::The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7362
更新日期:2000-05-01 00:00:00
abstract::As part of a wider investigation on brain structure and function in young rats with inherited hydrocephalus, this study was undertaken to develop a technique to monitor, and quantify, progressive changes in ventricle and cortical dimensions in hydrocephalic rats in vivo. Magnetic resonance images were obtained with a ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(92)90016-j
更新日期:1992-10-01 00:00:00
abstract::Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.03.014
更新日期:2017-06-01 00:00:00
abstract::Cortical and striatal cultures were prepared from the same embryonic rat brains and maintained in identical culture conditions. In this way, the intrinsic, genetically imprinted differences determine the responses of cortical and striatal neurons in comparative studies. Cortical and striatal neurons differed in their ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7576
更新日期:2001-03-01 00:00:00
abstract::Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7194
更新日期:1999-11-01 00:00:00
abstract::Chemotherapy-related cognitive deficits are a major neurological problem, but the underlying mechanisms are unclear. The death of neural stem/precursor cell (NSC) by cisplatin has been reported as a potential cause, but this requires high doses of chemotherapeutic agents. Cisplatin is frequently used in modern oncolog...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.02.020
更新日期:2014-05-01 00:00:00
abstract::We studied local autoimmune reactions in rat sciatic nerve after two successive injuries at the same site. The behavioral consequences of these injuries were also examined. We found that repetitive injuries had a moderately adverse effect on function and were accompanied by local autoimmune reactions. A causal relatio...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90200-6
更新日期:1985-05-01 00:00:00
abstract::Spinal ischemia is a frequent cause of paralysis. Here we explore the biological basis of ischemic preconditioning (IPC), the phenomenon in which a brief period of ischemia can confer protection against subsequent longer and normally injurious ischemia, to identify mediators of endogenous neuroprotection. Using microa...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2003.09.007
更新日期:2004-01-01 00:00:00
abstract::Contusive spinal cord injury (SCI) results in the formation of a chronic lesion cavity surrounded by a rim of spared fibers. Tissue bridges containing axons extend from the spared rim into the cavity dividing it into chambers. Whether descending axons can grow into these trabeculae or whether fibers within the trabecu...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2001.7734
更新日期:2001-09-01 00:00:00
abstract::The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90156-2
更新日期:1988-02-01 00:00:00
abstract::Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7101
更新日期:1999-07-01 00:00:00