Abstract:
:The members of the tenascin family are involved in a number of developmental processes, mainly by their ability to regulate cell adhesion. We have here studied the distribution of mRNAs for tenascin-X, -C, and -R and the closely related molecule tenascin/J1 in the olfactory system and spinal cord. The olfactory bulb and nasal mucosa were studied during late embryonic and early postnatal development as well as in the adult. The spinal cord was studied during late embryonic development and after mechanical lesions. In the normal rat, the spinal cord and olfactory bulb displayed similar patterns of tenascin expression. Tenascin-C, tenascin-R, and tenascin/J1 were all expressed in the olfactory bulb and spinal cord during development, while tenascin/J1 was the only extensively expressed tenascin molecule in the adult. In both regions tenascin/J1 was expressed in both nonneuronal and neuronal cells. After a spinal cord lesion, mRNAs for tenascin-C, -X, -R, and/J1 were all upregulated and had their own specific spatial and temporal expression patterns. Thus, even if axonal outgrowth occurs to some extent both in the adult rat primary olfactory system and in spinal cord scar tissue after lesion, the tenascin expression patterns in these two situations are totally different.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Deckner M,Lindholm T,Cullheim S,Risling Mdoi
10.1006/exnr.2000.7543keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
350-62issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(00)97543-5journal_volume
166pub_type
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