Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's disease.

abstract：:Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male...

journal_title：Experimental neurology

authors： Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

更新日期：2021-01-01 00:00:00

abstract：:The aim of the present study is to determine whether the expansion and mobilization of circulating bone marrow (BM) stem cells by in vivo treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) increase the amount of BM-derived neuronal cells in mouse brain. The presence of BM-derived c...

journal_title：Experimental neurology

authors： Corti S,Locatelli F,Strazzer S,Salani S,Del Bo R,Soligo D,Bossolasco P,Bresolin N,Scarlato G,Comi GP

更新日期：2002-10-01 00:00:00

abstract：:Various limbic system structures have been implicated in processing noxious information. One such structure is the anterior cingulate cortex (ACC), a region that is thought to modulate higher order processing of noxious input related to the affective/motivational component of pain. The present experiment examined the ...

journal_title：Experimental neurology

authors： LaGraize SC,Labuda CJ,Rutledge MA,Jackson RL,Fuchs PN

更新日期：2004-07-01 00:00:00

abstract：:The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression...

journal_title：Experimental neurology

authors： Spehlmann R,Norcross K

更新日期：1984-01-01 00:00:00

abstract：:Estrogens and N-methyl-D-aspartate (NMDA) receptors regulate multiple aspects of morphological and functional plasticity in young animals. For example, estrogens increase spine density in the hippocampus, and NMDA antagonists block these effects. Few studies have examined the effects of age, postovariectomy interval, ...

journal_title：Experimental neurology

authors： Adams MM,Oung T,Morrison JH,Gore AC

更新日期：2001-08-01 00:00:00

abstract：:Animal models treated with agricultural chemicals, such as rotenone, reproduce several degenerative features of human central nervous system (CNS) diseases. Glutamate is the most abundant excitatory amino acid transmitter in the mammalian central nervous system and its transmission is implicated in a variety of brain ...

journal_title：Experimental neurology

authors： Moussa CE,Rusnak M,Hailu A,Sidhu A,Fricke ST

更新日期：2008-01-01 00:00:00

abstract：:A cerebrospinal fluid (CSF) to brain exchange has been postulated for lipid-soluble and small molecular substances and has led to nearly 100 attempts per year to produce central effects via intrathecal injections. With few exceptions, however, modern neurological practice has avoided this approach because of its demon...

journal_title：Experimental neurology

authors： Aird RB

更新日期：1984-11-01 00:00:00

abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

journal_title：Experimental neurology

authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

更新日期：2006-03-01 00:00:00

abstract：:The effects of D-Ala2-Met5-enkephalinamide (DAME) upon the hissing component of hypothalamically elicited affective defense behavior in the cat were examined in this study. Microinjections of DAME placed into the nucleus accumbens significantly suppressed this response in a dose and time dependent manner. This dose de...

journal_title：Experimental neurology

authors： Brutus M,Zuabi S,Siegel A

更新日期：1989-04-01 00:00:00

abstract：:The chorda tympani (CT) nerve carries taste information from the anterior tongue to the brain stem. Injury to the chorda tympani may result in loss or distortion of taste information. This study examined changes occurring in the hamster peripheral taste system during recovery from injury. The hamster chorda tympani ne...

journal_title：Experimental neurology

authors： Cain P,Frank ME,Barry MA

更新日期：1996-10-01 00:00:00

abstract：:Oxaliplatin (OXA) is the common and extremely potent anti-advanced colorectal cancer chemotherapeutic. Accumulating evidence reveals that OXA evokes mechanical and cold hypersensitivity. However, the mechanism underlying these bothersome and dose-limiting adverse effects is poorly understood. It is well known that cyc...

journal_title：Experimental neurology

authors： Jiang SP,Zhang ZD,Kang LM,Wang QH,Zhang L,Chen HP

更新日期：2016-01-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic nucleus (STN) show both excitatory and inhibitory effects on the neural elements surrounding the electrode. Given these observations, the mechanism underlying the therapeutic effect of STN DBS on parkinsonian motor signs remains u...

journal_title：Experimental neurology

authors： Hahn PJ,Russo GS,Hashimoto T,Miocinovic S,Xu W,McIntyre CC,Vitek JL

更新日期：2008-05-01 00:00:00

abstract：:With the consideration of the multifactorial etiology of diabetic peripheral neuropathy, an ideal drug or drug combination should target at least several key pathogenetic mechanisms. The flavonoid baicalein (5,6,7-trihydroxyflavone) has been reported to counteract sorbitol accumulation, activation of 12/15-lipoxygenas...

journal_title：Experimental neurology

authors： Stavniichuk R,Drel VR,Shevalye H,Maksimchyk Y,Kuchmerovska TM,Nadler JL,Obrosova IG

更新日期：2011-07-01 00:00:00

abstract：:Pericytes are a major component of cerebrovasculature playing a key role in maintaining cerebrovascular homeostasis. These cells have also been suggested to regulate brain metabolism of amyloid-β (Aβ), disturbances of which are believed to contribute to the pathogenesis of Alzheimer's disease (AD). To examine the effe...

journal_title：Experimental neurology

authors： Tachibana M,Yamazaki Y,Liu CC,Bu G,Kanekiyo T

更新日期：2018-02-01 00:00:00

abstract：:Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

journal_title：Experimental neurology

authors： Han PJ,Shukla S,Subramanian PS,Hoffman PN

更新日期：2004-10-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:Polymerized collagen rolls enclosing Schwann cells (SCs) raised in culture were grafted into cystic cavities formed after lesioning the thoracic spinal cord of adult rats. Axons were already present within the graft by 14 days after implantation and both ensheathed and myelinated axons were numerous by 28 days. This a...

journal_title：Experimental neurology

authors： Paino CL,Bunge MB

更新日期：1991-11-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Cognitive impairment in humans with Alzheimer's disease (AD) and in animal models of Aβ-pathology can be ameliorated by treatments with the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARγ) agonists, such as rosiglitazone (RSG). Previously, we demonstrated that in the Tg2576 animal mo...

journal_title：Experimental neurology

authors： Hsu WJ,Wildburger NC,Haidacher SJ,Nenov MN,Folorunso O,Singh AK,Chesson BC,Franklin WF,Cortez I,Sadygov RG,Dineley KT,Rudra JS,Taglialatela G,Lichti CF,Denner L,Laezza F

更新日期：2017-09-01 00:00:00

abstract：:Accumulating evidence shows alterations in the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in ALS patients and in animal models of disease, mainly by endothelial cell (EC) damage. Repair of the altered barrier in the CNS by replacement of ECs via cell transplantation may be a new therapeutic approac...

journal_title：Experimental neurology

authors： Garbuzova-Davis S,Haller E,Navarro S,Besong TE,Boccio KJ,Hailu S,Khatib M,Sanberg PR,Appel SH,Borlongan CV

更新日期：2018-12-01 00:00:00

abstract：:Organotypic cultures of the brain provide a unique opportunity to directly examine the regional vulnerability of specific brain regions like the hippocampus. Two well-characterized models of oxidative stress were used to examine the regional vulnerability of the hippocampus. Endogenous oxidative stress was induced by ...

journal_title：Experimental neurology

authors： Vornov JJ,Park J,Thomas AG

更新日期：1998-01-01 00:00:00

abstract：:Stimulation of peripheral nerves activates corresponding regions in sensorimotor cortex. We have applied functional magnetic resonance imaging (fMRI) techniques to monitor activated brain regions by means of measuring changes of blood oxygenation level-dependent contrast during electric stimulation of the forepaw, hin...

journal_title：Experimental neurology

authors： Spenger C,Josephson A,Klason T,Hoehn M,Schwindt W,Ingvar M,Olson L

更新日期：2000-12-01 00:00:00

abstract：:The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala...

journal_title：Experimental neurology

authors： Stanford SC,Jefferys JG

更新日期：1985-10-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Recently it has been shown that there is impaired cerebral endothelial function in many chronic neurodegenerative disorders including Alzheimer's and Huntington's disease. Such problems have also been reported in Parkinson's disease, in which α-synuclein aggregation is the pathological hallmark. However, little is kno...

journal_title：Experimental neurology

authors： Kuan WL,Bennett N,He X,Skepper JN,Martynyuk N,Wijeyekoon R,Moghe PV,Williams-Gray CH,Barker RA

更新日期：2016-11-01 00:00:00

abstract：:The present study was carried out to investigate whether estrogen modulates the drinking response induced by activation of angiotensinergic neural pathways from the subfornical organ (SFO) to the median preoptic nucleus (MnPO). Microinjection of angiotensin II (ANG II, 10(-10) M, 0.2 microl) into the SFO elicited drin...

journal_title：Experimental neurology

authors： Tanaka J,Miyakubo H,Fujisawa S,Nomura M

更新日期：2003-01-01 00:00:00

abstract：:After injury of their axons, damaged neurons shift their metabolic activity into a reparative mode aimed at survival and regeneration or, alternatively, they undergo degeneration and die. Previous reports have shown that at the initial stages of the response to axonal injury, polyamines are essential for neuronal surv...

journal_title：Experimental neurology

authors： Dornay M,Gilad VH,Shiler I,Gilad GM

更新日期：1986-06-01 00:00:00

abstract：:The distribution and relative intrafascicular contribution of myelin fibers derived from spinal segments L-4 to L-6 were analyzed in adult rat sciatic nerve and its main branches, using 200-kDa neurofilament subunit immunodetection in previously injured nerve sections in the L-4 or L-5 spinal branch or both. These bra...

journal_title：Experimental neurology

authors： Montoya G JV,Ariza J,Sutachán JJ,Hurtado H

更新日期：2002-02-01 00:00:00

abstract：:The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), as a marker for myelinogenesis, was measured in different parts of the nervous system of dilute-lethal mutant mice (d1/d1). The activity in terms of micromoles of 2'-AMP formed per milligram of protein of homogenate per minute was found to be exceed...

journal_title：Experimental neurology

authors： Noguchi T,Sugisaki T,Tsukada Y

更新日期：1983-01-01 00:00:00