Abstract：
:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the cochlear blood vessels. The innervation of the cochlea from the trigeminal ganglion may provide the basis of an alternative mechanism for Ménière's syndrome (imbalance, hearing loss, tinnitus, and a sensation of fullness in the ear) for which a central neural basis has been speculated. Innervation patterns of sensory nerves from the trigeminal ganglion to the cochlear blood vessels were studied using retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP). Healthy and hydropic guinea pigs were unilaterally implanted with an osmotic pump and a cannula for cochlear delivery of 2% WGA-HRP or vehicle alone. In other guinea pigs the cochlea was pretreated with 100 micromol capsaicin before administering 2% WGA-HRP. Histological sections of the ipsi- and contralateral trigeminal ganglia were obtained 48 h after WGA-HRP infusion. In the hydropic guinea pig, the number of labeled nerve cell bodies observed in the anteriomedial portion of the trigeminal ganglion at the origin of the ophthalmic nerve was reduced by 70% relative to normal animals. Capsaicin pretreatment nearly eliminated the labeled sensory fibers as expected. These data indicate that the trigeminal innervation to the cochlea could be involved in inner ear homeostatic disturbances, including the hydrops that is symptomatic of Ménière's disease.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Vass Z,Shore SE,Nuttall AL,Miller JMdoi
10.1006/exnr.1998.6813subject
Has Abstractpub_date
1998-06-01 00:00:00pages
241-8issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(98)96813-3journal_volume
151pub_type
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journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2009.12.023
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2018.06.009
更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0014-4886(83)90251-0
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pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.11.018
更新日期：2009-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90029-r
更新日期：1990-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90051-7
更新日期：1984-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.03.005
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7826
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1983-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90174-x
更新日期：1989-07-01 00:00:00
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doi：10.1006/exnr.2001.7667
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