Levodopa induction of Fos immunoreactivity in rat brain following partial and complete lesions of the substantia nigra.

abstract：:Here, we describe a bilateral cervical contusion model for mice. Adult female mice received graded bilateral contusion injuries at cervical level 5 (C5) using a commercially available impactor (the IH device). Three separate experiments were carried out to define conditions that produce impairments in forelimb functio...

journal_title：Experimental neurology

authors： Aguilar RM,Steward O

更新日期：2010-01-01 00:00:00

abstract：:The response of the developing brain to traumatic injury is different from the response of the mature, adult brain. There are critical developmental trajectories in the young brain, whereby injury can lead to long term functional abnormalities. Emerging preclinical and clinical literature supports the presence of sign...

journal_title：Experimental neurology

authors： Arambula SE,Reinl EL,El Demerdash N,McCarthy MM,Robertson CL

更新日期：2019-07-01 00:00:00

abstract：:The development of the corpus callosum (CC) was examined in BALB/cCF mice in relation to the effects of a 32-h period of maternal fasting. The treatment was imposed on days 15 and 16 during gestation, which immediately precedes the time when the initial callosal axons cross the midline. The BALB/c strain was used beca...

journal_title：Experimental neurology

authors： Wainwright P,Gagnon M

更新日期：1984-07-01 00:00:00

abstract：:NMDA receptors in postmortem human spinal cord were analyzed using [3H]MK-801 ligand binding and immunoblotting with NMDA receptor subunit-specific antibodies. The average KD for [3H]MK-801 binding was 1.77 nM with a Bmax of 0.103 pmol/mg. The EC50 for stimulation of -3H-MK-801 binding with L-glutamate was 0.34 microM...

journal_title：Experimental neurology

authors： Sundström E,Whittemore S,Mo LL,Seiger A

更新日期：1997-12-01 00:00:00

abstract：:Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with progressive pathology involving the loss of midbrain dopaminergic neurons. Neurotrophic factors are promising for PD gene therapy; they are integrally involved in the development of the nigrostriatal system. Cerebral dopamine neurotrophic ...

journal_title：Experimental neurology

authors： Ren X,Zhang T,Gong X,Hu G,Ding W,Wang X

更新日期：2013-10-01 00:00:00

abstract：:Huntington's disease (HD) is an autosomal dominant neurodegenerative disease associated with a CAG trinucleotide repeat expansion in a large gene on chromosome 4. The gene encodes the protein huntingtin with a polyglutamine tract encoded by the CAG repeat at the N-terminus. The number of CAG repeats in HD are signific...

journal_title：Experimental neurology

authors： Singhrao SK,Thomas P,Wood JD,MacMillan JC,Neal JW,Harper PS,Jones AL

更新日期：1998-04-01 00:00:00

abstract：:Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these two events have not bee...

journal_title：Experimental neurology

authors： Wigerblad G,Huie JR,Yin HZ,Leinders M,Pritchard RA,Koehrn FJ,Xiao WH,Bennett GJ,Huganir RL,Ferguson AR,Weiss JH,Svensson CI,Sorkin LS

更新日期：2017-07-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:A previous study of our group demonstrated that movement performance induced by dopamine agonist drugs in hemiparkinsonian rats unilaterally lesioned with 6-hydroxydopamine (6-OHDA), governs the occurrence of a sensitized motor response to a subsequent dopaminergic challenge (priming model). In the present study, we e...

journal_title：Experimental neurology

authors： Frau L,Morelli M,Simola N

更新日期：2013-09-01 00:00:00

abstract：:Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...

journal_title：Experimental neurology

authors： Chen CC,Litvak V,Gilbertson T,Kühn A,Lu CS,Lee ST,Tsai CH,Tisch S,Limousin P,Hariz M,Brown P

更新日期：2007-05-01 00:00:00

abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...

journal_title：Experimental neurology

authors： Pajenda G,Hercher D,Márton G,Pajer K,Feichtinger GA,Maléth J,Redl H,Nógrádi A

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...

journal_title：Experimental neurology

authors： Wu D,Lai N,Deng R,Liang T,Pan P,Yuan G,Li X,Li H,Shen H,Wang Z,Chen G

更新日期：2020-10-01 00:00:00

abstract：:Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...

journal_title：Experimental neurology

authors： Ladewig G,Jestaedt L,Misselwitz B,Solymosi L,Toyka K,Bendszus M,Stoll G

更新日期：2009-11-01 00:00:00

abstract：:Pituitary adenylate cyclase activating polypeptide (PACAP) has neuroprotective effects against ischemia, even when given by intravenous (iv) administration 24 h after stroke. Transport of PACAP across the blood-brain barrier (BBB) by peptide transport system (PTS)-6 underlies its effectiveness after iv administration....

journal_title：Experimental neurology

authors： Nonaka N,Shioda S,Banks WA

更新日期：2005-01-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Dementia and parkinsonism are late-onset symptoms associated with repetitive head injury, as documented in multiple contact-sport athletes. Clinical symptomatology is the likely phenotype of chronic degeneration and circuit disruption in the substantia nigra (SN). To investigate the initiating neuropathology, we hypot...

journal_title：Experimental neurology

authors： van Bregt DR,Thomas TC,Hinzman JM,Cao T,Liu M,Bing G,Gerhardt GA,Pauly JR,Lifshitz J

更新日期：2012-03-01 00:00:00

abstract：:Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke mod...

journal_title：Experimental neurology

authors： Song S,Kamath S,Mosquera D,Zigova T,Sanberg P,Vesely DL,Sanchez-Ramos J

更新日期：2004-01-01 00:00:00

abstract：:Synthesis of leukemia inhibitory factor (LIF) is increased in lesioned peripheral nerves and it is thought that this may cause increased expression of galanin (GAL) in axotomized dorsal root ganglia (DRG) neurons and also to promote axonal regeneration. We therefore compared effects of LIF and nerve growth factor (NGF...

journal_title：Experimental neurology

authors： Oztürk G,Tonge DA

更新日期：2001-06-01 00:00:00

abstract：:Secondary degeneration is a form of 'bystander' damage that can affect neural tissue both nearby and remote from an initial injury. Partial optic nerve transection is an excellent model in which to unequivocally differentiate events occurring during secondary degeneration from those resulting from primary CNS injury. ...

journal_title：Experimental neurology

authors： Fitzgerald M,Bartlett CA,Evill L,Rodger J,Harvey AR,Dunlop SA

更新日期：2009-03-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Idiopathic inflammatory myopathies (IIMs), comprising of polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by muscle weakness and various types of inflammatory changes in muscle cells. They also show non-inflammatory changes, including perifascicular atrophy, mitochondrial changes, and amyl...

journal_title：Experimental neurology

authors： Nozaki K,Das A,Ray SK,Banik NL

更新日期：2010-10-01 00:00:00

abstract：:Stroke is a devastating neurological disease with no satisfactory therapies to preserve long-term neurological function, perhaps due to the sole emphasis on neuronal survival in most preclinical studies. Recent studies have revealed the importance of protecting multiple cell types in the injured brain, such as oligode...

journal_title：Experimental neurology

authors： Zhang W,Wang H,Zhang H,Leak RK,Shi Y,Hu X,Gao Y,Chen J

更新日期：2015-10-01 00:00:00

abstract：:Frequency information of the environment is an important feature for sensory perception. It has been demonstrated that cortical and thalamic neurons exhibited frequency-specific responses to peripheral stimulation. In the present study, we investigated the effects of 1-100 Hz peripheral electrical stimulations on vari...

journal_title：Experimental neurology

authors： Yang H,Chang JY,Woodward DJ,Baccalá LA,Han JS,Luo F

更新日期：2005-11-01 00:00:00

abstract：:In what ways do passive touch and active touch require particular properties of cortical physiology? Because it is not easy to make predictions "bottom up" from neurophysiology and anatomy to behavior, there have been surprises in studying behavioral deficits following selective ablations of SI versus SII. For example...

journal_title：Experimental neurology

authors： Glassman RB

更新日期：1994-01-01 00:00:00

abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...

journal_title：Experimental neurology

authors： Hatcher JM,Richardson JR,Guillot TS,McCormack AL,Di Monte DA,Jones DP,Pennell KD,Miller GW

更新日期：2007-04-01 00:00:00

abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

journal_title：Experimental neurology

authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

更新日期：1991-08-01 00:00:00

abstract：:Primary spinal cord trauma can initiate a cascade of pathophysiologic events which markedly contribute to the expansion and amplification of the primary insult. The detailed mechanisms of these secondary neurochemical reactions are largely unknown; however, they involve membrane lipid derangements with the release of ...

journal_title：Experimental neurology

authors： Toborek M,Garrido R,Malecki A,Kaiser S,Mattson MP,Hennig B,Young B

更新日期：2000-02-01 00:00:00

abstract：:An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as poor cognition, impai...

journal_title：Experimental neurology

authors： Fortress AM,Avcu P,Wagner AK,Dixon CE,Pang KCH

更新日期：2019-05-01 00:00:00

abstract：:Methylmalonic acidemia is an inherited metabolic disorder that leads to brain damage associated to the accumulation of methylmalonic acid (MMA) and impairment of energy metabolism. We demonstrate here that treatment with diazoxide, an agonist of mitochondrial ATP-sensitive K(+) channels (mitoK(ATP)), can prevent death...

journal_title：Experimental neurology

authors： Kowaltowski AJ,Maciel EN,Fornazari M,Castilho RF

更新日期：2006-09-01 00:00:00

abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

journal_title：Experimental neurology

authors： Sugimoto H,Monafo WW,Shimazaki S

更新日期：1987-08-01 00:00:00