Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats.

abstract：:The aim of this study was to elucidate whether oligodendrocytes die in fiber tracts that are spared by a spinal cord injury but are in close vicinity of inflammatory cells. Adult rat spinal cords were studied histologically 1 day to 2 weeks after a contusion lesion that left the ventral white matter largely intact. Ma...

journal_title：Experimental neurology

authors： Frei E,Klusman I,Schnell L,Schwab ME

更新日期：2000-06-01 00:00:00

abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...

journal_title：Experimental neurology

authors： Shen PJ,Gundlach AL

更新日期：1999-12-01 00:00:00

abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

journal_title：Experimental neurology

authors： Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:Mice lacking the gene encoding for substance P and neurokinin A, or the NK-1 receptor, exhibit alterations in behavior to various acute nociceptive stimuli. However, behavioral responses of NK-1 mutant animals have not been well characterized in models of chronic pain. We studied the behavioral responses of NK-1 knock...

journal_title：Experimental neurology

authors： Mansikka H,Sheth RN,DeVries C,Lee H,Winchurch R,Raja SN

更新日期：2000-04-01 00:00:00

abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

journal_title：Experimental neurology

authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

更新日期：2020-09-01 00:00:00

abstract：:The vibrissae of rats were shaved from one side of the face daily for 10 days. To see whether or not this treatment had an effect on crossed and uncrossed striatal afferent connections from the midbrain, the tract tracer horseradish peroxidase was applied to the caudate-putamen on day 11. When the tracer was deposited...

journal_title：Experimental neurology

authors： Huston JP,Morgan S,Lange KW,Steiner H

更新日期：1986-08-01 00:00:00

abstract：:We have analyzed a mouse model of Charcot-Marie-Tooth disease 2E (CMT2E) harboring a heterozygous p.Asn98Ser (p.N98S) Nefl mutation, whose human counterpart results in a severe, early-onset neuropathy. Behavioral, electrophysiological, and pathological analyses were done on separate cohorts of NeflN98S/+ mutant mice a...

journal_title：Experimental neurology

authors： Lancaster E,Li J,Hanania T,Liem R,Scheideler MA,Scherer SS

更新日期：2018-10-01 00:00:00

abstract：:Five subjects matched the force of a sustained isometric contraction with a contraction of the contralateral muscle. Estimates of the sustained constant forces increased with time despite the direction to disregard the increased effort associated with the fatiguing contraction. These instructions did not produce a not...

journal_title：Experimental neurology

authors： Jones LA

更新日期：1983-08-01 00:00:00

abstract：:It has been reported that the severe cerebral edema produced in experimental animals by Clostridium perfringens (Cl p) type D epsilon toxin can be prevented by prior treatment with its precursor prototoxin due to competitive binding to endothelial cells (ECs) at the blood-brain barrier (BBB). In this study we investig...

journal_title：Experimental neurology

authors： Zhu C,Ghabriel MN,Blumbergs PC,Reilly PL,Manavis J,Youssef J,Hatami S,Finnie JW

更新日期：2001-05-01 00:00:00

abstract：:Although transgenic expression of oncogenes typically leads to tumorigenesis, oncogene expression directed to the rod photoreceptors leads to cell death without tumor formation. To evaluate the cellular and functional changes induced in cone photoreceptors by an oncogene, the Mas1 protooncogene was targeted to the con...

journal_title：Experimental neurology

authors： Xu X,Quiambao AB,Roveri L,Pardue MT,Marx JL,Röhlich P,Peachey NS,Al-Ubaidi MR

更新日期：2000-05-01 00:00:00

abstract：:We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month...

journal_title：Experimental neurology

authors： Morelli E,Ghiglieri V,Pendolino V,Bagetta V,Pignataro A,Fejtova A,Costa C,Ammassari-Teule M,Gundelfinger ED,Picconi B,Calabresi P

更新日期：2014-11-01 00:00:00

abstract：:Cordotomy-denervation interactions were studied on contractile and myofibrillar properties of slow (soleus) and fast (extensor digitorum longus) muscles of the rat. The spinal cord was transected midthoracically in neonatal (2-day-old) animals. Two months after birth, a unilateral transection of the sciatic nerve was ...

journal_title：Experimental neurology

authors： Midrio M,Danieli Betto D,Betto R,Noventa D,Antico F

更新日期：1988-04-01 00:00:00

abstract：:Intranuclear inclusion bodies are a shared pathological feature of Huntington's disease (HD) and its transgenic mouse model. Using a panel of antibodies spanning the entire huntingtin molecule, we have investigated the pattern of immunoreactivity within the intranuclear inclusions in the frontal cortex and striatum of...

journal_title：Experimental neurology

authors： Sieradzan KA,Mechan AO,Jones L,Wanker EE,Nukina N,Mann DM

更新日期：1999-03-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:In previous studies on sensory axons we reported that the effect of a conditioning lesion on increasing regeneration rate was enhanced if the two lesions were superimposed, rather than made at separate sites on the nerve, and proposed that this was due to the growth of axons through nerve predegenerated by the conditi...

journal_title：Experimental neurology

authors： Bisby MA

更新日期：1985-11-01 00:00:00

abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...

journal_title：Experimental neurology

authors： Dinopoulos A,Dori I,Davies SW,Parnavelas JG

更新日期：1989-07-01 00:00:00

abstract：:We recently revealed a unique glycan on the Fc domain of IgG antibodies in ALS patients that mediates antibody-dependent cell cytotoxicity (ADCC). This glycan has a bi-antennary structure that lacks the core fucose and sialic acid residues but contains a bisecting GlcNAc (A2BG2). Little is known, however, about the in...

journal_title：Experimental neurology

authors： Edri-Brami M,Sharoni H,Hayoun D,Skutelsky L,Nemirovsky A,Porgador A,Lichtenstein RG

更新日期：2015-05-01 00:00:00

abstract：:Myelinated axons efficiently transmit information over long distances. The apposed myelin sheath confers favorable electrical properties, but restricts access of the axon to its extracellular milieu. Therefore, axonal metabolic support may require specific axo-myelinic communication. Here we explored activity-dependen...

journal_title：Experimental neurology

authors： Micu I,Plemel JR,Lachance C,Proft J,Jansen AJ,Cummins K,van Minnen J,Stys PK

更新日期：2016-02-01 00:00:00

abstract：:At the age of 31 days, Long-Evans female rats received electrolytic lesions either of the medial fimbria (N = 24), of the dorsal subcallosal fornix (N = 24), or of both structures (N = 24). Ten rats were used as sham-operated controls. Ten days later, half the rats of each lesion group received intrahippocampal grafts...

journal_title：Experimental neurology

authors： Cassel JC,Kelche C,Will BE

更新日期：1987-09-01 00:00:00

abstract：:Clinical studies have provided evidence that the progression of HIV-1-associated neurocognitive disorders (HAND) involves alterations in dopamine (DA) systems. Drugs of abuse that act on the brain DA system, such as cocaine (Coc), may exacerbate HIV-1 infection and consequent behavioral and neurological manifestations...

journal_title：Experimental neurology

authors： Moran LM,Booze RM,Webb KM,Mactutus CF

更新日期：2013-01-01 00:00:00

abstract：:The effects of unilateral intrahippocampal injection of kainic acid, a potent neuroexcitant and neurotoxin, on subsequent susceptibility to kindling of the contralateral hippocampus or contralateral amygdala were investigated in albino rats. At the chosen doses (0.20 to 1.25 micrograms dissolved in physiologic saline)...

journal_title：Experimental neurology

authors： Feldblum S,Ackermann RF

更新日期：1987-08-01 00:00:00

abstract：:The blood-central nervous system-barrier (B-CNS-B) is widely considered a significant impediment to the use of protein neurotrophic factors for the treatment of brain diseases and disorders. In this study, we tested the hypothesis that systemic administration of insulin-like growth factor I (IGF-I) can ameliorate func...

journal_title：Experimental neurology

authors： Pulford BE,Whalen LR,Ishii DN

更新日期：1999-09-01 00:00:00

abstract：:The role of central noradrenergic neurons in kindled seizures was assessed by comparison of alpha 2- and beta-adrenoceptor binding in the cerebral cortex from kindled and control rats. To minimize handling, which may modify kindling-induced changes in binding, the kindling protocol involved stimulation of the amygdala...

journal_title：Experimental neurology

authors： Stanford SC,Jefferys JG

更新日期：1985-10-01 00:00:00

abstract：:The vanilloid receptor TRPV(1) is a key nociceptive molecule located in primary afferent nociceptive neurons in dorsal root ganglia (DRG) for initiating neurogenic inflammation and pain. Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activati...

journal_title：Experimental neurology

authors： Xu X,Wang P,Zou X,Li D,Fang L,Gong K,Lin Q

更新日期：2010-03-01 00:00:00

abstract：:Electromyograms from the flexor and extensor muscles of normal human elbows were simultaneously recorded during maximal-effort isokinetic movement at 15 degrees/s over the joint's full range of motion. The antagonist electromyogram was normalized with respect to its electromyogram when acting as agonist at maximal eff...

journal_title：Experimental neurology

authors： Solomonow M,Baratta R,Zhou BH,D'Ambrosia R

更新日期：1988-06-01 00:00:00

abstract：:Previous studies have shown that the herpes simplex virus type 2 protein kinase ICP10 PK activates the Ras/MEK/MAPK pathway in nonneuronal cells. Here we report that ectopically expressed ICP10 PK has anti-apoptotic activity in various paradigms of neuronal cell death. Neuronally differentiated PC12 cells and primary ...

journal_title：Experimental neurology

authors： Perkins D,Yu Y,Bambrick LL,Yarowsky PJ,Aurelian L

更新日期：2002-03-01 00:00:00

abstract：:Amphetamine derivatives are the most commonly abused drugs. These compounds have been known for many years to induce neurotoxicity. However, recent findings have highlighted novel alterations produced by amphetamines in the central nervous system consisting of neuronal inclusions and the involvement of proteins belong...

journal_title：Experimental neurology

authors： Iacovelli L,Fulceri F,De Blasi A,Nicoletti F,Ruggieri S,Fornai F

更新日期：2006-09-01 00:00:00

abstract：:The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression...

journal_title：Experimental neurology

authors： Spehlmann R,Norcross K

更新日期：1984-01-01 00:00:00

abstract：:A sample of 504 single neurons isolated in three curvilinear arrays of 10 closely spaced tracks in primary somatosensory and in pericruciate sensorimotor cortex was studied in two awake, restrained domestic cats. Modality sensitivity and receptive field size and location were assessed for each neuron, along with respo...

journal_title：Experimental neurology

authors： Slimp JC,Towe AL

更新日期：1990-01-01 00:00:00

abstract：:Graft-induced dyskinesia has emerged as a problematic side effect after transplantation of fetal dopamine cells into the striatum of patients with Parkinson's disease. These adverse effects of dystonic and choreatiform hyperkinesias that persisted even after withdrawal of L-DOPA medication are not yet fully understood...

journal_title：Experimental neurology

authors： García J,Carlsson T,Döbrössy M,Nikkhah G,Winkler C

更新日期：2011-12-01 00:00:00