Effects of leukemia inhibitory factor on galanin expression and on axonal growth in adult dorsal root ganglion neurons in vitro.

abstract：:Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiolo...

journal_title：Experimental neurology

authors： Liu L,Xu H,Jiang H,Wang J,Song N,Xie J

更新日期：2010-03-01 00:00:00

abstract：:This study describes the short-term effects of intracaudate microinjections of carbachol in temporarily isolated and restrained Java monkeys. The monkeys were found to display a series of motor disturbances including blepharoptosis, facial twitches, tongue protrusions, ear flattening, torticollis, and compulsive alter...

journal_title：Experimental neurology

authors： Vrijmoed-de Vries MC,Cools AR

更新日期：1985-01-01 00:00:00

abstract：:This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral exte...

journal_title：Experimental neurology

authors： Biran V,Joly LM,Héron A,Vernet A,Véga C,Mariani J,Renolleau S,Charriaut-Marlangue C

更新日期：2006-05-01 00:00:00

abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...

journal_title：Experimental neurology

authors： Zhang J,Groff RF 4th,Chen XH,Browne KD,Huang J,Schwartz ED,Meaney DF,Johnson VE,Stein SC,Rojkjaer R,Smith DH

更新日期：2008-04-01 00:00:00

abstract：:Adenoviral-mediated gene transfer to the caudate nucleus of Macaca mulatta was accomplished using stereotactic injection of two distinct recombinant Ad5 vectors containing the gene for Escherichia coli beta-galactosidase and the cDNA for rat hypoxanthine-guanine phosphoribosylphosphotransferase (HPRT), respectively. M...

journal_title：Experimental neurology

authors： Davidson BL,Doran SE,Shewach DS,Latta JM,Hartman JW,Roessler BJ

更新日期：1994-02-01 00:00:00

abstract：:Grafts of embryonic ventral mesencephalic tissue placed in the striatum of 6-hydroxydopamine-lesioned rats survive, and make and receive connections to and from the host brain. The dopaminergic neurons of the graft can grow processes into the host brain, and thereby alleviate many of the behavioral deficits of this fo...

journal_title：Experimental neurology

authors： Barker RA,Dunnett SB,Faissner A,Fawcett JW

更新日期：1996-09-01 00:00:00

abstract：:The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

journal_title：Experimental neurology

authors： Hall ED,Oostveen JA,Dunn E,Carter DB

更新日期：1995-09-01 00:00:00

abstract：:In the human embryo, from approximately 6 weeks gestational age (GA), dopaminergic (DA) neurons can be found in the ventral mesencephalon (VM). More specifically, the post-mitotic neurons are located in the ventral part of the tegmentum (VT), whereas no mature DA neurons are found in the neighboring dorsal part. We us...

journal_title：Experimental neurology

authors： Jørgensen JR,Juliusson B,Henriksen KF,Hansen C,Knudsen S,Petersen TN,Blom N,Seiger A,Wahlberg LU

更新日期：2006-04-01 00:00:00

abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

journal_title：Experimental neurology

authors： Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

更新日期：2003-12-01 00:00:00

abstract：:Volume-regulated anion channels (VRACs) are critically involved in regulating cell volume, and leucine-rich repeat-containing protein 8A (LRRC8A, SWELL1) is an obligatory subunit of VRACs. Cell swelling occurs early after brain ischemia, but it is unclear whether neuronal LRRC8a contributes to ischemia-induced glutama...

journal_title：Experimental neurology

authors： Zhou JJ,Luo Y,Chen SR,Shao JY,Sah R,Pan HL

更新日期：2020-10-01 00:00:00

abstract：:Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

journal_title：Experimental neurology

authors： Kobylecki C,Crossman AR,Ravenscroft P

更新日期：2013-09-01 00:00:00

abstract：:In 3-, 9-, 24-, and 30-month-old male rats (Fischer 344), the nuclear perimeter and the density and diameter of nuclear pore complexes in the granule cells of the dentate fascia were studied. Whereas the nuclear perimeter and the diameter of nuclear pore complexes did not change as a function of age, there was a signi...

journal_title：Experimental neurology

authors： Fifková E,Tonks M,Cullen-Dockstader K

更新日期：1987-03-01 00:00:00

abstract：:Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the...

journal_title：Experimental neurology

authors： De Riu PL,Russo A,Pellitteri R,Stanzani S,Tringali G,Roccazzello AM,De Riu G,Marongiu P,Mameli O

更新日期：2008-09-01 00:00:00

abstract：:Ischemic stroke (IS) is one of the most common cerebrovascular diseases worldwide. The aberrant expression of BCL6 has been previously implicated in the pathogenesis of IS. Meanwhile, miR-31 is known as a target of BCL6, and has also been suggested to diminish cell damage by suppressing the PKD1 expression. Expanding ...

journal_title：Experimental neurology

authors： Wei P,Chen H,Lin B,Du T,Liu G,He J,You C

更新日期：2021-01-01 00:00:00

abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...

journal_title：Experimental neurology

authors： Mrak RE

更新日期：1983-06-01 00:00:00

abstract：:The rat model of combined central fluid percussion traumatic brain injury (TBI) and bilateral entorhinal cortical lesion (BEC) produces profound, persistent cognitive deficits, sequelae associated with human TBI. In contrast to percussive TBI alone, this combined injury induces maladaptive hippocampal plasticity. Rece...

journal_title：Experimental neurology

authors： Zhu J,Hamm RJ,Reeves TM,Povlishock JT,Phillips LL

更新日期：2000-11-01 00:00:00

abstract：:Ocular movements of alert cats were recorded by classical electronystagmography techniques during (a) vestibular stimulation (sinusoidal rotation of the cat in complete darkness), (b) optokinetic stimulation (sinusoidal rotation of the visual surroundings around the stationary cat), (c) additive visual-vestibular stim...

journal_title：Experimental neurology

authors： Godaux E,Gobert C,Halleux J

更新日期：1983-04-01 00:00:00

abstract：:Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in ...

journal_title：Experimental neurology

authors： Rosenblum LT,Shamamandri-Markandaiah S,Ghosh B,Foran E,Lepore AC,Pasinelli P,Trotti D

更新日期：2017-06-01 00:00:00

abstract：:The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, which produces Parkinsonism, is mediated by its metabolite 1-methyl-4-phenylpyridinium ion (MPP+). When injected into the striatum MPP+ is accumulated by dopaminergic nerve terminals and is then retrogradely transported to the substantia nigra compacta...

journal_title：Experimental neurology

authors： Fallon J,Matthews RT,Hyman BT,Beal MF

更新日期：1997-03-01 00:00:00

abstract：:Intracellular proteinaceous inclusions are well-documented hallmarks of the fatal motor neuron disorder amyotrophic lateral sclerosis (ALS). The pathological significance of these inclusions remains unknown. Peripherin, a type III intermediate filament protein, is upregulated in ALS and identified as a component withi...

journal_title：Experimental neurology

authors： McLean JR,Smith GA,Rocha EM,Osborn TM,Dib S,Hayes MA,Beagan JA,Brown TB,Lawson TF,Hallett PJ,Robertson J,Isacson O

更新日期：2014-11-01 00:00:00

abstract：:Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...

journal_title：Experimental neurology

authors： Brenner MJ,Tung TH,Mackinnon SE,Myckatyn TM,Hunter DA,Mohanakumar T

更新日期：2004-03-01 00:00:00

abstract：:The present experiments focused on the morphological interaction between serotonergic (5-HT) and noradrenergic (NA) axons during regeneration following partial axonal denervation in the cerebral cortex in adult rats. The denervation paradigm used employed two neurotoxins, one for 5-HT and one for NA axons, infused tog...

journal_title：Experimental neurology

authors： Liu Y,Ishida Y,Shinoda K,Nakamura S

更新日期：2003-11-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:Studies of the effects of lesions of the parietal cortex suggest that this region plays a critical role in visuomotor guidance, whereas experiments on the effects of disconnecting this region from visual input have been inconsistent in supporting this hypothesis. In the present experiment, monkeys with a unilateral oc...

journal_title：Experimental neurology

authors： Jason GW

更新日期：1983-07-01 00:00:00

abstract：:The GluN2 subunits that compose N-methyl-d-aspartate receptors (NMDARs) are attractive drug targets for therapeutic intervention in several diseases, in particular Parkinson's disease (PD). The precise roles and possible dysfunctions of NMDARs attributed to specific GluN2 subunits are however unresolved. Through the u...

journal_title：Experimental neurology

authors： Feng ZJ,Zhang X,Chergui K

更新日期：2014-05-01 00:00:00

abstract：:Opening of the mitochondrial permeability transition pore has increasingly been implicated in excitotoxic, ischemic, and apoptotic cell death, as well as in several neurodegenerative disease processes. However, much of the work directly characterizing properties of the transition pore has been performed in isolated li...

journal_title：Experimental neurology

authors： Berman SB,Watkins SC,Hastings TG

更新日期：2000-08-01 00:00:00

abstract：:In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions. These reductions likely follow regional synaptic loss or d...

journal_title：Experimental neurology

authors： Chandrasekaran K,Hatanpää K,Brady DR,Rapoport SI

更新日期：1996-11-01 00:00:00

abstract：:After optic nerve transection beta cells of cat retinal ganglion cells (RGCs) suffer from rapid cell death from 3 to 7 days, whereas alpha cells gradual cell death until 14 days. Here we report electrophysiological properties of Y- (morphological alpha) and X- (morphological beta) cells at 5 and 14 days after axotomy ...

journal_title：Experimental neurology

authors： Takao M,Miyoshi T,Watanabe M,Fukuda Y

更新日期：2002-09-01 00:00:00

abstract：:Diabetes mellitus is a common metabolic disease in human beings with characteristic symptoms of hyperglycemia, chronic inflammation and insulin resistance. One of the most common complications of early-onset diabetes mellitus is peripheral diabetic neuropathy, which is manifested either by loss of nociception or by al...

journal_title：Experimental neurology

authors： Heng LJ,Qi R,Yang RH,Xu GZ

更新日期：2015-09-01 00:00:00

abstract：:Photic entrainment of circadian rhythms in mammals is mediated through a direct retinal projection to the core region of the suprachiasmatic nucleus (SCN), the circadian clock. A proportion of this projection contains the low-affinity p75 neurotrophic receptor (p75NTR). Neonatal monosodium glutamate (MSG) treatment, w...

journal_title：Experimental neurology

authors： Beaulé C,Amir S

更新日期：2002-08-01 00:00:00