Abstract:
:In this study, the effects of testosterone propionate (TP) on recovery from facial paralysis following crush axotomy of the facial nerve in male hamsters were examined. In the first experiment, TP (5 mg/ml sesame oil; 0.1 ml) was injected subcutaneously and on alternate days in one-half of the animals subjected to crush axotomies of the facial nerve, with the second half receiving vehicle alone. An accelerative effect of TP on recovery from facial paralysis was observed near the end of the first and beginning of the second week after crush axotomy. When the dosage and frequency were doubled in the next experiment, a greater accelerative effect of TP on recovery from facial paralysis was observed. In the last experiment, castrated animals were used in order to eliminate the endogenous source of the hormone and two different modes of hormone administration, TP implants vs TP injections, were compared. The results of that experiment indicate that continuous exposure to the hormone, in the form of subcutaneous implants of 100% crystalline TP, had the most pronounced effect on acceleration of recovery from facial paralysis. In addition, no differences in the responses of the castrated, axotomized animals and the normal, axotomized animals were found. This suggests that the presence of endogenous hormone contributes little to the acceleration of functional recovery observed with TP. Finally, the time course of the accelerative effect of TP suggests that the hormone is acting primarily at the level of the facial neuron, which contains androgen receptors, and perhaps secondarily at the level of the facial muscles, which are also known to contain androgen receptors.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Kujawa KA,Kinderman NB,Jones KJdoi
10.1016/0014-4886(89)90174-xsubject
Has Abstractpub_date
1989-07-01 00:00:00pages
80-5issue
1eissn
0014-4886issn
1090-2430journal_volume
105pub_type
杂志文章abstract::Animal models treated with agricultural chemicals, such as rotenone, reproduce several degenerative features of human central nervous system (CNS) diseases. Glutamate is the most abundant excitatory amino acid transmitter in the mammalian central nervous system and its transmission is implicated in a variety of brain ...
journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1187
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 评论,杂志文章,评审
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7163
更新日期:1999-10-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90261-5
更新日期:1987-12-01 00:00:00
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journal_title:Experimental neurology
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doi:10.1016/j.expneurol.2010.10.016
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.07.015
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1086
更新日期:1994-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2018.01.016
更新日期:2018-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0198
更新日期:1996-12-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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doi:10.1006/exnr.2000.7451
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abstract::The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), as a marker for myelinogenesis, was measured in different parts of the nervous system of dilute-lethal mutant mice (d1/d1). The activity in terms of micromoles of 2'-AMP formed per milligram of protein of homogenate per minute was found to be exceed...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(83)90396-5
更新日期:1983-01-01 00:00:00
abstract::Mice lacking the gene encoding for substance P and neurokinin A, or the NK-1 receptor, exhibit alterations in behavior to various acute nociceptive stimuli. However, behavioral responses of NK-1 mutant animals have not been well characterized in models of chronic pain. We studied the behavioral responses of NK-1 knock...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7336
更新日期:2000-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90214-2
更新日期:1988-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2017.08.004
更新日期:2017-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(88)90172-0
更新日期:1988-03-01 00:00:00
abstract::As part of a wider investigation on brain structure and function in young rats with inherited hydrocephalus, this study was undertaken to develop a technique to monitor, and quantify, progressive changes in ventricle and cortical dimensions in hydrocephalic rats in vivo. Magnetic resonance images were obtained with a ...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(92)90016-j
更新日期:1992-10-01 00:00:00