Abstract：
:Overt behavioral symptoms of Parkinson's disease (PD) do not occur until over 80% of the striatal dopamine content has been lost. Diagnosis of the disorder relies on identifying clinical symptoms including akinesia, resting tremor, and rigidity. In retrospect, behavioral deficits are observed several years prior to diagnosis. Behavioral manifestations in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD, such as changes in general locomotor activity and rotorod performance, require large doses of MPTP and are often transient. We hypothesized that, as in PD, subtle behavioral changes also occur in the MPTP model. In this paper, we demonstrate that mice treated with moderate doses of the dopaminergic toxin MPTP display deficits in behavioral parameters that are significantly correlated with the loss of striatal dopamine. In addition, these behavioral measures are correlated to dopamine transporter, vesicular monoamine transporter, and tyrosine hydroxylase expression and are improved following L-DOPA administration. Detection of dopamine-modulated behavioral changes in moderately depleted MPTP mice will allow for more efficacious use of this model in PD research.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Tillerson JL,Caudle WM,Reverón ME,Miller GWdoi
10.1006/exnr.2002.8021keywords:
subject
Has Abstractpub_date
2002-11-01 00:00:00pages
80-90issue
1eissn
0014-4886issn
1090-2430pii
S0014488602980210journal_volume
178pub_type
杂志文章abstract：:The EEG of 20 Wistar rats inbred for audiogenic seizures was recorded during 40 daily auditory stimuli 90 s long. The first stimuli provoked wild running, with no cortical EEG abnormality, and then a tonic phase with a characteristic EEG of a brief flat trace 2 to 3 s long followed by low-amplitude regular activity, 1...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90290-1
更新日期：1987-07-01 00:00:00
abstract：:GAP-43 is a neuronal protein whose synthesis is elevated during developmental and regenerative axon growth. We propose that one consequence of this increased synthesis may be the delivery of calmodulin-like proteins to the distal portions of the growing axon at an increased velocity; this is because calmodulin, which ...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/0014-4886(92)90243-j
更新日期：1992-01-01 00:00:00
abstract：:Electrical stimulation of the midbrain tegmentum can produce differential modulation of quiet biting attack and affective defense behavior elicited from the hypothalamus of the cat. Stimulation of the lateral half of the tegmentum facilitated quiet biting attack and suppressed affective defense. Conversely, stimulatio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(84)90112-2
更新日期：1984-02-01 00:00:00
abstract：:The strength of contractures, produced by 15 to 146 mM [K]0 (as L-glutamate), was measured in isolated small bundles of muscle fibers from the fast-twitch extensor digitorum longus and from the slow-twitch soleus of normal and dystrophic (C57 BL/6J dy2J/dy2J) mice. The analysis of the relation between the maximal ampl...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90179-7
更新日期：1985-03-01 00:00:00
abstract：:The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation a...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7967
更新日期：2002-08-01 00:00:00
abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7408
更新日期：2000-07-01 00:00:00
abstract：:Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90229-3
更新日期：1986-12-01 00:00:00
abstract：:We have previously shown that lesions of the sensorimotor cortex induced by either thermocoagulation or aspiration produce different effects on axonal plasticity. We have now investigated whether these methods of lesion also influence the behavioral outcome. The behavioral effects of unilateral and bilateral lesions o...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6893
更新日期：1998-11-01 00:00:00
abstract：:Infusions of an excitant amino acid, N-methyl-D-aspartate (NMDA) into the inferior colliculus (IC) render normal rats susceptible to audiogenic seizures (AGS) and/or spontaneous audiogenic-like seizures without tonic components. The excess excitant amino acid in the IC and the anticonvulsant effects of NMDA antagonist...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90070-s
更新日期：1991-05-01 00:00:00
abstract：:Several independent lines of research suggest that disruption of the ubiquitin proteasome system (UPS) may play a role in the pathophysiology of Parkinson's disease. Direct intracerebral injection of UPS inhibitors (e.g. lactacystin) in animals has consistently produced important features of the disease. In this study...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.03.021
更新日期：2013-09-01 00:00:00
abstract：:Ca2+ influx through NMDA receptor-gated channels and the subsequent rise in intracellular Ca2+ concentration ([Ca2+]i) have been implicated in cytotoxic processes that lead to irreversible neuronal injury. While many studies have focused on cytosolic Ca2+ homeostasis, much less is known about Ca2+ fluxes in subcellula...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6599
更新日期：1998-01-01 00:00:00
abstract：:Three-day-old rats received an infusion of a small dose of 6-hydroxydopamine (6-OHDA) (12 micrograms) directly into the locus ceruleus nuclei, in order to induce a subtotal lesion of the noradrenergic system. Significant modifications in cerebellum maturation were observed, mainly a regression failure in the perisomat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90120-7
更新日期：1985-04-01 00:00:00
abstract：:Transplantation of stem cells and immature cells has been reported to ameliorate tissue damage, induce axonal regeneration, and improve locomotion following spinal cord injury. However, unless these cells are pushed down a neuronal lineage, the majority of cells become glia, suggesting that the alterations observed ma...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.043
更新日期：2004-12-01 00:00:00
abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6509
更新日期：1997-07-01 00:00:00
abstract：:An electron microscope study of 2- and 8-week-old normal and dystrophic chickens compared sarcomere lengths in relaxed and passively extended Patagialis (PAT) muscles. Sarcomeres were measured in dystrophic muscles only in fibers which exhibited no morphological signs of degeneration. Sarcomere lengths were not differ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90005-2
更新日期：1988-08-01 00:00:00
abstract：:In recent years, it has become evident that Parkinson's disease is associated with a self-sustaining cycle of neuroinflammation and neurodegeneration, with dying neurons activating microglia, which, once activated, can release several factors that kill further neurons. One emerging pharmacological target that has the ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2016.06.014
更新日期：2016-09-01 00:00:00
abstract：:The alpha-secretase-derived form of the amyloid precursor protein (sAPPalpha), which is released from neurons in an activity-dependent manner, has been shown to promote long-term survival of hippocampal and cortical neurons in culture and can protect those neurons against excitotoxic and ischemic injury in culture and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7920
更新日期：2002-06-01 00:00:00
abstract：:Mechanisms underlying affective and cognitive deficits in Parkinson's disease (PD) remain less studied than motor symptoms. Nucleus accumbens (NAc) is affected in PD and due to its well-known involvement in motivation is an interesting target in this context. Furthermore, PD is frequently asymmetrical, with side-speci...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113221
更新日期：2020-05-01 00:00:00
abstract：:Downregulation in the astroglial glutamate transporter EAAT2 in amyotrophic lateral sclerosis (ALS) patients and mutant SOD1 mouse models of ALS is believed to contribute to the death of motor neurons by excitotoxicity. We previously reported that caspase-3 cleaves EAAT2 at a unique cleavage consensus site located in ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.03.014
更新日期：2017-06-01 00:00:00
abstract：:The antinociceptive properties of a new synthetic dipeptide (N-hexanoyl-5-hydroxytryptophyl-5-hydroxytryptophan amide, or 5-HTP-DP-hex) were studied in rats by an electrophysiological method. After an i.p. injection of alpha-chloralose and urethane, the animals were prepared for stereotaxic approach to the nucleus ven...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90214-7
更新日期：1987-06-01 00:00:00
abstract：:Axonal injury close to cell bodies of motoneurons induces the death of the vast majority of affected cells. Neurotrophic factors, such as brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF), delivered close to the damaged motor pool in a non-regulated manner induce good survival ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.05.019
更新日期：2014-11-01 00:00:00
abstract：:In previous studies on sensory axons we reported that the effect of a conditioning lesion on increasing regeneration rate was enhanced if the two lesions were superimposed, rather than made at separate sites on the nerve, and proposed that this was due to the growth of axons through nerve predegenerated by the conditi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90027-5
更新日期：1985-11-01 00:00:00
abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90169-6
更新日期：1989-07-01 00:00:00
abstract：:Wnt5b, a member of Wnt family, plays multiple roles in tumor progression and metastasis. However, whether Wnt5b contributes to the sensitization of dorsal root ganglia (DRG) neurons and pathogenesis of bone cancer pain still remains unclear. Here, we found that the protein expression of Wnt5b and its atypical tyrosine...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113482
更新日期：2020-12-01 00:00:00
abstract：:Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimu...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.08.004
更新日期：2017-11-01 00:00:00
abstract：:Antegrade, target-directed axonal regeneration is the explicit goal of nerve repair. However, aberrant and dysfunctional regrowth is commonly observed as well. At the site of surgical nerve coaptation, axonal sprouts encounter fibrotic connective tissue rich in growth-inhibiting chondroitin sulfate proteoglycan that m...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.004
更新日期：2007-01-01 00:00:00
abstract：:The anticonvulsant long-term efficacy of diazepam was studied in amygdala-kindled rats. The drug was administered three times daily at doses of 5 mg/kg i.p. for 2 weeks in fully kindled animals. The severity of the kindled seizures was markedly reduced throughout the period of treatment, while tolerance developed to t...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90026-3
更新日期：1985-11-01 00:00:00
abstract：:The role of interferon-gamma (IFN-gamma) in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) is still controversial. We have studied the function of IFN-gamma and its receptor in the EAE model using two different IFN-gamma receptor knockout (IFN-gamma R(-/-)) mouse types: C57B...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7815
更新日期：2001-12-01 00:00:00
abstract：:The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat primary cortical neuronal cultures was compared with the apoptotic death induced by staurosporine and the necrotic death induced by glutamate. Both SIN-1 and Cu...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7322
更新日期：2000-03-01 00:00:00
abstract：:Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2015.05.013
更新日期：2015-12-01 00:00:00
