Influence of a serotonin receptor antagonist, 5-HTP-DP-hex, on spinal and thalamic nociceptive neurons in rats.

abstract：:Hemiparkinson-hemiatrophy syndrome (HP-HA) is associated with skeletal hemiatrophy and the later development of parkinsonism. It is generally assumed that this phenotype is due to the combination of dysfunction of the basal ganglia (e.g., substantia nigra compacta and/or other related structures), causing parkinsonism...

journal_title：Experimental neurology

authors： Hebb MO,Lang AE,Fletcher PJ,Chambers JW,Lozano AM

更新日期：2002-10-01 00:00:00

abstract：:Using a measure of nonlinear dynamical changes we term marginal predictability, we report evidence of robust changes in this parameter on scalp EEG in a cohort of patients with medically refractory mesiobasal temporal lobe epilepsy (MBTLE). In the baseline (interictal) state there are distinct differences in this nonl...

journal_title：Experimental neurology

authors： Drury I,Smith B,Li D,Savit R

更新日期：2003-11-01 00:00:00

abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...

journal_title：Experimental neurology

authors： Eckenstein FP,McGovern T,Kern D,Deignan J

更新日期：2006-04-01 00:00:00

abstract：:To determine whether or not brain damage is likely to occur in the repeated apneic episodes experienced by some alcoholics during intoxicated sleep, rats were anesthetized with alcohol and subjected to repeated episodes to asphyxia. Each episode lasted 90 s, arterial PO2 was less than 50 mm Hg for 60 s, and 30 episode...

journal_title：Experimental neurology

authors： Cragg B,Phillips S

更新日期：1984-04-01 00:00:00

abstract：:Amphetamine derivatives are the most commonly abused drugs. These compounds have been known for many years to induce neurotoxicity. However, recent findings have highlighted novel alterations produced by amphetamines in the central nervous system consisting of neuronal inclusions and the involvement of proteins belong...

journal_title：Experimental neurology

authors： Iacovelli L,Fulceri F,De Blasi A,Nicoletti F,Ruggieri S,Fornai F

更新日期：2006-09-01 00:00:00

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:One of the most interesting findings in the field of neurodegeneration in recent years is tfche discovery of a genetic mutation in the C9orf72 gene, the most common mutation found to be causative of sporadic and familial frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS) and concomitant FTD-...

journal_title：Experimental neurology

authors： Bennion Callister J,Pickering-Brown SM

更新日期：2014-12-01 00:00:00

abstract：:Death-associated protein kinase 1 (DAPK1) is a key protein that mediates neuronal death in ischemic stroke. Although the substrates of DAPK1 and molecular signal in stroke have been gradually discovered, the modulation of DAPK1 itself is still unclear. Here we first reveal that Caytaxin, a brain-specific member of BCL...

journal_title：Experimental neurology

authors： Wang S,Chen K,Yu J,Wang X,Li Q,Lv F,Shen H,Pei L

更新日期：2020-07-01 00:00:00

abstract：:The roles of inflammation and degeneration as well as of gray matter abnormalities in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) are controversial. We analyzed the pathological manifestations in two EAE models, the chronic oligodendrocyte glycoprotein (MOG)-induced ver...

journal_title：Experimental neurology

authors： Aharoni R,Sasson E,Blumenfeld-Katzir T,Eilam R,Sela M,Assaf Y,Arnon R

更新日期：2013-02-01 00:00:00

abstract：:Serotonergic neurons were recorded in the nucleus centralis superior (NCS) in freely moving cats and were initially identified on-line by their slow and regular spontaneous activity (mean 2.55 +/- 0.21 spikes/s). Discharge rates of NCS serotonergic neurons were highest during active waking (AW) (mean 2.94 +/- 0.28 spi...

journal_title：Experimental neurology

authors： Rasmussen K,Heym J,Jacobs BL

更新日期：1984-02-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Rationale exists for suspecting that angiotensin (Ang) and arginine vasopressin (AVP) given by the intracerebroventricular (IVT) route can affect cerebrospinal fluid (CSF) pressure. This hypothesis was tested in conscious, unrestrained adult male Sprague-Dawley rats with IVT and left carotid arterial catheters. The ra...

journal_title：Experimental neurology

authors： Barbella YR,Keil LC,Wurpel JN,Severs WB

更新日期：1983-11-01 00:00:00

abstract：:We recently reported structural changes in nodes of Ranvier of frog dorsal roots that are associated with activation at 20 or 50 Hz for 15 min. The structural effects co-occur with alterations in the latency, amplitude, and waveform of the compound action potential. The alterations in nodal morphology include formatio...

journal_title：Experimental neurology

authors： Wurtz CC,Ellisman MH

更新日期：1988-07-01 00:00:00

abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...

journal_title：Experimental neurology

authors： Vucic S,Cheah BC,Kiernan MC

更新日期：2009-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

journal_title：Experimental neurology

authors： Parameshwaran K,Dhanasekaran M,Suppiramaniam V

更新日期：2008-03-01 00:00:00

abstract：:In chronically implanted rats, we examined the respiratory EMG activity of the two parts of the diaphragm, costal and crural, during sleep and wakefulness. Their activity was compared and contrasted with that of the EMG activity of the cricothyroid muscle. Whether in wakefulness, while grooming and drinking, or in non...

journal_title：Experimental neurology

authors： Pollard MJ,Megirian D,Sherrey JH

更新日期：1985-10-01 00:00:00

abstract：:Neonatal stroke is increasingly recognized in preterm and term infants but the ability to study this condition has been limited by the technical challenges in developing suitable animal models. In the current study we report the use of transient filament middle cerebral artery occlusion for 1.5 h in 10-day-old rat pup...

journal_title：Experimental neurology

authors： Ashwal S,Tone B,Tian HR,Chong S,Obenaus A

更新日期：2006-12-01 00:00:00

abstract：:Sciatic cryoneurolysis (SCN) is an experimental rat mononeuropathy model that produces neuropathic behavioral sequelae distinct from other neuropathy models. Following SCN, there is limited autotomy peaking in severity and incidence at 7-14 days and delayed but sustained allodynia appearing at about 21 days, with no e...

journal_title：Experimental neurology

authors： Wagner R,DeLeo JA,Heckman HM,Myers RR

更新日期：1995-06-01 00:00:00

abstract：:We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...

journal_title：Experimental neurology

authors： Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu J

更新日期：2020-12-01 00:00:00

abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...

journal_title：Experimental neurology

authors： Brook GA,Spitzer C,Nacimiento W,Kouchtir-Devanne N,Woodhams PL,Noth J

更新日期：1997-07-01 00:00:00

abstract：:The inferior colliculus was selected as a brain stem site for study of neural grafting and identification of calcium binding proteins. Unilateral ablation sites of eight midbrain inferior colliculus in adult Long-Evans rats were implanted with E17-18 caudal tectum. After 2 to 9 months animals were sacrificed and secti...

journal_title：Experimental neurology

authors： Coleman JR,McDonald AJ,Pinek B,Zrull MC

更新日期：1992-01-01 00:00:00

abstract：:Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and ...

journal_title：Experimental neurology

authors： Sayeed I,Turan N,Stein DG,Wali B

更新日期：2019-02-01 00:00:00

abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

journal_title：Experimental neurology

authors： Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

更新日期：2019-12-01 00:00:00

abstract：:The control of gene expression by miRNAs has been widely investigated in different species and cell types. Following a probabilistic rather than a deterministic regimen, the action of these short nucleotide sequences on specific genes depends on intracellular concentration, which in turn reflects the balance between b...

journal_title：Experimental neurology

authors： Kinjo ER,Higa GS,de Sousa E,Casado OA,Damico MV,Britto LR,Kihara AH

更新日期：2013-10-01 00:00:00

abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

journal_title：Experimental neurology

authors： Lemons ML,Howland DR,Anderson DK

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:Neurofibromatosis type 1 (NF1) is associated with higher rates of epilepsy compared to the general population. Some NF1 patients with epilepsy do not have intracranial lesions, suggesting the genetic mutation itself may contribute to higher rates of epilepsy in these patients. We have recently demonstrated in...

journal_title：Experimental neurology

authors： Sabetghadam A,Wu C,Liu J,Zhang L,Reid AY

更新日期：2020-09-01 00:00:00

abstract：:Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

journal_title：Experimental neurology

authors： Karelina K,Gaier KR,Weil ZM

更新日期：2017-11-01 00:00:00

abstract：:The effects of sex differences and hormonal factors on the locomotor alterations following intrastriatal injections of quinolinic acid (QA) and the ability of fetal striatal transplants to reverse those effects were examined. Male, female, or ovariectomized female rats received bilateral injections of 150 nmol QA or v...

journal_title：Experimental neurology

authors： Emerich DF,Zubricki EM,Shipley MT,Norman AB,Sanberg PR

更新日期：1991-03-01 00:00:00

abstract：:Human spinal cord injury (SCI) can result in progressive degeneration that may continue for many years and lead to the formation of highly septated cystic cavities. This hallmark feature has been reproduced in experimental models, but neither its pathogenesis nor clinically relevant features have been fully elucidated...

journal_title：Experimental neurology

authors： Radojicic M,Reier PJ,Steward O,Keirstead HS

更新日期：2005-12-01 00:00:00

abstract：:Genetic and protein studies have indicated abnormalities in alpha-synuclein in neurodegenerative diseases. However, the developmental localization and cellular role of synuclein isoforms is contentious. We investigated the cellular localization of alpha-, beta-, and gamma-synuclein in developing cultured rat neurons a...

journal_title：Experimental neurology

authors： Quilty MC,Gai WP,Pountney DL,West AK,Vickers JC

更新日期：2003-07-01 00:00:00